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Gene: ENSG00000270885 |
Summary for RASL10B |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000270885 | Gene symbol | RASL10B |
| Gene name | RAS like family 10 member B | |
| HGNC | 30295 | |
| Entrez ID | 91608 | |
| Gene type | protein_coding | |
| Synonyms | RASL10B|VTS58635|RRP17 | |
| UniProtAcc | Q96S79 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for RASL10B |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RASL10B | 2.55e+02 | -1.60e+00 | 4.46e-01 | -3.59e+00 | 3.32e-04 | 1.70e-02 | ACC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RASL10B | 6.45e+02 | 2.08e+00 | 4.71e-01 | 4.41e+00 | 1.01e-05 | 4.01e-05 | LIHC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RASL10B | 3.42e+02 | -1.45e+00 | 1.58e-01 | -9.19e+00 | 3.80e-20 | 1.29e-19 | BRCA |
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Sex-biased somatic mutation for RASL10B |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RASL10B |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg02980604 | chr17:35731414 | CGI:chr17:35731530-35732316 | promoter | 5.69e-01 | 4.65e-01 | 2.06e+00 | 3.93e-02 | 4.57e-02 | 1.04e-01 |
| ACC | cg02980604 | chr17:35731414 | CGI:chr17:35731530-35732316 | promoter | 3.51e-01 | 4.69e-01 | -2.57e+00 | 1.02e-02 | 2.57e-02 | -1.18e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg02980604 | chr17:35731414 | CGI:chr17:35731530-35732316 | promoter | 4.85e-01 | 5.94e-01 | -4.26e+00 | 2.03e-05 | 5.04e-05 | -1.08e-01 |
| LUSC | cg06576742 | chr17:35730187 | CGI:chr17:35731530-35732316 | promoter | 6.89e-01 | 8.37e-01 | -3.17e+00 | 1.50e-03 | 3.42e-03 | -1.48e-01 |
| LUSC | cg02927346 | chr17:35732241 | CGI:chr17:35731530-35732316 | promoter,gene body | 3.35e-01 | 2.05e-01 | 3.01e+00 | 2.61e-03 | 5.06e-03 | 1.30e-01 |
| BLCA | cg03421926 | chr17:35730582 | CGI:chr17:35731530-35732316 | promoter | 7.63e-01 | 8.66e-01 | -4.62e+00 | 3.75e-06 | 6.63e-05 | -1.03e-01 |
| BLCA | cg02927346 | chr17:35732241 | CGI:chr17:35731530-35732316 | promoter,gene body | 3.92e-01 | 2.72e-01 | 2.15e+00 | 3.17e-02 | 3.51e-02 | 1.20e-01 |
| CHOL | cg02927346 | chr17:35732241 | CGI:chr17:35731530-35732316 | promoter,gene body | 5.39e-01 | 4.27e-01 | 2.21e+00 | 2.70e-02 | 3.50e-02 | 1.11e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg02927346 | chr17:35732241 | CGI:chr17:35731530-35732316 | promoter,gene body | 4.05e-01 | 2.15e-01 | 1.04e+01 | 1.55e-25 | 1.39e-24 | 1.90e-01 |
| LIHC | cg02927346 | chr17:35732241 | CGI:chr17:35731530-35732316 | promoter,gene body | 4.45e-01 | 3.29e-01 | 2.61e+00 | 9.06e-03 | 1.29e-02 | 1.16e-01 |
| KIRP | cg02927346 | chr17:35732241 | CGI:chr17:35731530-35732316 | promoter,gene body | 3.18e-01 | 1.93e-01 | 2.09e+00 | 3.67e-02 | 4.03e-02 | 1.25e-01 |
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Exon skipping events with PSI in TCGA for RASL10B |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RASL10B |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RASL10B |
| TFs related to RASL10B. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | SP1 | RASL10B | 3.94e+00 | 9.83e-01 | 3.04e+00 | 3.41e-03 | Male-biased |
| ESCA | ZNF792 | RASL10B | 4.50e+00 | 9.89e-01 | 3.68e+00 | 5.57e-03 | Male-biased |
| RASL10B related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RASL10B |
| RBPs related to ES in RASL10B. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RASL10B related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs67770569 | chr17:34795083:G:C | - | 0.15639354758646 | 0.000213818807424005 | SARC | Female-baised eQTL |
| rs66658256 | chr17:34795163:G:A | - | 0.149432682346855 | 0.00113900474889631 | SARC | Female-baised eQTL |
| rs66524373 | chr17:34795314:G:T | - | 0.149432682346855 | 0.00113900474889631 | SARC | Female-baised eQTL |
| rs12938847 | chr17:34818538:T:C | - | 0.130623373524033 | 0.00285856071969451 | SARC | Female-baised eQTL |
| rs11656105 | chr17:34820525:G:A | - | 0.130623373524033 | 0.00285856071969451 | SARC | Female-baised eQTL |
| rs11651825 | chr17:34820670:A:G | - | 0.130623373524033 | 0.00285856071969451 | SARC | Female-baised eQTL |
| rs11080306 | chr17:34820865:C:A | - | 0.130623373524033 | 0.00285856071969451 | SARC | Female-baised eQTL |
| rs34000583 | chr17:34795729:G:A | - | 0.130564557440721 | 0.00288840246100091 | SARC | Female-baised eQTL |
| rs11080301 | chr17:34785898:T:C | - | 0.138554703866085 | 0.0041541574754573 | SARC | Female-baised eQTL |
| rs11652253 | chr17:34787124:C:T | - | 0.138554703866085 | 0.0041541574754573 | SARC | Female-baised eQTL |
| rs10853173 | chr17:34787550:T:C | - | 0.138554703866085 | 0.0041541574754573 | SARC | Female-baised eQTL |
| rs11080302 | chr17:34788004:A:G | - | 0.138554703866085 | 0.0041541574754573 | SARC | Female-baised eQTL |
| rs11080303 | chr17:34789063:C:T | - | 0.138554703866085 | 0.0041541574754573 | SARC | Female-baised eQTL |
| rs12051759 | chr17:34789914:C:T | - | 0.138554703866085 | 0.0041541574754573 | SARC | Female-baised eQTL |
| rs12604000 | chr17:34792804:G:T | - | 0.130432429231096 | 0.00910648616442432 | SARC | Female-baised eQTL |
| rs11080304 | chr17:34793195:C:T | - | 0.130432429231096 | 0.00910648616442432 | SARC | Female-baised eQTL |
| rs11654328 | chr17:34801695:G:T | - | 0.123845625065684 | 0.0104712476044742 | SARC | Female-baised eQTL |
| rs11655777 | chr17:34802183:C:G | - | 0.123845625065684 | 0.0104712476044742 | SARC | Female-baised eQTL |
| rs11655780 | chr17:34802197:C:T | - | 0.123845625065684 | 0.0104712476044742 | SARC | Female-baised eQTL |
| rs34012495 | chr17:34802531:A:G | - | 0.123514688864415 | 0.0110564012338461 | SARC | Female-baised eQTL |
| rs34457255 | chr17:34805493:A:C | - | 0.123514688864415 | 0.0110564012338461 | SARC | Female-baised eQTL |
| rs714666 | chr17:34830992:A:G | - | 0.110064130687118 | 0.0116503035110199 | SARC | Female-baised eQTL |
| rs11650925 | chr17:34807446:A:G | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs12936984 | chr17:34808408:A:G | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs11657254 | chr17:34811392:T:C | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs56386895 | chr17:34816675:G:A | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs12947180 | chr17:34818303:C:T | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs11654996 | chr17:34819445:C:T | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs11656251 | chr17:34820159:C:T | - | 0.122942839943547 | 0.0117181443419317 | SARC | Female-baised eQTL |
| rs11656880 | chr17:34796018:G:A | - | 0.12174939775151 | 0.0136471361783414 | SARC | Female-baised eQTL |
| rs12603465 | chr17:34829296:T:C | - | 0.109065290157661 | 0.0138207459607326 | SARC | Female-baised eQTL |
| rs1860198 | chr17:34803290:C:T | - | 0.121403459076193 | 0.0143502064218008 | SARC | Female-baised eQTL |
| rs11652634 | chr17:34820081:T:C | - | 0.120871674014634 | 0.0151442357433621 | SARC | Female-baised eQTL |
| rs11080309 | chr17:34833868:A:C | - | 0.103268936330534 | 0.0260945016304257 | SARC | Female-baised eQTL |
| rs4796760 | chr17:42026197:G:A | - | -0.214868093489917 | 0.0117548164534515 | LIHC | Female-baised eQTL |
| rs34549927 | chr17:28203552:T:C | - | 0.107190863489724 | 0.0345982389068704 | LIHC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76277035 | chr17:35824996:T:C | - | 0.119711100835625 | 0.0219859546624132 | PAAD | Male-baised eQTL |
| rs117388283 | chr17:35867890:C:T | - | 0.119711100835625 | 0.0219859546624132 | PAAD | Male-baised eQTL |
| rs59613972 | chr17:31036348:G:A | - | 0.205771190792721 | 0.00816192444044655 | SARC | Male-baised eQTL |
| rs58744622 | chr17:31036376:C:T | - | 0.205771190792721 | 0.00816192444044655 | SARC | Male-baised eQTL |
| rs202008608 | chr17:31038647:C:G | - | 0.205771190792721 | 0.00816192444044655 | SARC | Male-baised eQTL |
| rs10432062 | chr17:36819173:C:T | - | 0.110334770500698 | 0.0127611611502007 | SARC | Male-baised eQTL |
| rs60647055 | chr17:36819404:G:A | - | 0.110334770500698 | 0.0127611611502007 | SARC | Male-baised eQTL |
| rs1553037 | chr17:36830747:T:A | - | 0.0989054297691905 | 0.0348040784966692 | SARC | Male-baised eQTL |
| rs57263207 | chr17:35248033:G:A | - | 0.091893681444686 | 0.045298328257721 | SARC | Male-baised eQTL |
| rs4795000 | chr17:34329264:T:A | - | 0.0832688911737596 | 0.0220686462182869 | LGG | Male-baised eQTL |
| rs114998457 | chr17:34194253:C:A | - | 0.111976943321987 | 0.0445731005476267 | LGG | Male-baised eQTL |
| rs17542175 | chr17:34194865:T:C | - | 0.111976943321987 | 0.0445731005476267 | LGG | Male-baised eQTL |
| rs77198702 | chr17:34196307:C:A | - | 0.111976943321987 | 0.0445731005476267 | LGG | Male-baised eQTL |
| rs78082508 | chr17:34196758:C:T | - | 0.111976943321987 | 0.0445731005476267 | LGG | Male-baised eQTL |
| rs12150027 | chr17:34344163:G:A | - | 0.0793868564036412 | 0.0466057112193514 | LGG | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000270885 |
| CpG Site: cg23451251 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.467775434580068 | |
 | Gene ID: ENSG00000270885 |
| CpG Site: cg17757575 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.427922734862964 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23451251 | chr17:35735554 | gene,enhancer | -0.467775434580068 | 5.92593887163758e-14 | -0.4904215961215443 | 7.761714685463627e-17 | LUAD |
| cg17757575 | chr17:35741872 | gene,exon,UTR | -0.427922734862964 | 7.21684248537791e-11 | -0.4306662093991949 | 6.139649082047863e-13 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RASL10B |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000270885 | RASL10B | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| ENSG00000270885 | RASL10B | C1136382 | Sclerocystic Ovaries | 1 | CTD_human |
