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Gene: ENSG00000262406 |
Summary for MMP12 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000262406 | Gene symbol | MMP12 |
| Gene name | matrix metallopeptidase 12 | |
| HGNC | 7158 | |
| Entrez ID | 4321 | |
| Gene type | protein_coding | |
| Synonyms | MMP12|HME | |
| UniProtAcc | P39900 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000262406 | MMP12 | DB00551 | Acetohydroxamic acid | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB00786 | Marimastat | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB02118 | CP-271485 | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB03367 | PF-00356231 | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB03880 | Batimastat | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB04405 | 2-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4'-Ethoxy-1,1'-Biphenyl-4-Yl)-4-Oxobutanoic Acid | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB05387 | AE-941 | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07026 | (1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDE | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07446 | N-(biphenyl-4-ylsulfonyl)-D-leucine | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07556 | CGS-27023 | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07683 | N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valine | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07920 | N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamide | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07921 | 2-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamide | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB07922 | N-oxo-2-(phenylsulfonylamino)ethanamide | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB08271 | N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID | SmallMoleculeDrug |
| ENSG00000262406 | MMP12 | DB08599 | N-[(4-methoxyphenyl)sulfonyl]-D-alanine | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for MMP12 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MMP12 | 3.97e+02 | -1.83e+00 | 6.89e-01 | -2.65e+00 | 8.06e-03 | 4.97e-02 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MMP12 | 1.22e+02 | 2.58e+00 | 6.22e-01 | 4.14e+00 | 3.43e-05 | 1.36e-04 | THCA |
| MMP12 | 1.81e+03 | 3.17e+00 | 7.71e-01 | 4.11e+00 | 3.93e-05 | 1.98e-04 | BLCA |
| MMP12 | 3.90e+03 | 3.74e+00 | 6.60e-01 | 5.67e+00 | 1.46e-08 | 7.52e-07 | ESCA |
| MMP12 | 1.13e+02 | 5.02e+00 | 1.11e+00 | 4.52e+00 | 6.31e-06 | 3.73e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MMP12 | 3.87e+02 | 2.74e+00 | 2.33e-01 | 1.17e+01 | 8.09e-32 | 4.41e-31 | BRCA |
| MMP12 | 1.43e+03 | 1.38e+00 | 4.84e-01 | 2.84e+00 | 4.45e-03 | 1.25e-02 | READ |
Top |
Sex-biased somatic mutation for MMP12 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MMP12 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg02368591 | chr11:102875635 | CGI:chr11:103091545-103092320 | promoter | 5.92e-01 | 7.46e-01 | -2.77e+00 | 5.60e-03 | 2.13e-02 | -1.53e-01 |
| DLBC | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 5.49e-01 | 6.80e-01 | -2.30e+00 | 2.16e-02 | 3.65e-02 | -1.31e-01 |
| DLBC | cg09002726 | chr11:102875204 | CGI:chr11:103091545-103092320 | promoter | 3.01e-01 | 4.09e-01 | -2.05e+00 | 4.05e-02 | 4.68e-02 | -1.08e-01 |
| CHOL | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 3.25e-01 | 4.71e-01 | -2.48e+00 | 1.30e-02 | 2.54e-02 | -1.46e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 7.08e-01 | 8.36e-01 | -2.92e+00 | 3.46e-03 | 5.51e-03 | -1.28e-01 |
| HNSC | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 4.87e-01 | 6.95e-01 | -3.31e+00 | 9.26e-04 | 1.70e-03 | -2.08e-01 |
| HNSC | cg09002726 | chr11:102875204 | CGI:chr11:103091545-103092320 | promoter | 7.37e-01 | 8.63e-01 | -3.47e+00 | 5.27e-04 | 1.05e-03 | -1.26e-01 |
| LUSC | cg20487452 | chr11:102874952 | CGI:chr11:103091545-103092320 | UTR,promoter,exon,gene body | 6.65e-01 | 8.60e-01 | -2.21e+00 | 2.72e-02 | 3.05e-02 | -1.95e-01 |
| LUSC | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 5.73e-01 | 8.55e-01 | -3.24e+00 | 1.21e-03 | 2.96e-03 | -2.82e-01 |
| BLCA | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 3.40e-01 | 6.23e-01 | -2.77e+00 | 5.61e-03 | 8.92e-03 | -2.84e-01 |
| BLCA | cg09002726 | chr11:102875204 | CGI:chr11:103091545-103092320 | promoter | 5.29e-01 | 7.27e-01 | -2.29e+00 | 2.19e-02 | 2.62e-02 | -1.97e-01 |
| LIHC | cg19304432 | chr11:102873769 | CGI:chr11:103091545-103092320 | promoter,gene body | 6.87e-01 | 8.94e-01 | -3.60e+00 | 3.15e-04 | 5.69e-04 | -2.07e-01 |
| LIHC | cg02368591 | chr11:102875635 | CGI:chr11:103091545-103092320 | promoter | 4.10e-01 | 5.83e-01 | -2.87e+00 | 4.08e-03 | 5.51e-03 | -1.74e-01 |
| CHOL | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 4.71e-01 | 6.84e-01 | -2.80e+00 | 5.09e-03 | 1.63e-02 | -2.14e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg23979520 | chr11:102875124 | CGI:chr11:103091545-103092320 | promoter | 5.05e-01 | 7.34e-01 | -5.22e+00 | 1.83e-07 | 3.65e-07 | -2.29e-01 |
Top |
Exon skipping events with PSI in TCGA for MMP12 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for MMP12 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for MMP12 |
| TFs related to MMP12. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF418 | MMP12 | 6.13e+00 | 9.85e-01 | 5.40e+00 | 1.40e-02 | Male-biased |
| BLCA | ZNF22 | MMP12 | 4.17e+00 | 1.49e-02 | 4.93e+00 | 9.81e-01 | Female-biased |
| BLCA | ZNF235 | MMP12 | 3.36e+00 | 6.39e-03 | 4.31e+00 | 9.83e-01 | Female-biased |
| BLCA | ZNF287 | MMP12 | 3.53e+00 | 9.57e-03 | 4.40e+00 | 9.81e-01 | Female-biased |
| BLCA | ZNF418 | MMP12 | 5.26e+00 | 8.67e-03 | 6.15e+00 | 9.91e-01 | Female-biased |
| DLBC | ZNF418 | MMP12 | 5.42e+00 | 1.21e-02 | 6.27e+00 | 9.87e-01 | Female-biased |
| GBM | NEUROD2 | MMP12 | 5.83e+00 | 3.67e-03 | 7.31e+00 | 9.96e-01 | Female-biased |
| GBM | ZNF22 | MMP12 | 6.27e+00 | 9.95e-01 | 4.89e+00 | 4.50e-03 | Male-biased |
| GBM | ZNF225 | MMP12 | 6.42e+00 | 9.94e-01 | 5.12e+00 | 5.65e-03 | Male-biased |
| GBM | ZNF235 | MMP12 | 6.19e+00 | 9.99e-01 | 4.25e+00 | 6.83e-04 | Male-biased |
| GBM | ZNF287 | MMP12 | 6.02e+00 | 9.98e-01 | 4.31e+00 | 1.52e-03 | Male-biased |
| GBM | ZNF418 | MMP12 | 7.16e+00 | 9.98e-01 | 5.40e+00 | 1.31e-03 | Male-biased |
| MESO | ZNF418 | MMP12 | 6.00e+00 | 9.82e-01 | 4.96e+00 | 1.76e-02 | Male-biased |
| PAAD | ZNF418 | MMP12 | 6.63e+00 | 9.91e-01 | 5.77e+00 | 8.63e-03 | Male-biased |
| PCPG | FOXQ1 | MMP12 | 7.85e+00 | 9.97e-01 | 6.74e+00 | 2.53e-03 | Male-biased |
| PCPG | ZIM3 | MMP12 | 7.28e+00 | 9.95e-01 | 6.32e+00 | 5.11e-03 | Male-biased |
| PCPG | ZNF22 | MMP12 | 5.54e+00 | 9.80e-01 | 4.86e+00 | 1.81e-02 | Male-biased |
| PCPG | ZNF225 | MMP12 | 5.86e+00 | 9.94e-01 | 4.88e+00 | 4.68e-03 | Male-biased |
| PCPG | ZNF235 | MMP12 | 5.13e+00 | 9.89e-01 | 4.29e+00 | 8.80e-03 | Male-biased |
| PCPG | ZNF287 | MMP12 | 5.11e+00 | 9.87e-01 | 4.31e+00 | 1.03e-02 | Male-biased |
| PCPG | ZNF384 | MMP12 | 5.78e+00 | 9.82e-01 | 5.08e+00 | 1.66e-02 | Male-biased |
| PCPG | ZNF418 | MMP12 | 6.89e+00 | 1.00e+00 | 4.95e+00 | 3.51e-05 | Male-biased |
| PCPG | ZNF613 | MMP12 | 5.92e+00 | 9.81e-01 | 5.25e+00 | 1.84e-02 | Male-biased |
| READ | ZNF418 | MMP12 | 4.01e+00 | 8.57e-03 | 4.88e+00 | 9.88e-01 | Female-biased |
| SKCM | FOXQ1 | MMP12 | 7.06e+00 | 9.04e-03 | 8.08e+00 | 9.91e-01 | Female-biased |
| SKCM | ZIM3 | MMP12 | 6.67e+00 | 8.26e-03 | 7.72e+00 | 9.92e-01 | Female-biased |
| SKCM | ZNF22 | MMP12 | 5.41e+00 | 1.30e-02 | 6.31e+00 | 9.86e-01 | Female-biased |
| SKCM | ZNF225 | MMP12 | 5.53e+00 | 6.71e-03 | 6.65e+00 | 9.93e-01 | Female-biased |
| SKCM | ZNF235 | MMP12 | 5.08e+00 | 1.25e-02 | 5.99e+00 | 9.86e-01 | Female-biased |
| SKCM | ZNF287 | MMP12 | 5.04e+00 | 1.46e-02 | 5.90e+00 | 9.84e-01 | Female-biased |
| SKCM | ZNF384 | MMP12 | 5.61e+00 | 1.07e-02 | 6.57e+00 | 9.89e-01 | Female-biased |
| SKCM | ZNF418 | MMP12 | 5.82e+00 | 7.70e-04 | 7.60e+00 | 9.99e-01 | Female-biased |
| SKCM | ZNF613 | MMP12 | 5.77e+00 | 1.08e-02 | 6.73e+00 | 9.89e-01 | Female-biased |
| THYM | ZNF22 | MMP12 | 6.72e+00 | 9.83e-01 | 6.16e+00 | 1.70e-02 | Male-biased |
| THYM | ZNF225 | MMP12 | 6.99e+00 | 9.82e-01 | 6.44e+00 | 1.79e-02 | Male-biased |
| THYM | ZNF235 | MMP12 | 6.54e+00 | 9.80e-01 | 6.01e+00 | 1.93e-02 | Male-biased |
| THYM | ZNF418 | MMP12 | 7.71e+00 | 9.91e-01 | 7.01e+00 | 9.07e-03 | Male-biased |
| UVM | FOXQ1 | MMP12 | 7.21e+00 | 1.86e-02 | 8.21e+00 | 9.81e-01 | Female-biased |
| UVM | ZNF225 | MMP12 | 6.06e+00 | 1.60e-02 | 7.14e+00 | 9.84e-01 | Female-biased |
| UVM | ZNF235 | MMP12 | 5.54e+00 | 1.50e-02 | 6.65e+00 | 9.84e-01 | Female-biased |
| UVM | ZNF418 | MMP12 | 6.42e+00 | 3.74e-03 | 8.24e+00 | 9.96e-01 | Female-biased |
| MMP12 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for MMP12 |
| RBPs related to ES in MMP12. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MMP12 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76735498 | chr11:104768680:G:T | - | 0.185627262792822 | 0.0142182217636183 | LIHC | Female-baised eQTL |
| rs78436240 | chr11:104768733:A:G | - | 0.185627262792822 | 0.0142182217636183 | LIHC | Female-baised eQTL |
| rs1944908 | chr11:104918235:A:C | - | 0.119986916267065 | 0.0187646705271727 | LIHC | Female-baised eQTL |
| rs7105346 | chr11:104922666:C:T | - | 0.119986916267065 | 0.0187646705271727 | LIHC | Female-baised eQTL |
| rs114907780 | chr11:104929638:T:C | - | 0.119986916267065 | 0.0187646705271727 | LIHC | Female-baised eQTL |
| rs111296179 | chr11:104929786:C:G | - | 0.119986916267065 | 0.0187646705271727 | LIHC | Female-baised eQTL |
| rs73520263 | chr11:95534311:G:A | - | 0.159812679443279 | 0.0197082023467406 | LIHC | Female-baised eQTL |
| rs12805982 | chr11:95531527:C:T | - | 0.146281615024065 | 0.042397309470101 | LIHC | Female-baised eQTL |
| rs34427564 | chr11:95532990:C:G | - | 0.146281615024065 | 0.042397309470101 | LIHC | Female-baised eQTL |
| rs1893151 | chr11:99137347:G:C | - | 0.143868458874769 | 0.0146806637042966 | BLCA | Female-baised eQTL |
| rs59260299 | chr11:99136142:T:C | - | 0.139873727145266 | 0.0205882029235399 | BLCA | Female-baised eQTL |
| rs4282949 | chr11:99136454:A:G | - | 0.139873727145266 | 0.0205882029235399 | BLCA | Female-baised eQTL |
| rs56082009 | chr11:99139055:A:T | - | 0.139873727145266 | 0.0205882029235399 | BLCA | Female-baised eQTL |
| rs57301838 | chr11:99127989:G:C | - | 0.134670313591003 | 0.0261879700893835 | BLCA | Female-baised eQTL |
| rs57826929 | chr11:99129454:G:A | - | 0.131244574209566 | 0.0338137921226648 | BLCA | Female-baised eQTL |
| rs61893379 | chr11:99128338:G:C | - | 0.131005546576855 | 0.0352480279760137 | BLCA | Female-baised eQTL |
| rs56804461 | chr11:99130982:G:T | - | 0.129517470667594 | 0.0367549076140892 | BLCA | Female-baised eQTL |
| rs61893413 | chr11:99132157:T:C | - | 0.129517470667594 | 0.0367549076140892 | BLCA | Female-baised eQTL |
| rs61893415 | chr11:99132993:C:T | - | 0.129517470667594 | 0.0367549076140892 | BLCA | Female-baised eQTL |
| rs12794588 | chr11:93930363:T:C | - | 0.060903170620995 | 0.00189720101715325 | LUAD | Female-baised eQTL |
| rs34451374 | chr11:93917409:G:T | - | 0.0601033748460812 | 0.00199053077723606 | LUAD | Female-baised eQTL |
| rs35919303 | chr11:93909187:A:G | - | 0.0596995497109008 | 0.00224330577948314 | LUAD | Female-baised eQTL |
| rs7117635 | chr11:100198801:C:T | - | -0.0608530792576041 | 0.00312100511661973 | LUAD | Female-baised eQTL |
| rs1939699 | chr11:100224984:C:G | - | -0.0569834003383888 | 0.0123066648862993 | LUAD | Female-baised eQTL |
| rs4636630 | chr11:100214899:A:C | - | -0.0547814484003755 | 0.0219540397715308 | LUAD | Female-baised eQTL |
| rs663051 | chr11:100239329:T:G | - | -0.0530132111211988 | 0.029697818139738 | LUAD | Female-baised eQTL |
| rs4143636 | chr11:100228802:G:A | - | -0.0536829419849997 | 0.0301246743545231 | LUAD | Female-baised eQTL |
| rs1939702 | chr11:100227236:A:G | - | -0.0519226589470679 | 0.0367430011073091 | LUAD | Female-baised eQTL |
| rs10894590 | chr11:100189162:C:T | - | 0.0557795606721924 | 0.0388650395329581 | LUAD | Female-baised eQTL |
| rs10831497 | chr11:96214246:G:A | - | 0.0550513922111219 | 0.0420230155493607 | LUAD | Female-baised eQTL |
| rs1939697 | chr11:100220961:T:G | - | -0.0492925230378704 | 0.0457551259442661 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7931520 | chr11:106737466:T:G | - | -0.20883727616269 | 0.0459434161997967 | PAAD | Male-baised eQTL |
| rs7930247 | chr11:95940999:G:T | - | 0.0851275900448858 | 0.0387346063911797 | SARC | Male-baised eQTL |
| rs723579 | chr11:109669067:T:C | - | 0.0977973994440399 | 0.00285337195250988 | LIHC | Male-baised eQTL |
| rs17106293 | chr11:106991597:T:C | - | 0.0591526854908465 | 0.00426936694064828 | LIHC | Male-baised eQTL |
| rs55738357 | chr11:109670715:A:G | - | 0.0919817586469616 | 0.00574032628524089 | LIHC | Male-baised eQTL |
| rs55900802 | chr11:109670805:A:G | - | 0.0919817586469616 | 0.00574032628524089 | LIHC | Male-baised eQTL |
| rs57321672 | chr11:109671895:T:A | - | 0.0919817586469616 | 0.00574032628524089 | LIHC | Male-baised eQTL |
| rs1487806 | chr11:109672662:A:G | - | 0.0880520031989044 | 0.00789813208714801 | LIHC | Male-baised eQTL |
| rs72998066 | chr11:109526562:T:C | - | 0.0794022132200313 | 0.00919066830782658 | LIHC | Male-baised eQTL |
| rs72998070 | chr11:109527000:G:A | - | 0.0794022132200313 | 0.00919066830782658 | LIHC | Male-baised eQTL |
| rs61913418 | chr11:109527012:C:G | - | 0.0794022132200313 | 0.00919066830782658 | LIHC | Male-baised eQTL |
| rs61913419 | chr11:109527090:C:T | - | 0.0794022132200313 | 0.00919066830782658 | LIHC | Male-baised eQTL |
| rs117696357 | chr11:109528297:C:G | - | 0.0794022132200313 | 0.00919066830782658 | LIHC | Male-baised eQTL |
| rs145610125 | chr11:109529483:C:G | - | 0.0794022132200313 | 0.00919066830782658 | LIHC | Male-baised eQTL |
| rs2716042 | chr11:109674789:C:A | - | 0.085069867240876 | 0.00935214942570475 | LIHC | Male-baised eQTL |
| rs2716029 | chr11:109676821:A:G | - | 0.0845447506574144 | 0.010411707472636 | LIHC | Male-baised eQTL |
| rs4630257 | chr11:109572279:G:A | - | 0.0816919120592544 | 0.0111637986302071 | LIHC | Male-baised eQTL |
| rs61913424 | chr11:109530113:C:T | - | 0.0757470808725758 | 0.0140746566693256 | LIHC | Male-baised eQTL |
| rs7102152 | chr11:109672960:A:G | - | 0.0806925816478594 | 0.0147951522377696 | LIHC | Male-baised eQTL |
| rs66508866 | chr11:109673952:G:A | - | 0.0806925816478594 | 0.0147951522377696 | LIHC | Male-baised eQTL |
| rs67453338 | chr11:109673983:A:G | - | 0.0806925816478594 | 0.0147951522377696 | LIHC | Male-baised eQTL |
| rs68069222 | chr11:109674035:A:G | - | 0.0806925816478594 | 0.0147951522377696 | LIHC | Male-baised eQTL |
| rs2852127 | chr11:109675650:A:G | - | 0.0806600646047511 | 0.0149126639985192 | LIHC | Male-baised eQTL |
| rs3898727 | chr11:109536755:C:T | - | 0.0727317702611498 | 0.0191688948872224 | LIHC | Male-baised eQTL |
| rs72998075 | chr11:109531928:C:T | - | 0.0726312224195171 | 0.019371799080689 | LIHC | Male-baised eQTL |
| rs72998080 | chr11:109531929:C:G | - | 0.0726312224195171 | 0.019371799080689 | LIHC | Male-baised eQTL |
| rs78544294 | chr11:100195904:G:T | - | 0.0677937979916487 | 0.0205315130398337 | LIHC | Male-baised eQTL |
| rs11223174 | chr11:100196350:C:T | - | 0.0677937979916487 | 0.0205315130398337 | LIHC | Male-baised eQTL |
| rs608820 | chr11:99671193:C:T | - | 0.0467806508207434 | 0.0215370015182485 | LIHC | Male-baised eQTL |
| rs1994446 | chr11:109658021:A:T | - | 0.0778425624400283 | 0.0217543426738957 | LIHC | Male-baised eQTL |
| rs7125233 | chr11:109658707:A:G | - | 0.0778425624400283 | 0.0217543426738957 | LIHC | Male-baised eQTL |
| rs58660859 | chr11:109660938:A:G | - | 0.0778425624400283 | 0.0217543426738957 | LIHC | Male-baised eQTL |
| rs57647628 | chr11:109661106:A:G | - | 0.0778425624400283 | 0.0217543426738957 | LIHC | Male-baised eQTL |
| rs1352305 | chr11:109669714:A:G | - | 0.0778425624400283 | 0.0217543426738957 | LIHC | Male-baised eQTL |
| rs7121398 | chr11:109658108:A:C | - | 0.0778346612157525 | 0.0218319057683344 | LIHC | Male-baised eQTL |
| rs11223171 | chr11:100192465:C:A | - | 0.0672371947498155 | 0.0226392973180187 | LIHC | Male-baised eQTL |
| rs7927842 | chr11:109543151:C:A | - | 0.0695661132279927 | 0.0268964555168749 | LIHC | Male-baised eQTL |
| rs72999911 | chr11:109544394:C:A | - | 0.0695661132279927 | 0.0268964555168749 | LIHC | Male-baised eQTL |
| rs61913454 | chr11:109537053:T:C | - | 0.0695648123197507 | 0.0270514367688416 | LIHC | Male-baised eQTL |
| rs61913455 | chr11:109537154:G:A | - | 0.0695648123197507 | 0.0270514367688416 | LIHC | Male-baised eQTL |
| rs7936391 | chr11:109545550:G:A | - | 0.0675534151220831 | 0.0310804645699532 | LIHC | Male-baised eQTL |
| rs4638281 | chr11:98572267:G:A | - | -0.0376728974942044 | 0.032353268109042 | LIHC | Male-baised eQTL |
| rs17109770 | chr11:109592649:C:A | - | 0.0721079975265739 | 0.0330088812289614 | LIHC | Male-baised eQTL |
| rs72999905 | chr11:109539539:T:C | - | 0.0671585646976294 | 0.0331135464469779 | LIHC | Male-baised eQTL |
| rs10891984 | chr11:98577584:G:A | - | -0.0433338617825416 | 0.0337365951947814 | LIHC | Male-baised eQTL |
| rs7118627 | chr11:98572850:G:A | - | -0.042323291564555 | 0.0384474474422504 | LIHC | Male-baised eQTL |
| rs4567424 | chr11:98574875:T:C | - | -0.0418257205173678 | 0.0415286910850819 | LIHC | Male-baised eQTL |
| rs7927793 | chr11:109542924:G:A | - | 0.0644782360230131 | 0.0432867750202564 | LIHC | Male-baised eQTL |
| rs72982198 | chr11:102558098:G:A | - | 0.174284419460153 | 0.000891223144271136 | COAD | Male-baised eQTL |
| rs72984003 | chr11:102558855:C:T | - | 0.174284419460153 | 0.000891223144271136 | COAD | Male-baised eQTL |
| rs72984004 | chr11:102558956:G:A | - | 0.174284419460153 | 0.000891223144271136 | COAD | Male-baised eQTL |
| rs72984007 | chr11:102558990:G:A | - | 0.174284419460153 | 0.000891223144271136 | COAD | Male-baised eQTL |
| rs72984009 | chr11:102560882:A:G | - | 0.174284419460153 | 0.000891223144271136 | COAD | Male-baised eQTL |
| rs72982184 | chr11:102553927:C:A | - | 0.173464011257916 | 0.000962363306759529 | COAD | Male-baised eQTL |
| rs72982186 | chr11:102553964:G:C | - | 0.173464011257916 | 0.000962363306759529 | COAD | Male-baised eQTL |
| rs72982189 | chr11:102555066:C:T | - | 0.173464011257916 | 0.000962363306759529 | COAD | Male-baised eQTL |
| rs10502004 | chr11:102579200:T:C | - | 0.163844510617202 | 0.00110393717059307 | COAD | Male-baised eQTL |
| rs17098479 | chr11:102573832:T:G | - | 0.165491888672492 | 0.00114137339569662 | COAD | Male-baised eQTL |
| rs17174277 | chr11:102575729:G:A | - | 0.165491888672492 | 0.00114137339569662 | COAD | Male-baised eQTL |
| rs17098554 | chr11:102577998:A:G | - | 0.165491888672492 | 0.00114137339569662 | COAD | Male-baised eQTL |
| rs17098593 | chr11:102578481:G:A | - | 0.165491888672492 | 0.00114137339569662 | COAD | Male-baised eQTL |
| rs17174291 | chr11:102579401:C:T | - | 0.165491888672492 | 0.00114137339569662 | COAD | Male-baised eQTL |
| rs17098481 | chr11:102574032:A:G | - | 0.165412033615563 | 0.00115877530664087 | COAD | Male-baised eQTL |
| rs72984010 | chr11:102563706:G:T | - | 0.164852161273703 | 0.00123405325633848 | COAD | Male-baised eQTL |
| rs112123501 | chr11:102564500:C:T | - | 0.164852161273703 | 0.00123405325633848 | COAD | Male-baised eQTL |
| rs10502003 | chr11:102566936:C:T | - | 0.164852161273703 | 0.00123405325633848 | COAD | Male-baised eQTL |
| rs72984015 | chr11:102567293:A:G | - | 0.164852161273703 | 0.00123405325633848 | COAD | Male-baised eQTL |
| rs12797633 | chr11:104648691:C:A | - | 0.165941659533791 | 0.00128026770096713 | COAD | Male-baised eQTL |
| rs10502079 | chr11:106848151:C:T | - | 0.09438452151669 | 0.00190262634368483 | COAD | Male-baised eQTL |
| rs61521523 | chr11:106865682:G:A | - | 0.0932052130111479 | 0.00243903693822201 | COAD | Male-baised eQTL |
| rs7952637 | chr11:103538239:A:G | - | 0.0841141323769702 | 0.00256190865181231 | COAD | Male-baised eQTL |
| rs72986526 | chr11:106851362:C:G | - | 0.0918501358187751 | 0.00292330862744488 | COAD | Male-baised eQTL |
| rs56349237 | chr11:106857518:A:G | - | 0.0911722433584398 | 0.00334859101163276 | COAD | Male-baised eQTL |
| rs17098383 | chr11:102555777:C:T | - | 0.153843562219552 | 0.00351264240951037 | COAD | Male-baised eQTL |
| rs55678916 | chr11:106883934:G:A | - | 0.0890871387690204 | 0.00442416429175416 | COAD | Male-baised eQTL |
| rs534224 | chr11:112815524:T:C | - | -0.0739140594247581 | 0.00549013677746475 | COAD | Male-baised eQTL |
| rs55816703 | chr11:106867429:C:T | - | 0.0862863797200403 | 0.00633095766430865 | COAD | Male-baised eQTL |
| rs682281 | chr11:112814433:T:A | - | -0.0715102857288497 | 0.00744873194761196 | COAD | Male-baised eQTL |
| rs55670820 | chr11:106870693:T:G | - | 0.0845236852157943 | 0.00835062560740964 | COAD | Male-baised eQTL |
| rs604967 | chr11:112815269:T:C | - | -0.0714121754912221 | 0.00844378939362196 | COAD | Male-baised eQTL |
| rs605343 | chr11:112815329:C:A | - | -0.0714121754912221 | 0.00844378939362196 | COAD | Male-baised eQTL |
| rs684127 | chr11:112814835:G:A | - | -0.0707707430570592 | 0.0085931862639638 | COAD | Male-baised eQTL |
| rs684590 | chr11:112814931:A:G | - | -0.0707707430570592 | 0.0085931862639638 | COAD | Male-baised eQTL |
| rs11825629 | chr11:106838785:G:T | - | 0.0737122963813548 | 0.0085967488772685 | COAD | Male-baised eQTL |
| rs608535 | chr11:112816099:T:C | - | -0.0710278198488108 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs643122 | chr11:112816746:C:T | - | -0.0710278198488108 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs643661 | chr11:112816922:G:T | - | -0.0710278198488108 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs623261 | chr11:112817019:A:G | - | -0.0710278198488108 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs7936574 | chr11:112817617:C:T | - | 0.0710278198488107 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs7936576 | chr11:112817626:C:T | - | 0.0710278198488107 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs12802525 | chr11:112817828:A:G | - | 0.0710278198488107 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs61901475 | chr11:112818023:T:C | - | 0.0710278198488107 | 0.0100492085107794 | COAD | Male-baised eQTL |
| rs7930222 | chr11:106823692:C:G | - | 0.126977663276733 | 0.0103422697488363 | COAD | Male-baised eQTL |
| rs77839304 | chr11:97740874:T:C | - | 0.117011369572591 | 0.0107959295223473 | COAD | Male-baised eQTL |
| rs67277244 | chr11:99935898:G:A | - | 0.0727886123516088 | 0.0145722585599374 | COAD | Male-baised eQTL |
| rs1943770 | chr11:101264885:C:T | - | 0.0814095542264512 | 0.0154634551987343 | COAD | Male-baised eQTL |
| rs61635490 | chr11:106891878:C:G | - | 0.0794220513335773 | 0.0208029521647901 | COAD | Male-baised eQTL |
| rs2124302 | chr11:107092523:T:C | - | 0.0816182287995624 | 0.0222007910562523 | COAD | Male-baised eQTL |
| rs1563330 | chr11:107101512:C:T | - | 0.0851243773114071 | 0.022296395840498 | COAD | Male-baised eQTL |
| rs12417648 | chr11:108106852:A:T | - | 0.0822253583490668 | 0.0229028348984871 | COAD | Male-baised eQTL |
| rs1944206 | chr11:106909185:G:C | - | 0.0789406253127701 | 0.0229044647215939 | COAD | Male-baised eQTL |
| rs10791675 | chr11:104157895:C:T | - | 0.0639814855774608 | 0.022943848598575 | COAD | Male-baised eQTL |
| rs534988 | chr11:112815466:G:A | - | -0.0660204902065626 | 0.0239285286262443 | COAD | Male-baised eQTL |
| rs10750686 | chr11:104150444:C:T | - | 0.0671270887552235 | 0.0242677306774301 | COAD | Male-baised eQTL |
| rs1255533 | chr11:95577813:G:A | - | 0.0953052692480703 | 0.0247865248118235 | COAD | Male-baised eQTL |
| rs1840695 | chr11:93531223:T:C | - | 0.0642578726354511 | 0.0255777578201814 | COAD | Male-baised eQTL |
| rs56402014 | chr11:104166260:G:T | - | 0.0762933042794674 | 0.0270680446408626 | COAD | Male-baised eQTL |
| rs55998450 | chr11:104166261:T:C | - | 0.0762933042794674 | 0.0270680446408626 | COAD | Male-baised eQTL |
| rs724082 | chr11:104167877:T:G | - | 0.0762933042794674 | 0.0270680446408626 | COAD | Male-baised eQTL |
| rs10895595 | chr11:104160722:C:T | - | 0.0764171010882281 | 0.0271113345354288 | COAD | Male-baised eQTL |
| rs11226209 | chr11:104161523:C:T | - | 0.0764171010882281 | 0.0271113345354288 | COAD | Male-baised eQTL |
| rs11214380 | chr11:112822739:C:G | - | 0.0661080075536575 | 0.0273881941150244 | COAD | Male-baised eQTL |
| rs2513124 | chr11:107091885:G:A | - | 0.0833613708519387 | 0.0277113505193912 | COAD | Male-baised eQTL |
| rs118122708 | chr11:107099257:A:T | - | 0.0840928731616483 | 0.0280016047885094 | COAD | Male-baised eQTL |
| rs7123807 | chr11:104150120:T:A | - | 0.0648066613163955 | 0.0281278816901693 | COAD | Male-baised eQTL |
| rs1374698 | chr11:112820526:C:A | - | 0.0656877087898448 | 0.0284318506941183 | COAD | Male-baised eQTL |
| rs1823202 | chr11:112821116:G:A | - | 0.0656877087898448 | 0.0284318506941183 | COAD | Male-baised eQTL |
| rs1374697 | chr11:112821314:A:G | - | 0.0656877087898448 | 0.0284318506941183 | COAD | Male-baised eQTL |
| rs10891449 | chr11:112822012:G:C | - | 0.0656877087898448 | 0.0284318506941183 | COAD | Male-baised eQTL |
| rs12286219 | chr11:96037740:G:A | - | 0.114600962347209 | 0.0288808106978125 | COAD | Male-baised eQTL |
| rs1374699 | chr11:112820460:A:G | - | 0.0653710534477433 | 0.0297266396837584 | COAD | Male-baised eQTL |
| rs7119186 | chr11:104158528:G:T | - | 0.0754458070327817 | 0.0299166600926956 | COAD | Male-baised eQTL |
| rs10750684 | chr11:104146361:A:G | - | 0.0638991411045652 | 0.0308247606317086 | COAD | Male-baised eQTL |
| rs12421599 | chr11:110829836:A:G | - | 0.116896879734237 | 0.0310659962503098 | COAD | Male-baised eQTL |
| rs12418689 | chr11:104162422:C:A | - | 0.0750258613733241 | 0.0321550947574313 | COAD | Male-baised eQTL |
| rs60758124 | chr11:106892169:T:C | - | 0.076558250070061 | 0.0358267780795147 | COAD | Male-baised eQTL |
| rs1824002 | chr11:107096422:T:C | - | 0.0804339936579491 | 0.041339896407785 | COAD | Male-baised eQTL |
| rs2509204 | chr11:107614838:G:A | - | -0.0590408829142225 | 0.0416146958173812 | COAD | Male-baised eQTL |
| rs56214765 | chr11:108041764:G:A | - | 0.0750996161619116 | 0.041830312818846 | COAD | Male-baised eQTL |
| rs520729 | chr11:107416413:T:A | - | -0.0587892126741785 | 0.0422555487021328 | COAD | Male-baised eQTL |
| rs2128806 | chr11:104155737:C:T | - | 0.0615471527775986 | 0.0462469685959942 | COAD | Male-baised eQTL |
| rs10791669 | chr11:104148787:A:C | - | 0.0612007139047289 | 0.0474338335330699 | COAD | Male-baised eQTL |
| rs10890745 | chr11:107615260:G:A | - | -0.0577282672395967 | 0.0478285610414909 | COAD | Male-baised eQTL |
| rs10890746 | chr11:107615330:G:A | - | -0.0577282672395967 | 0.0478285610414909 | COAD | Male-baised eQTL |
| rs4754237 | chr11:107615361:A:G | - | -0.0577282672395967 | 0.0478285610414909 | COAD | Male-baised eQTL |
| rs7943671 | chr11:107615872:A:G | - | -0.0577282672395967 | 0.0478285610414909 | COAD | Male-baised eQTL |
| rs7943986 | chr11:107615898:G:C | - | -0.0577282672395967 | 0.0478285610414909 | COAD | Male-baised eQTL |
| rs161133 | chr11:112792873:G:A | - | -0.0593106706624558 | 0.0489656746367599 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000262406 |
| CpG Site: cg23979520 | |
| Position to Gene: promoter | |
| Male Effect: -0.445199978090787 | |
| Female Effect: - | |
 | Gene ID: ENSG00000262406 |
| CpG Site: cg19304432 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.160630052304187 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23979520 | chr11:102875124 | promoter | -0.445199978090787 | 1.94874454033315e-05 | -0.35707540543512595 | 7.294163892059211e-08 | LUAD |
| cg19304432 | chr11:102873769 | gene,promoter | -0.160630052304187 | 1.0511958834466e-17 | -0.5152559152661645 | 3.3427564316081704e-21 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of MMP12 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000262406 | MMP12 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0000822 | Abortion, Tubal | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0007570 | Celiac Disease | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0034067 | Pulmonary Emphysema | 2 | CTD_human |
| ENSG00000262406 | MMP12 | C0038454 | Cerebrovascular accident | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0043094 | Weight Gain | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C0221227 | Centriacinar Emphysema | 2 | CTD_human |
| ENSG00000262406 | MMP12 | C0264393 | Panacinar Emphysema | 2 | CTD_human |
| ENSG00000262406 | MMP12 | C0751956 | Acute Cerebrovascular Accidents | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C2350878 | Focal Emphysema | 2 | CTD_human |
| ENSG00000262406 | MMP12 | C3830362 | Early Pregnancy Loss | 1 | CTD_human |
| ENSG00000262406 | MMP12 | C4552766 | Miscarriage | 1 | CTD_human |
