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Gene: ENSG00000198074 |
Summary for AKR1B10 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000198074 | Gene symbol | AKR1B10 |
| Gene name | aldo-keto reductase family 1 member B10 | |
| HGNC | 382 | |
| Entrez ID | 57016 | |
| Gene type | protein_coding | |
| Synonyms | AKR1B10|AKR1B12|ARL-1|HIS|ARL1|HSI|ALDRLn | |
| UniProtAcc | O60218 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000198074 | AKR1B10 | DB00605 | Sulindac | SmallMoleculeDrug |
| ENSG00000198074 | AKR1B10 | DB02021 | Fidarestat | SmallMoleculeDrug |
| ENSG00000198074 | AKR1B10 | DB02383 | Tolrestat | SmallMoleculeDrug |
| ENSG00000198074 | AKR1B10 | DB03461 | Nicotinamide adenine dinucleotide phosphate | SmallMoleculeDrug |
| ENSG00000198074 | AKR1B10 | DB06246 | Exisulind | SmallMoleculeDrug |
| ENSG00000198074 | AKR1B10 | DB08772 | Zopolrestat | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for AKR1B10 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKR1B10 | 1.45e+02 | -3.17e+00 | 7.93e-01 | -4.00e+00 | 6.33e-05 | 1.45e-03 | BRCA |
| AKR1B10 | 3.79e+03 | 1.29e+00 | 2.84e-01 | 4.53e+00 | 5.80e-06 | 2.10e-04 | LUAD |
| AKR1B10 | 4.35e+03 | -1.39e+00 | 3.30e-01 | -4.21e+00 | 2.50e-05 | 1.50e-03 | BLCA |
| AKR1B10 | 2.98e+04 | 1.25e+00 | 2.70e-01 | 4.63e+00 | 3.73e-06 | 7.88e-05 | LIHC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| AKR1B10 | 6.45e+02 | -2.74e+00 | 6.79e-01 | -4.04e+00 | 5.38e-05 | 2.80e-04 | READ |
Top |
Sex-biased somatic mutation for AKR1B10 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for AKR1B10 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg25171118 | chr7:134527711 | CGI:chr7:134458363-134459311 | UTR,promoter,exon,gene body | 4.89e-01 | 8.32e-01 | -4.20e+00 | 2.65e-05 | 5.26e-04 | -3.43e-01 |
| CHOL | cg25171118 | chr7:134527711 | CGI:chr7:134458363-134459311 | UTR,promoter,exon,gene body | 4.67e-01 | 7.38e-01 | -2.80e+00 | 5.09e-03 | 1.63e-02 | -2.71e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg12001930 | chr7:134527587 | CGI:chr7:134458363-134459311 | promoter | 4.05e-01 | 2.97e-01 | 2.41e+00 | 1.60e-02 | 2.42e-02 | 1.08e-01 |
Top |
Exon skipping events with PSI in TCGA for AKR1B10 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for AKR1B10 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| STAD | AKR1B10-005 | chr7_134535280_+ | 1.87e-01 | 2.44e-01 | -1.98e+00 | 4.76e-02 | 4.96e-02 | -5.70e-02 |
| LIHC | AKR1B10-005 | chr7_134535293_+ | 2.13e-01 | 2.66e-01 | -2.26e+00 | 2.38e-02 | 4.52e-02 | -5.36e-02 |
| ESCA | AKR1B10-005 | chr7_134533420_+ | 3.35e-01 | 2.29e-01 | 2.01e+00 | 4.45e-02 | 4.99e-02 | 1.06e-01 |
| ESCA | AKR1B10-005 | chr7_134535292_+ | 3.94e-01 | 2.47e-01 | 2.68e+00 | 7.39e-03 | 4.99e-02 | 1.47e-01 |
| ESCA | AKR1B10-005 | chr7_134535306_+ | 6.40e-01 | 4.64e-01 | 2.31e+00 | 2.07e-02 | 4.99e-02 | 1.76e-01 |
| ESCA | AKR1B10-005 | chr7_134535322_+ | 6.22e-01 | 4.62e-01 | 2.04e+00 | 4.15e-02 | 4.99e-02 | 1.60e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| ESCA | AKR1B10-005 | chr7_134535306_+ | 6.40e-01 | 4.06e-01 | 2.58e+00 | 9.98e-03 | 2.05e-02 | 2.34e-01 |
| ESCA | AKR1B10-005 | chr7_134535322_+ | 6.22e-01 | 4.20e-01 | 2.61e+00 | 9.15e-03 | 2.00e-02 | 2.02e-01 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for AKR1B10 |
| TFs related to AKR1B10. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | ZNF121 | AKR1B10 | 4.06e+00 | 9.86e-01 | 2.85e+00 | 3.66e-03 | Male-biased |
| CHOL | ZNF181 | AKR1B10 | 3.99e+00 | 9.84e-01 | 2.82e+00 | 4.45e-03 | Male-biased |
| CHOL | ZNF235 | AKR1B10 | 4.02e+00 | 9.80e-01 | 3.02e+00 | 8.68e-03 | Male-biased |
| CHOL | ZNF33A | AKR1B10 | 3.94e+00 | 9.82e-01 | 2.80e+00 | 4.87e-03 | Male-biased |
| CHOL | ZNF443 | AKR1B10 | 4.17e+00 | 9.88e-01 | 2.91e+00 | 3.02e-03 | Male-biased |
| CHOL | ZNF496 | AKR1B10 | 4.14e+00 | 9.87e-01 | 2.92e+00 | 3.54e-03 | Male-biased |
| ESCA | ZNF283 | AKR1B10 | 3.96e+00 | 9.86e-01 | 2.77e+00 | 6.37e-04 | Male-biased |
| ESCA | ZNF529 | AKR1B10 | 3.79e+00 | 9.81e-01 | 2.74e+00 | 1.40e-03 | Male-biased |
| ESCA | ZNF548 | AKR1B10 | 3.91e+00 | 9.85e-01 | 2.70e+00 | 5.92e-04 | Male-biased |
| ESCA | ZNF93 | AKR1B10 | 3.82e+00 | 9.82e-01 | 2.68e+00 | 8.73e-04 | Male-biased |
| ESCA | ZSCAN22 | AKR1B10 | 3.84e+00 | 9.83e-01 | 2.77e+00 | 1.26e-03 | Male-biased |
| PAAD | TFAP2B | AKR1B10 | 3.97e+00 | 9.82e-01 | 2.91e+00 | 2.93e-03 | Male-biased |
| AKR1B10 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for AKR1B10 |
| RBPs related to ES in AKR1B10. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | KHDRBS3 | exon_skip_471356 | 9.64e+00 | 9.86e-01 | 9.25e+00 | 1.18e-02 | Male-biased |
| AKR1B10 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs3857868 | chr7:138113018:T:A | - | -0.103537186596268 | 0.0122471476302165 | STAD | Female-baised eQTL |
| rs2035647 | chr7:138114823:A:G | - | -0.102695585637842 | 0.0258277931098701 | STAD | Female-baised eQTL |
| rs9642091 | chr7:138114542:T:C | - | -0.102103075555316 | 0.0275360260532588 | STAD | Female-baised eQTL |
| rs9642092 | chr7:138114577:C:T | - | -0.102103075555316 | 0.0275360260532588 | STAD | Female-baised eQTL |
| rs9642093 | chr7:138114616:T:C | - | -0.102103075555316 | 0.0275360260532588 | STAD | Female-baised eQTL |
| rs1038626 | chr7:138112731:A:T | - | -0.0978973602518815 | 0.0285676807261291 | STAD | Female-baised eQTL |
| rs1872930 | chr7:138116698:C:T | - | -0.100745791059121 | 0.0303468924037088 | STAD | Female-baised eQTL |
| rs116359423 | chr7:141996279:T:G | - | 0.0801048499939042 | 0.0035558527312253 | KIRC | Female-baised eQTL |
| rs17166082 | chr7:132028601:G:A | - | 0.0817266992858559 | 0.0111435036154308 | KIRC | Female-baised eQTL |
| rs7802437 | chr7:132319472:G:A | - | 0.0708801482002464 | 0.0114096691514296 | KIRC | Female-baised eQTL |
| rs13437780 | chr7:141994422:T:A | - | 0.0690341601143762 | 0.0167924126316886 | KIRC | Female-baised eQTL |
| rs7807933 | chr7:132378763:A:G | - | 0.0614544501654734 | 0.0173199786241593 | KIRC | Female-baised eQTL |
| rs62466387 | chr7:132361086:A:G | - | 0.0610886471460613 | 0.0195339657596949 | KIRC | Female-baised eQTL |
| rs141731363 | chr7:126195604:C:T | - | 0.149381929662075 | 0.00300931552113425 | BLCA | Female-baised eQTL |
| rs660143 | chr7:126201197:G:A | - | 0.155637432293877 | 0.00513100008084689 | BLCA | Female-baised eQTL |
| rs12669433 | chr7:126188914:C:A | - | 0.14312309128725 | 0.00556506947177135 | BLCA | Female-baised eQTL |
| rs478612 | chr7:126193009:C:A | - | 0.142072912636965 | 0.00646724773150956 | BLCA | Female-baised eQTL |
| rs672097 | chr7:126194275:T:C | - | 0.142072912636965 | 0.00646724773150956 | BLCA | Female-baised eQTL |
| rs201328104 | chr7:126194710:G:A | - | 0.142072912636965 | 0.00646724773150956 | BLCA | Female-baised eQTL |
| rs512340 | chr7:126197190:C:T | - | 0.142072912636965 | 0.00646724773150956 | BLCA | Female-baised eQTL |
| rs572137 | chr7:126188342:T:G | - | 0.136513792256669 | 0.0105377445134627 | BLCA | Female-baised eQTL |
| rs7800937 | chr7:143396214:G:A | - | -0.196087741093287 | 0.0202055257429726 | BLCA | Female-baised eQTL |
| rs672668 | chr7:126194112:A:C | - | 0.118403245448396 | 0.034295462312581 | BLCA | Female-baised eQTL |
| rs533960 | chr7:126194456:C:A | - | 0.118403245448396 | 0.034295462312581 | BLCA | Female-baised eQTL |
| rs112579032 | chr7:126195380:C:T | - | 0.118403245448396 | 0.034295462312581 | BLCA | Female-baised eQTL |
| rs611923 | chr7:126197123:A:G | - | 0.118403245448396 | 0.034295462312581 | BLCA | Female-baised eQTL |
| rs611470 | chr7:126197205:G:A | - | 0.118403245448396 | 0.034295462312581 | BLCA | Female-baised eQTL |
| rs60630803 | chr7:127437452:G:T | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs60267009 | chr7:127437522:T:A | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs60908730 | chr7:127437619:G:A | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs6942979 | chr7:127438034:G:A | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs6963225 | chr7:127438185:T:C | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs28557454 | chr7:127438235:A:G | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs10269088 | chr7:127438436:A:T | - | 0.0641049783031636 | 2.56668931304232e-05 | LUAD | Female-baised eQTL |
| rs17867253 | chr7:127437075:A:G | - | 0.062621739964756 | 3.91928471269885e-05 | LUAD | Female-baised eQTL |
| rs10243114 | chr7:127435651:T:C | - | 0.0595721534467732 | 8.09189278290182e-05 | LUAD | Female-baised eQTL |
| rs10243876 | chr7:127436222:T:A | - | 0.0595721534467732 | 8.09189278290182e-05 | LUAD | Female-baised eQTL |
| rs17150883 | chr7:127439417:C:G | - | 0.054560320205694 | 0.000185189870289757 | LUAD | Female-baised eQTL |
| rs17864160 | chr7:127210841:A:G | - | 0.0682152318382452 | 0.000398659277697836 | LUAD | Female-baised eQTL |
| rs17863242 | chr7:127211394:C:T | - | 0.066266680528682 | 0.000559144943069884 | LUAD | Female-baised eQTL |
| rs7808800 | chr7:137958976:T:C | - | 0.0550215574388657 | 0.000711088713116362 | LUAD | Female-baised eQTL |
| rs10241965 | chr7:127265034:T:A | - | 0.0655289101171526 | 0.00126621125424552 | LUAD | Female-baised eQTL |
| rs1419390 | chr7:127284480:A:G | - | 0.0394034950899493 | 0.0016272061811786 | LUAD | Female-baised eQTL |
| rs834093 | chr7:137525268:T:C | - | 0.0580536545074473 | 0.00233989934652655 | LUAD | Female-baised eQTL |
| rs9649546 | chr7:130891687:T:C | - | 0.046703576328346 | 0.00264601501167421 | LUAD | Female-baised eQTL |
| rs17718364 | chr7:127735293:A:T | - | 0.0456433493544137 | 0.00327911180537985 | LUAD | Female-baised eQTL |
| rs664794 | chr7:129523285:T:A | - | -0.0521357335435135 | 0.00330938170804747 | LUAD | Female-baised eQTL |
| rs73456395 | chr7:135804900:C:T | - | 0.0563867596319905 | 0.00439260042844753 | LUAD | Female-baised eQTL |
| rs28653652 | chr7:137519937:A:T | - | 0.0536042314170841 | 0.00543372009501278 | LUAD | Female-baised eQTL |
| rs3808115 | chr7:127653909:T:C | - | 0.0426252552122838 | 0.0065059173959509 | LUAD | Female-baised eQTL |
| rs7784737 | chr7:135739564:A:G | - | 0.0396410424898246 | 0.00694784226797043 | LUAD | Female-baised eQTL |
| rs7789029 | chr7:142854611:A:C | - | 0.05080434990215 | 0.0073394696211443 | LUAD | Female-baised eQTL |
| rs8177102 | chr7:142855480:C:T | - | 0.0507826315067239 | 0.00740074882374916 | LUAD | Female-baised eQTL |
| rs73158426 | chr7:142118538:A:G | - | 0.0439547782063652 | 0.00945222193398734 | LUAD | Female-baised eQTL |
| rs62489532 | chr7:135737749:A:G | - | 0.0379273934567372 | 0.0103313407597995 | LUAD | Female-baised eQTL |
| rs28600942 | chr7:135737975:G:A | - | 0.0379273934567372 | 0.0103313407597995 | LUAD | Female-baised eQTL |
| rs28450660 | chr7:135738071:G:A | - | 0.0379273934567372 | 0.0103313407597995 | LUAD | Female-baised eQTL |
| rs56401922 | chr7:135738234:C:G | - | 0.0379273934567372 | 0.0103313407597995 | LUAD | Female-baised eQTL |
| rs28684664 | chr7:135738340:T:C | - | 0.0379273934567372 | 0.0103313407597995 | LUAD | Female-baised eQTL |
| rs73157232 | chr7:132263462:C:T | - | 0.049519198368987 | 0.0118501611128482 | LUAD | Female-baised eQTL |
| rs143276958 | chr7:132264805:C:A | - | 0.049519198368987 | 0.0118501611128482 | LUAD | Female-baised eQTL |
| rs73157238 | chr7:132265347:T:C | - | 0.049519198368987 | 0.0118501611128482 | LUAD | Female-baised eQTL |
| rs73157245 | chr7:132271765:T:G | - | 0.049519198368987 | 0.0118501611128482 | LUAD | Female-baised eQTL |
| rs73157247 | chr7:132272483:A:T | - | 0.049519198368987 | 0.0118501611128482 | LUAD | Female-baised eQTL |
| rs6951752 | chr7:135864750:G:A | - | 0.038349617313834 | 0.0138431548824922 | LUAD | Female-baised eQTL |
| rs12540818 | chr7:135847235:A:G | - | 0.0382134635856853 | 0.0145672239971361 | LUAD | Female-baised eQTL |
| rs7783988 | chr7:127448187:T:C | - | 0.0421912576496726 | 0.0146351730461811 | LUAD | Female-baised eQTL |
| rs12537834 | chr7:128186233:G:A | - | -0.0380623865226887 | 0.0158054616348907 | LUAD | Female-baised eQTL |
| rs896182 | chr7:128167720:T:G | - | -0.0380605332203329 | 0.0158147179293224 | LUAD | Female-baised eQTL |
| rs10271253 | chr7:143107156:G:A | - | 0.0460521654264131 | 0.0158337347731896 | LUAD | Female-baised eQTL |
| rs9690338 | chr7:130892534:A:G | - | 0.0431262114262096 | 0.0161046721654964 | LUAD | Female-baised eQTL |
| rs13438609 | chr7:140967968:C:T | - | 0.0465495573274702 | 0.0162953272078798 | LUAD | Female-baised eQTL |
| rs7782840 | chr7:129676389:G:A | - | 0.0416616861445514 | 0.0172032817229349 | LUAD | Female-baised eQTL |
| rs6950129 | chr7:132280708:A:G | - | 0.0446699565455976 | 0.0172394972172556 | LUAD | Female-baised eQTL |
| rs3805362 | chr7:138109642:A:G | - | 0.0344448535574108 | 0.0200093081146898 | LUAD | Female-baised eQTL |
| rs3902226 | chr7:138113109:G:T | - | 0.0376710537870071 | 0.0200132533582617 | LUAD | Female-baised eQTL |
| rs6950381 | chr7:142136794:T:C | - | 0.039159271360069 | 0.020240422756468 | LUAD | Female-baised eQTL |
| rs76993758 | chr7:131899388:G:A | - | 0.0420227637216733 | 0.0202723057888617 | LUAD | Female-baised eQTL |
| rs73460689 | chr7:137720888:C:T | - | 0.0403803232125194 | 0.0211694624748739 | LUAD | Female-baised eQTL |
| rs57957290 | chr7:137721994:G:A | - | 0.0403612238164568 | 0.0213668545454669 | LUAD | Female-baised eQTL |
| rs322723 | chr7:128158890:A:G | - | 0.0362672338026957 | 0.0216961617199399 | LUAD | Female-baised eQTL |
| rs55953418 | chr7:137724961:G:A | - | 0.0397362919150254 | 0.0219415465405786 | LUAD | Female-baised eQTL |
| rs67812259 | chr7:130865774:C:T | - | 0.0413611533332278 | 0.0221167109270057 | LUAD | Female-baised eQTL |
| rs4731406 | chr7:128161154:C:T | - | -0.0362334250692691 | 0.0221742764650027 | LUAD | Female-baised eQTL |
| rs4395807 | chr7:143050190:A:G | - | 0.0403236181012877 | 0.0230029951811305 | LUAD | Female-baised eQTL |
| rs10243337 | chr7:127414851:C:T | - | 0.0453521152076105 | 0.0234819483353833 | LUAD | Female-baised eQTL |
| rs35580626 | chr7:130871160:T:C | - | 0.0405573917689288 | 0.0235046058250636 | LUAD | Female-baised eQTL |
| rs3800638 | chr7:137719322:A:G | - | 0.0396871400840189 | 0.0236329590067231 | LUAD | Female-baised eQTL |
| rs10229838 | chr7:136077526:G:T | - | 0.0391388201444914 | 0.0242183580534275 | LUAD | Female-baised eQTL |
| rs10245681 | chr7:136077852:T:C | - | 0.0391388201444914 | 0.0242183580534275 | LUAD | Female-baised eQTL |
| rs73155740 | chr7:138093655:T:C | - | 0.0331018404023617 | 0.0259154565312963 | LUAD | Female-baised eQTL |
| rs73155742 | chr7:138094537:G:T | - | 0.0331018404023617 | 0.0259154565312963 | LUAD | Female-baised eQTL |
| rs7783021 | chr7:138092865:A:C | - | 0.0330609797455781 | 0.0270788009938423 | LUAD | Female-baised eQTL |
| rs73155745 | chr7:138100005:G:T | - | 0.0327272263694807 | 0.0281861955420147 | LUAD | Female-baised eQTL |
| rs7804281 | chr7:128165102:T:C | - | -0.0351804966909626 | 0.0282027565306975 | LUAD | Female-baised eQTL |
| rs56868289 | chr7:133617429:A:C | - | 0.0367124218835892 | 0.0284130548847121 | LUAD | Female-baised eQTL |
| rs3857857 | chr7:130712771:T:A | - | -0.0432867020191423 | 0.0287294252696693 | LUAD | Female-baised eQTL |
| rs17160984 | chr7:129681483:G:A | - | 0.0384662719662173 | 0.0289415594985648 | LUAD | Female-baised eQTL |
| rs1582260 | chr7:127251602:A:G | - | 0.0300383892904506 | 0.0289714098019264 | LUAD | Female-baised eQTL |
| rs59961804 | chr7:143123225:G:A | - | 0.0400388805883956 | 0.0289730657077606 | LUAD | Female-baised eQTL |
| rs489655 | chr7:126155976:A:G | - | 0.0330495891574953 | 0.0291027408867032 | LUAD | Female-baised eQTL |
| rs4731813 | chr7:131771896:C:G | - | 0.0430375340130065 | 0.029307017366915 | LUAD | Female-baised eQTL |
| rs56073764 | chr7:131774610:G:A | - | 0.0430329209050493 | 0.0293378477904319 | LUAD | Female-baised eQTL |
| rs7808322 | chr7:135844366:A:C | - | 0.0298761250977765 | 0.0300701662177296 | LUAD | Female-baised eQTL |
| rs322725 | chr7:128158529:C:T | - | 0.034740754097126 | 0.0303699648742217 | LUAD | Female-baised eQTL |
| rs157912 | chr7:130883264:G:A | - | -0.0390550257099332 | 0.0304753285130565 | LUAD | Female-baised eQTL |
| rs157914 | chr7:130883697:T:C | - | -0.0390550257099332 | 0.0304753285130565 | LUAD | Female-baised eQTL |
| rs4728089 | chr7:128161890:A:G | - | -0.0346911042510171 | 0.0313189476778461 | LUAD | Female-baised eQTL |
| rs117303154 | chr7:137846951:C:A | - | 0.0444711839787799 | 0.0313790793162705 | LUAD | Female-baised eQTL |
| rs34309725 | chr7:137847206:C:T | - | 0.0444711839787799 | 0.0313790793162705 | LUAD | Female-baised eQTL |
| rs1109272 | chr7:137847453:C:A | - | 0.0444711839787799 | 0.0313790793162705 | LUAD | Female-baised eQTL |
| rs62483172 | chr7:127573502:G:A | - | 0.0343132193997108 | 0.0321162724497364 | LUAD | Female-baised eQTL |
| rs11972987 | chr7:135874899:A:G | - | 0.0429050082148986 | 0.0322566926558814 | LUAD | Female-baised eQTL |
| rs11979851 | chr7:135874902:C:T | - | 0.0429050082148986 | 0.0322566926558814 | LUAD | Female-baised eQTL |
| rs10263086 | chr7:137726361:G:C | - | 0.0337727447360116 | 0.0324123073300597 | LUAD | Female-baised eQTL |
| rs3778804 | chr7:137728587:G:A | - | 0.0337727447360116 | 0.0324123073300597 | LUAD | Female-baised eQTL |
| rs73725075 | chr7:143126386:C:A | - | 0.0392371023967536 | 0.0332086240200265 | LUAD | Female-baised eQTL |
| rs3800639 | chr7:137729071:G:A | - | 0.0337951978071542 | 0.0338101541039079 | LUAD | Female-baised eQTL |
| rs901795 | chr7:136034261:T:C | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs901794 | chr7:136034522:C:T | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs1290727 | chr7:136034659:C:A | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs1290728 | chr7:136034697:A:G | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs1290729 | chr7:136034783:A:G | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs1290730 | chr7:136034813:C:T | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs1290731 | chr7:136034909:C:T | - | 0.0327448000124508 | 0.0345200240151807 | LUAD | Female-baised eQTL |
| rs1290733 | chr7:136035409:C:G | - | 0.0326653090388063 | 0.0347895677952082 | LUAD | Female-baised eQTL |
| rs1290735 | chr7:136035602:A:G | - | 0.0326326497317009 | 0.0354448510024168 | LUAD | Female-baised eQTL |
| rs1290736 | chr7:136035608:C:A | - | 0.0326326497317009 | 0.0354448510024168 | LUAD | Female-baised eQTL |
| rs2306846 | chr7:138107028:A:C | - | 0.0317083287001206 | 0.0360839271888058 | LUAD | Female-baised eQTL |
| rs62471382 | chr7:133655196:T:A | - | 0.0336031387679799 | 0.0362497113620854 | LUAD | Female-baised eQTL |
| rs10215103 | chr7:128159998:T:A | - | -0.0338139148742295 | 0.0365946275349719 | LUAD | Female-baised eQTL |
| rs55675608 | chr7:132272048:T:C | - | 0.0392228641179888 | 0.0368095927300706 | LUAD | Female-baised eQTL |
| rs12539650 | chr7:127545901:A:G | - | 0.0334585919827426 | 0.0372872854973668 | LUAD | Female-baised eQTL |
| rs73155730 | chr7:138081056:T:G | - | 0.0348224035706402 | 0.0377614879488919 | LUAD | Female-baised eQTL |
| rs17164103 | chr7:143052640:C:T | - | 0.0371452986447071 | 0.039137524765418 | LUAD | Female-baised eQTL |
| rs156944 | chr7:132460031:T:C | - | -0.0432539845995035 | 0.0400723374532713 | LUAD | Female-baised eQTL |
| rs56408170 | chr7:131903890:A:G | - | 0.0402023987067756 | 0.0405063438527836 | LUAD | Female-baised eQTL |
| rs17165207 | chr7:130880938:G:C | - | 0.0368249224277902 | 0.0423941215887425 | LUAD | Female-baised eQTL |
| rs57853761 | chr7:133629836:C:T | - | 0.0327627515259712 | 0.0429970701291293 | LUAD | Female-baised eQTL |
| rs17167179 | chr7:133630768:A:G | - | 0.0327627515259712 | 0.0429970701291293 | LUAD | Female-baised eQTL |
| rs17167187 | chr7:133646100:C:T | - | 0.0327627515259712 | 0.0429970701291293 | LUAD | Female-baised eQTL |
| rs11562040 | chr7:133651797:G:A | - | 0.0327627515259712 | 0.0429970701291293 | LUAD | Female-baised eQTL |
| rs1582259 | chr7:127251839:G:A | - | 0.0283449950134302 | 0.0431286424866243 | LUAD | Female-baised eQTL |
| rs4725429 | chr7:140942428:A:T | - | 0.0340041123722774 | 0.0437133554032749 | LUAD | Female-baised eQTL |
| rs1290737 | chr7:136035639:T:C | - | 0.0314550348778055 | 0.0443815856761532 | LUAD | Female-baised eQTL |
| rs1646746 | chr7:134399172:G:C | - | -0.0406232705192176 | 0.0454663756850628 | LUAD | Female-baised eQTL |
| rs10257746 | chr7:137730427:G:A | - | 0.0319754876737861 | 0.0462409496974561 | LUAD | Female-baised eQTL |
| rs28672333 | chr7:143129705:G:A | - | 0.0369188093845286 | 0.0462952395825991 | LUAD | Female-baised eQTL |
| rs73452602 | chr7:143131238:A:T | - | 0.0369188093845286 | 0.0462952395825991 | LUAD | Female-baised eQTL |
| rs34599926 | chr7:127620899:C:G | - | 0.0343927232319052 | 0.0465012136723332 | LUAD | Female-baised eQTL |
| rs77019628 | chr7:133572532:T:A | - | 0.0325809676368937 | 0.0468445001026093 | LUAD | Female-baised eQTL |
| rs17167177 | chr7:133625465:G:C | - | 0.0323336289973736 | 0.0470875250544615 | LUAD | Female-baised eQTL |
| rs62470055 | chr7:133633167:A:G | - | 0.0323336289973736 | 0.0470875250544615 | LUAD | Female-baised eQTL |
| rs17167183 | chr7:133637753:A:G | - | 0.0323336289973736 | 0.0470875250544615 | LUAD | Female-baised eQTL |
| rs7794849 | chr7:133652450:A:T | - | 0.0323336289973736 | 0.0470875250544615 | LUAD | Female-baised eQTL |
| rs58783780 | chr7:138084209:G:A | - | 0.0301093728468644 | 0.0480463834723167 | LUAD | Female-baised eQTL |
| rs3800643 | chr7:137735903:C:T | - | 0.0349761327314526 | 0.0488168595644011 | LUAD | Female-baised eQTL |
| rs9986765 | chr7:143138146:A:G | - | 0.039123738223687 | 0.0496146896956958 | LUAD | Female-baised eQTL |
| rs2284199 | chr7:139889851:C:T | - | -0.0640730918903568 | 0.00508057718115625 | COAD | Female-baised eQTL |
| rs76501725 | chr7:134741970:T:C | - | 0.146020123939894 | 0.00763504722080829 | COAD | Female-baised eQTL |
| rs76274238 | chr7:134740855:A:C | - | 0.145358414486584 | 0.0108026134424876 | COAD | Female-baised eQTL |
| rs1015571 | chr7:139886815:G:T | - | -0.0610817442475291 | 0.0166028212606939 | COAD | Female-baised eQTL |
| rs1015570 | chr7:139887008:G:T | - | -0.0610817442475291 | 0.0166028212606939 | COAD | Female-baised eQTL |
| rs2267683 | chr7:139870867:C:T | - | -0.0581529769864242 | 0.0170007172542862 | COAD | Female-baised eQTL |
| rs2299888 | chr7:139884257:C:T | - | -0.0582330180287698 | 0.022720729418781 | COAD | Female-baised eQTL |
| rs2299889 | chr7:139884462:C:T | - | -0.0582330180287698 | 0.022720729418781 | COAD | Female-baised eQTL |
| rs2299890 | chr7:139884706:G:A | - | -0.0582330180287698 | 0.022720729418781 | COAD | Female-baised eQTL |
| rs7796912 | chr7:139861098:C:T | - | -0.0572042586425917 | 0.0311131388804639 | COAD | Female-baised eQTL |
| rs34765434 | chr7:139881463:T:C | - | -0.0554096358484387 | 0.0320522430576729 | COAD | Female-baised eQTL |
| rs6464154 | chr7:139860410:C:T | - | -0.0563293430683481 | 0.0334657896465698 | COAD | Female-baised eQTL |
| rs7778515 | chr7:139883561:G:A | - | -0.0546019374915761 | 0.0361899176571055 | COAD | Female-baised eQTL |
| rs2299887 | chr7:139884030:A:G | - | -0.0546019374915761 | 0.0361899176571055 | COAD | Female-baised eQTL |
| rs8192817 | chr7:139884997:T:C | - | -0.0546019374915761 | 0.0361899176571055 | COAD | Female-baised eQTL |
| rs7809583 | chr7:139859874:G:C | - | -0.0538729669097694 | 0.0411454104381983 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10808236 | chr7:129537780:G:T | - | 0.247682157635698 | 0.0331124203833867 | READ | Male-baised eQTL |
| rs12056128 | chr7:129538198:C:T | - | 0.247682157635698 | 0.0331124203833867 | READ | Male-baised eQTL |
| rs76528286 | chr7:136214402:A:T | - | 0.136190392409834 | 0.000284919086075146 | SARC | Male-baised eQTL |
| rs834824 | chr7:136213113:A:T | - | 0.12094044590356 | 0.00156104342048369 | SARC | Male-baised eQTL |
| rs10249296 | chr7:136492089:T:A | - | -0.118509789179915 | 0.0017174248964829 | SARC | Male-baised eQTL |
| rs3778851 | chr7:134846325:G:A | - | 0.0627995186696986 | 0.0421773989036378 | KIRC | Male-baised eQTL |
| rs3800725 | chr7:134846991:A:G | - | 0.0627995186696986 | 0.0421773989036378 | KIRC | Male-baised eQTL |
| rs3800727 | chr7:134847093:G:A | - | 0.0627995186696986 | 0.0421773989036378 | KIRC | Male-baised eQTL |
| rs1361944 | chr7:127369461:G:A | - | -0.0810184032983355 | 0.0265782913765328 | LUAD | Male-baised eQTL |
| rs1419422 | chr7:127377854:T:C | - | -0.0810184032983355 | 0.0265782913765328 | LUAD | Male-baised eQTL |
| rs1419397 | chr7:127366571:G:T | - | -0.0763528920662511 | 0.0440072237074047 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000198074 |
| CpG Site: cg25171118 | |
| Position to Gene: gene,exon,promoter,UTR | |
| Male Effect: - | |
| Female Effect: -0.163141634530837 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg25171118 | chr7:134527711 | gene,exon,promoter,UTR | -0.163141634530837 | 9.22538435237415e-14 | -0.4966962639401997 | 2.7210077037183116e-17 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of AKR1B10 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000198074 | AKR1B10 | C0006826 | Malignant Neoplasms | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0011616 | Contact Dermatitis | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0025202 | melanoma | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0027651 | Neoplasms | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0086692 | Benign Neoplasm | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0162351 | Contact hypersensitivity | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
| ENSG00000198074 | AKR1B10 | C2239176 | Liver carcinoma | 1 | CTD_human |
