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Gene: ENSG00000243364

Summary for EFNA4

Gene summary

Gene information	Ensembl ID	ENSG00000243364
	Gene symbol	EFNA4
	Gene name	ephrin A4
	HGNC	3224
	Entrez ID	1945
	Gene type	protein_coding
	Synonyms	EFNA4\|LERK4
	UniProtAcc	P52798

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for EFNA4

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
EFNA4	9.83e+02	1.98e+00	2.49e-01	7.92e+00	2.36e-15	1.71e-13	BLCA
EFNA4	6.98e+02	2.26e+00	4.93e-01	4.59e+00	4.51e-06	2.78e-05	CHOL

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
EFNA4	1.42e+03	1.27e+00	9.51e-02	1.34e+01	8.52e-41	6.34e-40	BRCA
EFNA4	1.08e+03	1.09e+00	2.22e-01	4.93e+00	8.42e-07	7.50e-06	READ

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Sex-biased somatic mutation for EFNA4

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for EFNA4

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg11491247	chr1:155063054	CGI:chr1:155062449-155064102	promoter	2.65e-01	1.62e-01	2.93e+00	3.41e-03	1.74e-02	1.02e-01
BRCA	cg16905506	chr1:155063272	CGI:chr1:155062449-155064102	promoter	3.18e-01	1.96e-01	2.53e+00	1.13e-02	2.79e-02	1.22e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
LUAD	cg13069100	chr1:155062532	CGI:chr1:155062449-155064102	promoter	3.71e-01	4.73e-01	-4.15e+00	3.28e-05	1.11e-04	-1.01e-01
LUSC	cg00585901	chr1:155062912	CGI:chr1:155062449-155064102	promoter	4.18e-02	2.41e-01	-4.23e+00	2.39e-05	5.26e-04	-1.99e-01
LUSC	cg18832152	chr1:155062707	CGI:chr1:155062449-155064102	promoter	1.63e-01	3.10e-01	-4.20e+00	2.65e-05	5.26e-04	-1.47e-01
LUSC	cg11491247	chr1:155063054	CGI:chr1:155062449-155064102	promoter	1.57e-01	3.15e-01	-4.26e+00	2.02e-05	5.26e-04	-1.58e-01
LUSC	cg16905506	chr1:155063272	CGI:chr1:155062449-155064102	promoter	1.74e-01	3.81e-01	-4.24e+00	2.20e-05	5.26e-04	-2.07e-01
LUSC	cg23008177	chr1:155064101	CGI:chr1:155062449-155064102	promoter,gene body	2.81e-01	9.04e-02	4.29e+00	1.78e-05	5.26e-04	1.91e-01
KIRP	cg16905506	chr1:155063272	CGI:chr1:155062449-155064102	promoter	2.07e-01	3.39e-01	-4.43e+00	9.59e-06	3.60e-05	-1.32e-01
ESCA	cg23008177	chr1:155064101	CGI:chr1:155062449-155064102	promoter,gene body	2.97e-01	1.75e-01	2.68e+00	7.35e-03	3.54e-02	1.22e-01
CHOL	cg13069100	chr1:155062532	CGI:chr1:155062449-155064102	promoter	3.42e-01	4.59e-01	-2.51e+00	1.22e-02	2.39e-02	-1.17e-01
CHOL	cg16905506	chr1:155063272	CGI:chr1:155062449-155064102	promoter	1.85e-01	3.39e-01	-3.10e+00	1.96e-03	1.07e-02	-1.54e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg23008177	chr1:155064101	CGI:chr1:155062449-155064102	promoter,gene body	2.46e-01	1.16e-01	1.21e+01	1.01e-33	2.43e-32	1.30e-01
HNSC	cg13069100	chr1:155062532	CGI:chr1:155062449-155064102	promoter	5.40e-01	4.00e-01	2.58e+00	9.91e-03	1.85e-02	1.40e-01

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Exon skipping events with PSI in TCGA for EFNA4

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for EFNA4

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for EFNA4

TFs related to EFNA4.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
BRCA	HIC1	EFNA4	3.07e+00	3.69e-03	4.60e+00	9.88e-01	Female-biased
BRCA	HIC2	EFNA4	2.82e+00	4.48e-03	4.28e+00	9.81e-01	Female-biased
BRCA	KLF3	EFNA4	2.54e+00	2.04e-03	4.25e+00	9.82e-01	Female-biased
BRCA	MYC	EFNA4	2.64e+00	1.61e-03	4.43e+00	9.87e-01	Female-biased
BRCA	NHLH1	EFNA4	2.28e+00	1.00e-03	4.21e+00	9.82e-01	Female-biased
BRCA	PLAGL2	EFNA4	2.42e+00	2.08e-04	4.81e+00	9.94e-01	Female-biased
BRCA	ZNF101	EFNA4	2.53e+00	1.78e-03	4.28e+00	9.84e-01	Female-biased
BRCA	ZNF28	EFNA4	2.55e+00	1.15e-03	4.44e+00	9.88e-01	Female-biased
BRCA	ZNF331	EFNA4	2.33e+00	8.85e-04	4.30e+00	9.85e-01	Female-biased
BRCA	ZNF682	EFNA4	2.70e+00	3.36e-03	4.25e+00	9.81e-01	Female-biased
BRCA	ZNF891	EFNA4	2.45e+00	1.41e-03	4.27e+00	9.84e-01	Female-biased

EFNA4 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for EFNA4

RBPs related to ES in EFNA4.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

EFNA4 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID	ceRNA(lncRNA-miRNA-mRNA)	Group	Cancer Type
ENSG00000243364	AC010615.2,hsa-mir-340,EFNA4	Male-specific ceRNA	TCGA-BLCA
ENSG00000243364	AC026191.1,hsa-mir-340,EFNA4	Male-specific ceRNA	TCGA-BLCA
ENSG00000243364	LINC00858,hsa-mir-340,EFNA4	Male-specific ceRNA	TCGA-BLCA
ENSG00000243364	AC099342.1,hsa-mir-340,EFNA4	Male-specific ceRNA	TCGA-BLCA
ENSG00000243364	RUSC1-AS1,hsa-mir-340,EFNA4	Male-specific ceRNA	TCGA-BLCA
ENSG00000243364	SNHG1,hsa-mir-340,EFNA4	Male-specific ceRNA	TCGA-BLCA

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs12036538	chr1:161770010:A:T	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs4657104	chr1:161770836:A:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs4494120	chr1:161771610:C:T	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs2340823	chr1:161776888:T:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs59199825	chr1:161777881:C:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs16844014	chr1:161777883:A:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs2070151	chr1:161778266:C:T	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs10799979	chr1:161778862:C:T	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12407741	chr1:161780225:C:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs6669440	chr1:161781436:A:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs2271012	chr1:161784051:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs1910480	chr1:161784127:G:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12037837	chr1:161786278:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs6427630	chr1:161787837:A:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12045431	chr1:161791155:C:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12046853	chr1:161791159:A:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12047724	chr1:161791272:T:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs1135983	chr1:161791522:C:T	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs10917946	chr1:161792834:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12409812	chr1:161793939:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs75309567	chr1:161794462:T:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs59021559	chr1:161794514:A:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs2879841	chr1:161797031:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs114002867	chr1:161797810:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs2036494	chr1:161799346:T:G	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs1394067	chr1:161800856:T:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs12402256	chr1:161801382:T:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs3738326	chr1:161802452:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs16847590	chr1:161804782:T:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs4656333	chr1:161808028:T:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs4656334	chr1:161808904:G:A	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs4657108	chr1:161809374:T:C	-	0.233368342028386	0.00657766647975828	GBM	Female-baised eQTL
rs1779991	chr1:162763619:C:T	-	-0.256374219678939	0.0198150914928433	GBM	Female-baised eQTL
rs4657102	chr1:161770624:T:A	-	0.196136839851755	0.0399632412498168	GBM	Female-baised eQTL
rs12405111	chr1:161821937:C:A	-	0.196136839851755	0.0399632412498168	GBM	Female-baised eQTL
rs16860777	chr1:161888802:C:G	-	0.196136839851755	0.0399632412498168	GBM	Female-baised eQTL
rs35429672	chr1:145880861:T:C	-	0.0750300982212719	0.00194627575200475	LGG	Female-baised eQTL
rs10494309	chr1:157148629:T:C	-	0.0719189765844038	0.0157823736860072	LGG	Female-baised eQTL
rs6679296	chr1:157147835:A:T	-	0.0718830273923898	0.0168267399067881	LGG	Female-baised eQTL
rs11264622	chr1:157145059:T:C	-	0.0697907916462983	0.0255983802268671	LGG	Female-baised eQTL
rs373691590	chr1:158953474:C:A	-	0.117506106206063	0.0264198041611761	LGG	Female-baised eQTL
rs6656937	chr1:161924302:G:C	-	-0.0544285281204623	0.0265751540548528	LGG	Female-baised eQTL
rs10800109	chr1:161927216:G:A	-	-0.0544285281204623	0.0265751540548528	LGG	Female-baised eQTL
rs7516104	chr1:161932855:T:G	-	-0.0544285281204623	0.0265751540548528	LGG	Female-baised eQTL
rs16827987	chr1:161936002:T:C	-	-0.0544285281204623	0.0265751540548528	LGG	Female-baised eQTL
rs10737517	chr1:161938548:G:A	-	-0.0544285281204623	0.0265751540548528	LGG	Female-baised eQTL
rs4657127	chr1:161941965:C:T	-	-0.0544285281204623	0.0265751540548528	LGG	Female-baised eQTL
rs4657319	chr1:163943286:G:C	-	0.103981608893176	0.0282913632078861	LGG	Female-baised eQTL
rs857789	chr1:158815904:A:C	-	-0.0637917793001886	0.0304447036703303	LGG	Female-baised eQTL
rs6682753	chr1:158951999:G:T	-	0.101474654920603	0.0335198294021932	LGG	Female-baised eQTL
rs10753679	chr1:161923146:C:A	-	-0.0529123194836031	0.0349233497350104	LGG	Female-baised eQTL
rs6688754	chr1:158959129:G:C	-	0.113246642299332	0.0350816018511948	LGG	Female-baised eQTL
rs6671373	chr1:161921006:C:G	-	-0.0566690167789984	0.0358083477442591	LGG	Female-baised eQTL
rs7417576	chr1:161927708:C:G	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10918214	chr1:161929671:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10918215	chr1:161929941:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs7514053	chr1:161933245:A:G	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs4570397	chr1:161933893:C:T	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs2341481	chr1:161934708:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10918224	chr1:161936323:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10918225	chr1:161936415:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10753685	chr1:161936692:C:T	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10753686	chr1:161936880:A:G	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10918227	chr1:161937276:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs12142836	chr1:161937844:C:T	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10737518	chr1:161938601:T:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs4657124	chr1:161939809:G:C	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs4657125	chr1:161940173:C:T	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs4657126	chr1:161940249:A:G	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10159039	chr1:161941583:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10800137	chr1:161942942:G:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10733046	chr1:161943462:C:A	-	-0.0521096733431831	0.0376087242144695	LGG	Female-baised eQTL
rs10800106	chr1:161923222:T:C	-	-0.0521189767184822	0.0379283279647299	LGG	Female-baised eQTL
rs12562272	chr1:161946350:T:C	-	-0.0521189767184822	0.0379283279647299	LGG	Female-baised eQTL
rs2341480	chr1:161926148:G:T	-	-0.0536571499441976	0.0431340153745562	LGG	Female-baised eQTL
rs12044241	chr1:152472235:G:A	-	0.103434707964321	0.000736682862633373	LUAD	Female-baised eQTL
rs10888490	chr1:152473617:T:C	-	0.103434707964321	0.000736682862633373	LUAD	Female-baised eQTL
rs61815564	chr1:152462692:C:A	-	0.101110026344709	0.000942150369517951	LUAD	Female-baised eQTL
rs12567242	chr1:152464548:G:A	-	0.101110026344709	0.000942150369517951	LUAD	Female-baised eQTL
rs11205005	chr1:152464972:T:A	-	0.101110026344709	0.000942150369517951	LUAD	Female-baised eQTL
rs12081541	chr1:152468890:T:C	-	0.101110026344709	0.000942150369517951	LUAD	Female-baised eQTL
rs144881827	chr1:152472624:C:T	-	0.100117759627098	0.00115399770182024	LUAD	Female-baised eQTL
rs1853690	chr1:157378559:A:T	-	-0.0574849696930929	0.0273630053353023	LUAD	Female-baised eQTL
rs10793697	chr1:147038047:C:G	-	-0.0613833927684744	0.0318558709407399	LUAD	Female-baised eQTL
rs1969871	chr1:147038647:G:A	-	-0.0613833927684744	0.0318558709407399	LUAD	Female-baised eQTL
rs10793698	chr1:147038246:C:T	-	-0.0605671861319297	0.0366132733069865	LUAD	Female-baised eQTL
rs1853783	chr1:147037471:C:T	-	-0.0603426719550807	0.0384583511146526	LUAD	Female-baised eQTL
rs10793699	chr1:147038256:A:T	-	-0.0600157559314403	0.0399006168375224	LUAD	Female-baised eQTL
rs72999485	chr1:154586884:G:C	-	0.0854676308072523	0.0422767406377621	LUAD	Female-baised eQTL
rs61300392	chr1:154603209:A:T	-	0.0854676308072523	0.0422767406377621	LUAD	Female-baised eQTL
rs73001418	chr1:154613118:T:A	-	0.0854676308072523	0.0422767406377621	LUAD	Female-baised eQTL
rs73001420	chr1:154614283:C:G	-	0.0854676308072523	0.0422767406377621	LUAD	Female-baised eQTL

Female-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs77829725	chr1:162677591:C:G	-	0.0871778942367254	0.0483615492864884	LIHC	Male-baised eQTL
rs6427418	chr1:158059057:A:T	-	-0.101228229170744	0.0423587702856928	LUAD	Male-baised eQTL
rs13376489	chr1:158815857:C:A	-	-0.0607259327619151	0.00633864146017727	COAD	Male-baised eQTL
rs75699174	chr1:158820990:T:C	-	-0.093909770990289	0.0377767897048153	COAD	Male-baised eQTL
rs58608164	chr1:158825602:T:A	-	-0.0930384667813701	0.0414256081269924	COAD	Male-baised eQTL
rs201638960	chr1:158827556:T:C	-	-0.0930384667813701	0.0414256081269924	COAD	Male-baised eQTL

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

Top

Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000243364
	CpG Site: cg23008177
	Position to Gene: gene,promoter
	Male Effect: -
	Female Effect: 0.0490856867302088
	Gene ID: ENSG00000243364
	CpG Site: cg13069100
	Position to Gene: promoter
	Male Effect: -0.116240349608279
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg13069100	chr1:155062532	promoter	-0.116240349608279	3.41653550536908e-08	-0.335476388352583	3.946558329565651e-11	HNSC

Female-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg23008177	chr1:155064101	gene,promoter	0.0490856867302088	6.42035831679507e-05	0.31273718049265975	3.4339932328943375e-07	LUAD

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

Top

Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of EFNA4

Diseases associated with this gene (DisGeNET).

Gene ID

Gene Symbol

Disease ID

Disease Name

Number of PMID

Source

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene