|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000253958 |
Summary for CLDN23 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000253958 | Gene symbol | CLDN23 |
| Gene name | claudin 23 | |
| HGNC | 17591 | |
| Entrez ID | 137075 | |
| Gene type | protein_coding | |
| Synonyms | CLDN23|CLDNL | |
| UniProtAcc | Q96B33 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CLDN23 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CLDN23 | 3.11e+02 | -1.40e+00 | 1.76e-01 | -7.93e+00 | 2.11e-15 | 7.63e-15 | LUSC |
| CLDN23 | 8.96e+02 | 1.11e+00 | 1.61e-01 | 6.88e+00 | 5.97e-12 | 4.65e-11 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CLDN23 | 9.08e+02 | -2.68e+00 | 3.82e-01 | -7.01e+00 | 2.35e-12 | 9.79e-11 | READ |
Top |
Sex-biased somatic mutation for CLDN23 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for CLDN23 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| MESO | cg06671706 | chr8:8702489 | CGI:chr8:8701621-8703357 | promoter,exon,CDS,gene body | 3.00e-01 | 4.04e-01 | -2.40e+00 | 1.66e-02 | 3.60e-02 | -1.03e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for CLDN23 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for CLDN23 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for CLDN23 |
| TFs related to CLDN23. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | DNMT1 | CLDN23 | 4.58e+00 | 9.81e-01 | 3.85e+00 | 1.32e-02 | Male-biased |
| BLCA | ZNF611 | CLDN23 | 4.88e+00 | 9.82e-01 | 4.17e+00 | 1.41e-02 | Male-biased |
| GBM | MSANTD3 | CLDN23 | 3.50e+00 | 1.05e-02 | 4.54e+00 | 9.84e-01 | Female-biased |
| GBM | ZNF2 | CLDN23 | 2.47e+00 | 2.63e-03 | 4.02e+00 | 9.83e-01 | Female-biased |
| GBM | ZNF320 | CLDN23 | 2.36e+00 | 1.20e-03 | 4.21e+00 | 9.89e-01 | Female-biased |
| GBM | ZNF333 | CLDN23 | 3.11e+00 | 4.38e-03 | 4.49e+00 | 9.90e-01 | Female-biased |
| GBM | ZNF479 | CLDN23 | 2.71e+00 | 3.36e-03 | 4.18e+00 | 9.86e-01 | Female-biased |
| GBM | ZNF530 | CLDN23 | 2.49e+00 | 1.75e-03 | 4.20e+00 | 9.89e-01 | Female-biased |
| GBM | ZNF534 | CLDN23 | 2.46e+00 | 2.62e-03 | 4.02e+00 | 9.83e-01 | Female-biased |
| GBM | ZNF548 | CLDN23 | 2.31e+00 | 2.23e-03 | 3.93e+00 | 9.81e-01 | Female-biased |
| GBM | ZNF550 | CLDN23 | 3.31e+00 | 1.01e-02 | 4.36e+00 | 9.82e-01 | Female-biased |
| GBM | ZNF554 | CLDN23 | 2.59e+00 | 3.66e-03 | 4.02e+00 | 9.82e-01 | Female-biased |
| GBM | ZNF611 | CLDN23 | 1.95e+00 | 7.73e-04 | 3.95e+00 | 9.83e-01 | Female-biased |
| GBM | ZNF616 | CLDN23 | 2.97e+00 | 5.04e-03 | 4.29e+00 | 9.86e-01 | Female-biased |
| GBM | ZNF692 | CLDN23 | 2.75e+00 | 1.97e-03 | 4.43e+00 | 9.92e-01 | Female-biased |
| MESO | MEF2A | CLDN23 | 2.64e+00 | 2.35e-04 | 4.91e+00 | 9.96e-01 | Female-biased |
| MESO | NANOG | CLDN23 | 2.74e+00 | 3.84e-04 | 4.90e+00 | 9.96e-01 | Female-biased |
| MESO | STAT2 | CLDN23 | 2.10e+00 | 6.55e-05 | 4.68e+00 | 9.95e-01 | Female-biased |
| MESO | ZNF333 | CLDN23 | 4.21e+00 | 9.84e-01 | 2.82e+00 | 5.36e-03 | Male-biased |
| MESO | ZNF692 | CLDN23 | 4.17e+00 | 9.87e-01 | 2.53e+00 | 2.22e-03 | Male-biased |
| MESO | ZNF71 | CLDN23 | 3.11e+00 | 2.89e-03 | 4.76e+00 | 9.92e-01 | Female-biased |
| MESO | ZNF74 | CLDN23 | 3.77e+00 | 6.29e-03 | 5.20e+00 | 9.91e-01 | Female-biased |
| MESO | ZNF879 | CLDN23 | 1.80e+00 | 7.05e-06 | 5.03e+00 | 9.97e-01 | Female-biased |
| READ | MEF2A | CLDN23 | 2.90e+00 | 1.04e-03 | 4.34e+00 | 9.89e-01 | Female-biased |
| READ | NANOG | CLDN23 | 3.55e+00 | 3.53e-03 | 4.66e+00 | 9.91e-01 | Female-biased |
| READ | STAT2 | CLDN23 | 2.11e+00 | 2.12e-04 | 4.04e+00 | 9.84e-01 | Female-biased |
| READ | ZNF333 | CLDN23 | 4.47e+00 | 9.86e-01 | 3.53e+00 | 6.00e-03 | Male-biased |
| READ | ZNF71 | CLDN23 | 3.24e+00 | 2.83e-03 | 4.40e+00 | 9.88e-01 | Female-biased |
| READ | ZNF74 | CLDN23 | 4.09e+00 | 1.25e-02 | 4.87e+00 | 9.84e-01 | Female-biased |
| READ | ZNF879 | CLDN23 | 1.49e+00 | 3.85e-05 | 3.93e+00 | 9.81e-01 | Female-biased |
| SARC | ZNF200 | CLDN23 | 4.64e+00 | 9.85e-01 | 4.07e+00 | 9.25e-03 | Male-biased |
| CLDN23 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for CLDN23 |
| RBPs related to ES in CLDN23. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CLDN23 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000253958 | B3GALT5-AS1,hsa-mir-340,CLDN23 | Male-specific ceRNA | TCGA-KIRP |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7843198 | chr8:16815624:A:G | - | 0.0945215954160407 | 0.00520002646424651 | HNSC | Female-baised eQTL |
| rs55942327 | chr8:16821998:A:G | - | 0.0781855726176066 | 0.0377823112805845 | HNSC | Female-baised eQTL |
| rs11994341 | chr8:18321985:C:T | - | 0.565034611648467 | 0.000435851225404434 | GBM | Female-baised eQTL |
| rs7837620 | chr8:8680321:T:C | - | 0.224510523647333 | 0.0407907248683104 | GBM | Female-baised eQTL |
| rs79178831 | chr8:15480276:T:C | - | 0.342931546494852 | 4.35167188367636e-05 | LIHC | Female-baised eQTL |
| rs13276561 | chr8:17523424:C:G | - | 0.192792641754556 | 0.000454114011064971 | LIHC | Female-baised eQTL |
| rs80049714 | chr8:16043239:G:T | - | 0.142275200514192 | 0.00650263603429422 | LIHC | Female-baised eQTL |
| rs116865601 | chr8:16043992:C:A | - | 0.142275200514192 | 0.00650263603429422 | LIHC | Female-baised eQTL |
| rs17676668 | chr8:16042186:G:C | - | 0.146442524101458 | 0.00945147191685404 | LIHC | Female-baised eQTL |
| rs35541477 | chr8:17514276:C:T | - | 0.135487073545169 | 0.0118667477412327 | LIHC | Female-baised eQTL |
| rs13249384 | chr8:17515356:C:T | - | 0.135487073545169 | 0.0118667477412327 | LIHC | Female-baised eQTL |
| rs13256875 | chr8:17515539:C:A | - | 0.135487073545169 | 0.0118667477412327 | LIHC | Female-baised eQTL |
| rs17065054 | chr8:499424:C:G | - | 0.131835348081712 | 0.0195792851419885 | LIHC | Female-baised eQTL |
| rs34309110 | chr8:17518290:C:G | - | 0.126981816236059 | 0.0235013587762893 | LIHC | Female-baised eQTL |
| rs12056434 | chr8:16056448:C:G | - | 0.145707826929143 | 0.0276427306508978 | LIHC | Female-baised eQTL |
| rs12056776 | chr8:16056613:G:T | - | 0.145707826929143 | 0.0276427306508978 | LIHC | Female-baised eQTL |
| rs76261256 | chr8:16057114:C:T | - | 0.145707826929143 | 0.0276427306508978 | LIHC | Female-baised eQTL |
| rs17065051 | chr8:499260:G:A | - | 0.130817789059826 | 0.0317517607717048 | LIHC | Female-baised eQTL |
| rs138158964 | chr8:16032225:C:T | - | 0.148148407122445 | 0.0346489182168554 | LIHC | Female-baised eQTL |
| rs767238 | chr8:5551876:C:G | - | 0.140762523675617 | 0.000273247794620721 | LUSC | Female-baised eQTL |
| rs10098342 | chr8:10099229:G:A | - | 0.0920242275737204 | 0.0270652378208714 | LUSC | Female-baised eQTL |
| rs4370534 | chr8:10229870:T:C | - | 0.155028442791242 | 0.0274218840930557 | LUSC | Female-baised eQTL |
| rs76491595 | chr8:17384707:T:C | - | 0.128744684491214 | 0.0440013106360835 | LUSC | Female-baised eQTL |
| rs10282848 | chr8:11139157:A:G | - | 0.185954852779353 | 0.000134623155405589 | STAD | Female-baised eQTL |
| rs17152921 | chr8:11139284:G:C | - | 0.185954852779353 | 0.000134623155405589 | STAD | Female-baised eQTL |
| rs73547435 | chr8:11139404:T:C | - | 0.185954852779353 | 0.000134623155405589 | STAD | Female-baised eQTL |
| rs73665032 | chr8:11219077:T:G | - | 0.202849712547945 | 0.000179301108633465 | STAD | Female-baised eQTL |
| rs597074 | chr8:9937572:C:G | - | -0.144522920617123 | 0.000246380087916024 | STAD | Female-baised eQTL |
| rs80265125 | chr8:10865256:C:A | - | 0.166350509139487 | 0.000266830947226619 | STAD | Female-baised eQTL |
| rs28544576 | chr8:11139475:T:C | - | 0.173168321128581 | 0.000365645339375283 | STAD | Female-baised eQTL |
| rs74470319 | chr8:11217116:G:A | - | 0.197407564775901 | 0.00037320125976491 | STAD | Female-baised eQTL |
| rs76485520 | chr8:11217279:G:C | - | 0.197407564775901 | 0.00037320125976491 | STAD | Female-baised eQTL |
| rs17152623 | chr8:10855471:G:A | - | 0.156721148114389 | 0.000571336294709596 | STAD | Female-baised eQTL |
| rs56368704 | chr8:11215631:A:C | - | 0.181143099515605 | 0.000968472154605185 | STAD | Female-baised eQTL |
| rs79505632 | chr8:11222287:C:G | - | 0.178985625684922 | 0.00125559621327866 | STAD | Female-baised eQTL |
| rs7000298 | chr8:11173672:A:T | - | 0.157975982934007 | 0.00133086646315778 | STAD | Female-baised eQTL |
| rs73532835 | chr8:11209304:C:T | - | 0.178036834385166 | 0.00140532198244925 | STAD | Female-baised eQTL |
| rs73532838 | chr8:11210501:G:A | - | 0.178036834385166 | 0.00140532198244925 | STAD | Female-baised eQTL |
| rs73532843 | chr8:11211948:G:A | - | 0.178036834385166 | 0.00140532198244925 | STAD | Female-baised eQTL |
| rs76921214 | chr8:11225908:C:T | - | 0.176969855515469 | 0.00156329963269522 | STAD | Female-baised eQTL |
| rs28685039 | chr8:9835415:G:A | - | 0.12174480657371 | 0.00245975263870332 | STAD | Female-baised eQTL |
| rs74386265 | chr8:9836427:C:T | - | 0.12174480657371 | 0.00245975263870332 | STAD | Female-baised eQTL |
| rs140387412 | chr8:9841858:G:T | - | 0.12174480657371 | 0.00245975263870332 | STAD | Female-baised eQTL |
| rs58354703 | chr8:9844545:G:A | - | 0.12174480657371 | 0.00245975263870332 | STAD | Female-baised eQTL |
| rs9644712 | chr8:9848243:A:T | - | 0.12174480657371 | 0.00245975263870332 | STAD | Female-baised eQTL |
| rs10092948 | chr8:9851972:C:G | - | 0.122992076766603 | 0.0029141508579332 | STAD | Female-baised eQTL |
| rs55942327 | chr8:16821998:A:G | - | 0.0948054990995704 | 0.00351320129511809 | STAD | Female-baised eQTL |
| rs4922242 | chr8:16817131:A:C | - | 0.0945730764556978 | 0.00362272785169024 | STAD | Female-baised eQTL |
| rs73199845 | chr8:16818609:T:C | - | 0.0945730764556978 | 0.00362272785169024 | STAD | Female-baised eQTL |
| rs7843198 | chr8:16815624:A:G | - | 0.0918049456039282 | 0.00487044372446542 | STAD | Female-baised eQTL |
| rs73199846 | chr8:16819265:C:T | - | 0.0920722316979346 | 0.0051812376490305 | STAD | Female-baised eQTL |
| rs7833469 | chr8:16599252:G:T | - | 0.139349375240043 | 0.00524721281709889 | STAD | Female-baised eQTL |
| rs1433295 | chr8:16599580:T:C | - | 0.139118751751784 | 0.00544021353716918 | STAD | Female-baised eQTL |
| rs17152997 | chr8:11226971:G:A | - | 0.160021919565421 | 0.00545388511732353 | STAD | Female-baised eQTL |
| rs13248665 | chr8:9852928:T:C | - | -0.0966000271407159 | 0.00568254610725804 | STAD | Female-baised eQTL |
| rs7002971 | chr8:9850730:G:A | - | 0.111283338254302 | 0.00632867499270663 | STAD | Female-baised eQTL |
| rs6651475 | chr8:16598920:A:G | - | 0.131649089405341 | 0.00937619386259853 | STAD | Female-baised eQTL |
| rs9657529 | chr8:9834824:C:A | - | 0.107357399084388 | 0.00944520407037129 | STAD | Female-baised eQTL |
| rs9657530 | chr8:9835557:C:A | - | 0.107357399084388 | 0.00944520407037129 | STAD | Female-baised eQTL |
| rs7843807 | chr8:9846455:G:A | - | 0.107357399084388 | 0.00944520407037129 | STAD | Female-baised eQTL |
| rs9657510 | chr8:9847828:A:T | - | 0.107357399084388 | 0.00944520407037129 | STAD | Female-baised eQTL |
| rs11249963 | chr8:9849241:G:A | - | 0.107357399084388 | 0.00944520407037129 | STAD | Female-baised eQTL |
| rs1399054 | chr8:9927993:G:A | - | -0.0820645319321533 | 0.0200635536433131 | STAD | Female-baised eQTL |
| rs7821773 | chr8:9853946:G:A | - | -0.0827422258562973 | 0.0219593680001296 | STAD | Female-baised eQTL |
| rs112970562 | chr8:13255515:A:G | - | 0.104061276473841 | 0.0253744928690054 | STAD | Female-baised eQTL |
| rs12056794 | chr8:9696405:A:G | - | 0.0937267062828594 | 0.0286397643253589 | STAD | Female-baised eQTL |
| rs59924971 | chr8:9843898:G:A | - | 0.0948365286390444 | 0.0300032981048916 | STAD | Female-baised eQTL |
| rs2449219 | chr8:3627301:G:A | - | 0.137791205805549 | 0.0358906806444314 | STAD | Female-baised eQTL |
| rs17396710 | chr8:3628178:T:C | - | 0.137778275123559 | 0.0365042809869223 | STAD | Female-baised eQTL |
| rs78438976 | chr8:2324332:G:C | - | 0.128713269840559 | 0.0379515264639266 | STAD | Female-baised eQTL |
| rs139106544 | chr8:16791059:G:C | - | 0.125108811927851 | 0.0384899127197891 | STAD | Female-baised eQTL |
| rs4320547 | chr8:9610114:T:C | - | 0.0647426232487082 | 0.0393971224142909 | STAD | Female-baised eQTL |
| rs79314948 | chr8:16692483:T:C | - | 0.128069828579457 | 0.0404090735953857 | STAD | Female-baised eQTL |
| rs2449220 | chr8:3627006:A:G | - | 0.135797615771531 | 0.0434977256511308 | STAD | Female-baised eQTL |
| rs3817709 | chr8:2106982:G:A | - | -0.0847798579915533 | 0.0157365231581488 | KIRC | Female-baised eQTL |
| rs2920618 | chr8:6372144:C:T | - | 0.074195037664777 | 0.0267382182367588 | KIRC | Female-baised eQTL |
| rs10112893 | chr8:10185646:C:T | - | 0.0949988787885547 | 0.030560330544935 | KIRC | Female-baised eQTL |
| rs10088890 | chr8:10151816:C:T | - | 0.121147650698526 | 0.0378087436243807 | KIRC | Female-baised eQTL |
| rs10088663 | chr8:10151628:C:T | - | 0.120791243227693 | 0.0390478093939359 | KIRC | Female-baised eQTL |
| rs2213909 | chr8:18083001:T:A | - | 0.0734234909275288 | 0.0419523122609271 | KIRC | Female-baised eQTL |
| rs17761841 | chr8:2870990:T:C | - | 0.107746037817017 | 0.0420637057006346 | KIRC | Female-baised eQTL |
| rs74979979 | chr8:10166651:C:G | - | 0.10307431494536 | 0.0494596635347404 | KIRC | Female-baised eQTL |
| rs115320315 | chr8:5076821:G:C | - | 0.0893046716159867 | 0.0220422326150191 | LUAD | Female-baised eQTL |
| rs17123691 | chr8:16807295:A:G | - | 0.0696576872901074 | 0.038257369977016 | LUAD | Female-baised eQTL |
| rs62501884 | chr8:15446399:C:T | - | 0.18074569953353 | 0.00221940401401164 | COAD | Female-baised eQTL |
| rs78901497 | chr8:15449865:T:C | - | 0.17002849908825 | 0.00485429689248369 | COAD | Female-baised eQTL |
| rs2976955 | chr8:8385550:C:T | - | 0.114035553431734 | 0.0051072455526998 | COAD | Female-baised eQTL |
| rs76622454 | chr8:10727684:T:C | - | 0.143108471243482 | 0.00620661557670418 | COAD | Female-baised eQTL |
| rs1053036 | chr8:9202567:A:G | - | 0.0731926088467259 | 0.00634720748946656 | COAD | Female-baised eQTL |
| rs2945842 | chr8:8385925:G:T | - | 0.115694491777555 | 0.00791917209306954 | COAD | Female-baised eQTL |
| rs3779818 | chr8:2138475:G:T | - | 0.137813812679319 | 0.0130578660549432 | COAD | Female-baised eQTL |
| rs3779816 | chr8:2138583:A:G | - | 0.137813812679319 | 0.0130578660549432 | COAD | Female-baised eQTL |
| rs13252442 | chr8:14651659:T:A | - | 0.0841847966413168 | 0.0133264846588256 | COAD | Female-baised eQTL |
| rs4599837 | chr8:2129606:G:C | - | 0.134600810861023 | 0.0153258381756588 | COAD | Female-baised eQTL |
| rs73169431 | chr8:2130175:G:A | - | 0.134600810861023 | 0.0153258381756588 | COAD | Female-baised eQTL |
| rs73169432 | chr8:2130451:C:T | - | 0.134600810861023 | 0.0153258381756588 | COAD | Female-baised eQTL |
| rs73169434 | chr8:2131551:T:C | - | 0.134600810861023 | 0.0153258381756588 | COAD | Female-baised eQTL |
| rs77698197 | chr8:4953947:C:G | - | 0.130382543413689 | 0.0154593618138073 | COAD | Female-baised eQTL |
| rs34021868 | chr8:4954791:T:C | - | 0.130382543413689 | 0.0154593618138073 | COAD | Female-baised eQTL |
| rs80311029 | chr8:15309790:C:T | - | 0.14658922340371 | 0.0184564036224434 | COAD | Female-baised eQTL |
| rs17854780 | chr8:2123301:T:C | - | 0.131934100201619 | 0.0198913363148638 | COAD | Female-baised eQTL |
| rs17367922 | chr8:6147588:G:A | - | 0.11691797845311 | 0.0202347505861524 | COAD | Female-baised eQTL |
| rs13248197 | chr8:2153511:C:G | - | 0.129550877899808 | 0.0255453655470401 | COAD | Female-baised eQTL |
| rs13270863 | chr8:2151161:T:C | - | 0.129334364264724 | 0.0262075470081253 | COAD | Female-baised eQTL |
| rs35077455 | chr8:2151275:G:A | - | 0.129334364264724 | 0.0262075470081253 | COAD | Female-baised eQTL |
| rs13263461 | chr8:6934879:C:T | - | 0.0830537171386847 | 0.0297845106224988 | COAD | Female-baised eQTL |
| rs10503504 | chr8:14651399:A:G | - | 0.0766264882849062 | 0.0312401953133972 | COAD | Female-baised eQTL |
| rs73169451 | chr8:2148755:A:G | - | 0.124152884271618 | 0.0313616941869176 | COAD | Female-baised eQTL |
| rs35241794 | chr8:2146164:C:T | - | 0.123974551600401 | 0.0320073063540963 | COAD | Female-baised eQTL |
| rs13264810 | chr8:2147909:G:A | - | 0.123974551600401 | 0.0320073063540963 | COAD | Female-baised eQTL |
| rs13267188 | chr8:2148004:C:T | - | 0.123974551600401 | 0.0320073063540963 | COAD | Female-baised eQTL |
| rs17752149 | chr8:2148355:C:A | - | 0.123974551600401 | 0.0320073063540963 | COAD | Female-baised eQTL |
| rs17684913 | chr8:2148544:A:G | - | 0.123974551600401 | 0.0320073063540963 | COAD | Female-baised eQTL |
| rs13261705 | chr8:6934318:C:T | - | 0.0819423441345852 | 0.0334631618644549 | COAD | Female-baised eQTL |
| rs79653955 | chr8:17112773:C:T | - | 0.116268142323427 | 0.0340684694453562 | COAD | Female-baised eQTL |
| rs76068614 | chr8:17112783:C:G | - | 0.116268142323427 | 0.0340684694453562 | COAD | Female-baised eQTL |
| rs118154318 | chr8:1592158:C:G | - | 0.146060313872455 | 0.0353636214470425 | COAD | Female-baised eQTL |
| rs2239667 | chr8:6936685:G:A | - | 0.0814994964727239 | 0.0359708386223682 | COAD | Female-baised eQTL |
| rs13262140 | chr8:6934079:A:G | - | 0.0811251845622745 | 0.036287303727536 | COAD | Female-baised eQTL |
| rs10448135 | chr8:17001889:C:G | - | -0.0807444327364057 | 0.0370135510444701 | COAD | Female-baised eQTL |
| rs56248548 | chr8:6933030:C:T | - | 0.0810305441789357 | 0.0390185000980363 | COAD | Female-baised eQTL |
| rs13251814 | chr8:6935220:G:T | - | 0.0812079169629697 | 0.040177651242644 | COAD | Female-baised eQTL |
| rs7001061 | chr8:17005393:G:T | - | -0.0791061491179306 | 0.0412902608943115 | COAD | Female-baised eQTL |
| rs3887306 | chr8:6931766:C:G | - | 0.0800505373136037 | 0.042075659681851 | COAD | Female-baised eQTL |
| rs2188014 | chr8:17004693:C:A | - | -0.0793009698209889 | 0.0421487892579692 | COAD | Female-baised eQTL |
| rs34547976 | chr8:2141971:T:C | - | 0.119483997968602 | 0.042478922599403 | COAD | Female-baised eQTL |
| rs3779814 | chr8:2142968:C:A | - | 0.119483997968602 | 0.042478922599403 | COAD | Female-baised eQTL |
| rs35140981 | chr8:2143598:C:T | - | 0.119483997968602 | 0.042478922599403 | COAD | Female-baised eQTL |
| rs2280905 | chr8:2143303:A:C | - | 0.119346798874415 | 0.0431714097447405 | COAD | Female-baised eQTL |
| rs77467206 | chr8:17110216:G:C | - | 0.112444868567582 | 0.0432155057976552 | COAD | Female-baised eQTL |
| rs13263510 | chr8:6934929:C:G | - | 0.0803801116215503 | 0.0434011818658585 | COAD | Female-baised eQTL |
| rs13254588 | chr8:6935118:A:G | - | 0.0803801116215503 | 0.0434011818658585 | COAD | Female-baised eQTL |
| rs17752076 | chr8:2143324:A:G | - | 0.119196770079728 | 0.0437041199927607 | COAD | Female-baised eQTL |
| rs13274891 | chr8:6932362:G:A | - | 0.0798832014931501 | 0.0439854856296629 | COAD | Female-baised eQTL |
| rs13250769 | chr8:6932462:T:C | - | 0.0798779464525709 | 0.0446258314512833 | COAD | Female-baised eQTL |
| rs75014326 | chr8:17112256:A:G | - | 0.112184831788748 | 0.044754791853298 | COAD | Female-baised eQTL |
| rs75285252 | chr8:5956353:C:G | - | 0.0962589099662936 | 0.0481166594670386 | COAD | Female-baised eQTL |
| rs80323779 | chr8:5957204:T:G | - | 0.0959911855530688 | 0.0496786827741645 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9657490 | chr8:18655108:G:A | - | 0.295526597804373 | 0.0405304787358021 | GBM | Male-baised eQTL |
| rs17676484 | chr8:15999996:A:T | - | 0.0757430574360828 | 0.0051514403061232 | STAD | Male-baised eQTL |
| rs151178180 | chr8:16003924:T:G | - | 0.0733521829035135 | 0.00760257655165572 | STAD | Male-baised eQTL |
| rs77007524 | chr8:16004487:T:C | - | 0.0733521829035135 | 0.00760257655165572 | STAD | Male-baised eQTL |
| rs2618485 | chr8:11471736:T:G | - | -0.0572762546507387 | 0.0165791263774138 | STAD | Male-baised eQTL |
| rs60045749 | chr8:15979366:G:C | - | 0.0673016443385828 | 0.0169781855218759 | STAD | Male-baised eQTL |
| rs2948369 | chr8:12878878:T:C | - | -0.0621635501794066 | 0.02568949333971 | STAD | Male-baised eQTL |
| rs4524790 | chr8:12878720:A:T | - | -0.062020895644601 | 0.0266564975226663 | STAD | Male-baised eQTL |
| rs6989010 | chr8:12915246:G:T | - | 0.0796417804733179 | 0.0341031482477851 | STAD | Male-baised eQTL |
| rs62473913 | chr8:3599820:T:C | - | 0.0794837173362822 | 0.0439671844832173 | STAD | Male-baised eQTL |
| rs1429080 | chr8:15622258:G:A | - | -0.0521233362564057 | 0.0130516833932678 | KIRC | Male-baised eQTL |
| rs6558700 | chr8:381550:A:G | - | 0.0601073014296228 | 0.0137975179016686 | KIRC | Male-baised eQTL |
| rs1522839 | chr8:8722943:C:T | - | 0.0428566906631592 | 0.0216850194431342 | KIRC | Male-baised eQTL |
| rs4735971 | chr8:1046634:C:T | - | -0.0801544726170589 | 0.0306053641142336 | KIRC | Male-baised eQTL |
| rs7822301 | chr8:13415916:T:G | - | -0.0327467252081445 | 0.038918601321063 | KIRC | Male-baised eQTL |
| rs2085640 | chr8:9407954:C:A | - | -0.0334756743248877 | 0.0416546131987025 | KIRC | Male-baised eQTL |
| rs1109619 | chr8:8714106:G:T | - | 0.0392737398558107 | 0.0433772224158968 | KIRC | Male-baised eQTL |
| rs2467555 | chr8:18010736:C:A | - | -0.0386918358245253 | 0.0456400022054976 | KIRC | Male-baised eQTL |
| rs13255655 | chr8:8720226:C:T | - | 0.0404811867305295 | 0.0468762498042893 | KIRC | Male-baised eQTL |
| rs12545771 | chr8:8710467:C:G | - | 0.0388772881880773 | 0.0490641245327489 | KIRC | Male-baised eQTL |
| rs72607315 | chr8:14609767:G:C | - | 0.0827275390630398 | 0.0142578817131077 | BLCA | Male-baised eQTL |
| rs1912472 | chr8:14630067:G:A | - | 0.0742425887017252 | 0.0420212796755395 | BLCA | Male-baised eQTL |
| rs13272409 | chr8:4953824:G:T | - | 0.0996796497218677 | 0.0499845459292327 | BLCA | Male-baised eQTL |
| rs76386173 | chr8:4954054:T:C | - | 0.0996796497218677 | 0.0499845459292327 | BLCA | Male-baised eQTL |
| rs7004486 | chr8:5884127:T:G | - | -0.0561604425837788 | 0.0212882579344158 | LUAD | Male-baised eQTL |
| rs7000623 | chr8:5884201:A:C | - | -0.0534777037263429 | 0.0346247936067477 | LUAD | Male-baised eQTL |
| rs34277278 | chr8:4356504:G:A | - | 0.100230209485013 | 0.03866113682771 | LUAD | Male-baised eQTL |
| rs4563903 | chr8:5885431:G:C | - | -0.0516954566871732 | 0.0421178130618972 | LUAD | Male-baised eQTL |
| rs73207299 | chr8:11833636:G:A | - | 0.0650150394824407 | 0.0474086370422145 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000253958 |
| CpG Site: cg15441656 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.200134084091626 | |
| Female Effect: - | |
 | Gene ID: ENSG00000253958 |
| CpG Site: cg19436804 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.423957419051229 | |
| Female Effect: - | |
 | Gene ID: ENSG00000253958 |
| CpG Site: cg15441656 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.423434465739745 | |
| Female Effect: - | |
 | Gene ID: ENSG00000253958 |
| CpG Site: cg15441656 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: - | |
| Female Effect: -0.460349837659743 | |
 | Gene ID: ENSG00000253958 |
| CpG Site: cg15441656 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: -0.174248078102606 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15441656 | chr8:8703424 | gene,exon,promoter,UTR | -0.200134084091626 | 2.91057449259586e-05 | -0.3536111213962438 | 1.9822114208364747e-07 | LUAD |
| cg19436804 | chr8:8703356 | gene,exon,promoter,UTR | -0.423957419051229 | 5.20401131520953e-10 | -0.43871589520310333 | 2.516875219107123e-13 | LIHC |
| cg15441656 | chr8:8703424 | gene,exon,promoter,UTR | -0.423434465739745 | 5.55377746494311e-10 | -0.48969561669195516 | 6.985412802833936e-14 | LIHC |
| cg15441656 | chr8:8703424 | gene,exon,promoter,UTR | -0.174248078102606 | 3.69981308112696e-05 | -0.31137476689863985 | 1.1541222632340183e-07 | BLCA |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15441656 | chr8:8703424 | gene,exon,promoter,UTR | -0.460349837659743 | 5.81601578651915e-23 | -0.8528775212627661 | 7.486231529696719e-27 | LUSC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of CLDN23 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
