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Gene: ENSG00000198680 |
Summary for TUSC1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000198680 | Gene symbol | TUSC1 |
| Gene name | tumor suppressor candidate 1 | |
| HGNC | 31010 | |
| Entrez ID | 286319 | |
| Gene type | protein_coding | |
| Synonyms | TUSC1|TSG-9|CCDC89B | |
| UniProtAcc | Q2TAM9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TUSC1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for TUSC1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TUSC1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg00781519 | chr9:25678685 | CGI:chr9:25677496-25678686 | promoter | 2.60e-01 | 1.48e-01 | 3.80e+00 | 1.45e-04 | 3.85e-04 | 1.12e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg13985784 | chr9:25678017 | CGI:chr9:25677496-25678686 | promoter,exon,CDS,gene body | 1.78e-01 | 7.57e-02 | 2.77e+00 | 5.62e-03 | 1.04e-02 | 1.02e-01 |
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Exon skipping events with PSI in TCGA for TUSC1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TUSC1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TUSC1 |
| TFs related to TUSC1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | E2F6 | TUSC1 | 6.30e+00 | 9.90e-01 | 5.50e+00 | 9.91e-03 | Male-biased |
| ACC | SOX8 | TUSC1 | 7.01e+00 | 1.44e-02 | 7.76e+00 | 9.85e-01 | Female-biased |
| ACC | TFAP2A | TUSC1 | 6.55e+00 | 9.95e-01 | 5.58e+00 | 4.99e-03 | Male-biased |
| ACC | ZNF45 | TUSC1 | 6.53e+00 | 1.92e-02 | 7.21e+00 | 9.80e-01 | Female-biased |
| ACC | ZNF566 | TUSC1 | 5.82e+00 | 9.91e-01 | 4.97e+00 | 8.11e-03 | Male-biased |
| BLCA | E2F6 | TUSC1 | 7.21e+00 | 9.91e-01 | 6.36e+00 | 8.48e-03 | Male-biased |
| BLCA | ZNF383 | TUSC1 | 6.49e+00 | 9.90e-01 | 5.66e+00 | 9.36e-03 | Male-biased |
| BLCA | ZNF566 | TUSC1 | 7.01e+00 | 9.95e-01 | 5.97e+00 | 4.57e-03 | Male-biased |
| DLBC | ZNF383 | TUSC1 | 5.54e+00 | 9.95e-01 | 4.42e+00 | 3.77e-03 | Male-biased |
| DLBC | ZNF566 | TUSC1 | 5.93e+00 | 9.84e-01 | 5.17e+00 | 1.51e-02 | Male-biased |
| ESCA | TEAD4 | TUSC1 | 6.32e+00 | 1.78e-02 | 6.99e+00 | 9.82e-01 | Female-biased |
| LGG | E2F6 | TUSC1 | 6.67e+00 | 9.85e-01 | 6.26e+00 | 1.44e-02 | Male-biased |
| LGG | IKZF3 | TUSC1 | 6.66e+00 | 9.86e-01 | 6.25e+00 | 1.39e-02 | Male-biased |
| LGG | TFAP2A | TUSC1 | 7.24e+00 | 9.82e-01 | 6.86e+00 | 1.78e-02 | Male-biased |
| LGG | ZNF383 | TUSC1 | 5.66e+00 | 9.83e-01 | 5.27e+00 | 1.61e-02 | Male-biased |
| LGG | ZNF566 | TUSC1 | 6.08e+00 | 9.87e-01 | 5.65e+00 | 1.25e-02 | Male-biased |
| PAAD | GATA1 | TUSC1 | 8.83e+00 | 1.10e-02 | 9.62e+00 | 9.89e-01 | Female-biased |
| PAAD | LHX2 | TUSC1 | 7.38e+00 | 5.61e-03 | 8.30e+00 | 9.94e-01 | Female-biased |
| PAAD | SOX8 | TUSC1 | 6.27e+00 | 5.95e-03 | 7.18e+00 | 9.94e-01 | Female-biased |
| PAAD | TEAD4 | TUSC1 | 5.48e+00 | 4.10e-03 | 6.47e+00 | 9.95e-01 | Female-biased |
| PAAD | TOPORS | TUSC1 | 5.61e+00 | 9.90e-01 | 4.74e+00 | 8.39e-03 | Male-biased |
| PAAD | ZNF383 | TUSC1 | 5.55e+00 | 9.92e-01 | 4.61e+00 | 6.09e-03 | Male-biased |
| PAAD | ZNF45 | TUSC1 | 5.94e+00 | 1.25e-02 | 6.71e+00 | 9.87e-01 | Female-biased |
| PCPG | LHX2 | TUSC1 | 8.72e+00 | 9.93e-01 | 7.83e+00 | 6.91e-03 | Male-biased |
| PCPG | SOX8 | TUSC1 | 8.01e+00 | 9.99e-01 | 6.69e+00 | 9.38e-04 | Male-biased |
| PCPG | TFAP2A | TUSC1 | 5.84e+00 | 8.16e-03 | 6.69e+00 | 9.91e-01 | Female-biased |
| PCPG | ZNF383 | TUSC1 | 4.78e+00 | 6.60e-03 | 5.69e+00 | 9.92e-01 | Female-biased |
| PCPG | ZNF45 | TUSC1 | 7.41e+00 | 9.95e-01 | 6.43e+00 | 4.79e-03 | Male-biased |
| READ | CTCF | TUSC1 | 6.00e+00 | 9.84e-01 | 5.29e+00 | 1.57e-02 | Male-biased |
| READ | LHX2 | TUSC1 | 8.23e+00 | 9.83e-01 | 7.53e+00 | 1.64e-02 | Male-biased |
| READ | SOX8 | TUSC1 | 7.24e+00 | 9.91e-01 | 6.37e+00 | 8.25e-03 | Male-biased |
| READ | TFAP2A | TUSC1 | 5.40e+00 | 5.94e-03 | 6.37e+00 | 9.94e-01 | Female-biased |
| READ | ZNF45 | TUSC1 | 6.99e+00 | 9.95e-01 | 5.99e+00 | 5.08e-03 | Male-biased |
| SARC | E2F6 | TUSC1 | 6.64e+00 | 1.87e-02 | 7.18e+00 | 9.81e-01 | Female-biased |
| SARC | ZNF566 | TUSC1 | 6.17e+00 | 5.45e-03 | 6.93e+00 | 9.94e-01 | Female-biased |
| TUSC1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TUSC1 |
| RBPs related to ES in TUSC1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TUSC1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7024968 | chr9:28286398:T:C | - | 0.24354729160177 | 0.00194545481780943 | READ | Female-baised eQTL |
| rs10738553 | chr9:19892035:C:G | - | 0.0588441890129275 | 0.0297990622437129 | LUAD | Female-baised eQTL |
| rs1970082 | chr9:25533573:A:G | - | -0.0559355740803201 | 0.0334224136814884 | LUAD | Female-baised eQTL |
| rs1970083 | chr9:25533814:A:G | - | -0.0559355740803201 | 0.0334224136814884 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7852712 | chr9:26439644:T:A | - | 0.104797564311596 | 0.0160599473721593 | KIRP | Male-baised eQTL |
| rs3808693 | chr9:17708336:G:A | - | 0.110549150312752 | 0.0261171428129154 | KIRP | Male-baised eQTL |
| rs72700426 | chr9:19377873:T:C | - | 0.0702257349918014 | 0.0373272339097494 | LUAD | Male-baised eQTL |
| rs35567310 | chr9:19378206:C:T | - | 0.0702257349918014 | 0.0373272339097494 | LUAD | Male-baised eQTL |
| rs10119465 | chr9:19376146:C:T | - | 0.0701450448236942 | 0.0376350969444054 | LUAD | Male-baised eQTL |
| rs67710536 | chr9:19376257:A:C | - | 0.0701450448236942 | 0.0376350969444054 | LUAD | Male-baised eQTL |
| rs12682702 | chr9:17836751:A:G | - | -0.0604691767531154 | 0.0321866360584057 | COAD | Male-baised eQTL |
| rs73426592 | chr9:17835939:C:T | - | -0.0605546943710886 | 0.0363478017011486 | COAD | Male-baised eQTL |
| rs7041618 | chr9:17828439:T:C | - | -0.0575589093384345 | 0.0422163587524663 | COAD | Male-baised eQTL |
| rs7869619 | chr9:20127866:C:T | - | -0.101619355709282 | 0.0426983669564361 | COAD | Male-baised eQTL |
| rs7035414 | chr9:20134661:T:A | - | -0.102698283602114 | 0.0445527585233411 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TUSC1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
