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Gene: ENSG00000204642 |
Summary for HLA-F |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000204642 | Gene symbol | HLA-F |
| Gene name | major histocompatibility complex, class I, F | |
| HGNC | 4963 | |
| Entrez ID | 3134 | |
| Gene type | protein_coding | |
| Synonyms | HLA-F| | |
| UniProtAcc | P30511 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for HLA-F |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HLA-F | 4.23e+03 | -1.20e+00 | 3.60e-01 | -3.34e+00 | 8.27e-04 | 9.83e-03 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HLA-F | 4.02e+03 | 1.11e+00 | 2.60e-01 | 4.28e+00 | 1.90e-05 | 8.02e-05 | THCA |
| HLA-F | 4.93e+03 | 1.29e+00 | 4.92e-01 | 2.62e+00 | 8.74e-03 | 2.13e-02 | BLCA |
| HLA-F | 4.15e+03 | 1.33e+00 | 1.86e-01 | 7.11e+00 | 1.18e-12 | 1.01e-11 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| HLA-F | 3.96e+03 | 1.01e+00 | 2.68e-01 | 3.79e+00 | 1.49e-04 | 4.60e-04 | LIHC |
Top |
Sex-biased somatic mutation for HLA-F |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for HLA-F |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19070841 | chr6:29723866 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 1.46e-01 | 2.61e-01 | -2.24e+00 | 2.51e-02 | 3.82e-02 | -1.16e-01 |
| KIRP | cg20927242 | chr6:29724234 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 2.57e-01 | 1.40e-01 | 2.78e+00 | 5.48e-03 | 1.46e-02 | 1.18e-01 |
| KIRP | cg07016276 | chr6:29724232 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 2.17e-01 | 8.92e-02 | 2.73e+00 | 6.32e-03 | 1.60e-02 | 1.28e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg20927242 | chr6:29724234 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 3.01e-02 | 1.39e-01 | -6.00e+00 | 1.94e-09 | 1.98e-08 | -1.09e-01 |
| KIRC | cg11617938 | chr6:29724504 | CGI:chr6:29723329-29724316 | promoter,gene body | 4.73e-01 | 5.91e-01 | -4.03e+00 | 5.69e-05 | 1.24e-04 | -1.18e-01 |
| LUAD | cg11201654 | chr6:29722989 | CGI:chr6:29723329-29724316 | UTR,promoter,exon,gene body | 1.13e-01 | 2.16e-01 | -4.65e+00 | 3.32e-06 | 1.73e-05 | -1.03e-01 |
| LUAD | cg22298860 | chr6:29723045 | CGI:chr6:29723329-29724316 | promoter,gene body | 2.48e-01 | 3.69e-01 | -5.46e+00 | 4.87e-08 | 7.86e-07 | -1.22e-01 |
| LUAD | cg11617938 | chr6:29724504 | CGI:chr6:29723329-29724316 | promoter,gene body | 5.77e-01 | 4.76e-01 | 3.39e+00 | 7.05e-04 | 1.45e-03 | 1.02e-01 |
| THCA | cg04186657 | chr6:29723116 | CGI:chr6:29723329-29724316 | promoter,gene body | 2.28e-01 | 4.07e-01 | -3.00e+00 | 2.70e-03 | 6.44e-03 | -1.78e-01 |
| THCA | cg11768167 | chr6:29723112 | CGI:chr6:29723329-29724316 | promoter,gene body | 2.82e-01 | 4.07e-01 | -2.30e+00 | 2.16e-02 | 2.84e-02 | -1.25e-01 |
| THCA | cg00504902 | chr6:29724406 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.35e-01 | 3.29e-01 | 2.25e+00 | 2.43e-02 | 3.08e-02 | 1.06e-01 |
| HNSC | cg08698936 | chr6:29722032 | CGI:chr6:29723329-29724316 | promoter | 7.45e-01 | 8.57e-01 | -1.97e+00 | 4.91e-02 | 4.92e-02 | -1.12e-01 |
| LUSC | cg20927242 | chr6:29724234 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 2.31e-01 | 1.58e-02 | 3.32e+00 | 9.13e-04 | 2.45e-03 | 2.16e-01 |
| LUSC | cg12588917 | chr6:29724305 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.70e-01 | 3.11e-01 | 2.28e+00 | 2.29e-02 | 2.66e-02 | 1.59e-01 |
| LUSC | cg07016276 | chr6:29724232 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 2.05e-01 | 1.07e-02 | 3.69e+00 | 2.22e-04 | 1.03e-03 | 1.94e-01 |
| LUSC | cg01405582 | chr6:29724588 | CGI:chr6:29723329-29724316 | promoter,gene body | 7.15e-01 | 5.85e-01 | 3.22e+00 | 1.27e-03 | 3.06e-03 | 1.31e-01 |
| LUSC | cg23892836 | chr6:29724308 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 5.31e-01 | 3.97e-01 | 2.55e+00 | 1.08e-02 | 1.47e-02 | 1.34e-01 |
| LUSC | cg24351901 | chr6:29724315 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 3.96e-01 | 2.76e-01 | 2.12e+00 | 3.36e-02 | 3.62e-02 | 1.20e-01 |
| LUSC | cg15331332 | chr6:29724334 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.21e-01 | 3.15e-01 | 2.08e+00 | 3.78e-02 | 3.98e-02 | 1.06e-01 |
| LUSC | cg00504902 | chr6:29724406 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 5.70e-01 | 3.95e-01 | 3.24e+00 | 1.21e-03 | 2.96e-03 | 1.76e-01 |
| LUSC | cg05358170 | chr6:29724622 | CGI:chr6:29723329-29724316 | promoter,gene body | 8.31e-01 | 6.99e-01 | 3.66e+00 | 2.52e-04 | 1.10e-03 | 1.31e-01 |
| COAD | cg08698936 | chr6:29722032 | CGI:chr6:29723329-29724316 | promoter | 6.91e-01 | 8.17e-01 | -2.11e+00 | 3.47e-02 | 3.79e-02 | -1.26e-01 |
| BLCA | cg26069562 | chr6:29724204 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 2.22e-01 | 3.07e-02 | 2.57e+00 | 1.01e-02 | 1.42e-02 | 1.91e-01 |
| BLCA | cg11201654 | chr6:29722989 | CGI:chr6:29723329-29724316 | UTR,promoter,exon,gene body | 1.66e-01 | 3.59e-01 | -3.03e+00 | 2.41e-03 | 4.55e-03 | -1.93e-01 |
| BLCA | cg22298860 | chr6:29723045 | CGI:chr6:29723329-29724316 | promoter,gene body | 2.64e-01 | 4.04e-01 | -3.19e+00 | 1.44e-03 | 3.02e-03 | -1.40e-01 |
| BLCA | cg11768167 | chr6:29723112 | CGI:chr6:29723329-29724316 | promoter,gene body | 1.74e-01 | 2.79e-01 | -2.61e+00 | 8.97e-03 | 1.30e-02 | -1.05e-01 |
| LIHC | cg20927242 | chr6:29724234 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 3.41e-01 | 1.51e-01 | 2.80e+00 | 5.18e-03 | 6.81e-03 | 1.90e-01 |
| LIHC | cg26069562 | chr6:29724204 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 1.85e-01 | 6.94e-02 | 2.30e+00 | 2.15e-02 | 2.39e-02 | 1.16e-01 |
| LIHC | cg07016276 | chr6:29724232 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 3.10e-01 | 8.49e-02 | 2.63e+00 | 8.50e-03 | 1.05e-02 | 2.25e-01 |
| LIHC | cg08698936 | chr6:29722032 | CGI:chr6:29723329-29724316 | promoter | 8.00e-01 | 9.06e-01 | -3.18e+00 | 1.47e-03 | 2.23e-03 | -1.06e-01 |
| LIHC | cg24351901 | chr6:29724315 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 5.40e-01 | 4.21e-01 | 4.09e+00 | 4.39e-05 | 9.99e-05 | 1.19e-01 |
| KIRP | cg01405582 | chr6:29724588 | CGI:chr6:29723329-29724316 | promoter,gene body | 8.37e-01 | 7.14e-01 | 5.01e+00 | 5.48e-07 | 3.34e-06 | 1.23e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg20927242 | chr6:29724234 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.28e-01 | 1.83e-01 | 7.21e+00 | 5.75e-13 | 1.80e-12 | 2.45e-01 |
| BRCA | cg26069562 | chr6:29724204 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 2.86e-01 | 7.87e-02 | 7.55e+00 | 4.41e-14 | 1.50e-13 | 2.08e-01 |
| BRCA | cg07016276 | chr6:29724232 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.19e-01 | 1.50e-01 | 6.92e+00 | 4.65e-12 | 1.36e-11 | 2.70e-01 |
| BRCA | cg11423684 | chr6:29724216 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 3.01e-01 | 1.31e-01 | 6.49e+00 | 8.74e-11 | 2.31e-10 | 1.70e-01 |
| BRCA | cg24351901 | chr6:29724315 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 5.22e-01 | 4.05e-01 | 7.06e+00 | 1.63e-12 | 4.93e-12 | 1.18e-01 |
| LUAD | cg23892836 | chr6:29724308 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.77e-01 | 3.68e-01 | 2.07e+00 | 3.88e-02 | 4.16e-02 | 1.09e-01 |
| LUAD | cg05358170 | chr6:29724622 | CGI:chr6:29723329-29724316 | promoter,gene body | 7.94e-01 | 6.90e-01 | 3.14e+00 | 1.71e-03 | 4.58e-03 | 1.04e-01 |
| BLCA | cg20927242 | chr6:29724234 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 3.48e-01 | 7.80e-02 | 2.34e+00 | 1.91e-02 | 2.63e-02 | 2.70e-01 |
| BLCA | cg23892836 | chr6:29724308 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 5.61e-01 | 4.45e-01 | 2.51e+00 | 1.22e-02 | 1.98e-02 | 1.16e-01 |
| BLCA | cg24351901 | chr6:29724315 | CGI:chr6:29723329-29724316 | promoter,exon,CDS,gene body | 4.36e-01 | 3.22e-01 | 1.98e+00 | 4.81e-02 | 4.85e-02 | 1.14e-01 |
| LIHC | cg04186657 | chr6:29723116 | CGI:chr6:29723329-29724316 | promoter,gene body | 1.02e-01 | 3.67e-01 | -5.26e+00 | 1.41e-07 | 3.55e-06 | -2.65e-01 |
| LIHC | cg11201654 | chr6:29722989 | CGI:chr6:29723329-29724316 | UTR,promoter,exon,gene body | 1.53e-01 | 3.61e-01 | -4.59e+00 | 4.39e-06 | 3.77e-05 | -2.08e-01 |
Top |
Exon skipping events with PSI in TCGA for HLA-F |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| KIRC | exon_skip_448978 | 4.26e-01 | 3.06e-01 | -5.40e+00 | 6.81e-08 | 6.75e-07 | 1.20e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for HLA-F |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for HLA-F |
| TFs related to HLA-F. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | ALX3 | HLA-F | 3.38e+00 | 6.01e-03 | 4.93e+00 | 9.86e-01 | Female-biased |
| UVM | ALX4 | HLA-F | 3.38e+00 | 5.50e-03 | 4.98e+00 | 9.87e-01 | Female-biased |
| UVM | DRGX | HLA-F | 3.09e+00 | 4.48e-03 | 4.78e+00 | 9.86e-01 | Female-biased |
| UVM | MIXL1 | HLA-F | 3.61e+00 | 8.26e-03 | 5.01e+00 | 9.85e-01 | Female-biased |
| UVM | PHOX2A | HLA-F | 3.16e+00 | 4.41e-03 | 4.86e+00 | 9.87e-01 | Female-biased |
| UVM | PROP1 | HLA-F | 3.42e+00 | 6.44e-03 | 4.94e+00 | 9.86e-01 | Female-biased |
| UVM | PRRX1 | HLA-F | 2.99e+00 | 5.55e-03 | 4.57e+00 | 9.81e-01 | Female-biased |
| UVM | ZNF580 | HLA-F | 2.60e+00 | 1.69e-03 | 4.71e+00 | 9.88e-01 | Female-biased |
| HLA-F related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for HLA-F |
| RBPs related to ES in HLA-F. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| HLA-F related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000204642 | HCP5,hsa-mir-409,HLA-F | Female-specific ceRNA | TCGA-LIHC |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17639988 | chr6:37712816:A:C | - | 0.197624685866429 | 0.0272582423486726 | PAAD | Female-baised eQTL |
| rs9369114 | chr6:39402894:G:A | - | 0.0678062711117101 | 0.0312291391981001 | LGG | Female-baised eQTL |
| rs9471092 | chr6:39405574:T:C | - | -0.0534023130076593 | 0.0347320824963888 | LGG | Female-baised eQTL |
| rs1114648 | chr6:39404432:C:T | - | -0.0526997392595452 | 0.0393845532165181 | LGG | Female-baised eQTL |
| rs9471090 | chr6:39401623:G:C | - | 0.0677864068221502 | 0.0440453549825092 | LGG | Female-baised eQTL |
| rs707901 | chr6:26132436:C:T | - | 0.0859269277455638 | 0.00112676451722904 | LUAD | Female-baised eQTL |
| rs16891344 | chr6:26133882:G:T | - | 0.0897920393531675 | 0.00121602112965076 | LUAD | Female-baised eQTL |
| rs806976 | chr6:26129371:C:T | - | 0.0830968219509216 | 0.00173763858875155 | LUAD | Female-baised eQTL |
| rs707899 | chr6:26129720:C:T | - | 0.0830968219509216 | 0.00173763858875155 | LUAD | Female-baised eQTL |
| rs707898 | chr6:26116992:T:C | - | 0.0819012071950618 | 0.00211425922745106 | LUAD | Female-baised eQTL |
| rs1773285 | chr6:26122471:G:T | - | 0.0819012071950618 | 0.00211425922745106 | LUAD | Female-baised eQTL |
| rs6931863 | chr6:26125596:G:A | - | 0.0819012071950618 | 0.00211425922745106 | LUAD | Female-baised eQTL |
| rs6931542 | chr6:26125598:C:A | - | 0.0819012071950618 | 0.00211425922745106 | LUAD | Female-baised eQTL |
| rs1150663 | chr6:26127024:A:G | - | 0.0819012071950618 | 0.00211425922745106 | LUAD | Female-baised eQTL |
| rs707891 | chr6:26106009:G:T | - | 0.0805188082983759 | 0.00421428823633348 | LUAD | Female-baised eQTL |
| rs1773284 | chr6:26122225:C:A | - | 0.0742877323547653 | 0.0060568371334318 | LUAD | Female-baised eQTL |
| rs707892 | chr6:26109005:T:G | - | 0.0693383260756507 | 0.0162159492497734 | LUAD | Female-baised eQTL |
| rs707893 | chr6:26109150:C:T | - | 0.0693383260756507 | 0.0162159492497734 | LUAD | Female-baised eQTL |
| rs707894 | chr6:26110371:A:C | - | 0.0693383260756507 | 0.0162159492497734 | LUAD | Female-baised eQTL |
| rs707896 | chr6:26116196:G:A | - | 0.0693383260756507 | 0.0162159492497734 | LUAD | Female-baised eQTL |
| rs707890 | chr6:26105276:A:C | - | 0.0664766963932791 | 0.0274390258892247 | LUAD | Female-baised eQTL |
| rs13217173 | chr6:33023961:G:T | - | 0.0735780258444201 | 0.0355513724356014 | LUAD | Female-baised eQTL |
| rs139089699 | chr6:32630403:G:A | - | 0.118533145094568 | 0.0373450418131086 | COAD | Female-baised eQTL |
| rs115826298 | chr6:32629208:G:A | - | 0.111486699785019 | 0.0407177885376216 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7751856 | chr6:32731211:C:A | - | -0.0471647015831671 | 0.0492410443787238 | LIHC | Male-baised eQTL |
| rs1476570 | chr6:29842083:G:A | - | 0.0545429939262592 | 0.0176187269541979 | KIRC | Male-baised eQTL |
| rs2975039 | chr6:29958602:T:C | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs9260682 | chr6:29958699:A:T | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs9260683 | chr6:29958710:T:C | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs9260684 | chr6:29958877:C:T | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs9260686 | chr6:29958919:T:C | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs2523939 | chr6:29959163:A:G | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs2517697 | chr6:29959174:T:C | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs2571398 | chr6:29959526:C:T | - | 0.0779773992390291 | 0.0431651479654547 | KIRC | Male-baised eQTL |
| rs2524075 | chr6:31276082:C:T | - | 0.0544614911075136 | 0.0477486237643571 | KIRC | Male-baised eQTL |
| rs3130696 | chr6:31276107:G:A | - | 0.0544614911075136 | 0.0477486237643571 | KIRC | Male-baised eQTL |
| rs2057016 | chr6:22656099:T:C | - | 0.0505246389486946 | 0.0185509753342029 | BLCA | Male-baised eQTL |
| rs11755054 | chr6:22656836:A:C | - | 0.0504932843955977 | 0.0187069209346461 | BLCA | Male-baised eQTL |
| rs2057017 | chr6:22657385:A:G | - | 0.0472202790537012 | 0.0353330622791223 | BLCA | Male-baised eQTL |
| rs9393320 | chr6:22638343:C:A | - | 0.0477005100948469 | 0.044575896332395 | BLCA | Male-baised eQTL |
| rs2328724 | chr6:22635115:C:G | - | 0.047497764650473 | 0.0463887165638774 | BLCA | Male-baised eQTL |
| rs9394049 | chr6:31276251:C:A | - | 0.110280699947889 | 0.0104386262118045 | LUAD | Male-baised eQTL |
| rs2853943 | chr6:31280094:T:C | - | 0.0721244356499617 | 0.0134303135501322 | LUAD | Male-baised eQTL |
| rs6912893 | chr6:31279218:C:T | - | 0.0997751622918801 | 0.0281931381959167 | LUAD | Male-baised eQTL |
| rs6919310 | chr6:31276939:A:T | - | 0.0967016510516799 | 0.0379027541264208 | LUAD | Male-baised eQTL |
| rs9391715 | chr6:31277437:T:C | - | 0.0967016510516799 | 0.0379027541264208 | LUAD | Male-baised eQTL |
| rs6921855 | chr6:31283535:T:C | - | 0.0831421002852076 | 0.000256684675822357 | COAD | Male-baised eQTL |
| rs114985235 | chr6:31301916:T:C | - | 0.088527556016851 | 0.000327201000256196 | COAD | Male-baised eQTL |
| rs116589426 | chr6:31301917:T:A | - | 0.088527556016851 | 0.000327201000256196 | COAD | Male-baised eQTL |
| rs114151681 | chr6:31301920:G:A | - | 0.088527556016851 | 0.000327201000256196 | COAD | Male-baised eQTL |
| rs9380241 | chr6:31301924:C:T | - | 0.088527556016851 | 0.000327201000256196 | COAD | Male-baised eQTL |
| rs9380242 | chr6:31304615:G:A | - | 0.088527556016851 | 0.000327201000256196 | COAD | Male-baised eQTL |
| rs56244255 | chr6:31299141:G:A | - | 0.088124938102546 | 0.000370551449214385 | COAD | Male-baised eQTL |
| rs56334149 | chr6:31299156:A:G | - | 0.088124938102546 | 0.000370551449214385 | COAD | Male-baised eQTL |
| rs12526259 | chr6:31299415:C:T | - | 0.088124938102546 | 0.000370551449214385 | COAD | Male-baised eQTL |
| rs17198727 | chr6:31288236:C:T | - | 0.0713760076125202 | 0.000584674319061758 | COAD | Male-baised eQTL |
| rs9366776 | chr6:31288853:G:A | - | 0.0713760076125202 | 0.000584674319061758 | COAD | Male-baised eQTL |
| rs10947169 | chr6:31289139:T:C | - | 0.0713760076125202 | 0.000584674319061758 | COAD | Male-baised eQTL |
| rs6899660 | chr6:31283866:A:G | - | 0.0705713341054518 | 0.000655680992733665 | COAD | Male-baised eQTL |
| rs9380236 | chr6:31286887:A:G | - | 0.0705713341054518 | 0.000655680992733665 | COAD | Male-baised eQTL |
| rs9368671 | chr6:31286927:C:T | - | 0.0705713341054518 | 0.000655680992733665 | COAD | Male-baised eQTL |
| rs72861464 | chr6:31287286:A:G | - | 0.0705713341054518 | 0.000655680992733665 | COAD | Male-baised eQTL |
| rs16899147 | chr6:31287424:A:G | - | 0.0699903721762194 | 0.000768340842032838 | COAD | Male-baised eQTL |
| rs72861465 | chr6:31287567:G:A | - | 0.0699903721762194 | 0.000768340842032838 | COAD | Male-baised eQTL |
| rs3873377 | chr6:31291091:T:C | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs6916525 | chr6:31292125:A:G | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs6939681 | chr6:31292175:T:G | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs9357122 | chr6:31292568:T:C | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs9394051 | chr6:31292792:G:C | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs9394052 | chr6:31292931:C:T | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs9295969 | chr6:31293693:G:A | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs9348863 | chr6:31294684:T:C | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs3873381 | chr6:31295454:T:G | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs3873382 | chr6:31295479:A:G | - | 0.0706224003124155 | 0.000831466715532347 | COAD | Male-baised eQTL |
| rs9394054 | chr6:31300803:T:C | - | 0.087739820495225 | 0.000860826190179148 | COAD | Male-baised eQTL |
| rs9368677 | chr6:31304544:G:A | - | 0.0756760531625497 | 0.00214184312996785 | COAD | Male-baised eQTL |
| rs9357124 | chr6:31305777:C:A | - | 0.0747284026629524 | 0.0026916599177408 | COAD | Male-baised eQTL |
| rs9368678 | chr6:31304686:T:C | - | 0.0678600127968482 | 0.00423610254490596 | COAD | Male-baised eQTL |
| rs7770635 | chr6:31303358:T:A | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs77078553 | chr6:31303360:G:C | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs7750695 | chr6:31303364:G:A | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs7750269 | chr6:31303380:A:G | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9368673 | chr6:31303980:T:C | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9368674 | chr6:31303981:G:A | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9368675 | chr6:31304380:G:A | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9368676 | chr6:31304432:G:A | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9394055 | chr6:31304777:A:G | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9368679 | chr6:31304952:C:T | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9368680 | chr6:31305067:G:C | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs7760988 | chr6:31305253:C:T | - | 0.0653148258453842 | 0.00479212021606408 | COAD | Male-baised eQTL |
| rs9394056 | chr6:31305556:A:G | - | 0.064408611139757 | 0.00597799753488797 | COAD | Male-baised eQTL |
| rs7761515 | chr6:31305589:C:A | - | 0.064408611139757 | 0.00597799753488797 | COAD | Male-baised eQTL |
| rs9357125 | chr6:31305801:C:T | - | 0.064408611139757 | 0.00597799753488797 | COAD | Male-baised eQTL |
| rs9366779 | chr6:31305914:C:T | - | 0.064408611139757 | 0.00597799753488797 | COAD | Male-baised eQTL |
| rs9394057 | chr6:31305915:A:G | - | 0.064408611139757 | 0.00597799753488797 | COAD | Male-baised eQTL |
| rs7746336 | chr6:31303210:C:T | - | 0.0623797049456377 | 0.00836471529613657 | COAD | Male-baised eQTL |
| rs1737030 | chr6:29769786:A:G | - | -0.0365722593569304 | 0.0151900121420976 | COAD | Male-baised eQTL |
| rs6930660 | chr6:31302862:T:G | - | 0.0499264298882503 | 0.0152314707225511 | COAD | Male-baised eQTL |
| rs9295982 | chr6:31342147:G:C | - | 0.0613349044461747 | 0.0197371667599169 | COAD | Male-baised eQTL |
| rs16899208 | chr6:31299719:A:G | - | 0.0727194075952143 | 0.0238209084815753 | COAD | Male-baised eQTL |
| rs16885627 | chr6:22115568:C:G | - | 0.0349854193866308 | 0.0243487035244778 | COAD | Male-baised eQTL |
| rs2524076 | chr6:31276053:G:A | - | -0.0362652139714458 | 0.0262192186627239 | COAD | Male-baised eQTL |
| rs3094680 | chr6:31276118:C:T | - | -0.0362652139714458 | 0.0262192186627239 | COAD | Male-baised eQTL |
| rs72882038 | chr6:33641397:G:T | - | 0.0498798777877923 | 0.0275691591453164 | COAD | Male-baised eQTL |
| rs2524075 | chr6:31276082:C:T | - | 0.0394322868319892 | 0.0276203733743256 | COAD | Male-baised eQTL |
| rs3130696 | chr6:31276107:G:A | - | 0.0394322868319892 | 0.0276203733743256 | COAD | Male-baised eQTL |
| rs1202301 | chr6:19925970:C:T | - | -0.0501682814756864 | 0.0349146201248197 | COAD | Male-baised eQTL |
| rs2516655 | chr6:30522601:G:A | - | -0.0327010473782686 | 0.0430796338594972 | COAD | Male-baised eQTL |
| rs2516657 | chr6:30499136:G:A | - | -0.0326067183500262 | 0.0439703182933287 | COAD | Male-baised eQTL |
| rs994645 | chr6:19921997:A:G | - | -0.0485209618157512 | 0.0465444721711731 | COAD | Male-baised eQTL |
| rs4711325 | chr6:33464932:A:G | - | 0.0338553156605124 | 0.0484757812411537 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000204642 |
| CpG Site: cg10601943 | |
| Position to Gene: gene,exon,enhancer,CDS | |
| Male Effect: -0.451147397386465 | |
| Female Effect: - | |
 | Gene ID: ENSG00000204642 |
| CpG Site: cg15331332 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: - | |
| Female Effect: -0.131682017654106 | |
 | Gene ID: ENSG00000204642 |
| CpG Site: cg05358170 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.429096400044208 | |
| Female Effect: - | |
 | Gene ID: ENSG00000204642 |
| CpG Site: cg10601943 | |
| Position to Gene: gene,exon,enhancer,CDS | |
| Male Effect: -0.186500017299188 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg10601943 | chr6:29725047 | gene,exon,enhancer,CDS | -0.451147397386465 | 8.82283314835304e-38 | -0.7763580538533317 | 9.31812300180218e-42 | KIRP |
| cg05358170 | chr6:29724622 | gene,promoter | -0.429096400044208 | 5.2163675363238e-10 | -0.4335700976505865 | 5.103961115372561e-13 | LIHC |
| cg10601943 | chr6:29725047 | gene,exon,enhancer,CDS | -0.186500017299188 | 2.52927793456788e-05 | -0.3241347335308692 | 1.3406455348092992e-07 | LIHC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15331332 | chr6:29724334 | gene,exon,CDS,promoter | -0.131682017654106 | 1.08155933665566e-08 | -0.4146640705527319 | 5.114533017604508e-12 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of HLA-F |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
