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Gene: ENSG00000198732 |
Summary for SMOC1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000198732 | Gene symbol | SMOC1 |
| Gene name | SPARC related modular calcium binding 1 | |
| HGNC | 20318 | |
| Entrez ID | 64093 | |
| Gene type | protein_coding | |
| Synonyms | SMOC1| | |
| UniProtAcc | Q9H4F8 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SMOC1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMOC1 | 6.59e+02 | -3.97e+00 | 6.74e-01 | -5.89e+00 | 3.88e-09 | 7.88e-07 | BRCA |
| SMOC1 | 2.51e+02 | 1.18e+00 | 2.14e-01 | 5.51e+00 | 3.65e-08 | 1.46e-06 | KIRC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMOC1 | 6.91e+02 | 1.16e+00 | 4.58e-01 | 2.53e+00 | 1.13e-02 | 2.35e-02 | STAD |
| SMOC1 | 1.32e+02 | -1.07e+00 | 4.74e-01 | -2.26e+00 | 2.37e-02 | 3.83e-02 | KIRP |
| SMOC1 | 2.81e+03 | -3.60e+00 | 5.40e-01 | -6.67e+00 | 2.59e-11 | 5.04e-10 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SMOC1 | 1.66e+02 | -1.38e+00 | 4.85e-01 | -2.85e+00 | 4.33e-03 | 8.25e-03 | KIRC |
| SMOC1 | 4.51e+03 | -1.08e+00 | 2.26e-01 | -4.77e+00 | 1.83e-06 | 8.69e-06 | LIHC |
| SMOC1 | 3.73e+02 | 1.93e+00 | 6.70e-01 | 2.88e+00 | 3.93e-03 | 1.12e-02 | READ |
Top |
Sex-biased somatic mutation for SMOC1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SMOC1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SMOC1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SMOC1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SMOC1 |
| TFs related to SMOC1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SMOC1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SMOC1 |
| RBPs related to ES in SMOC1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LIHC | SAMD4A | exon_skip_107776 | 8.39e+00 | 9.86e-01 | 7.95e+00 | 6.82e-03 | Male-biased |
| LGG | SAMD4A | exon_skip_107775 | 8.44e+00 | 9.34e-04 | 9.02e+00 | 9.95e-01 | Female-biased |
| SMOC1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000198732 | AC024563.1,hsa-mir-93,SMOC1 | Female-specific ceRNA | TCGA-KIRC |
| ENSG00000198732 | AC114811.2,hsa-mir-93,SMOC1 | Female-specific ceRNA | TCGA-KIRC |
| ENSG00000198732 | Z99572.1,hsa-mir-142,SMOC1 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000198732 | AC016705.2,hsa-mir-211,SMOC1 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000198732 | AC090241.2,hsa-mir-211,SMOC1 | Male-specific ceRNA | TCGA-KIRP |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2236222 | chr14:64448464:A:G | - | 0.156238194102728 | 0.0173959216297611 | PCPG | Female-baised eQTL |
| rs3742609 | chr14:64469934:T:C | - | 0.156238194102728 | 0.0173959216297611 | PCPG | Female-baised eQTL |
| rs11621442 | chr14:64447434:A:G | - | 0.148569480192672 | 0.0318967220356109 | PCPG | Female-baised eQTL |
| rs34772331 | chr14:78777276:G:A | - | 0.208618681257248 | 0.0413267801887657 | GBM | Female-baised eQTL |
| rs12896562 | chr14:78778100:A:G | - | 0.207785893371653 | 0.0441546004539545 | GBM | Female-baised eQTL |
| rs71429045 | chr14:74267836:G:A | - | 0.0653394907083756 | 0.00152387712939175 | THCA | Female-baised eQTL |
| rs2159146 | chr14:71971934:T:A | - | 0.117683752787025 | 0.0197203434843779 | LUSC | Female-baised eQTL |
| rs7155726 | chr14:67415379:C:T | - | 0.0959273494390373 | 0.0228546762134628 | LUSC | Female-baised eQTL |
| rs58002698 | chr14:71987829:T:A | - | 0.124526451570334 | 0.0270769877887471 | LUSC | Female-baised eQTL |
| rs60545259 | chr14:71988216:G:A | - | 0.124526451570334 | 0.0270769877887471 | LUSC | Female-baised eQTL |
| rs4902965 | chr14:71992978:C:A | - | 0.123470012322915 | 0.0305082434293079 | LUSC | Female-baised eQTL |
| rs764624 | chr14:71993857:A:G | - | 0.123470012322915 | 0.0305082434293079 | LUSC | Female-baised eQTL |
| rs9323498 | chr14:67408794:T:G | - | 0.0909137032101888 | 0.0410066895034384 | LUSC | Female-baised eQTL |
| rs10148577 | chr14:67409066:A:G | - | 0.0909137032101888 | 0.0410066895034384 | LUSC | Female-baised eQTL |
| rs8014780 | chr14:78457743:A:G | - | 0.117367990442766 | 0.042052401207614 | LUSC | Female-baised eQTL |
| rs8015993 | chr14:78458275:G:A | - | 0.117367990442766 | 0.042052401207614 | LUSC | Female-baised eQTL |
| rs2192412 | chr14:78460941:C:T | - | 0.117367990442766 | 0.042052401207614 | LUSC | Female-baised eQTL |
| rs4903762 | chr14:78463448:A:G | - | 0.117367990442766 | 0.042052401207614 | LUSC | Female-baised eQTL |
| rs2238276 | chr14:71989510:C:T | - | 0.1158660990675 | 0.0486700126868944 | LUSC | Female-baised eQTL |
| rs1860105 | chr14:71990196:G:A | - | 0.1158660990675 | 0.0486700126868944 | LUSC | Female-baised eQTL |
| rs2238275 | chr14:71990648:T:G | - | 0.1158660990675 | 0.0486700126868944 | LUSC | Female-baised eQTL |
| rs2238274 | chr14:71991471:G:A | - | 0.1158660990675 | 0.0486700126868944 | LUSC | Female-baised eQTL |
| rs8021398 | chr14:76380583:C:T | - | 0.136625708612414 | 0.000904535028529426 | STAD | Female-baised eQTL |
| rs1473130 | chr14:71618079:C:G | - | 0.115163942296876 | 0.0126690443680654 | STAD | Female-baised eQTL |
| rs111731099 | chr14:71627227:C:T | - | 0.115163942296876 | 0.0126690443680654 | STAD | Female-baised eQTL |
| rs11624555 | chr14:71464361:G:A | - | 0.110330660599137 | 0.0198714336503946 | STAD | Female-baised eQTL |
| rs17109764 | chr14:79690330:C:T | - | 0.133229863977744 | 0.0228085153309079 | STAD | Female-baised eQTL |
| rs61995219 | chr14:79676586:G:T | - | 0.132976477728728 | 0.0237628498134508 | STAD | Female-baised eQTL |
| rs61995220 | chr14:79678981:A:T | - | 0.132976477728728 | 0.0237628498134508 | STAD | Female-baised eQTL |
| rs61991704 | chr14:60788212:A:G | - | 0.0663710353017171 | 0.0268816032149613 | STAD | Female-baised eQTL |
| rs2284704 | chr14:60745150:T:C | - | 0.0657453457297686 | 0.0316969169653784 | STAD | Female-baised eQTL |
| rs17109739 | chr14:79681938:T:C | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs61995221 | chr14:79683208:G:A | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs61995222 | chr14:79684324:A:T | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs61995223 | chr14:79684533:T:C | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs17109747 | chr14:79685084:T:G | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs61995224 | chr14:79685227:T:C | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs61995225 | chr14:79686701:T:C | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs17109760 | chr14:79689072:A:G | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs17109772 | chr14:79693008:T:C | - | 0.1242754049637 | 0.0418272989084589 | STAD | Female-baised eQTL |
| rs2160920 | chr14:79694765:G:T | - | 0.124103554635001 | 0.0428762555151058 | STAD | Female-baised eQTL |
| rs10483933 | chr14:79701116:C:T | - | 0.123980181127202 | 0.0429469121276008 | STAD | Female-baised eQTL |
| rs61993166 | chr14:79702547:C:T | - | 0.123980181127202 | 0.0429469121276008 | STAD | Female-baised eQTL |
| rs12587061 | chr14:60862272:A:G | - | 0.0626497433232484 | 0.0449936387512977 | STAD | Female-baised eQTL |
| rs112528420 | chr14:74264719:G:A | - | 0.0811900231875549 | 0.0471835671472422 | STAD | Female-baised eQTL |
| rs4903091 | chr14:73009047:C:T | - | 0.0954314579934872 | 4.38373031425966e-05 | KIRC | Female-baised eQTL |
| rs1024253 | chr14:61642063:G:A | - | -0.0851069024306568 | 8.62338813440491e-05 | KIRC | Female-baised eQTL |
| rs55986487 | chr14:61646264:C:T | - | 0.0799465129563919 | 0.000245250655587015 | KIRC | Female-baised eQTL |
| rs1957758 | chr14:61645437:G:A | - | 0.0799461533886372 | 0.000246755178474764 | KIRC | Female-baised eQTL |
| rs11845359 | chr14:61645923:C:T | - | 0.0799461533886372 | 0.000246755178474764 | KIRC | Female-baised eQTL |
| rs67988556 | chr14:70615431:T:C | - | 0.0884430232316242 | 0.000558389217451307 | KIRC | Female-baised eQTL |
| rs17099010 | chr14:61642912:C:T | - | 0.0753907933589256 | 0.000626742728881978 | KIRC | Female-baised eQTL |
| rs1032306 | chr14:62715539:C:A | - | -0.0739152686755771 | 0.00527687036749291 | KIRC | Female-baised eQTL |
| rs1951108 | chr14:60751521:A:G | - | -0.0584289396935677 | 0.0237557197291443 | KIRC | Female-baised eQTL |
| rs4902001 | chr14:60759709:T:C | - | -0.0584289396935677 | 0.0237557197291443 | KIRC | Female-baised eQTL |
| rs1951109 | chr14:60698128:T:C | - | -0.0570838125869146 | 0.0288872377126508 | KIRC | Female-baised eQTL |
| rs11623654 | chr14:60701524:T:G | - | -0.0570838125869146 | 0.0288872377126508 | KIRC | Female-baised eQTL |
| rs4901998 | chr14:60691827:G:A | - | -0.0573789052538621 | 0.0305995870912472 | KIRC | Female-baised eQTL |
| rs11158986 | chr14:72892237:A:C | - | -0.099576063053742 | 0.0346685170387994 | KIRC | Female-baised eQTL |
| rs7150625 | chr14:72892938:T:C | - | -0.099576063053742 | 0.0346685170387994 | KIRC | Female-baised eQTL |
| rs8008453 | chr14:72893755:T:C | - | -0.099576063053742 | 0.0346685170387994 | KIRC | Female-baised eQTL |
| rs2215901 | chr14:72894241:A:G | - | -0.099576063053742 | 0.0346685170387994 | KIRC | Female-baised eQTL |
| rs1018456 | chr14:60692075:A:C | - | -0.056075733642102 | 0.0362999251359842 | KIRC | Female-baised eQTL |
| rs8008936 | chr14:65213489:C:T | - | 0.0509384389075583 | 0.0364081258122676 | KIRC | Female-baised eQTL |
| rs10142362 | chr14:60708301:T:A | - | -0.0560066072304206 | 0.0370065564644068 | KIRC | Female-baised eQTL |
| rs12885986 | chr14:60728934:C:G | - | -0.053276382638261 | 0.0497128925427798 | KIRC | Female-baised eQTL |
| rs1974670 | chr14:75538727:A:C | - | -0.0761417622424581 | 0.0102725591961576 | LUAD | Female-baised eQTL |
| rs850739 | chr14:76640113:C:T | - | 0.0600616502671145 | 0.0138212470373734 | COAD | Female-baised eQTL |
| rs850742 | chr14:76642027:C:T | - | 0.0586725566773249 | 0.0185101887731557 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs35007217 | chr14:78413707:G:A | - | 0.251710676255897 | 0.000126733383428165 | READ | Male-baised eQTL |
| rs72681532 | chr14:78409922:C:G | - | 0.269766444889379 | 0.000130048855599925 | READ | Male-baised eQTL |
| rs12893431 | chr14:78412884:G:A | - | 0.263570418970357 | 0.000557467844902696 | READ | Male-baised eQTL |
| rs76545605 | chr14:77570315:C:G | - | 0.0432565205323922 | 0.0183419396209326 | HNSC | Male-baised eQTL |
| rs55697089 | chr14:77570856:T:C | - | 0.0432565205323922 | 0.0183419396209326 | HNSC | Male-baised eQTL |
| rs56286233 | chr14:77570988:G:A | - | 0.0432565205323922 | 0.0183419396209326 | HNSC | Male-baised eQTL |
| rs55776552 | chr14:77570819:G:C | - | 0.0432360296277526 | 0.0183880352191094 | HNSC | Male-baised eQTL |
| rs79047197 | chr14:77567768:T:G | - | 0.0427987996605609 | 0.0191550506626423 | HNSC | Male-baised eQTL |
| rs56264628 | chr14:77568436:T:C | - | 0.0427987996605609 | 0.0191550506626423 | HNSC | Male-baised eQTL |
| rs117754564 | chr14:77571945:C:T | - | 0.0420512893086902 | 0.0228357202962265 | HNSC | Male-baised eQTL |
| rs4903497 | chr14:76837949:T:C | - | 0.0612432503861949 | 0.0289433627851693 | STAD | Male-baised eQTL |
| rs10139392 | chr14:63300845:C:T | - | 0.0712709397400879 | 0.000338813080822712 | KIRC | Male-baised eQTL |
| rs77012013 | chr14:72549230:T:G | - | 0.0701865568055745 | 0.00431474172466811 | BLCA | Male-baised eQTL |
| rs76317564 | chr14:72549231:T:C | - | 0.0701865568055745 | 0.00431474172466811 | BLCA | Male-baised eQTL |
| rs710061 | chr14:61638109:G:A | - | -0.0731053725419932 | 0.0118110001264594 | BLCA | Male-baised eQTL |
| rs61986934 | chr14:73255139:C:T | - | 0.0435064565007595 | 0.0237347716886749 | BLCA | Male-baised eQTL |
| rs17182300 | chr14:73301440:T:C | - | 0.0351847068642172 | 0.0268701944303225 | BLCA | Male-baised eQTL |
| rs17182307 | chr14:73302849:T:A | - | 0.0351847068642172 | 0.0268701944303225 | BLCA | Male-baised eQTL |
| rs55788386 | chr14:73304816:G:A | - | 0.0351847068642172 | 0.0268701944303225 | BLCA | Male-baised eQTL |
| rs17781956 | chr14:73305677:G:A | - | 0.034914122350729 | 0.028678733567332 | BLCA | Male-baised eQTL |
| rs61985767 | chr14:73331833:G:A | - | 0.0349008108223597 | 0.0287955857735528 | BLCA | Male-baised eQTL |
| rs7156584 | chr14:73331812:T:C | - | -0.0349008108223597 | 0.0287955857735528 | BLCA | Male-baised eQTL |
| rs77769776 | chr14:69349683:C:T | - | 0.0650410873418899 | 0.029837708921762 | BLCA | Male-baised eQTL |
| rs55995054 | chr14:73307014:A:C | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs61985761 | chr14:73310443:T:C | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs61985764 | chr14:73311279:C:A | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs17182335 | chr14:73317225:T:C | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs72734499 | chr14:73321062:C:A | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs17781998 | chr14:73322096:G:C | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs17182356 | chr14:73322774:G:A | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs61985766 | chr14:73329217:C:T | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs2214664 | chr14:73333388:A:T | - | 0.0346475284099252 | 0.0305184038343696 | BLCA | Male-baised eQTL |
| rs72734501 | chr14:73324422:T:C | - | 0.0346176051643922 | 0.0310155626813942 | BLCA | Male-baised eQTL |
| rs17781895 | chr14:73271435:C:A | - | 0.0339948698846468 | 0.0338154784410016 | BLCA | Male-baised eQTL |
| rs3087637 | chr14:73272342:C:A | - | 0.0339948698846468 | 0.0338154784410016 | BLCA | Male-baised eQTL |
| rs61986959 | chr14:73292314:G:C | - | 0.0339948698846468 | 0.0338154784410016 | BLCA | Male-baised eQTL |
| rs61985809 | chr14:73368247:A:G | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs61985811 | chr14:73374428:T:C | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs72736334 | chr14:73374696:T:C | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs72736335 | chr14:73374972:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs12147594 | chr14:73377312:G:C | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs61985839 | chr14:73383932:G:A | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs56324454 | chr14:73391199:G:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs72736345 | chr14:73392875:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs61985842 | chr14:73394001:T:C | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs61985843 | chr14:73398461:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs112289998 | chr14:73401664:G:A | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs149850834 | chr14:73413241:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs4491438 | chr14:73414742:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs112286376 | chr14:73419238:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs61985846 | chr14:73420799:C:T | - | 0.0337790187042751 | 0.0356852825547753 | BLCA | Male-baised eQTL |
| rs113969979 | chr14:73401697:G:A | - | 0.0337540728276204 | 0.0362010665101028 | BLCA | Male-baised eQTL |
| rs56382393 | chr14:73268898:C:T | - | 0.0337090909928443 | 0.0364707091885311 | BLCA | Male-baised eQTL |
| rs61985840 | chr14:73385146:T:G | - | 0.0338215768824991 | 0.0366680684106839 | BLCA | Male-baised eQTL |
| rs2003632 | chr14:73273478:C:T | - | 0.0336997460059059 | 0.0368164049812275 | BLCA | Male-baised eQTL |
| rs1047849 | chr14:73274478:T:C | - | 0.0336997460059059 | 0.0368164049812275 | BLCA | Male-baised eQTL |
| rs17492268 | chr14:73344841:A:C | - | 0.0335289774650766 | 0.0377775219086435 | BLCA | Male-baised eQTL |
| rs61985805 | chr14:73353834:T:C | - | 0.0335289774650766 | 0.0377775219086435 | BLCA | Male-baised eQTL |
| rs61985806 | chr14:73354235:G:A | - | 0.0335289774650766 | 0.0377775219086435 | BLCA | Male-baised eQTL |
| rs1005013 | chr14:73252570:C:T | - | 0.0416269760049926 | 0.0381989085970798 | BLCA | Male-baised eQTL |
| rs17781962 | chr14:73306478:G:A | - | 0.0332837733357093 | 0.0431106567085228 | BLCA | Male-baised eQTL |
| rs61985847 | chr14:73424694:G:A | - | 0.0326441162095372 | 0.0444126025632579 | BLCA | Male-baised eQTL |
| rs61985849 | chr14:73431325:G:A | - | 0.0326441162095372 | 0.0444126025632579 | BLCA | Male-baised eQTL |
| rs72736372 | chr14:73440620:C:T | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs78502395 | chr14:73440698:G:A | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs35850292 | chr14:73445131:G:A | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs61987081 | chr14:73448394:G:A | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs61987085 | chr14:73449324:C:T | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs61987087 | chr14:73450616:G:A | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs7350737 | chr14:73452575:G:A | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs72736380 | chr14:73454115:G:A | - | 0.0326193575894353 | 0.0450264395518494 | BLCA | Male-baised eQTL |
| rs710062 | chr14:61637612:G:A | - | -0.0606739635408565 | 0.0464410155488641 | BLCA | Male-baised eQTL |
| rs8022782 | chr14:72975314:C:T | - | 0.0464788431595371 | 0.0488878188434079 | BLCA | Male-baised eQTL |
| rs61988556 | chr14:72972550:T:C | - | 0.0464379595184483 | 0.0494573200635243 | BLCA | Male-baised eQTL |
| rs61988558 | chr14:72972856:C:T | - | 0.0464379595184483 | 0.0494573200635243 | BLCA | Male-baised eQTL |
| rs146305080 | chr14:64975693:C:A | - | 0.137993281049121 | 0.0210308075801952 | LUAD | Male-baised eQTL |
| rs111412722 | chr14:79609963:G:C | - | 0.0919538935990431 | 0.0264512140173849 | LUAD | Male-baised eQTL |
| rs11851989 | chr14:79606698:T:C | - | 0.0908914669677231 | 0.0283139114375194 | LUAD | Male-baised eQTL |
| rs112708450 | chr14:79670436:A:G | - | 0.0934204745473359 | 0.0433762156193054 | LUAD | Male-baised eQTL |
| rs79897323 | chr14:79597685:A:T | - | 0.0866131477347286 | 0.0436916960172958 | LUAD | Male-baised eQTL |
| rs76465392 | chr14:79600239:T:C | - | 0.0866131477347286 | 0.0436916960172958 | LUAD | Male-baised eQTL |
| rs78139009 | chr14:79600713:C:T | - | 0.0866131477347286 | 0.0436916960172958 | LUAD | Male-baised eQTL |
| rs11847149 | chr14:79601485:C:T | - | 0.0866131477347286 | 0.0436916960172958 | LUAD | Male-baised eQTL |
| rs8023144 | chr14:62347053:A:C | - | -0.0910533897496944 | 0.0438369148273929 | LUAD | Male-baised eQTL |
| rs6573434 | chr14:62367724:T:C | - | -0.0910533897496944 | 0.0438369148273929 | LUAD | Male-baised eQTL |
| rs17179828 | chr14:72172323:T:G | - | 0.105382143891853 | 0.0491192475136285 | LUAD | Male-baised eQTL |
| rs4899050 | chr14:61477168:A:G | - | 0.0417686184570926 | 0.00368600273739707 | COAD | Male-baised eQTL |
| rs117901939 | chr14:76199486:T:A | - | 0.0766361766117111 | 0.00725190847474749 | COAD | Male-baised eQTL |
| rs72688844 | chr14:77824284:C:T | - | 0.0514649883594789 | 0.00778295922258941 | COAD | Male-baised eQTL |
| rs1256063 | chr14:64235499:A:G | - | -0.0768136465511215 | 0.00945604052847816 | COAD | Male-baised eQTL |
| rs55967811 | chr14:77837057:C:T | - | 0.0473484452365055 | 0.00987342957495347 | COAD | Male-baised eQTL |
| rs55976930 | chr14:77836935:G:A | - | 0.0453073733380141 | 0.0108450200731373 | COAD | Male-baised eQTL |
| rs11159295 | chr14:77839692:G:C | - | 0.0346967052416109 | 0.0126210100411475 | COAD | Male-baised eQTL |
| rs761547 | chr14:64630267:C:T | - | -0.0415002255127895 | 0.0152398769160878 | COAD | Male-baised eQTL |
| rs11158546 | chr14:64635834:T:C | - | -0.0415002255127895 | 0.0152398769160878 | COAD | Male-baised eQTL |
| rs4902297 | chr14:64605477:T:C | - | -0.041058114050949 | 0.0177065717105755 | COAD | Male-baised eQTL |
| rs8016170 | chr14:64593507:G:A | - | -0.0405094122233094 | 0.0181142118071839 | COAD | Male-baised eQTL |
| rs8018169 | chr14:64594087:T:C | - | -0.0405094122233094 | 0.0181142118071839 | COAD | Male-baised eQTL |
| rs34616731 | chr14:64462569:T:A | - | 0.0414530230002021 | 0.018289412383637 | COAD | Male-baised eQTL |
| rs2092718 | chr14:64664638:G:T | - | -0.0383414800720809 | 0.018400600229078 | COAD | Male-baised eQTL |
| rs1256150 | chr14:64470462:C:T | - | 0.0415426212975741 | 0.0187000494245927 | COAD | Male-baised eQTL |
| rs61053946 | chr14:77837433:C:T | - | 0.0422561915847511 | 0.0196931119060455 | COAD | Male-baised eQTL |
| rs55898434 | chr14:77839795:C:T | - | 0.0422561915847511 | 0.0196931119060455 | COAD | Male-baised eQTL |
| rs4902296 | chr14:64605109:C:T | - | -0.0389945546794664 | 0.0244764390411272 | COAD | Male-baised eQTL |
| rs4902298 | chr14:64605661:T:C | - | -0.0389945546794664 | 0.0244764390411272 | COAD | Male-baised eQTL |
| rs1040612 | chr14:64614835:C:T | - | -0.0389945546794664 | 0.0244764390411272 | COAD | Male-baised eQTL |
| rs7148289 | chr14:64600095:C:T | - | -0.039021905066372 | 0.0247762503992073 | COAD | Male-baised eQTL |
| rs4902287 | chr14:64515615:A:G | - | -0.0395226619257446 | 0.0252457655629412 | COAD | Male-baised eQTL |
| rs4902288 | chr14:64516222:T:C | - | -0.0395226619257446 | 0.0252457655629412 | COAD | Male-baised eQTL |
| rs1901737 | chr14:64527541:A:G | - | -0.0395226619257446 | 0.0252457655629412 | COAD | Male-baised eQTL |
| rs4902295 | chr14:64598246:G:A | - | -0.0389758440422074 | 0.0253216289260971 | COAD | Male-baised eQTL |
| rs9972189 | chr14:77823877:C:T | - | 0.0427017286008928 | 0.0254282548616891 | COAD | Male-baised eQTL |
| rs1453005 | chr14:64485337:C:T | - | -0.0393679745953698 | 0.0264124887230479 | COAD | Male-baised eQTL |
| rs12894807 | chr14:64576686:A:G | - | -0.0378286338352905 | 0.0298238572627445 | COAD | Male-baised eQTL |
| rs10147438 | chr14:75555157:C:T | - | 0.0564580142571037 | 0.0309765045968399 | COAD | Male-baised eQTL |
| rs10431708 | chr14:64498624:G:A | - | -0.0381633001554755 | 0.0312536180360162 | COAD | Male-baised eQTL |
| rs8018233 | chr14:77830374:C:T | - | 0.0395576928643358 | 0.0320892083000572 | COAD | Male-baised eQTL |
| rs8022447 | chr14:64492594:G:A | - | -0.0377730793317882 | 0.033782485565342 | COAD | Male-baised eQTL |
| rs1256146 | chr14:64453947:G:A | - | 0.0369507414116955 | 0.0343963893172668 | COAD | Male-baised eQTL |
| rs7149487 | chr14:68967278:C:G | - | 0.0393137711773192 | 0.0355116995278504 | COAD | Male-baised eQTL |
| rs2024892 | chr14:68965767:A:G | - | 0.0388590489994487 | 0.0375414909356295 | COAD | Male-baised eQTL |
| rs10150706 | chr14:77827045:C:G | - | 0.0399681649607741 | 0.0393691139460778 | COAD | Male-baised eQTL |
| rs7156953 | chr14:64549984:T:G | - | -0.0366588157933615 | 0.0398618822910483 | COAD | Male-baised eQTL |
| rs2012515 | chr14:64775561:G:C | - | -0.0298209177879562 | 0.0446286200519659 | COAD | Male-baised eQTL |
| rs10139828 | chr14:77826961:T:C | - | 0.0386093339829636 | 0.0449748693026601 | COAD | Male-baised eQTL |
| rs10138481 | chr14:69642312:A:C | - | 0.0491160859874616 | 0.0471222700643402 | COAD | Male-baised eQTL |
| rs77387808 | chr14:72509922:G:A | - | 0.0517608004445723 | 0.0479756579664759 | COAD | Male-baised eQTL |
| rs28489182 | chr14:77828999:G:A | - | 0.0382428661153923 | 0.0497130170969203 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000198732 |
| CpG Site: cg04913114 | |
| Position to Gene: gene | |
| Male Effect: -0.375616149819795 | |
| Female Effect: - | |
 | Gene ID: ENSG00000198732 |
| CpG Site: cg09998189 | |
| Position to Gene: gene | |
| Male Effect: 0.0548302116220766 | |
| Female Effect: - | |
 | Gene ID: ENSG00000198732 |
| CpG Site: cg15897368 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.269368492818533 | |
 | Gene ID: ENSG00000198732 |
| CpG Site: cg24158599 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.422717520988582 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg04913114 | chr14:69881744 | gene | -0.375616149819795 | 1.01240169374357e-20 | -0.8201800027899133 | 9.038768774831718e-25 | PAAD |
| cg09998189 | chr14:69881387 | gene | 0.0548302116220766 | 4.90108104064716e-05 | 0.36165582770012833 | 2.703101371100615e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15897368 | chr14:69999405 | gene | -0.269368492818533 | 4.12674615817888e-06 | -0.3491037915658948 | 1.0126473528230283e-08 | LUAD |
| cg24158599 | chr14:69969498 | gene | -0.422717520988582 | 2.66647016188104e-09 | -0.42521734242318304 | 6.511967250038228e-12 | LGG |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SMOC1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000198732 | SMOC1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ENSG00000198732 | SMOC1 | C0599973 | Waardenburg Anophthalmia Syndrome | 1 | CTD_human |
