SexAnnoDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structure and Gene expression level

leaf

Sex-biased somatic mutation

leaf

DNA methylation with beta values in gene

leaf

Exon skipping events with PSI in TCGA

leaf

RNA A-to-I editing events in TCGA

leaf

Sex-biased TF-Gene network of gene

leaf

Sex-biased RBP-ES network of gene

leaf

Sex-biased CeRNA regulation of gene

leaf

Sex-biased eQTL regulation of gene

leaf

Sex-biased eQTM regulation of gene

leaf

Sex-biased sQTL regulation of gene

leaf

Sex-biased sQTM regulation of gene

leaf

Related disease information of gene

Gene: ENSG00000253313

Summary for C1orf210

check button Gene summary

Gene informationEnsembl ID

ENSG00000253313

Gene symbol

C1orf210

Gene namechromosome 1 open reading frame 210
HGNC

28755

Entrez ID

149466

Gene typeprotein_coding
SynonymsC1orf210|MGC52423|TEMP
UniProtAcc

Q8IVY1


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

Top

Structure and expression level for C1orf210

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
C1orf2104.83e+021.31e+004.03e-013.26e+001.12e-033.64e-03BLCA
C1orf2101.09e+03-1.03e+003.76e-01-2.73e+006.38e-031.35e-02KICH
C1orf2107.52e+021.46e+004.42e-013.32e+009.11e-043.13e-03CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
C1orf2109.46e+02-1.18e+002.52e-01-4.67e+002.99e-062.27e-05READ

Top

Sex-biased somatic mutation for C1orf210

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

Top

DNA methylation with beta values for C1orf210

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg23800435chr1:43285705CGI:chr1:43272813-43273158promoter3.61e-012.54e-012.79e+005.26e-032.08e-021.07e-01
BRCAcg01413566chr1:43284969CGI:chr1:43272813-43273158promoter,gene body4.75e-013.71e-013.06e+002.22e-031.43e-021.04e-01
BRCAcg12752420chr1:43285692CGI:chr1:43272813-43273158promoter4.62e-013.25e-012.86e+004.18e-031.89e-021.37e-01
BRCAcg00500789chr1:43285699CGI:chr1:43272813-43273158promoter4.24e-013.11e-012.52e+001.16e-022.82e-021.13e-01
BRCAcg09988116chr1:43285022CGI:chr1:43272813-43273158promoter,gene body5.56e-014.31e-012.75e+005.91e-032.18e-021.25e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg01413566chr1:43284969CGI:chr1:43272813-43273158promoter,gene body5.45e-014.25e-015.58e+002.48e-081.53e-071.20e-01
KIRCcg24464789chr1:43285826CGI:chr1:43272813-43273158promoter5.28e-014.04e-014.43e+009.21e-062.52e-051.24e-01
LUSCcg23800435chr1:43285705CGI:chr1:43272813-43273158promoter4.15e-015.47e-01-3.49e+004.83e-041.62e-03-1.31e-01
LUSCcg04289036chr1:43285599CGI:chr1:43272813-43273158UTR,promoter,exon,gene body4.42e-015.73e-01-3.84e+001.21e-047.60e-04-1.30e-01
LUSCcg12752420chr1:43285692CGI:chr1:43272813-43273158promoter5.20e-016.91e-01-3.40e+006.72e-042.00e-03-1.70e-01
LUSCcg00500789chr1:43285699CGI:chr1:43272813-43273158promoter4.78e-016.46e-01-3.67e+002.43e-041.08e-03-1.67e-01
LUSCcg24464789chr1:43285826CGI:chr1:43272813-43273158promoter4.85e-017.27e-01-3.95e+007.91e-056.37e-04-2.42e-01
LUSCcg02990330chr1:43285833CGI:chr1:43272813-43273158promoter4.79e-016.10e-01-3.53e+004.11e-041.47e-03-1.30e-01
LUSCcg14036856chr1:43285892CGI:chr1:43272813-43273158promoter4.03e-015.74e-01-3.79e+001.52e-048.45e-04-1.70e-01
COADcg24464789chr1:43285826CGI:chr1:43272813-43273158promoter3.40e-014.41e-01-2.55e+001.07e-021.51e-02-1.01e-01
CHOLcg01413566chr1:43284969CGI:chr1:43272813-43273158promoter,gene body4.50e-017.62e-01-3.54e+004.02e-048.32e-03-3.12e-01
CHOLcg09988116chr1:43285022CGI:chr1:43272813-43273158promoter,gene body5.15e-018.71e-01-3.54e+004.02e-048.32e-03-3.56e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg23800435chr1:43285705CGI:chr1:43272813-43273158promoter3.61e-014.82e-01-8.16e+003.36e-161.34e-15-1.21e-01
BRCAcg01413566chr1:43284969CGI:chr1:43272813-43273158promoter,gene body4.75e-015.80e-01-9.01e+001.99e-191.02e-18-1.05e-01
BRCAcg12752420chr1:43285692CGI:chr1:43272813-43273158promoter4.62e-016.34e-01-8.63e+006.22e-182.84e-17-1.72e-01
BRCAcg00500789chr1:43285699CGI:chr1:43272813-43273158promoter4.24e-015.80e-01-8.41e+003.96e-171.70e-16-1.56e-01
BRCAcg09988116chr1:43285022CGI:chr1:43272813-43273158promoter,gene body5.56e-016.85e-01-7.65e+002.08e-147.26e-14-1.29e-01
BRCAcg24464789chr1:43285826CGI:chr1:43272813-43273158promoter4.33e-016.80e-01-1.04e+012.45e-252.15e-24-2.47e-01
BRCAcg02990330chr1:43285833CGI:chr1:43272813-43273158promoter4.51e-016.16e-01-9.37e+007.59e-214.41e-20-1.65e-01
BRCAcg14036856chr1:43285892CGI:chr1:43272813-43273158promoter3.56e-014.93e-01-8.71e+002.99e-181.40e-17-1.37e-01
HNSCcg00500789chr1:43285699CGI:chr1:43272813-43273158promoter5.12e-013.95e-011.98e+004.78e-024.82e-021.18e-01
HNSCcg09988116chr1:43285022CGI:chr1:43272813-43273158promoter,gene body7.38e-015.43e-012.71e+006.64e-031.52e-021.96e-01
HNSCcg14036856chr1:43285892CGI:chr1:43272813-43273158promoter4.26e-013.18e-012.10e+003.54e-023.95e-021.08e-01
HNSCcg19086488chr1:43286514CGI:chr1:43272813-43273158promoter7.98e-019.04e-01-3.16e+001.60e-039.36e-03-1.05e-01
BLCAcg23800435chr1:43285705CGI:chr1:43272813-43273158promoter3.54e-015.37e-01-3.19e+001.44e-035.74e-03-1.83e-01
BLCAcg04289036chr1:43285599CGI:chr1:43272813-43273158UTR,promoter,exon,gene body3.74e-015.36e-01-3.09e+002.01e-036.81e-03-1.62e-01

Top

Exon skipping events with PSI in TCGA for C1orf210

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

Top

RNA A-to-I editing events in TCGA for C1orf210

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

Top

Sex-biased TF-Gene network for C1orf210

check buttonTFs related to C1orf210.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
CHOLSNAI1C1orf2104.00e+009.83e-012.87e+005.14e-03Male-biased
CHOLZNF200C1orf2104.28e+009.84e-013.27e+008.48e-03Male-biased
GBMZNF235C1orf2103.04e+001.33e-034.87e+009.95e-01Female-biased
GBMZNF287C1orf2103.00e+001.85e-034.71e+009.94e-01Female-biased
GBMZNF487C1orf2103.07e+003.16e-034.58e+009.92e-01Female-biased

check buttonC1orf210 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

Top

Sex-biased RBP-ES network for C1orf210

check buttonRBPs related to ES in C1orf210.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonC1orf210 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

Top

Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000253313ZNF687-AS1,hsa-mir-665,C1orf210Male-specific ceRNATCGA-BLCA

Top

Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs12409819chr1:41548263:T:C-0.1334714412752080.00764603714884252COADFemale-baised eQTL
rs78710926chr1:41549529:G:T-0.1334714412752080.00764603714884252COADFemale-baised eQTL
rs80115073chr1:41550141:C:A-0.1334714412752080.00764603714884252COADFemale-baised eQTL
rs72951401chr1:41556685:T:C-0.1334714412752080.00764603714884252COADFemale-baised eQTL
rs57379984chr1:41560408:G:A-0.1334714412752080.00764603714884252COADFemale-baised eQTL
rs56256181chr1:41562708:A:G-0.1334714412752080.00764603714884252COADFemale-baised eQTL
rs2181276chr1:41563463:G:A-0.1288984530588730.0113255576801295COADFemale-baised eQTL
rs66604456chr1:41539512:G:A-0.1315401353456320.012728679357504COADFemale-baised eQTL
rs59330427chr1:41534896:G:C-0.1312182658081270.0133791348215805COADFemale-baised eQTL
rs1258012chr1:46606472:A:G-0.07529399373687270.0142977108731903COADFemale-baised eQTL
rs11211323chr1:46605736:G:C--0.07437799187993420.0154552477966695COADFemale-baised eQTL
rs11264095chr1:37734325:G:C-0.09266273112808250.0171031120205822COADFemale-baised eQTL
rs10890406chr1:46603005:C:T--0.07388588011438070.0171714362355717COADFemale-baised eQTL
rs2297850chr1:46576940:C:T-0.06977290931823610.0174423615393848COADFemale-baised eQTL
rs942083chr1:46611309:G:C-0.07261582025626760.0179759397481444COADFemale-baised eQTL
rs10890408chr1:46610826:A:G--0.07289956274711320.019106988503438COADFemale-baised eQTL
rs11211324chr1:46610916:C:A--0.07106818531398890.0194956150661361COADFemale-baised eQTL
rs11211325chr1:46610927:A:C--0.07106818531398890.0194956150661361COADFemale-baised eQTL
rs11211326chr1:46612637:C:G--0.07169557494971660.0225433100432593COADFemale-baised eQTL
rs11211327chr1:46612646:T:C--0.07169557494971660.0225433100432593COADFemale-baised eQTL
rs4660357chr1:46601601:C:T--0.07211624597969720.0230248039215923COADFemale-baised eQTL
rs6687832chr1:46602151:T:C--0.07211624597969720.0230248039215923COADFemale-baised eQTL
rs36058295chr1:46602823:A:G--0.07135475382429080.0249066500598968COADFemale-baised eQTL
rs956527chr1:46590320:T:C-0.06705008146469120.0271579882031085COADFemale-baised eQTL
rs11211319chr1:46600711:T:C--0.07129718692364160.0271925871653082COADFemale-baised eQTL
rs11211320chr1:46601073:T:C--0.07129718692364160.0271925871653082COADFemale-baised eQTL
rs12136479chr1:46602678:A:G--0.07138737316647740.0276828238928945COADFemale-baised eQTL
rs10890407chr1:46604058:A:G--0.07063024213273050.0298516944363036COADFemale-baised eQTL
rs4660947chr1:46612965:T:C--0.06765547845781970.0371314663461941COADFemale-baised eQTL
rs116516140chr1:40012377:A:T-0.1143534267633990.0372375841175174COADFemale-baised eQTL
rs12022855chr1:46602912:C:T--0.06974179941738070.0407413316081878COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs2810581chr1:41471224:T:C--0.1475074528990430.0233414988916025KIRPMale-baised eQTL
rs523755chr1:43048650:G:A-0.08096119186573290.0457967164522068KIRPMale-baised eQTL
rs16828535chr1:41676802:G:A-0.1318800607252130.00667778050616806LUADMale-baised eQTL
rs12409546chr1:36016250:C:T-0.142653269873060.0404039047823042LUADMale-baised eQTL
rs55657908chr1:43261717:G:A-0.05842782308965530.0292609269742866COADMale-baised eQTL
rs2764417chr1:43242901:G:T-0.05850399145969410.0305045542640212COADMale-baised eQTL
rs35509903chr1:43247986:G:A-0.05759055630182010.0330610747666123COADMale-baised eQTL
rs2484713chr1:43258759:G:A-0.05716990343420520.0343576152418847COADMale-baised eQTL
rs6657897chr1:43247770:C:T-0.05694327340724310.0357606237216231COADMale-baised eQTL
rs9429132chr1:43265670:A:G-0.05615779779980010.0378080275596838COADMale-baised eQTL
rs524158chr1:47467422:G:T--0.04954118792095770.0404900478407521COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

Top

Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000253313
CpG Site: cg19234495
Position to Gene: gene,exon,CDS
Male Effect: -
Female Effect: -0.413331571101973
eQTM boxplot analysisGene ID: ENSG00000253313
CpG Site: cg09988116
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.447453847007151
eQTM boxplot analysisGene ID: ENSG00000253313
CpG Site: cg02990330
Position to Gene: promoter
Male Effect: -
Female Effect: -0.447453847007151

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg19234495chr1:43282992gene,exon,CDS-0.4133315711019734.61618165179225e-09-0.67616871319799555.8754765921287225e-12PAAD
cg09988116chr1:43285022gene,promoter-0.4474538470071513.61704256955315e-23-0.60594024220347015.99796020665408e-27LUAD
cg02990330chr1:43285833promoter-0.4474538470071513.61704256955315e-23-0.60594024220347015.99796020665408e-27LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

Top

Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

Top

Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

Top

Related disease information of C1orf210

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource