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Gene: ENSG00000204381 |
Summary for LAYN |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000204381 | Gene symbol | LAYN |
| Gene name | layilin | |
| HGNC | 29471 | |
| Entrez ID | 143903 | |
| Gene type | protein_coding | |
| Synonyms | LAYN|FLJ30977|FLJ31092 | |
| UniProtAcc | Q6UX15 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000204381 | LAYN | DB08818 | Hyaluronic acid | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for LAYN |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LAYN | 8.26e+02 | 1.27e+00 | 2.31e-01 | 5.51e+00 | 3.59e-08 | 1.66e-07 | HNSC |
| LAYN | 3.16e+02 | 2.83e+00 | 8.14e-01 | 3.47e+00 | 5.11e-04 | 1.87e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LAYN | 2.09e+02 | -1.50e+00 | 4.28e-01 | -3.50e+00 | 4.72e-04 | 1.82e-03 | READ |
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Sex-biased somatic mutation for LAYN |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for LAYN |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg02871995 | chr11:111540235 | CGI:chr11:111540207-111541474 | promoter | 2.81e-01 | 1.69e-01 | 5.48e+00 | 4.37e-08 | 2.47e-07 | 1.12e-01 |
| LUAD | cg04610224 | chr11:111541031 | CGI:chr11:111540207-111541474 | promoter,gene body | 1.46e-01 | 4.29e-02 | 4.17e+00 | 3.11e-05 | 1.06e-04 | 1.03e-01 |
| HNSC | cg08603829 | chr11:111539044 | CGI:chr11:111540207-111541474 | promoter | 7.53e-01 | 9.06e-01 | -3.99e+00 | 6.74e-05 | 1.86e-04 | -1.53e-01 |
| LUSC | cg08603829 | chr11:111539044 | CGI:chr11:111540207-111541474 | promoter | 7.69e-01 | 9.23e-01 | -3.32e+00 | 8.98e-04 | 2.42e-03 | -1.54e-01 |
| BLCA | cg21703322 | chr11:111540351 | CGI:chr11:111540207-111541474 | promoter,gene body | 3.62e-01 | 2.11e-01 | 2.23e+00 | 2.58e-02 | 2.99e-02 | 1.51e-01 |
| BLCA | cg03864000 | chr11:111540656 | CGI:chr11:111540207-111541474 | UTR,promoter,exon,gene body | 2.08e-01 | 4.38e-02 | 2.38e+00 | 1.72e-02 | 2.17e-02 | 1.64e-01 |
| BLCA | cg08603829 | chr11:111539044 | CGI:chr11:111540207-111541474 | promoter | 5.69e-01 | 8.66e-01 | -2.07e+00 | 3.85e-02 | 4.08e-02 | -2.97e-01 |
| BLCA | cg21060796 | chr11:111541254 | CGI:chr11:111540207-111541474 | promoter,gene body | 3.24e-01 | 1.69e-01 | 3.03e+00 | 2.41e-03 | 4.55e-03 | 1.55e-01 |
| LIHC | cg21060796 | chr11:111541254 | CGI:chr11:111540207-111541474 | promoter,gene body | 3.11e-01 | 2.01e-01 | 4.68e+00 | 2.94e-06 | 9.40e-06 | 1.11e-01 |
| CHOL | cg02871995 | chr11:111540235 | CGI:chr11:111540207-111541474 | promoter | 5.15e-01 | 2.89e-01 | 2.51e+00 | 1.22e-02 | 2.39e-02 | 2.26e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg04226536 | chr11:111540346 | CGI:chr11:111540207-111541474 | promoter,gene body | 4.94e-01 | 2.63e-01 | 1.22e+01 | 5.59e-34 | 1.40e-32 | 2.31e-01 |
| BRCA | cg21703322 | chr11:111540351 | CGI:chr11:111540207-111541474 | promoter,gene body | 5.13e-01 | 2.82e-01 | 1.19e+01 | 9.90e-33 | 2.05e-31 | 2.32e-01 |
| BRCA | cg02532096 | chr11:111540564 | CGI:chr11:111540207-111541474 | UTR,promoter,exon,gene body | 3.50e-01 | 8.98e-02 | 1.03e+01 | 6.83e-25 | 5.74e-24 | 2.60e-01 |
| BRCA | cg03864000 | chr11:111540656 | CGI:chr11:111540207-111541474 | UTR,promoter,exon,gene body | 2.45e-01 | 5.30e-02 | 9.99e+00 | 1.63e-23 | 1.21e-22 | 1.92e-01 |
| BRCA | cg12506005 | chr11:111540451 | CGI:chr11:111540207-111541474 | promoter,gene body | 1.45e-01 | 2.70e-02 | 9.58e+00 | 9.92e-22 | 6.23e-21 | 1.18e-01 |
| BRCA | cg08603829 | chr11:111539044 | CGI:chr11:111540207-111541474 | promoter | 7.80e-01 | 9.18e-01 | -5.98e+00 | 2.17e-09 | 5.13e-09 | -1.38e-01 |
| BRCA | cg02871995 | chr11:111540235 | CGI:chr11:111540207-111541474 | promoter | 5.43e-01 | 3.19e-01 | 1.23e+01 | 7.73e-35 | 2.21e-33 | 2.25e-01 |
| BRCA | cg06459000 | chr11:111540474 | CGI:chr11:111540207-111541474 | promoter,gene body | 1.62e-01 | 5.54e-02 | 8.85e+00 | 9.15e-19 | 4.47e-18 | 1.06e-01 |
| BRCA | cg19820372 | chr11:111540491 | CGI:chr11:111540207-111541474 | promoter,gene body | 3.67e-01 | 1.62e-01 | 1.10e+01 | 3.90e-28 | 4.56e-27 | 2.05e-01 |
| BRCA | cg04610224 | chr11:111541031 | CGI:chr11:111540207-111541474 | promoter,gene body | 2.26e-01 | 5.06e-02 | 9.87e+00 | 5.78e-23 | 4.06e-22 | 1.76e-01 |
| BRCA | cg21060796 | chr11:111541254 | CGI:chr11:111540207-111541474 | promoter,gene body | 2.99e-01 | 1.65e-01 | 7.25e+00 | 4.21e-13 | 1.33e-12 | 1.34e-01 |
| HNSC | cg04226536 | chr11:111540346 | CGI:chr11:111540207-111541474 | promoter,gene body | 3.31e-01 | 1.96e-01 | 2.33e+00 | 1.98e-02 | 2.74e-02 | 1.34e-01 |
| HNSC | cg21703322 | chr11:111540351 | CGI:chr11:111540207-111541474 | promoter,gene body | 3.47e-01 | 2.05e-01 | 2.33e+00 | 1.98e-02 | 2.74e-02 | 1.42e-01 |
| HNSC | cg02871995 | chr11:111540235 | CGI:chr11:111540207-111541474 | promoter | 4.38e-01 | 2.89e-01 | 2.41e+00 | 1.60e-02 | 2.42e-02 | 1.49e-01 |
| HNSC | cg04610224 | chr11:111541031 | CGI:chr11:111540207-111541474 | promoter,gene body | 1.58e-01 | 4.64e-02 | 1.98e+00 | 4.78e-02 | 4.82e-02 | 1.12e-01 |
| LIHC | cg04610224 | chr11:111541031 | CGI:chr11:111540207-111541474 | promoter,gene body | 2.73e-01 | 1.25e-01 | 2.43e+00 | 1.49e-02 | 1.91e-02 | 1.48e-01 |
Top |
Exon skipping events with PSI in TCGA for LAYN |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for LAYN |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for LAYN |
| TFs related to LAYN. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | HOXB8 | LAYN | 3.99e+00 | 9.80e-01 | 3.15e+00 | 7.93e-03 | Male-biased |
| BRCA | ZNF287 | LAYN | 4.05e+00 | 9.80e-01 | 2.49e+00 | 3.60e-03 | Male-biased |
| LAYN related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for LAYN |
| RBPs related to ES in LAYN. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| THCA | SRSF2 | exon_skip_64866 | 8.70e+00 | 7.28e-03 | 9.02e+00 | 9.89e-01 | Female-biased |
| LAYN related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs61902982 | chr11:106859686:C:T | - | 0.34805494758145 | 0.00888202147541081 | KIRP | Female-baised eQTL |
| rs4938294 | chr11:116644703:C:T | - | 0.168397173547223 | 0.0304628440756247 | KIRP | Female-baised eQTL |
| rs12294065 | chr11:116800824:G:C | - | 0.189070405249575 | 0.0421425736222932 | KIRP | Female-baised eQTL |
| rs111530588 | chr11:117051870:G:A | - | 0.166974089067463 | 0.0471567203022661 | KIRP | Female-baised eQTL |
| rs12099244 | chr11:101990738:A:G | - | 0.116780893739998 | 0.0322031542072621 | BLCA | Female-baised eQTL |
| rs1509714 | chr11:109058570:G:A | - | 0.146770468631524 | 0.0434377906232656 | BLCA | Female-baised eQTL |
| rs12293526 | chr11:109060933:C:A | - | 0.146800112039576 | 0.0438154022265825 | BLCA | Female-baised eQTL |
| rs508760 | chr11:105053224:G:T | - | 0.06857050170559 | 0.00653900659143122 | LUAD | Female-baised eQTL |
| rs56316161 | chr11:116090833:C:T | - | 0.0716265656683574 | 0.0080364004434335 | LUAD | Female-baised eQTL |
| rs6589236 | chr11:111423664:T:C | - | -0.0729950739189923 | 0.0168561882679872 | LUAD | Female-baised eQTL |
| rs4938582 | chr11:111424498:C:G | - | -0.0729515642380376 | 0.0215130820768139 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11226796 | chr11:105593184:A:T | - | 0.103250819762384 | 0.0352949700643718 | LUSC | Male-baised eQTL |
| rs11226799 | chr11:105600740:T:A | - | 0.103250819762384 | 0.0352949700643718 | LUSC | Male-baised eQTL |
| rs11226800 | chr11:105600756:G:A | - | 0.103250819762384 | 0.0352949700643718 | LUSC | Male-baised eQTL |
| rs12791868 | chr11:105602897:T:C | - | 0.103250819762384 | 0.0352949700643718 | LUSC | Male-baised eQTL |
| rs2615727 | chr11:108786165:A:G | - | -0.0411180147915874 | 0.0466225522930051 | KIRC | Male-baised eQTL |
| rs10892109 | chr11:117451158:C:G | - | 0.09832209657219 | 0.0373786517315905 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000204381 |
| CpG Site: cg02871995 | |
| Position to Gene: promoter | |
| Male Effect: -0.171260196020261 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg02871995 | chr11:111540235 | promoter | -0.171260196020261 | 5.43902844456737e-06 | -0.3694299526115438 | 1.2833568169146356e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs12275419 | chr11:110742540:T:C | Distant upstream | -0.0379196354823686 | 0.0184178172223145 | LUSC | Female-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs61151418 | chr11:110740804:A:G | Distant upstream | -0.042367294205658 | 0.0398390198017316 | LUSC | Female-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs7115311 | chr11:110738741:T:C | Distant upstream | -0.0408869599507377 | 0.0410181900711297 | LUSC | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs35337756 | chr11:112486307:G:A | Distant downstream | -0.0156044260994835 | 0.0136416385822703 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs7127888 | chr11:112486015:T:C | Distant downstream | -0.0154379220570096 | 0.0145892265545441 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs6589297 | chr11:112479854:T:C | Distant downstream | -0.014549111254481 | 0.0250299050195569 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs11214224 | chr11:112484244:C:T | Distant downstream | -0.0146022833500991 | 0.0253601814268527 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs1945108 | chr11:112482533:T:C | Distant downstream | -0.0142382164775689 | 0.0327465492669043 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs1945110 | chr11:112482431:A:T | Distant downstream | -0.0141429773975549 | 0.0331625407713821 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs7934997 | chr11:112483406:C:T | Distant downstream | -0.0141199561426106 | 0.0355921720988193 | LUSC | Male-baised sQTL |
| exon_skip_64866 | chr11:111549617:111549775 | Frame-shift | rs9667356 | chr11:112483695:T:C | Distant downstream | -0.0141199561426106 | 0.0355921720988193 | LUSC | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of LAYN |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
