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Gene: ENSG00000243147 |
Summary for MRPL33 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000243147 | Gene symbol | MRPL33 |
| Gene name | mitochondrial ribosomal protein L33 | |
| HGNC | 14487 | |
| Entrez ID | 9553 | |
| Gene type | protein_coding | |
| Synonyms | MRPL33|RPL33L | |
| UniProtAcc | O75394 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MRPL33 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for MRPL33 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MRPL33 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg05938007 | chr2:27771151 | CGI:chr2:27771603-27772077 | promoter | 2.22e-01 | 3.35e-01 | -5.78e+00 | 7.45e-09 | 6.27e-08 | -1.13e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for MRPL33 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| LUSC | exon_skip_324294 | 5.72e-01 | 4.64e-01 | 6.17e+00 | 6.65e-10 | 5.65e-09 | 1.09e-01 |
| COAD | exon_skip_324294 | 5.45e-01 | 4.19e-01 | 5.21e+00 | 1.91e-07 | 3.75e-06 | 1.26e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_324294 | 5.51e-01 | 3.83e-01 | 4.06e+00 | 4.83e-05 | 3.42e-03 | 1.68e-01 |
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RNA A-to-I editing events in TCGA for MRPL33 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MRPL33 |
| TFs related to MRPL33. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | IRF1 | MRPL33 | 3.97e+00 | 9.83e-01 | 3.00e+00 | 4.67e-03 | Male-biased |
| ACC | PBX2 | MRPL33 | 4.61e+00 | 9.88e-01 | 3.74e+00 | 7.49e-03 | Male-biased |
| ACC | POU4F2 | MRPL33 | 4.49e+00 | 9.93e-01 | 3.32e+00 | 2.11e-03 | Male-biased |
| ACC | ZKSCAN2 | MRPL33 | 4.54e+00 | 9.94e-01 | 3.27e+00 | 1.36e-03 | Male-biased |
| ACC | ZNF175 | MRPL33 | 4.25e+00 | 9.90e-01 | 3.06e+00 | 1.94e-03 | Male-biased |
| ACC | ZNF260 | MRPL33 | 4.34e+00 | 9.88e-01 | 3.38e+00 | 5.15e-03 | Male-biased |
| ACC | ZNF620 | MRPL33 | 4.20e+00 | 9.82e-01 | 3.39e+00 | 9.49e-03 | Male-biased |
| ACC | ZNF85 | MRPL33 | 4.17e+00 | 9.86e-01 | 3.21e+00 | 4.93e-03 | Male-biased |
| MRPL33 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MRPL33 |
| RBPs related to ES in MRPL33. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MRPL33 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6543895 | chr2:34989426:T:G | - | 0.0369699028517143 | 0.0331994596879449 | LUAD | Female-baised eQTL |
| rs55939505 | chr2:34251428:T:G | - | 0.092705195974873 | 0.0365647510585883 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6731768 | chr2:20946531:G:T | - | 0.117623968810189 | 0.0226165089920147 | KIRP | Male-baised eQTL |
| rs13010638 | chr2:20948729:G:A | - | 0.117623968810189 | 0.0226165089920147 | KIRP | Male-baised eQTL |
| rs12474041 | chr2:19974133:G:A | - | 0.0712900824178659 | 0.00882045206492534 | LGG | Male-baised eQTL |
| rs62109400 | chr2:19883962:G:A | - | 0.0691076752593067 | 0.00922192031476582 | LGG | Male-baised eQTL |
| rs6531217 | chr2:20177309:C:T | - | 0.0479848347009761 | 0.0295080810949905 | LGG | Male-baised eQTL |
| rs219141 | chr2:32982803:A:G | - | 0.0482678102223657 | 0.00993445775327552 | BLCA | Male-baised eQTL |
| rs219165 | chr2:32996472:A:G | - | 0.0469725127697472 | 0.0122982718228755 | BLCA | Male-baised eQTL |
| rs219143 | chr2:32984257:T:C | - | 0.0470163563440674 | 0.0127464438840291 | BLCA | Male-baised eQTL |
| rs12469899 | chr2:18198486:A:G | - | -0.049799584828085 | 0.012829702258779 | BLCA | Male-baised eQTL |
| rs7584431 | chr2:19582955:C:T | - | 0.0436219930328804 | 0.0142088679723127 | BLCA | Male-baised eQTL |
| rs750404 | chr2:18197748:G:T | - | 0.0428459802161892 | 0.0147749215003486 | BLCA | Male-baised eQTL |
| rs219140 | chr2:32981882:G:A | - | 0.0471699200333498 | 0.0149790533868109 | BLCA | Male-baised eQTL |
| rs35338937 | chr2:18194887:A:G | - | 0.0418393509262909 | 0.0161152324980423 | BLCA | Male-baised eQTL |
| rs7598487 | chr2:18195298:G:A | - | 0.041921956496478 | 0.018854865977587 | BLCA | Male-baised eQTL |
| rs4832551 | chr2:18190614:A:G | - | 0.0429835247300339 | 0.0190332354112648 | BLCA | Male-baised eQTL |
| rs7601701 | chr2:18195910:G:A | - | 0.0419067970043567 | 0.019236503277455 | BLCA | Male-baised eQTL |
| rs1427541 | chr2:19590861:T:G | - | 0.0420158442183237 | 0.0198323913062466 | BLCA | Male-baised eQTL |
| rs219180 | chr2:33009050:C:T | - | 0.0392890922253504 | 0.0208461631325497 | BLCA | Male-baised eQTL |
| rs7598847 | chr2:18195646:G:A | - | 0.0453431501222618 | 0.0216394315627126 | BLCA | Male-baised eQTL |
| rs399420 | chr2:34824928:T:C | - | -0.0461605989490334 | 0.02188783808601 | BLCA | Male-baised eQTL |
| rs11889602 | chr2:19586331:G:C | - | 0.0417008539578708 | 0.0227598816348518 | BLCA | Male-baised eQTL |
| rs4832549 | chr2:18187089:G:A | - | 0.0427621794402875 | 0.0230843285700579 | BLCA | Male-baised eQTL |
| rs1346345 | chr2:19587956:T:C | - | 0.0414891919851551 | 0.0235866502504157 | BLCA | Male-baised eQTL |
| rs1377085 | chr2:18185867:A:G | - | 0.0415334669634961 | 0.0328377652444321 | BLCA | Male-baised eQTL |
| rs35583076 | chr2:19532069:C:T | - | -0.0500941306847334 | 0.0447106617758798 | BLCA | Male-baised eQTL |
| rs6531208 | chr2:20123917:G:A | - | -0.0470517369339281 | 0.0449103646138578 | BLCA | Male-baised eQTL |
| rs10191140 | chr2:17868161:G:A | - | 0.0839166675935966 | 0.00268461084365179 | LUAD | Male-baised eQTL |
| rs2219008 | chr2:19683646:A:G | - | -0.0574359657461354 | 0.0141866389099145 | LUAD | Male-baised eQTL |
| rs66553925 | chr2:31010327:T:C | - | 0.0596888815499923 | 0.0317342540101646 | LUAD | Male-baised eQTL |
| rs7596636 | chr2:19611624:T:G | - | -0.0475735605055547 | 0.0321346016983696 | LUAD | Male-baised eQTL |
| rs57867296 | chr2:37788719:T:G | - | 0.092983916590522 | 0.0413346321866176 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000243147 |
| CpG Site: cg22759265 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.411715334178949 | |
 | Gene ID: ENSG00000243147 |
| CpG Site: cg18712919 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.430384878804571 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg22759265 | chr2:27775297 | gene,enhancer | -0.411715334178949 | 2.6946309135467e-05 | -0.6386446851875137 | 4.6372763985416814e-09 | LAML |
| cg18712919 | chr2:27889303 | gene | -0.430384878804571 | 2.03297518339645e-19 | -0.5764078315283431 | 5.621474152947369e-24 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_324294 | chr2:27774423:27774530 | Frame-shift | rs2141371 | chr2:27637391:G:A | Distant upstream | 0.0371255386754041 | 0.0208119355477615 | LIHC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_324294 |
| CpG Site: cg13174651 | |
| Position to EX: Distant upstream | |
| Male Effect: 0.0683637175009627 | |
| Female Effect: - |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_324294 | chr2:27774423:27774530 | cg13174651 | chr2:27263099 | Distant upstream | 0.0683637175009627 | 7.18458564611499e-05 | 0.3673311015218741 | 1.7210328278159865e-07 | Frame-shift | STAD |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MRPL33 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
