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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000198183

Summary for BPIFA1

check button Gene summary

Gene informationEnsembl ID

ENSG00000198183

Gene symbol

BPIFA1

Gene nameBPI fold containing family A member 1
HGNC

15749

Entrez ID

51297

Gene typeprotein_coding
SynonymsBPIFA1|LUNX|bA49G10.5|SPLUNC1
UniProtAcc

Q9NP55


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for BPIFA1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BPIFA11.64e+01-6.95e+001.82e+00-3.82e+001.35e-042.58e-03BRCA
BPIFA11.20e+041.11e+002.70e-014.12e+003.73e-059.36e-04LUAD
BPIFA13.92e+00-1.91e+006.06e-01-3.16e+001.58e-039.59e-03LIHC

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BPIFA12.08e+015.91e+001.51e+003.91e+009.33e-054.19e-04BLCA
BPIFA11.31e+012.88e+008.85e-013.26e+001.12e-033.11e-03STAD

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BPIFA16.42e+004.81e+001.33e+003.61e+003.08e-048.85e-04LIHC
BPIFA11.52e+013.65e+005.89e-016.19e+005.97e-101.27e-09BRCA

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Sex-biased somatic mutation for BPIFA1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for BPIFA1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
ACCcg01910481chr20:33236262CGI:chr20:33401338-33401612promoter,gene body8.01e-016.60e-012.25e+002.45e-023.84e-021.41e-01
KICHcg10655041chr20:33236091CGI:chr20:33401338-33401612promoter,gene body8.58e-017.53e-012.56e+001.05e-022.79e-021.05e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg11846968chr20:33235739CGI:chr20:33401338-33401612promoter7.01e-018.30e-01-2.62e+008.84e-031.20e-02-1.30e-01
LUADcg19059861chr20:33235955CGI:chr20:33401338-33401612promoter4.72e-015.76e-01-3.03e+002.48e-034.17e-03-1.04e-01
HNSCcg17884201chr20:33235566CGI:chr20:33401338-33401612promoter7.97e-019.23e-01-2.51e+001.22e-021.52e-02-1.25e-01
LUSCcg20893898chr20:33235071CGI:chr20:33401338-33401612promoter6.63e-018.98e-01-4.44e+008.92e-065.26e-04-2.35e-01
LUSCcg17884201chr20:33235566CGI:chr20:33401338-33401612promoter7.53e-019.38e-01-3.20e+001.36e-033.20e-03-1.85e-01
LUSCcg11846968chr20:33235739CGI:chr20:33401338-33401612promoter5.23e-018.70e-01-4.28e+001.90e-055.26e-04-3.47e-01
LUSCcg19059861chr20:33235955CGI:chr20:33401338-33401612promoter3.19e-015.52e-01-4.26e+002.02e-055.26e-04-2.32e-01
LUSCcg10655041chr20:33236091CGI:chr20:33401338-33401612promoter,gene body4.50e-017.32e-01-4.03e+005.64e-055.75e-04-2.83e-01
LUSCcg01910481chr20:33236262CGI:chr20:33401338-33401612promoter,gene body6.82e-019.57e-01-4.18e+002.94e-055.26e-04-2.76e-01
COADcg19059861chr20:33235955CGI:chr20:33401338-33401612promoter2.60e-013.76e-01-4.41e+001.05e-056.10e-05-1.16e-01
LIHCcg20893898chr20:33235071CGI:chr20:33401338-33401612promoter5.61e-018.05e-01-5.37e+007.95e-084.35e-07-2.44e-01
LIHCcg17884201chr20:33235566CGI:chr20:33401338-33401612promoter5.21e-018.72e-01-4.72e+002.34e-067.73e-06-3.51e-01
LIHCcg19059861chr20:33235955CGI:chr20:33401338-33401612promoter2.40e-014.24e-01-7.04e+001.95e-122.15e-10-1.83e-01
ESCAcg20893898chr20:33235071CGI:chr20:33401338-33401612promoter6.59e-017.73e-01-2.09e+003.62e-024.56e-02-1.14e-01
ESCAcg17884201chr20:33235566CGI:chr20:33401338-33401612promoter7.65e-019.28e-01-2.32e+002.02e-024.04e-02-1.63e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg11846968chr20:33235739CGI:chr20:33401338-33401612promoter5.47e-018.02e-01-1.24e+013.67e-351.11e-33-2.55e-01
BRCAcg19059861chr20:33235955CGI:chr20:33401338-33401612promoter3.08e-014.78e-01-1.33e+014.21e-403.40e-38-1.70e-01
BRCAcg10655041chr20:33236091CGI:chr20:33401338-33401612promoter,gene body4.93e-017.14e-01-1.17e+011.10e-311.98e-30-2.21e-01

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Exon skipping events with PSI in TCGA for BPIFA1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for BPIFA1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for BPIFA1

check buttonTFs related to BPIFA1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
MESOFOXA1BPIFA14.86e+009.96e-012.60e+002.48e-04Male-biased
MESOFOXA3BPIFA14.93e+009.96e-012.78e+003.72e-04Male-biased
MESOHESX1BPIFA15.63e+009.94e-014.19e+004.81e-03Male-biased
MESOLHX9BPIFA15.60e+009.94e-014.12e+004.32e-03Male-biased
MESOPOU3F1BPIFA16.26e+009.85e-015.15e+001.42e-02Male-biased
MESOTBPBPIFA15.05e+009.94e-013.50e+003.34e-03Male-biased
MESOYY1BPIFA15.04e+009.90e-013.70e+006.63e-03Male-biased
MESOZFP69BPIFA14.40e+009.81e-013.23e+001.11e-02Male-biased
MESOZKSCAN2BPIFA15.02e+009.96e-013.15e+001.06e-03Male-biased
MESOZNF184BPIFA14.39e+009.80e-013.25e+001.20e-02Male-biased
MESOZNF620BPIFA14.77e+009.91e-013.31e+004.49e-03Male-biased
MESOZNF74BPIFA15.11e+009.90e-013.80e+007.23e-03Male-biased
MESOZSCAN16BPIFA14.99e+009.82e-013.89e+001.47e-02Male-biased
MESOZSCAN4BPIFA14.49e+009.82e-013.31e+001.10e-02Male-biased
PAADFOXA1BPIFA12.95e+006.36e-044.28e+009.91e-01Female-biased
PAADFOXA3BPIFA13.09e+009.37e-044.34e+009.91e-01Female-biased
PAADHESX1BPIFA14.37e+001.36e-025.11e+009.84e-01Female-biased
PAADLHX9BPIFA14.32e+009.20e-035.14e+009.88e-01Female-biased
PAADTBPBPIFA13.74e+006.90e-034.62e+009.88e-01Female-biased
PAADZFP69BPIFA13.29e+008.03e-034.13e+009.81e-01Female-biased
PAADZKSCAN2BPIFA13.38e+002.18e-034.48e+009.92e-01Female-biased
PAADZNF620BPIFA13.53e+007.11e-034.40e+009.86e-01Female-biased
PAADZNF74BPIFA13.96e+001.08e-024.75e+009.85e-01Female-biased
THYMFOXA1BPIFA14.51e+009.92e-012.32e+002.39e-05Male-biased
THYMFOXA3BPIFA14.64e+009.94e-012.47e+002.63e-05Male-biased
THYMHESX1BPIFA15.43e+009.98e-013.94e+003.67e-04Male-biased
THYMHOXA5BPIFA15.39e+009.95e-014.38e+002.62e-03Male-biased
THYMKLF17BPIFA13.06e+001.02e-034.31e+009.88e-01Female-biased
THYMLHX9BPIFA15.46e+009.98e-013.91e+002.98e-04Male-biased
THYMLYL1BPIFA13.04e+001.79e-034.15e+009.85e-01Female-biased
THYMPOU3F1BPIFA16.24e+009.99e-014.93e+007.80e-04Male-biased
THYMRUNX2BPIFA14.63e+009.87e-013.87e+006.98e-03Male-biased
THYMTBPBPIFA14.88e+009.96e-013.30e+002.53e-04Male-biased
THYMTCF3BPIFA13.03e+004.83e-044.47e+009.91e-01Female-biased
THYMTEAD2BPIFA15.24e+009.91e-014.45e+006.42e-03Male-biased
THYMYY1BPIFA14.83e+009.94e-013.65e+001.28e-03Male-biased
THYMZFP69BPIFA14.23e+009.87e-013.15e+001.84e-03Male-biased
THYMZIC3BPIFA13.56e+002.35e-034.61e+009.91e-01Female-biased
THYMZIC4BPIFA13.51e+002.40e-034.55e+009.90e-01Female-biased
THYMZIC5BPIFA13.57e+002.79e-034.58e+009.90e-01Female-biased
THYMZKSCAN2BPIFA14.58e+009.93e-012.91e+001.70e-04Male-biased
THYMZNF17BPIFA13.23e+001.36e-034.41e+009.89e-01Female-biased
THYMZNF184BPIFA14.28e+009.84e-013.45e+004.98e-03Male-biased
THYMZNF415BPIFA12.89e+004.62e-044.34e+009.89e-01Female-biased
THYMZNF530BPIFA12.58e+003.25e-044.11e+009.85e-01Female-biased
THYMZNF573BPIFA13.49e+002.14e-034.56e+009.90e-01Female-biased
THYMZNF594BPIFA13.31e+005.76e-034.13e+009.80e-01Female-biased
THYMZNF620BPIFA14.41e+009.91e-013.00e+004.88e-04Male-biased
THYMZNF74BPIFA14.95e+009.95e-013.68e+008.70e-04Male-biased
THYMZNF768BPIFA12.71e+005.75e-044.10e+009.85e-01Female-biased
THYMZNF778BPIFA13.88e+005.05e-034.74e+009.89e-01Female-biased
THYMZSCAN16BPIFA14.78e+009.88e-014.02e+007.03e-03Male-biased
THYMZSCAN30BPIFA12.55e+002.08e-044.20e+009.87e-01Female-biased
THYMZSCAN4BPIFA14.43e+009.88e-013.50e+003.44e-03Male-biased

check buttonBPIFA1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for BPIFA1

check buttonRBPs related to ES in BPIFA1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonBPIFA1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs1547159chr20:39845696:G:T-0.08976887405785520.0244050829463711HNSCFemale-baised eQTL
rs13045202chr20:39839369:G:A-0.08718974133527550.0312943494139436HNSCFemale-baised eQTL
rs8121497chr20:39838790:T:C-0.08477833289009820.0395320655044451HNSCFemale-baised eQTL
rs62211642chr20:25095671:T:C-0.1896338149580740.00162925151975233BLCAFemale-baised eQTL
rs4330176chr20:25093285:G:A-0.1720373533973280.00521580926550926BLCAFemale-baised eQTL
rs11904867chr20:25095696:G:A-0.1573531969758940.0129785205172867BLCAFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs6028574chr20:39648298:G:A-0.03301928382981610.0271972679734173HNSCMale-baised eQTL
rs73104854chr20:23942910:C:T-0.05301353626541690.00851609193058877BLCAMale-baised eQTL
rs6076170chr20:23973194:A:G-0.04445065755965810.0304205535832821BLCAMale-baised eQTL
rs73101504chr20:37525419:C:T-0.05679117161398670.00943433341378079LUADMale-baised eQTL
rs2425349chr20:37508358:T:C-0.05642524259271290.00969285637324146LUADMale-baised eQTL
rs2425352chr20:37513430:T:A-0.05593973640033050.0106788844304746LUADMale-baised eQTL
rs2425353chr20:37513808:C:T-0.05593973640033050.0106788844304746LUADMale-baised eQTL
rs2425354chr20:37513879:C:T-0.05593973640033050.0106788844304746LUADMale-baised eQTL
rs2425355chr20:37514319:G:A-0.05593973640033050.0106788844304746LUADMale-baised eQTL
rs11696280chr20:37551632:G:A-0.05551898716850430.0116746002789567LUADMale-baised eQTL
rs6019103chr20:37524958:A:C--0.05443868475871480.0141233275361573LUADMale-baised eQTL
rs6090836chr20:37525602:T:C--0.05443868475871480.0141233275361573LUADMale-baised eQTL
rs10854179chr20:37527967:A:C--0.05443868475871480.0141233275361573LUADMale-baised eQTL
rs6019062chr20:37520583:T:C--0.05366863654038550.0156916700681054LUADMale-baised eQTL
rs6063269chr20:37536239:G:A-0.05334360575373930.0167291879092272LUADMale-baised eQTL
rs2425348chr20:37505713:G:C-0.0536206333929080.0175314958339783LUADMale-baised eQTL
rs6019159chr20:37529088:A:C-0.05283315782146340.0189208052704503LUADMale-baised eQTL
rs2024794chr20:37541595:T:C--0.05126235314409270.0234358906073382LUADMale-baised eQTL
rs4810777chr20:37511248:T:C--0.05036779116682060.0300824703701834LUADMale-baised eQTL
rs4810805chr20:37536191:G:T--0.05002017988494220.0301950982206327LUADMale-baised eQTL
rs910596chr20:37544147:C:T--0.04820446155110450.0446681007021324LUADMale-baised eQTL
rs910595chr20:37544277:A:C--0.04820446155110450.0446681007021324LUADMale-baised eQTL
rs910594chr20:37544324:C:A--0.04820446155110450.0446681007021324LUADMale-baised eQTL
rs910593chr20:37544395:C:T--0.04820446155110450.0446681007021324LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000198183
CpG Site: cg10655041
Position to Gene: gene,promoter
Male Effect: -0.315021357632005
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg10655041chr20:33236091gene,promoter-0.3150213576320052.85176291673023e-06-0.378565407284795935.212864231380924e-09LUAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of BPIFA1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000198183BPIFA1C0015923Fetal Alcohol Syndrome1CTD_human
ENSG00000198183BPIFA1C0814154Alcohol Related Neurodevelopmental Disorder1CTD_human
ENSG00000198183BPIFA1C2985290Fetal Alcohol Spectrum Disorders1CTD_human
ENSG00000198183BPIFA1C3146244Alcohol Related Birth Defect1CTD_human
ENSG00000198183BPIFA1C3661483Partial Fetal Alcohol Syndrome1CTD_human