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Gene: ENSG00000221914 |
Summary for PPP2R2A |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000221914 | Gene symbol | PPP2R2A |
| Gene name | protein phosphatase 2 regulatory subunit Balpha | |
| HGNC | 9304 | |
| Entrez ID | 5520 | |
| Gene type | protein_coding | |
| Synonyms | PPP2R2A|PR52A|PR55A|B55A|PR55alpha|B55alpha | |
| UniProtAcc | P63151 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000221914 | PPP2R2A | DB02506 | 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PPP2R2A |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for PPP2R2A |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PPP2R2A |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg16896031 | chr8:26290589 | CGI:chr8:26382774-26383748 | promoter | 7.15e-01 | 9.06e-01 | -3.38e+00 | 7.33e-04 | 1.78e-03 | -1.92e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for PPP2R2A |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PPP2R2A |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PPP2R2A |
| TFs related to PPP2R2A. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF334 | PPP2R2A | 2.46e+00 | 1.99e-03 | 4.18e+00 | 9.80e-01 | Female-biased |
| SARC | DMRT2 | PPP2R2A | 4.11e+00 | 9.82e-01 | 3.42e+00 | 4.52e-03 | Male-biased |
| PPP2R2A related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PPP2R2A |
| RBPs related to ES in PPP2R2A. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | NOVA2 | exon_skip_482373 | 7.00e+00 | 3.98e-03 | 7.52e+00 | 9.85e-01 | Female-biased |
| THYM | KHDRBS2 | exon_skip_482374 | 8.74e+00 | 9.89e-01 | 8.36e+00 | 5.30e-03 | Male-biased |
| THYM | SFPQ | exon_skip_482374 | 1.15e+01 | 9.97e-01 | 1.11e+01 | 2.47e-03 | Male-biased |
| COAD | SFPQ | exon_skip_482374 | 1.15e+01 | 9.84e-01 | 1.12e+01 | 1.50e-02 | Male-biased |
| COAD | U2AF2 | exon_skip_482379 | 8.67e+00 | 6.60e-03 | 9.04e+00 | 9.89e-01 | Female-biased |
| DLBC | NOVA2 | exon_skip_482372 | 7.11e+00 | 3.08e-03 | 7.54e+00 | 9.86e-01 | Female-biased |
| LUAD | HNRNPH2 | exon_skip_482369 | 8.39e+00 | 9.87e-01 | 8.02e+00 | 6.40e-03 | Male-biased |
| ESCA | HNRNPH2 | exon_skip_482369 | 8.58e+00 | 9.83e-01 | 8.16e+00 | 1.17e-02 | Male-biased |
| READ | U2AF2 | exon_skip_482379 | 8.93e+00 | 1.36e-02 | 9.25e+00 | 9.83e-01 | Female-biased |
| MESO | NOVA2 | exon_skip_482372 | 7.10e+00 | 4.65e-03 | 7.52e+00 | 9.85e-01 | Female-biased |
| PAAD | KHDRBS2 | exon_skip_482374 | 8.42e+00 | 7.22e-03 | 8.75e+00 | 9.87e-01 | Female-biased |
| PAAD | SFPQ | exon_skip_482374 | 1.11e+01 | 1.20e-03 | 1.16e+01 | 9.98e-01 | Female-biased |
| KIRC | HNRNPH2 | exon_skip_482369 | 8.13e+00 | 6.68e-04 | 8.72e+00 | 9.94e-01 | Female-biased |
| KIRC | KHDRBS2 | exon_skip_482374 | 8.21e+00 | 1.24e-02 | 8.51e+00 | 9.81e-01 | Female-biased |
| KIRC | SFPQ | exon_skip_482374 | 1.10e+01 | 1.41e-03 | 1.15e+01 | 9.98e-01 | Female-biased |
| KICH | NOVA2 | exon_skip_482373 | 7.45e+00 | 9.85e-01 | 7.04e+00 | 3.87e-03 | Male-biased |
| KICH | RBM6 | exon_skip_482372 | 7.41e+00 | 6.21e-03 | 7.77e+00 | 9.84e-01 | Female-biased |
| SARC | KHDRBS2 | exon_skip_482374 | 8.23e+00 | 2.50e-03 | 8.75e+00 | 9.92e-01 | Female-biased |
| SARC | SFPQ | exon_skip_482374 | 1.09e+01 | 1.97e-03 | 1.14e+01 | 9.97e-01 | Female-biased |
| PPP2R2A related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10503587 | chr8:16966139:C:T | - | 0.0833244675537588 | 0.0176950293936073 | LUAD | Female-baised eQTL |
| rs6992868 | chr8:18586770:G:A | - | 0.078450136176427 | 0.0217892191638502 | LUAD | Female-baised eQTL |
| rs12679219 | chr8:16954430:A:C | - | 0.0747953985159628 | 0.028503974812714 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7816609 | chr8:26344966:A:C | gene | 0.0405460377644306 | 0.0367710778796474 | KIRC | Male-baised eQTL |
| rs7828560 | chr8:26331482:G:A | gene | 0.0409221054528374 | 0.0397139280877554 | KIRC | Male-baised eQTL |
| rs6557911 | chr8:26331714:G:T | gene | 0.0409221054528374 | 0.0397139280877554 | KIRC | Male-baised eQTL |
| rs626222 | chr8:16828208:T:G | - | 0.0409921322678408 | 0.0480302369156637 | KIRC | Male-baised eQTL |
| rs2976519 | chr8:32683389:A:G | - | -0.0616118726981671 | 0.00581008116011701 | BLCA | Male-baised eQTL |
| rs2919379 | chr8:32710447:A:G | - | -0.0542298473157695 | 0.0178131601178496 | BLCA | Male-baised eQTL |
| rs12675084 | chr8:18154771:G:T | - | 0.0706029120433582 | 0.0173886306960308 | LUAD | Male-baised eQTL |
| rs12680827 | chr8:21445472:T:A | - | 0.0669667955080493 | 0.0335571605732657 | LUAD | Male-baised eQTL |
| rs56309320 | chr8:23370951:A:C | - | 0.0615915610664517 | 0.0366478450437109 | LUAD | Male-baised eQTL |
| rs1996363 | chr8:33346208:T:C | - | 0.0487881350801838 | 0.0491388260936657 | LUAD | Male-baised eQTL |
| rs144235657 | chr8:24558054:T:C | - | 0.203419648882481 | 0.000159403343908384 | COAD | Male-baised eQTL |
| rs75342448 | chr8:24587582:C:T | - | 0.185893755139669 | 0.00060029453964973 | COAD | Male-baised eQTL |
| rs7843386 | chr8:24568811:G:A | - | -0.120917281547865 | 0.0129758235401122 | COAD | Male-baised eQTL |
| rs11781460 | chr8:24585646:G:T | - | -0.117080628807171 | 0.0146284801158416 | COAD | Male-baised eQTL |
| rs9632853 | chr8:24586077:A:G | - | -0.117080628807171 | 0.0146284801158416 | COAD | Male-baised eQTL |
| rs7465275 | chr8:17648676:A:G | - | 0.0684118674391536 | 0.0161365951503746 | COAD | Male-baised eQTL |
| rs2320345 | chr8:24591979:C:G | - | -0.115233268712784 | 0.0188928166259638 | COAD | Male-baised eQTL |
| rs7817172 | chr8:24573524:A:T | - | -0.115945599270709 | 0.0192521367513698 | COAD | Male-baised eQTL |
| rs7820210 | chr8:24578997:T:C | - | -0.114868450536687 | 0.0195678429452392 | COAD | Male-baised eQTL |
| rs7835853 | chr8:26804729:C:T | - | 0.0816648507275857 | 0.0205079820006126 | COAD | Male-baised eQTL |
| rs7013423 | chr8:24581205:G:A | - | -0.114302646657282 | 0.0205606263415777 | COAD | Male-baised eQTL |
| rs11785828 | chr8:17822910:C:G | - | -0.105168991496066 | 0.0220504666266309 | COAD | Male-baised eQTL |
| rs13254674 | chr8:21450389:G:A | - | -0.0642624506949504 | 0.0280162901574683 | COAD | Male-baised eQTL |
| rs2320347 | chr8:24592538:G:A | - | -0.109857598033677 | 0.0288503068940803 | COAD | Male-baised eQTL |
| rs7003522 | chr8:29963644:G:T | - | -0.105996917567379 | 0.0326680268748005 | COAD | Male-baised eQTL |
| rs521882 | chr8:16786917:G:A | - | -0.064398400557159 | 0.037001454535906 | COAD | Male-baised eQTL |
| rs7843529 | chr8:23432023:G:A | - | -0.0596736108294445 | 0.0378804960637862 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000221914 |
| CpG Site: cg14194344 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.438479476839191 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg14194344 | chr8:26294335 | gene,enhancer | -0.438479476839191 | 3.95083598883941e-26 | -0.6659207987431727 | 1.0915206174703904e-29 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PPP2R2A |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000221914 | PPP2R2A | C0013990 | Pathological accumulation of air in tissues | 1 | CTD_human |
| ENSG00000221914 | PPP2R2A | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000221914 | PPP2R2A | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
| ENSG00000221914 | PPP2R2A | C1257806 | Chromosomal Instability | 1 | CTD_human |
| ENSG00000221914 | PPP2R2A | C1449861 | Micronuclei, Chromosome-Defective | 1 | CTD_human |
| ENSG00000221914 | PPP2R2A | C1449862 | Micronuclei, Genotoxicant-Induced | 1 | CTD_human |
