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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000263639

Summary for MSMB

check button Gene summary

Gene informationEnsembl ID

ENSG00000263639

Gene symbol

MSMB

Gene namemicroseminoprotein beta
HGNC

7372

Entrez ID

4477

Gene typeprotein_coding
SynonymsMSMB|PSP-94|PSP57|PSP94|IGBF|MSP|MSPB|PN44|PRPS|PSP
UniProtAcc

P08118


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for MSMB

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MSMB1.38e+032.59e+008.75e-012.95e+003.13e-032.55e-02BRCA
MSMB2.32e+021.11e+002.55e-014.36e+001.28e-053.08e-04HNSC
MSMB3.64e+002.78e+005.53e-015.02e+005.14e-073.06e-05SARC

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MSMB8.58e+02-1.30e+005.80e-01-2.20e+002.80e-024.60e-02HNSC
MSMB1.53e+011.60e+004.86e-013.29e+001.02e-032.55e-03LIHC

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
MSMB4.25e+022.95e+002.49e-011.19e+012.07e-321.15e-31BRCA

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Sex-biased somatic mutation for MSMB

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for MSMB

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg23975355chr10:46047738CGI:chr10:46030173-46030750promoter8.39e-015.79e-013.94e+008.20e-051.42e-032.61e-01
BRCAcg27607126chr10:46046926CGI:chr10:46030173-46030750promoter7.22e-015.26e-012.98e+002.91e-031.63e-021.96e-01
BRCAcg17030820chr10:46046561CGI:chr10:46030173-46030750promoter8.71e-016.96e-013.28e+001.04e-039.62e-031.75e-01
LUADcg10326726chr10:46046316CGI:chr10:46030173-46030750promoter5.49e-014.35e-014.22e+002.47e-051.68e-041.13e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg10326726chr10:46046316CGI:chr10:46030173-46030750promoter4.35e-018.23e-01-3.68e+002.29e-045.63e-04-3.88e-01
LUADcg27607126chr10:46046926CGI:chr10:46030173-46030750promoter7.25e-018.41e-01-3.78e+001.55e-044.06e-04-1.16e-01
LUADcg17030820chr10:46046561CGI:chr10:46030173-46030750promoter6.61e-018.79e-01-4.36e+001.27e-055.11e-05-2.18e-01
LUADcg12083644chr10:46046165CGI:chr10:46030173-46030750promoter,gene body7.87e-019.33e-01-3.11e+001.84e-033.24e-03-1.47e-01
HNSCcg27607126chr10:46046926CGI:chr10:46030173-46030750promoter7.32e-018.52e-01-4.87e+001.13e-066.40e-06-1.20e-01
LUSCcg21033494chr10:46045707CGI:chr10:46030173-46030750promoter,gene body7.84e-018.88e-01-2.66e+007.89e-031.15e-02-1.04e-01
COADcg10326726chr10:46046316CGI:chr10:46030173-46030750promoter2.87e-016.46e-01-3.92e+008.94e-053.21e-04-3.59e-01
BLCAcg10326726chr10:46046316CGI:chr10:46030173-46030750promoter2.76e-014.69e-01-2.27e+002.34e-022.77e-02-1.93e-01
BLCAcg21033494chr10:46045707CGI:chr10:46030173-46030750promoter,gene body7.27e-018.84e-01-3.38e+007.23e-041.77e-03-1.56e-01
LIHCcg27607126chr10:46046926CGI:chr10:46030173-46030750promoter7.66e-018.67e-01-5.70e+001.23e-089.39e-08-1.00e-01
LIHCcg21033494chr10:46045707CGI:chr10:46030173-46030750promoter,gene body7.98e-019.06e-01-4.04e+005.29e-051.18e-04-1.07e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg27607126chr10:46046926CGI:chr10:46030173-46030750promoter7.22e-018.48e-01-9.04e+001.53e-197.98e-19-1.26e-01
HNSCcg10326726chr10:46046316CGI:chr10:46030173-46030750promoter7.88e-019.27e-01-2.09e+003.64e-024.02e-02-1.39e-01
COADcg27607126chr10:46046926CGI:chr10:46030173-46030750promoter7.21e-018.36e-01-2.26e+002.40e-022.97e-02-1.15e-01
BLCAcg12083644chr10:46046165CGI:chr10:46030173-46030750promoter,gene body7.36e-018.86e-01-2.22e+002.61e-023.23e-02-1.50e-01

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Exon skipping events with PSI in TCGA for MSMB

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for MSMB

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for MSMB

check buttonTFs related to MSMB.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
BRCAASCL1MSMB3.19e+008.12e-034.46e+009.81e-01Female-biased
BRCAPATZ1MSMB3.12e+002.82e-034.73e+009.91e-01Female-biased
BRCATCF12MSMB3.14e+006.22e-034.49e+009.84e-01Female-biased
BRCATCF3MSMB3.25e+003.49e-034.81e+009.91e-01Female-biased
BRCAZIC5MSMB3.77e+001.35e-024.89e+009.81e-01Female-biased
BRCAZNF300MSMB3.10e+005.27e-034.52e+009.85e-01Female-biased
BRCAZNF331MSMB3.20e+002.77e-034.82e+009.92e-01Female-biased
BRCAZNF793MSMB3.55e+009.34e-034.79e+009.85e-01Female-biased
BRCAZNF860MSMB3.09e+003.84e-034.61e+009.88e-01Female-biased
CHOLZNF331MSMB2.64e+002.85e-033.87e+009.82e-01Female-biased
ESCAZNF660MSMB4.24e+009.80e-013.54e+001.13e-02Male-biased
PAADPDX1MSMB4.62e+001.34e-025.37e+009.85e-01Female-biased
PAADSOX6MSMB4.06e+001.09e-024.85e+009.86e-01Female-biased

check buttonMSMB related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for MSMB

check buttonRBPs related to ES in MSMB.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonMSMB related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs75374708chr10:53007965:C:A-0.09963991610590710.0185808766509967HNSCFemale-baised eQTL
rs145418530chr10:37049130:G:A-0.1269032690361110.0351194855765342HNSCFemale-baised eQTL
rs11003368chr10:53077420:T:C-0.1232242572541060.00351578502554924LIHCFemale-baised eQTL
rs12767906chr10:53077558:A:G-0.1232242572541060.00351578502554924LIHCFemale-baised eQTL
rs11003370chr10:53078122:T:A-0.1232242572541060.00351578502554924LIHCFemale-baised eQTL
rs80054115chr10:51958030:T:A-0.1096964667835590.014277537869308LIHCFemale-baised eQTL
rs10508951chr10:51967704:G:T-0.1097506045923930.0143230211721294LIHCFemale-baised eQTL
rs80117039chr10:51959035:C:T-0.1096658673942930.0144990720984473LIHCFemale-baised eQTL
rs75884457chr10:51965887:C:T-0.1096836510702920.0147772274381998LIHCFemale-baised eQTL
rs74586695chr10:51965913:G:A-0.1041267933139950.0245090510306641LIHCFemale-baised eQTL
rs74132820chr10:51933857:A:C-0.1030967355848090.0288008639121931LIHCFemale-baised eQTL
rs114500910chr10:51957453:G:A-0.09908317831637360.0363916383286719LIHCFemale-baised eQTL
rs79764379chr10:36248786:C:T-0.1010431378513610.037876962999722LIHCFemale-baised eQTL
rs79343325chr10:51962574:C:T-0.09905022210942110.0381277412251312LIHCFemale-baised eQTL
rs11003369chr10:53077818:C:T-0.09352574928172710.0491853816533538LIHCFemale-baised eQTL
rs80296314chr10:51975590:G:C-0.1119572931076440.0130112975851681LUSCFemale-baised eQTL
rs1904044chr10:51980502:G:A-0.1119572931076440.0130112975851681LUSCFemale-baised eQTL
rs60914779chr10:44135745:C:A-0.1372437272179840.0135801302872988LUSCFemale-baised eQTL
rs4565852chr10:50947713:T:C-0.1179065716335140.018474398707287LUSCFemale-baised eQTL
rs16905780chr10:54217158:T:A-0.1283703310201220.0203922645424801LUSCFemale-baised eQTL
rs142317614chr10:54219566:T:C-0.1283703310201220.0203922645424801LUSCFemale-baised eQTL
rs4275567chr10:51998529:A:C-0.1016411362616150.0222051572130042LUSCFemale-baised eQTL
rs79380677chr10:37080070:G:T-0.1886864870345990.00411395204034392STADFemale-baised eQTL
rs7894252chr10:37087060:T:C-0.1776271545817910.00806166534373397STADFemale-baised eQTL
rs78131676chr10:37091193:A:G-0.1776271545817910.00806166534373397STADFemale-baised eQTL
rs143153175chr10:37099073:A:T-0.1776271545817910.00806166534373397STADFemale-baised eQTL
rs149171158chr10:37099856:T:C-0.1776271545817910.00806166534373397STADFemale-baised eQTL
rs7918642chr10:43843209:A:G-0.1468369091105910.0332211327267447STADFemale-baised eQTL
rs912801chr10:43963906:C:T-0.2167614929141824.66770984506995e-05BLCAFemale-baised eQTL
rs58297052chr10:43969908:G:A-0.2167614929141824.66770984506995e-05BLCAFemale-baised eQTL
rs1408941chr10:43956392:G:T-0.2164641221648865.0458348730769e-05BLCAFemale-baised eQTL
rs78621342chr10:43960213:C:A-0.2164641221648865.0458348730769e-05BLCAFemale-baised eQTL
rs12570158chr10:43972072:C:T-0.1971653652903780.00028208694310361BLCAFemale-baised eQTL
rs4948796chr10:43967129:C:T-0.1814809712371040.00101146298716263BLCAFemale-baised eQTL
rs11000634chr10:52058737:G:A-0.236699003106330.00679150383915453BLCAFemale-baised eQTL
rs10900239chr10:42495395:C:G-0.2158182876830220.0356882586412673BLCAFemale-baised eQTL
rs2016678chr10:42558912:C:T-0.2158182876830220.0356882586412673BLCAFemale-baised eQTL
rs10900248chr10:42564224:T:C-0.2158182876830220.0356882586412673BLCAFemale-baised eQTL
rs12219326chr10:42565149:G:A-0.2158182876830220.0356882586412673BLCAFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs755120chr10:47091849:A:G-0.1644096595367790.011402309307163PAADMale-baised eQTL
rs786822chr10:47093223:A:G-0.1644096595367790.011402309307163PAADMale-baised eQTL
rs72792211chr10:47094148:C:A-0.1644096595367790.011402309307163PAADMale-baised eQTL
rs709624chr10:47080725:T:C-0.151019209531830.0275377139130219PAADMale-baised eQTL
rs786787chr10:47082777:G:C-0.151019209531830.0275377139130219PAADMale-baised eQTL
rs813092chr10:47086246:A:T-0.151019209531830.0275377139130219PAADMale-baised eQTL
rs34350875chr10:55891235:T:G-0.04525912973360760.0373060873346239LIHCMale-baised eQTL
rs12773955chr10:55913284:T:G-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs11005109chr10:55913532:G:A-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs11005110chr10:55915821:A:G-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs11005112chr10:55917967:T:C-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs11005113chr10:55921377:T:C-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs12098453chr10:55922115:C:A-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs11005114chr10:55922363:G:A-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs34517594chr10:55923684:A:G-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs12777762chr10:55924028:C:A-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs12782822chr10:55924133:C:T-0.04247379803505420.0430080426911431LIHCMale-baised eQTL
rs2066057chr10:55925124:A:G-0.04245485159627370.0436605989842482LIHCMale-baised eQTL
rs71492672chr10:55917283:G:A-0.04171926678944390.0487459141539157LIHCMale-baised eQTL
rs72785049chr10:49104531:G:A-0.05714597363509620.0151017161919801BLCAMale-baised eQTL
rs61848419chr10:49111920:T:G-0.05709613266024160.0152389025170602BLCAMale-baised eQTL
rs17011698chr10:49048898:G:C-0.06026040008794020.0178949536490968BLCAMale-baised eQTL
rs57328384chr10:49051023:G:T-0.06023491198675430.0180225914331606BLCAMale-baised eQTL
rs7097429chr10:45397960:C:G-0.07673261836334930.00148540552857007LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000263639
CpG Site: cg17030820
Position to Gene: promoter
Male Effect: -0.157674022788071
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000263639
CpG Site: cg12083644
Position to Gene: gene,promoter
Male Effect: -0.250827966212425
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg17030820chr10:46046561promoter-0.1576740227880719.85453639711947e-05-0.47324212166028898.60729459886272e-07PAAD
cg12083644chr10:46046165gene,promoter-0.2508279662124251.59798825524546e-19-0.61577308345837511.1473088231016212e-24LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of MSMB

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000263639MSMBC0033578Prostatic Neoplasms3CTD_human
ENSG00000263639MSMBC0376358Malignant neoplasm of prostate3CTD_human
ENSG00000263639MSMBC2677821Prostate Cancer, Hereditary, 131CTD_human