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Gene: ENSG00000251258 |
Summary for RFPL4B |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000251258 | Gene symbol | RFPL4B |
| Gene name | ret finger protein like 4B | |
| HGNC | 33264 | |
| Entrez ID | 442247 | |
| Gene type | protein_coding | |
| Synonyms | RFPL4B|RNF211 | |
| UniProtAcc | Q6ZWI9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for RFPL4B |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for RFPL4B |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RFPL4B |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg17093867 | chr6:112347369 | CGI:chr6:112362557-112362777 | UTR,promoter,exon,gene body | 7.95e-01 | 9.55e-01 | -2.91e+00 | 3.63e-03 | 6.38e-03 | -1.60e-01 |
| BLCA | cg01986631 | chr6:112346778 | CGI:chr6:112362557-112362777 | promoter | 8.33e-01 | 9.35e-01 | -2.51e+00 | 1.20e-02 | 1.63e-02 | -1.02e-01 |
| LIHC | cg01986631 | chr6:112346778 | CGI:chr6:112362557-112362777 | promoter | 7.35e-01 | 8.90e-01 | -3.65e+00 | 2.63e-04 | 4.85e-04 | -1.54e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for RFPL4B |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RFPL4B |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RFPL4B |
| TFs related to RFPL4B. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | FOXL1 | RFPL4B | 5.49e+00 | 9.81e-01 | 4.84e+00 | 1.79e-02 | Male-biased |
| BLCA | ZNF334 | RFPL4B | 5.30e+00 | 9.85e-01 | 4.55e+00 | 1.25e-02 | Male-biased |
| CHOL | FOXL1 | RFPL4B | 4.68e+00 | 1.71e-02 | 5.48e+00 | 9.81e-01 | Female-biased |
| CHOL | ZNF334 | RFPL4B | 4.68e+00 | 1.09e-02 | 5.60e+00 | 9.88e-01 | Female-biased |
| CHOL | ZNF487 | RFPL4B | 3.51e+00 | 1.26e-02 | 4.38e+00 | 9.80e-01 | Female-biased |
| GBM | FOXL1 | RFPL4B | 4.65e+00 | 1.26e-02 | 5.64e+00 | 9.86e-01 | Female-biased |
| GBM | FOXR2 | RFPL4B | 4.52e+00 | 1.07e-02 | 5.57e+00 | 9.88e-01 | Female-biased |
| GBM | PRDM6 | RFPL4B | 4.13e+00 | 1.07e-02 | 5.18e+00 | 9.87e-01 | Female-biased |
| GBM | ZNF334 | RFPL4B | 4.48e+00 | 6.80e-03 | 5.71e+00 | 9.92e-01 | Female-biased |
| GBM | ZNF487 | RFPL4B | 4.06e+00 | 9.80e-03 | 5.14e+00 | 9.88e-01 | Female-biased |
| MESO | FOXL1 | RFPL4B | 4.92e+00 | 9.90e-01 | 3.57e+00 | 6.47e-03 | Male-biased |
| MESO | FOXR2 | RFPL4B | 4.86e+00 | 9.91e-01 | 3.43e+00 | 4.91e-03 | Male-biased |
| MESO | ZNF263 | RFPL4B | 3.54e+00 | 1.34e-02 | 4.72e+00 | 9.81e-01 | Female-biased |
| MESO | ZNF334 | RFPL4B | 4.84e+00 | 9.93e-01 | 3.25e+00 | 2.85e-03 | Male-biased |
| PAAD | FOXL1 | RFPL4B | 4.42e+00 | 7.91e-03 | 5.27e+00 | 9.90e-01 | Female-biased |
| PAAD | FOXR2 | RFPL4B | 4.30e+00 | 4.82e-03 | 5.26e+00 | 9.93e-01 | Female-biased |
| PAAD | MEOX2 | RFPL4B | 5.01e+00 | 1.76e-02 | 5.70e+00 | 9.81e-01 | Female-biased |
| PAAD | ZNF334 | RFPL4B | 4.25e+00 | 2.44e-03 | 5.34e+00 | 9.96e-01 | Female-biased |
| SARC | FOXL1 | RFPL4B | 4.94e+00 | 9.93e-01 | 4.22e+00 | 3.84e-03 | Male-biased |
| SARC | FOXR2 | RFPL4B | 5.12e+00 | 9.96e-01 | 4.26e+00 | 1.79e-03 | Male-biased |
| SARC | IRX3 | RFPL4B | 7.10e+00 | 9.89e-01 | 6.55e+00 | 1.08e-02 | Male-biased |
| SARC | MEOX2 | RFPL4B | 6.25e+00 | 9.95e-01 | 5.55e+00 | 4.18e-03 | Male-biased |
| SARC | SIX2 | RFPL4B | 6.30e+00 | 9.87e-01 | 5.77e+00 | 1.21e-02 | Male-biased |
| SARC | ZNF154 | RFPL4B | 6.67e+00 | 9.83e-01 | 6.18e+00 | 1.62e-02 | Male-biased |
| SARC | ZNF334 | RFPL4B | 5.01e+00 | 9.94e-01 | 4.21e+00 | 2.42e-03 | Male-biased |
| SKCM | KLF3 | RFPL4B | 4.50e+00 | 9.36e-03 | 5.51e+00 | 9.88e-01 | Female-biased |
| SKCM | KLF7 | RFPL4B | 3.61e+00 | 8.26e-03 | 4.64e+00 | 9.81e-01 | Female-biased |
| THYM | DUX4 | RFPL4B | 7.09e+00 | 9.90e-01 | 6.40e+00 | 9.79e-03 | Male-biased |
| THYM | DUXA | RFPL4B | 7.06e+00 | 9.85e-01 | 6.47e+00 | 1.43e-02 | Male-biased |
| THYM | FOXL1 | RFPL4B | 5.66e+00 | 9.98e-01 | 4.40e+00 | 9.51e-04 | Male-biased |
| THYM | FOXR2 | RFPL4B | 5.65e+00 | 9.98e-01 | 4.41e+00 | 1.01e-03 | Male-biased |
| THYM | IRX3 | RFPL4B | 7.19e+00 | 9.88e-01 | 6.55e+00 | 1.16e-02 | Male-biased |
| THYM | MEOX2 | RFPL4B | 6.34e+00 | 9.97e-01 | 5.35e+00 | 2.72e-03 | Male-biased |
| THYM | PRDM6 | RFPL4B | 4.18e+00 | 9.81e-01 | 3.41e+00 | 6.65e-03 | Male-biased |
| THYM | SIX2 | RFPL4B | 6.16e+00 | 9.89e-01 | 5.49e+00 | 1.03e-02 | Male-biased |
| THYM | ZNF154 | RFPL4B | 6.70e+00 | 9.84e-01 | 6.12e+00 | 1.60e-02 | Male-biased |
| THYM | ZNF334 | RFPL4B | 5.97e+00 | 9.99e-01 | 4.34e+00 | 2.15e-04 | Male-biased |
| RFPL4B related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RFPL4B |
| RBPs related to ES in RFPL4B. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RFPL4B related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RFPL4B |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
