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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000206077

Summary for ZDHHC11B

check button Gene summary

Gene informationEnsembl ID

ENSG00000206077

Gene symbol

ZDHHC11B

Gene namezinc finger DHHC-type containing 11B
HGNC

32962

Entrez ID

653082

Gene typeprotein_coding
SynonymsZDHHC11B|
UniProtAcc

P0C7U3


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for ZDHHC11B

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ZDHHC11B2.45e+021.37e+002.24e-016.11e+001.00e-095.68e-08KIRP

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ZDHHC11B2.75e+021.10e+003.83e-012.87e+004.08e-037.71e-03KIRP

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ZDHHC11B3.49e+021.81e+003.61e-015.01e+005.38e-072.05e-06KIRC
ZDHHC11B1.55e+02-1.70e+004.80e-01-3.54e+003.96e-041.91e-03HNSC
ZDHHC11B1.67e+021.12e+003.80e-012.93e+003.34e-036.42e-03COAD

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Sex-biased somatic mutation for ZDHHC11B

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for ZDHHC11B

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg02265758chr5:767325CGI:chr5:755758-756139promoter5.40e-016.66e-01-4.49e+007.29e-062.93e-05-1.26e-01
LUSCcg02265758chr5:767325CGI:chr5:755758-756139promoter5.33e-017.21e-01-3.90e+009.43e-056.81e-04-1.88e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

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Exon skipping events with PSI in TCGA for ZDHHC11B

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for ZDHHC11B

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for ZDHHC11B

check buttonTFs related to ZDHHC11B.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
BRCAPLAGL2ZDHHC11B2.89e+003.84e-034.40e+009.84e-01Female-biased

check buttonZDHHC11B related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for ZDHHC11B

check buttonRBPs related to ES in ZDHHC11B.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonZDHHC11B related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs6863138chr5:2172141:T:C--0.07870858659197090.0307730011803822LGGFemale-baised eQTL
rs6878643chr5:2174199:T:C--0.07816228563657180.0342434309710274LGGFemale-baised eQTL
rs6555067chr5:2172942:T:C--0.0748651723544110.0449227134653909LGGFemale-baised eQTL
rs10475319chr5:6158031:G:A-0.06467278677840690.00391325190036418LUADFemale-baised eQTL
rs141595836chr5:6138337:C:T-0.066735899186520.00418037048447317LUADFemale-baised eQTL
rs6861277chr5:6136012:T:C-0.06650233163446880.00447277855754032LUADFemale-baised eQTL
rs10475317chr5:6137072:T:C-0.06650233163446880.00447277855754032LUADFemale-baised eQTL
rs77578019chr5:6159692:A:G-0.06378280269173640.00498966081009411LUADFemale-baised eQTL
rs6863223chr5:6160101:A:G-0.06378280269173640.00498966081009411LUADFemale-baised eQTL
rs11749899chr5:6162061:G:T-0.0646867232934150.00529242518865752LUADFemale-baised eQTL
rs6875094chr5:6158715:G:C-0.06241079494919180.00609431271791551LUADFemale-baised eQTL
rs6867634chr5:6139830:G:A-0.06405710931004790.00688150895093252LUADFemale-baised eQTL
rs62337717chr5:4883158:G:A-0.06702781397748120.00731319228052401LUADFemale-baised eQTL
rs6880638chr5:6149941:T:C-0.05910939493288540.00745626776130353LUADFemale-baised eQTL
rs61407897chr5:6151022:G:A-0.05910939493288540.00745626776130353LUADFemale-baised eQTL
rs10061703chr5:6143272:G:A-0.06366768914256420.00749364609453908LUADFemale-baised eQTL
rs3913374chr5:4884896:C:T-0.06336840252400540.00757414671930929LUADFemale-baised eQTL
rs76329833chr5:6152892:A:G-0.05468172147578860.00838406972503752LUADFemale-baised eQTL
rs34196778chr5:6936461:A:C-0.07364480167491550.00976688745792792LUADFemale-baised eQTL
rs114481154chr5:6153061:G:A-0.05722261297619320.0106284372640529LUADFemale-baised eQTL
rs409949chr5:3239009:T:C--0.03630510271978480.0111304925438612LUADFemale-baised eQTL
rs452324chr5:3241635:T:C--0.03780138518514590.0113688495113833LUADFemale-baised eQTL
rs1691016chr5:3246805:G:T--0.03814096974587830.0132189645936567LUADFemale-baised eQTL
rs6870199chr5:6157489:C:T-0.05706928474227930.0133225785843139LUADFemale-baised eQTL
rs1661057chr5:3246652:C:G--0.03803113278350760.0134810161927588LUADFemale-baised eQTL
rs16876952chr5:6138053:A:T-0.04843900986752680.013951055991383LUADFemale-baised eQTL
rs7722528chr5:6145491:A:G-0.05795855091373320.0149891470212321LUADFemale-baised eQTL
rs7702090chr5:6145492:G:T-0.05795855091373320.0149891470212321LUADFemale-baised eQTL
rs7703251chr5:6145530:C:T-0.05795855091373320.0149891470212321LUADFemale-baised eQTL
rs7702247chr5:6145597:G:A-0.05795855091373320.0149891470212321LUADFemale-baised eQTL
rs138356297chr5:6147724:C:T-0.05756732862639120.016446194349058LUADFemale-baised eQTL
rs1346551chr5:6154192:A:T-0.04984619664591240.0170679150804972LUADFemale-baised eQTL
rs10063833chr5:6156809:C:G-0.0539529550103610.0185697476524088LUADFemale-baised eQTL
rs7714915chr5:6140944:C:T-0.05691933697176370.0188019081434899LUADFemale-baised eQTL
rs75091564chr5:6152916:G:T-0.05311169800873720.0190595504057946LUADFemale-baised eQTL
rs77373695chr5:6152918:T:G-0.05311169800873720.0190595504057946LUADFemale-baised eQTL
rs112469411chr5:6152955:T:G-0.05311169800873720.0190595504057946LUADFemale-baised eQTL
rs79266160chr5:6152994:T:C-0.05311169800873720.0190595504057946LUADFemale-baised eQTL
rs78402863chr5:6149112:C:T-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs76938645chr5:6149177:A:G-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs1351285chr5:6149905:G:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs7724990chr5:6150350:T:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs7700498chr5:6150498:G:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs11744549chr5:6150635:G:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs11742206chr5:6150648:T:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs36009273chr5:6150680:G:T-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs57783292chr5:6150937:G:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs58653855chr5:6151121:G:C-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs13357375chr5:6151687:T:C-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs76043979chr5:6151869:T:C-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs114208442chr5:6151965:C:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs60923238chr5:6152212:A:G-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs113716728chr5:6153032:G:A-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs111946797chr5:6153060:T:C-0.05304910596990260.019248218172751LUADFemale-baised eQTL
rs3100118chr5:4864743:G:A-0.05274509514470080.0196843583846714LUADFemale-baised eQTL
rs7714878chr5:6140849:C:T-0.05603744615123310.0204222192300738LUADFemale-baised eQTL
rs73736484chr5:6149108:G:A-0.0522038379591110.0213937928619083LUADFemale-baised eQTL
rs11739356chr5:6146421:C:T-0.05304060312398310.0267633272483069LUADFemale-baised eQTL
rs6868270chr5:6146724:C:T-0.05304060312398310.0267633272483069LUADFemale-baised eQTL
rs6893635chr5:6146794:T:C-0.05304060312398310.0267633272483069LUADFemale-baised eQTL
rs6868727chr5:6157347:G:C-0.05036065132858250.0273342469459164LUADFemale-baised eQTL
rs77775063chr5:6148253:A:G-0.05326238230709250.0281545218930323LUADFemale-baised eQTL
rs113000764chr5:6147609:A:G-0.05304205131298850.0293176172458891LUADFemale-baised eQTL
rs142723051chr5:6147792:C:T-0.05304205131298850.0293176172458891LUADFemale-baised eQTL
rs111621638chr5:6147943:C:A-0.05304205131298850.0293176172458891LUADFemale-baised eQTL
rs113066623chr5:6147952:C:A-0.05304205131298850.0293176172458891LUADFemale-baised eQTL
rs13180181chr5:6148501:G:A-0.05304205131298850.0293176172458891LUADFemale-baised eQTL
rs77721995chr5:6148928:A:G-0.05304205131298850.0293176172458891LUADFemale-baised eQTL
rs80320409chr5:6155994:G:C-0.05009944577033620.0311119335661468LUADFemale-baised eQTL
rs79728461chr5:6156039:G:T-0.05009944577033620.0311119335661468LUADFemale-baised eQTL
rs78429589chr5:6156057:G:A-0.05009944577033620.0311119335661468LUADFemale-baised eQTL
rs10061909chr5:6156106:C:A-0.05009944577033620.0311119335661468LUADFemale-baised eQTL
rs10073098chr5:6156732:T:C-0.05009944577033620.0311119335661468LUADFemale-baised eQTL
rs10078233chr5:6156808:G:T-0.05009944577033620.0311119335661468LUADFemale-baised eQTL
rs80302401chr5:6136697:C:T-0.05973824429526210.031150330508642LUADFemale-baised eQTL
rs10071441chr5:6156595:A:C-0.05004166513800010.0315848350740886LUADFemale-baised eQTL
rs1346550chr5:6154207:T:G-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs78765889chr5:6154660:G:A-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs79404027chr5:6154681:G:A-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs11134140chr5:6154970:A:G-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs12234065chr5:6154973:G:A-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs12233974chr5:6154985:C:T-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs12233975chr5:6155138:C:T-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs12233983chr5:6155187:C:T-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs12233984chr5:6155288:C:T-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs75395162chr5:6155431:C:T-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs78399101chr5:6155868:A:T-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs2928181chr5:6155870:T:A-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs6890934chr5:6157452:A:G-0.04986498169927410.0325749583620828LUADFemale-baised eQTL
rs9313150chr5:6399083:C:G-0.03051939431934330.0425585628250036LUADFemale-baised eQTL
rs2106546chr5:9967675:T:C-0.02773315950789590.0464930137428169LUADFemale-baised eQTL
rs7710554chr5:9968564:C:T-0.02773315950789590.0464930137428169LUADFemale-baised eQTL
rs184364chr5:3136704:C:T--0.1027177875131630.0430838135965982COADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs6889904chr5:177149:A:C-0.1402135440429230.0393009145075413STADMale-baised eQTL
rs6555602chr5:9332205:C:A--0.1188662180884727.2168871530871e-05LUADMale-baised eQTL
rs2526124chr5:9351264:T:C--0.07694426231651878.85348675865626e-05LUADMale-baised eQTL
rs668776chr5:3933341:C:G-0.08948539126474360.000386303841431361LUADMale-baised eQTL
rs587434chr5:3934607:T:C-0.08916975600679120.000790894010120923LUADMale-baised eQTL
rs600970chr5:3938965:A:G-0.08916975600679120.000790894010120923LUADMale-baised eQTL
rs1505065chr5:9094634:C:T-0.09888211590199810.00134798372505952LUADMale-baised eQTL
rs588343chr5:3934821:A:C-0.07900661985597590.00226950562790523LUADMale-baised eQTL
rs4702621chr5:9300463:G:A--0.08136581414659250.00612467921822396LUADMale-baised eQTL
rs6897386chr5:6621335:C:T-0.08914443785930770.00733629737725628LUADMale-baised eQTL
rs3822790chr5:9352102:T:G--0.06420670271584610.00775733707891355LUADMale-baised eQTL
rs3797996chr5:9360529:C:T-0.07699843705923950.0150966686215634LUADMale-baised eQTL
rs2652043chr5:5099203:T:C--0.07143567564309580.016764642526442LUADMale-baised eQTL
rs2619793chr5:5099204:A:T--0.07145273515265160.0167649043332299LUADMale-baised eQTL
rs6555601chr5:9318209:C:T-0.06961941746197810.0192809929813858LUADMale-baised eQTL
rs113247673chr5:6622676:C:T-0.07403490880131110.0248598711013622LUADMale-baised eQTL
rs56128930chr5:3900938:C:T-0.0733258365128090.027662401270404LUADMale-baised eQTL
rs686273chr5:3960381:C:T-0.0703113898342240.0281899790267957LUADMale-baised eQTL
rs4235594chr5:9306076:T:C--0.06686467593613450.0320573029139713LUADMale-baised eQTL
rs4701840chr5:9306599:T:C--0.06686467593613450.0320573029139713LUADMale-baised eQTL
rs11958394chr5:3926453:T:C-0.07169789393877580.0365563332020576LUADMale-baised eQTL
rs1546167chr5:3903760:A:T-0.07237622155880330.0413041532601088LUADMale-baised eQTL
rs74698330chr5:9341232:T:C-0.08374682416949760.0419115042314899LUADMale-baised eQTL
rs75285610chr5:9347564:T:C-0.08374682416949760.0419115042314899LUADMale-baised eQTL
rs4702620chr5:9299849:A:G--0.06359140735656840.0475696460915694LUADMale-baised eQTL
rs4701839chr5:9304042:G:A--0.06356645447193930.0476259916247475LUADMale-baised eQTL
rs6555412chr5:6899179:G:A--0.05578750457942440.0490789455905197LUADMale-baised eQTL
rs4513659chr5:6900329:G:T--0.05578750457942440.0490789455905197LUADMale-baised eQTL
rs7734081chr5:6126602:C:T-0.08679477621005980.0496757285804106COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000206077
CpG Site: cg00578511
Position to Gene: gene
Male Effect: -
Female Effect: -0.220221199151118

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg00578511chr5:758145gene-0.2202211991511187.8176628249749e-10-0.43327249398505224.3007473308995837e-13LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of ZDHHC11B

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource