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Gene: ENSG00000205336 |
Summary for GPR56 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000205336 | Gene symbol | GPR56 |
| Gene name | adhesion G protein-coupled receptor G1 | |
| HGNC | 4512 | |
| Entrez ID | 9289 | |
| Gene type | protein_coding | |
| Synonyms | ADGRG1|TM7LN4|TM7XN1 | |
| UniProtAcc | Q9Y653 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for GPR56 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| GPR56 | 1.22e+04 | 1.26e+00 | 3.15e-01 | 4.00e+00 | 6.29e-05 | 2.96e-04 | BLCA |
| GPR56 | 1.36e+04 | 1.24e+00 | 2.16e-01 | 5.73e+00 | 9.77e-09 | 8.97e-08 | STAD |
| GPR56 | 8.61e+03 | 3.55e+00 | 3.08e-01 | 1.15e+01 | 8.65e-31 | 3.84e-28 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| GPR56 | 1.60e+03 | 2.14e+00 | 3.34e-01 | 6.42e+00 | 1.38e-10 | 1.55e-09 | LIHC |
| GPR56 | 1.01e+04 | 1.88e+00 | 2.51e-01 | 7.47e+00 | 7.75e-14 | 4.86e-12 | READ |
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Sex-biased somatic mutation for GPR56 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for GPR56 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 6.24e-01 | 7.48e-01 | -2.43e+00 | 1.52e-02 | 3.14e-02 | -1.24e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 2.73e-01 | 1.72e-01 | 1.97e+00 | 4.83e-02 | 4.88e-02 | 1.01e-01 |
| KIRP | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 8.02e-01 | 6.48e-01 | 4.71e+00 | 2.49e-06 | 1.17e-05 | 1.54e-01 |
| ESCA | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 3.54e-01 | 1.01e-01 | 3.33e+00 | 8.82e-04 | 3.37e-02 | 2.53e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 6.24e-01 | 4.60e-01 | 8.71e+00 | 3.02e-18 | 1.41e-17 | 1.65e-01 |
| LUAD | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 3.82e-01 | 1.90e-01 | 2.73e+00 | 6.27e-03 | 1.13e-02 | 1.92e-01 |
| LIHC | cg00531137 | chr16:57610020 | CGI:chr16:57535936-57536932 | promoter | 5.36e-01 | 3.42e-01 | 3.57e+00 | 3.58e-04 | 1.02e-03 | 1.94e-01 |
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Exon skipping events with PSI in TCGA for GPR56 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_137035 | 5.41e-01 | 4.09e-01 | 3.26e+00 | 1.13e-03 | 7.59e-03 | 1.32e-01 |
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RNA A-to-I editing events in TCGA for GPR56 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for GPR56 |
| TFs related to GPR56. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| GPR56 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for GPR56 |
| RBPs related to ES in GPR56. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | HNRNPH2 | exon_skip_137044 | 6.58e+00 | 9.83e-01 | 5.64e+00 | 4.46e-04 | Male-biased |
| SKCM | Fusip1 | exon_skip_137113 | 8.46e+00 | 8.99e-03 | 8.82e+00 | 9.86e-01 | Female-biased |
| GPR56 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7196405 | chr16:60392124:G:A | - | -0.0713412796304242 | 0.0273931576616827 | LUAD | Female-baised eQTL |
| rs12596593 | chr16:60390722:G:A | - | -0.0712000091391791 | 0.0291269905181338 | LUAD | Female-baised eQTL |
| rs78578929 | chr16:53547207:C:A | - | 0.130574812229322 | 0.0439983853417661 | LUAD | Female-baised eQTL |
| rs61640683 | chr16:64054758:G:A | - | 0.107928552579503 | 0.0488071958865221 | LUAD | Female-baised eQTL |
| rs35103613 | chr16:64057680:C:A | - | 0.107928552579503 | 0.0488071958865221 | LUAD | Female-baised eQTL |
| rs2024473 | chr16:53546083:C:T | - | 0.106029918136412 | 0.0491049721688451 | LUAD | Female-baised eQTL |
| rs2024474 | chr16:53546370:G:C | - | 0.106029918136412 | 0.0491049721688451 | LUAD | Female-baised eQTL |
| rs12445553 | chr16:53546830:T:C | - | 0.106029918136412 | 0.0491049721688451 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11643228 | chr16:64502917:T:C | - | 0.231591068182974 | 0.000659415795917236 | SARC | Male-baised eQTL |
| rs74711817 | chr16:64521565:T:G | - | 0.231591068182974 | 0.000659415795917236 | SARC | Male-baised eQTL |
| rs79756528 | chr16:65910027:C:T | - | 0.128584326283759 | 0.0462783598969716 | LUAD | Male-baised eQTL |
| rs113979345 | chr16:64091864:G:C | - | -0.0885200465079222 | 0.00437437849166272 | COAD | Male-baised eQTL |
| rs4327050 | chr16:65562799:A:G | - | -0.0635632134915152 | 0.00744305749775595 | COAD | Male-baised eQTL |
| rs55987128 | chr16:48533526:T:A | - | 0.0874755224713866 | 0.0080672844072615 | COAD | Male-baised eQTL |
| rs72792631 | chr16:64077215:A:G | - | -0.0978618118376575 | 0.00853586086049034 | COAD | Male-baised eQTL |
| rs12443883 | chr16:48568822:C:T | - | 0.0875113539918475 | 0.00877370950112811 | COAD | Male-baised eQTL |
| rs6499766 | chr16:55570216:A:T | - | 0.0582267804056704 | 0.00905026348293643 | COAD | Male-baised eQTL |
| rs2192855 | chr16:55534733:G:A | - | -0.0577648300612417 | 0.00936023349234364 | COAD | Male-baised eQTL |
| rs4785523 | chr16:48575244:A:C | - | 0.088715116285383 | 0.0103783771431078 | COAD | Male-baised eQTL |
| rs7185033 | chr16:66423204:T:C | - | 0.0719180541411169 | 0.0106638113539244 | COAD | Male-baised eQTL |
| rs111744743 | chr16:65543210:T:C | - | 0.0846870532865688 | 0.0110494043743553 | COAD | Male-baised eQTL |
| rs72792650 | chr16:64110283:C:T | - | -0.0762201194748024 | 0.0128592327101467 | COAD | Male-baised eQTL |
| rs12447283 | chr16:65561736:G:A | - | -0.0602647270854601 | 0.0158187782427587 | COAD | Male-baised eQTL |
| rs10852424 | chr16:65561282:T:G | - | -0.0598166288180425 | 0.0176755729235939 | COAD | Male-baised eQTL |
| rs9928070 | chr16:65586361:T:A | - | 0.081467528697474 | 0.0183528189938346 | COAD | Male-baised eQTL |
| rs9927289 | chr16:65547424:G:A | - | 0.0943486533363435 | 0.022306102912196 | COAD | Male-baised eQTL |
| rs111297574 | chr16:65537003:A:G | - | 0.0760215686432871 | 0.0268195436517661 | COAD | Male-baised eQTL |
| rs3785162 | chr16:55569314:C:T | - | 0.0539518441316087 | 0.0279381554044925 | COAD | Male-baised eQTL |
| rs72792652 | chr16:64113702:A:G | - | -0.0856920685851374 | 0.0311933778573502 | COAD | Male-baised eQTL |
| rs4332746 | chr16:65562917:G:C | - | -0.0564212943396994 | 0.0314536336836406 | COAD | Male-baised eQTL |
| rs8051638 | chr16:61504858:T:C | - | -0.059402075198759 | 0.0318762599332997 | COAD | Male-baised eQTL |
| rs12597314 | chr16:48638806:G:A | - | 0.0762190841590288 | 0.0327758664932503 | COAD | Male-baised eQTL |
| rs12446683 | chr16:48695472:T:C | - | 0.0762190841590288 | 0.0327758664932503 | COAD | Male-baised eQTL |
| rs7205294 | chr16:65540709:G:A | - | 0.0763472137956154 | 0.0333576900847125 | COAD | Male-baised eQTL |
| rs28397059 | chr16:66416489:T:C | - | 0.0705054993502991 | 0.0340890326095777 | COAD | Male-baised eQTL |
| rs12446691 | chr16:64151847:G:A | - | -0.0733534071400916 | 0.0354554315259358 | COAD | Male-baised eQTL |
| rs11862010 | chr16:65550627:T:C | - | 0.0853044807948475 | 0.0356934188998487 | COAD | Male-baised eQTL |
| rs11862164 | chr16:65551017:T:C | - | 0.0853044807948475 | 0.0356934188998487 | COAD | Male-baised eQTL |
| rs10744979 | chr16:65560876:A:G | - | -0.0544369383577793 | 0.041316450647119 | COAD | Male-baised eQTL |
| rs12935096 | chr16:65556940:T:C | - | -0.0549675419569106 | 0.0435260540391861 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000205336 |
| CpG Site: cg04001668 | |
| Position to Gene: gene | |
| Male Effect: -0.377181079041729 | |
| Female Effect: - | |
 | Gene ID: ENSG00000205336 |
| CpG Site: cg03032770 | |
| Position to Gene: gene | |
| Male Effect: -0.377181079041729 | |
| Female Effect: - | |
 | Gene ID: ENSG00000205336 |
| CpG Site: cg00531137 | |
| Position to Gene: promoter | |
| Male Effect: -0.0761851900200464 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04001668 | chr16:57620435 | gene | -0.377181079041729 | 2.41963957699872e-05 | -0.3617072896453585 | 5.958702753318223e-08 | KIRC |
| cg03032770 | chr16:57635607 | gene | -0.377181079041729 | 2.41963957699872e-05 | -0.3617072896453585 | 5.958702753318223e-08 | KIRC |
| cg00531137 | chr16:57610020 | promoter | -0.0761851900200464 | 9.54961546510741e-05 | -0.3258193551559107 | 6.538609449286828e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of GPR56 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
