|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000204209 |
Summary for DAXX |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000204209 | Gene symbol | DAXX |
| Gene name | death domain associated protein | |
| HGNC | 2681 | |
| Entrez ID | 1616 | |
| Gene type | protein_coding | |
| Synonyms | DAXX|DAP6 | |
| UniProtAcc | Q9UER7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for DAXX |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for DAXX |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for DAXX |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for DAXX |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for DAXX |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for DAXX |
| TFs related to DAXX. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | ELK4 | DAXX | 4.18e+00 | 9.85e-01 | 3.37e+00 | 5.73e-03 | Male-biased |
| ESCA | FEV | DAXX | 4.22e+00 | 9.87e-01 | 3.37e+00 | 4.50e-03 | Male-biased |
| ESCA | GABPA | DAXX | 4.18e+00 | 9.87e-01 | 3.29e+00 | 3.85e-03 | Male-biased |
| ESCA | ZNF200 | DAXX | 4.22e+00 | 9.86e-01 | 3.39e+00 | 5.51e-03 | Male-biased |
| DAXX related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for DAXX |
| RBPs related to ES in DAXX. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DAXX related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs763018 | chr6:36321368:A:C | - | 0.0920244265201218 | 0.0431514308500075 | LUSC | Female-baised eQTL |
| rs73728845 | chr6:31339404:G:C | - | -0.0836742054041629 | 0.0466524526798928 | LUAD | Female-baised eQTL |
| rs41272176 | chr6:36741738:G:T | - | -0.108471137092153 | 0.0310578315491023 | COAD | Female-baised eQTL |
| rs6914780 | chr6:32248752:T:A | - | -0.14536405565923 | 0.0327267558521678 | COAD | Female-baised eQTL |
| rs6906662 | chr6:32298729:G:A | - | -0.149520568627537 | 0.0337434382599821 | COAD | Female-baised eQTL |
| rs28895018 | chr6:32256601:T:C | - | -0.148494484088942 | 0.0361586632073857 | COAD | Female-baised eQTL |
| rs28732185 | chr6:32276406:C:A | - | -0.148494484088942 | 0.0361586632073857 | COAD | Female-baised eQTL |
| rs28732186 | chr6:32287640:G:A | - | -0.148494484088942 | 0.0361586632073857 | COAD | Female-baised eQTL |
| rs17208363 | chr6:32329432:G:A | - | -0.147016072061356 | 0.040115751951129 | COAD | Female-baised eQTL |
| rs28732192 | chr6:32338703:A:T | - | -0.147016072061356 | 0.040115751951129 | COAD | Female-baised eQTL |
| rs28732194 | chr6:32344180:T:C | - | -0.147016072061356 | 0.040115751951129 | COAD | Female-baised eQTL |
| rs28732195 | chr6:32349354:A:G | - | -0.147016072061356 | 0.040115751951129 | COAD | Female-baised eQTL |
| rs141186884 | chr6:37031432:T:C | - | -0.147116157805413 | 0.0430859905743066 | COAD | Female-baised eQTL |
| rs28732188 | chr6:32311755:C:A | - | -0.142719543984631 | 0.0461718648058443 | COAD | Female-baised eQTL |
| rs28732189 | chr6:32318673:T:G | - | -0.142719543984631 | 0.0461718648058443 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9263970 | chr6:31218824:A:C | - | -0.0602150061265045 | 0.0178141354744869 | KIRC | Male-baised eQTL |
| rs9263969 | chr6:31218757:C:T | - | -0.0564385315628879 | 0.035358511547245 | KIRC | Male-baised eQTL |
| rs28744282 | chr6:31249041:T:A | - | -0.0960390518016054 | 0.0480933860177634 | KIRC | Male-baised eQTL |
| rs16869652 | chr6:33883396:G:A | - | 0.0794313394060222 | 0.0478066368774794 | BLCA | Male-baised eQTL |
| rs573580 | chr6:23980298:C:T | - | -0.104317459060389 | 0.0335718722227995 | LUAD | Male-baised eQTL |
| rs806521 | chr6:23979138:G:C | - | -0.104159933547918 | 0.0388342309076074 | LUAD | Male-baised eQTL |
| rs9394680 | chr6:40305512:G:A | - | -0.0675344488747752 | 1.30617207094788e-05 | COAD | Male-baised eQTL |
| rs2758905 | chr6:39292851:T:A | - | -0.0500065160910174 | 0.00275671768883925 | COAD | Male-baised eQTL |
| rs2815060 | chr6:39293021:A:T | - | -0.0488097809154622 | 0.00328122851866287 | COAD | Male-baised eQTL |
| rs2815059 | chr6:39292691:C:A | - | -0.0487015840059944 | 0.00449059553644185 | COAD | Male-baised eQTL |
| rs2758902 | chr6:39290261:G:A | - | -0.0475815854563756 | 0.00798451807121588 | COAD | Male-baised eQTL |
| rs2758896 | chr6:39287092:A:G | - | -0.0469516852625427 | 0.00938046687315797 | COAD | Male-baised eQTL |
| rs60502082 | chr6:39291735:G:T | - | -0.0468074646570382 | 0.00987464623238387 | COAD | Male-baised eQTL |
| rs55812552 | chr6:39285083:C:A | - | -0.04661294655657 | 0.0104446314770184 | COAD | Male-baised eQTL |
| rs2758886 | chr6:39283061:G:A | - | -0.0457037117641035 | 0.0128734963465506 | COAD | Male-baised eQTL |
| rs3132556 | chr6:31111032:A:T | - | 0.0499255148063407 | 0.0208793589937549 | COAD | Male-baised eQTL |
| rs12198313 | chr6:38711534:T:C | - | -0.0392141356336751 | 0.0215867624861892 | COAD | Male-baised eQTL |
| rs7764323 | chr6:36378063:A:G | - | 0.0535668581341302 | 0.0239136229172252 | COAD | Male-baised eQTL |
| rs12202097 | chr6:38713427:T:G | - | -0.0385382234298449 | 0.0259756908147971 | COAD | Male-baised eQTL |
| rs71571343 | chr6:38713215:A:G | - | -0.0385825594609505 | 0.0260002376558643 | COAD | Male-baised eQTL |
| rs2477229 | chr6:33921550:T:A | - | 0.0372097177254067 | 0.0274804141388773 | COAD | Male-baised eQTL |
| rs2233974 | chr6:31112239:C:G | - | 0.0484879155645162 | 0.028252260067897 | COAD | Male-baised eQTL |
| rs2815043 | chr6:39276058:G:A | - | -0.0427425516444536 | 0.0288792539710298 | COAD | Male-baised eQTL |
| rs2758873 | chr6:39279080:G:A | - | -0.0427425516444536 | 0.0288792539710298 | COAD | Male-baised eQTL |
| rs2815047 | chr6:39279630:C:A | - | -0.0427425516444536 | 0.0288792539710298 | COAD | Male-baised eQTL |
| rs143277513 | chr6:31067497:G:A | - | 0.0453549744209856 | 0.0296089862013723 | COAD | Male-baised eQTL |
| rs75640484 | chr6:33920798:T:G | - | 0.0368096292209419 | 0.030598455004095 | COAD | Male-baised eQTL |
| rs2499757 | chr6:33920841:A:G | - | 0.0368096292209419 | 0.030598455004095 | COAD | Male-baised eQTL |
| rs148418023 | chr6:31067143:C:T | - | 0.044795655868419 | 0.0328295485715998 | COAD | Male-baised eQTL |
| rs9379689 | chr6:24806549:T:A | - | -0.0355231372479201 | 0.0358341720568646 | COAD | Male-baised eQTL |
| rs2523845 | chr6:31059616:A:C | - | 0.043739992995271 | 0.0419919260554151 | COAD | Male-baised eQTL |
| rs2428515 | chr6:31059731:G:A | - | 0.043739992995271 | 0.0419919260554151 | COAD | Male-baised eQTL |
| rs2523847 | chr6:31058757:C:T | - | 0.0436943957025422 | 0.0420039270085243 | COAD | Male-baised eQTL |
| rs2517519 | chr6:31060164:A:G | - | 0.0436943957025422 | 0.0420039270085243 | COAD | Male-baised eQTL |
| rs2517518 | chr6:31060568:C:T | - | 0.0436943957025422 | 0.0420039270085243 | COAD | Male-baised eQTL |
| rs2517517 | chr6:31060973:C:T | - | 0.0436943957025422 | 0.0420039270085243 | COAD | Male-baised eQTL |
| rs2517514 | chr6:31061624:A:T | - | 0.0436943957025422 | 0.0420039270085243 | COAD | Male-baised eQTL |
| rs2758880 | chr6:39281413:G:A | - | -0.0403997340871494 | 0.0438759576314227 | COAD | Male-baised eQTL |
| rs140645738 | chr6:31067557:A:C | - | 0.04321814014642 | 0.0468986811041975 | COAD | Male-baised eQTL |
| rs2815033 | chr6:39273910:G:A | - | -0.0399625446364683 | 0.0481676289833295 | COAD | Male-baised eQTL |
| rs2815034 | chr6:39274285:A:G | - | -0.0399625446364683 | 0.0481676289833295 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000204209 |
| CpG Site: cg16315106 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: - | |
| Female Effect: -0.326245826116911 | |
 | Gene ID: ENSG00000204209 |
| CpG Site: cg15070677 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: - | |
| Female Effect: -0.375035450115103 | |
 | Gene ID: ENSG00000204209 |
| CpG Site: cg20552903 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: - | |
| Female Effect: -0.375035450115103 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg16315106 | chr6:33320784 | gene,exon,CDS | -0.326245826116911 | 6.13723360272543e-05 | -0.32589656005892087 | 1.0114251809510952e-07 | LUAD |
| cg15070677 | chr6:33321027 | gene,exon,CDS | -0.375035450115103 | 6.20555234768967e-05 | -0.4198371503772436 | 4.4234620503857244e-07 | HNSC |
| cg20552903 | chr6:33321901 | gene,exon,CDS | -0.375035450115103 | 6.20555234768967e-05 | -0.4198371503772436 | 4.4234620503857244e-07 | HNSC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of DAXX |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000204209 | DAXX | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| ENSG00000204209 | DAXX | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| ENSG00000204209 | DAXX | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| ENSG00000204209 | DAXX | C0346647 | Malignant neoplasm of pancreas | 1 | CTD_human |
