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Gene: ENSG00000197122

Summary for SRC

Gene summary

Gene information	Ensembl ID	ENSG00000197122
	Gene symbol	SRC
	Gene name	SRC proto-oncogene, non-receptor tyrosine kinase
	HGNC	11283
	Entrez ID	6714
	Gene type	protein_coding
	Synonyms	SRC\|ASV\|c-src
	UniProtAcc	P12931

Drugs associated with this gene(DrugBank).

Gene ID	Gene Symbol	Drug ID	Drug Name	Drug Type
ENSG00000197122	SRC	DB01254	Dasatinib	SmallMoleculeDrug
ENSG00000197122	SRC	DB01678	RU84687	SmallMoleculeDrug
ENSG00000197122	SRC	DB01866	RU79256	SmallMoleculeDrug
ENSG00000197122	SRC	DB01893	N6-Benzyl Adenosine-5'-Diphosphate	SmallMoleculeDrug
ENSG00000197122	SRC	DB01908	RU85493	SmallMoleculeDrug
ENSG00000197122	SRC	DB01947	RU78262	SmallMoleculeDrug
ENSG00000197122	SRC	DB01962	Phosphonotyrosine	SmallMoleculeDrug
ENSG00000197122	SRC	DB02175	Malonic acid	SmallMoleculeDrug
ENSG00000197122	SRC	DB02336	RU83876	SmallMoleculeDrug
ENSG00000197122	SRC	DB02432	RU90395	SmallMoleculeDrug
ENSG00000197122	SRC	DB02762	RU79072	SmallMoleculeDrug
ENSG00000197122	SRC	DB02908	RU78783	SmallMoleculeDrug
ENSG00000197122	SRC	DB03023	1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine	SmallMoleculeDrug
ENSG00000197122	SRC	DB03078	PASBN	SmallMoleculeDrug
ENSG00000197122	SRC	DB03104	2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid	SmallMoleculeDrug
ENSG00000197122	SRC	DB03114	PAS219	SmallMoleculeDrug
ENSG00000197122	SRC	DB03217	DPI59	SmallMoleculeDrug
ENSG00000197122	SRC	DB03268	RU82197	SmallMoleculeDrug
ENSG00000197122	SRC	DB03298	Phenylphosphate	SmallMoleculeDrug
ENSG00000197122	SRC	DB03306	RU78300	SmallMoleculeDrug
ENSG00000197122	SRC	DB03525	RU79073	SmallMoleculeDrug
ENSG00000197122	SRC	DB03591	RU82209	SmallMoleculeDrug
ENSG00000197122	SRC	DB03628	ISO24	SmallMoleculeDrug
ENSG00000197122	SRC	DB03712	RU85053	SmallMoleculeDrug
ENSG00000197122	SRC	DB03828	RU78299	SmallMoleculeDrug
ENSG00000197122	SRC	DB03902	Oxalic Acid	SmallMoleculeDrug
ENSG00000197122	SRC	DB04080	RU78191	SmallMoleculeDrug
ENSG00000197122	SRC	DB04272	Citric acid	SmallMoleculeDrug
ENSG00000197122	SRC	DB04495	Paratoulene phosphate	SmallMoleculeDrug
ENSG00000197122	SRC	DB04739	4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE	SmallMoleculeDrug
ENSG00000197122	SRC	DB04751	Purvalanol A	SmallMoleculeDrug
ENSG00000197122	SRC	DB05184	XL228	SmallMoleculeDrug
ENSG00000197122	SRC	DB06137	Tirbanibulin	SmallMoleculeDrug
ENSG00000197122	SRC	DB06616	Bosutinib	SmallMoleculeDrug
ENSG00000197122	SRC	DB06882	1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea	SmallMoleculeDrug
ENSG00000197122	SRC	DB06883	1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea	SmallMoleculeDrug
ENSG00000197122	SRC	DB07335	3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL	SmallMoleculeDrug
ENSG00000197122	SRC	DB07662	PD-168393	SmallMoleculeDrug
ENSG00000197122	SRC	DB07966	[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile	SmallMoleculeDrug
ENSG00000197122	SRC	DB08052	PP-121	SmallMoleculeDrug
ENSG00000197122	SRC	DB08053	1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	SmallMoleculeDrug
ENSG00000197122	SRC	DB08054	1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	SmallMoleculeDrug
ENSG00000197122	SRC	DB08192	2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE	SmallMoleculeDrug
ENSG00000197122	SRC	DB08462	N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE	SmallMoleculeDrug
ENSG00000197122	SRC	DB08564	(2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide	SmallMoleculeDrug
ENSG00000197122	SRC	DB08901	Ponatinib	SmallMoleculeDrug
ENSG00000197122	SRC	DB09079	Nintedanib	SmallMoleculeDrug
ENSG00000197122	SRC	DB12010	Fostamatinib	SmallMoleculeDrug

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID	Gene Name	Drug ID	Drug Name	Drug Type	Cancer
ENSG00000197122	SRC	DB01254	Dasatinib	SmallMoleculeDrug	Acute Lymphoblastic Leukemia (ALL),Chronic Myelogenous Leukemia (CML),Myeloproliferative Neoplasms
ENSG00000197122	SRC	DB06616	Bosutinib	SmallMoleculeDrug	Chronic Myelogenous Leukemia (CML)
ENSG00000197122	SRC	DB08901	Ponatinib	SmallMoleculeDrug	Acute Lymphoblastic Leukemia (ALL),Chronic Myelogenous Leukemia (CML)

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Structure and expression level for SRC

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
SRC	3.27e+03	2.06e+00	3.04e-01	6.79e+00	1.13e-11	2.37e-10	CHOL

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
SRC	1.57e+03	1.74e+00	2.73e-01	6.38e+00	1.81e-10	1.98e-09	LIHC

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Sex-biased somatic mutation for SRC

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for SRC

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type

CpG Site

Position

CpG Island

Position to Gene

ave1

ave2

wilcoxon.w

wilcoxon.p

padj

dBeta

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRC	cg19757422	chr20:37344661	CGI:chr20:37345774-37346445	promoter	5.69e-01	4.60e-01	4.35e+00	1.36e-05	3.55e-05	1.09e-01
THCA	cg24384816	chr20:37343909	CGI:chr20:37345774-37346445	promoter	1.88e-01	2.97e-01	-4.07e+00	4.72e-05	3.54e-04	-1.09e-01
THCA	cg05498681	chr20:37344915	CGI:chr20:37345774-37346445	promoter,gene body	8.39e-01	7.32e-01	3.31e+00	9.35e-04	2.98e-03	1.07e-01
HNSC	cg05498681	chr20:37344915	CGI:chr20:37345774-37346445	promoter,gene body	6.53e-01	7.77e-01	-2.75e+00	6.04e-03	8.35e-03	-1.24e-01
LUSC	cg10865498	chr20:37346619	CGI:chr20:37345774-37346445	promoter,gene body	3.38e-01	4.84e-01	-3.74e+00	1.84e-04	9.29e-04	-1.46e-01
LUSC	cg18858144	chr20:37344554	CGI:chr20:37345774-37346445	promoter	4.05e-01	5.64e-01	-3.41e+00	6.60e-04	1.98e-03	-1.59e-01
LUSC	cg24055525	chr20:37344639	CGI:chr20:37345774-37346445	promoter	4.97e-01	6.54e-01	-3.23e+00	1.23e-03	2.99e-03	-1.57e-01
LUSC	cg19757422	chr20:37344661	CGI:chr20:37345774-37346445	promoter	5.39e-01	7.18e-01	-3.12e+00	1.79e-03	3.87e-03	-1.80e-01
COAD	cg11210813	chr20:37343982	CGI:chr20:37345774-37346445	promoter	2.28e-01	3.28e-01	-4.03e+00	5.67e-05	2.23e-04	-1.00e-01
COAD	cg22437284	chr20:37344133	CGI:chr20:37345774-37346445	promoter	5.88e-01	7.05e-01	-3.58e+00	3.45e-04	9.46e-04	-1.17e-01
COAD	cg18858144	chr20:37344554	CGI:chr20:37345774-37346445	promoter	2.61e-01	4.34e-01	-4.44e+00	8.86e-06	5.38e-05	-1.73e-01
COAD	cg24055525	chr20:37344639	CGI:chr20:37345774-37346445	promoter	3.01e-01	4.81e-01	-4.36e+00	1.31e-05	7.20e-05	-1.80e-01
COAD	cg19757422	chr20:37344661	CGI:chr20:37345774-37346445	promoter	3.45e-01	5.51e-01	-4.27e+00	1.92e-05	9.64e-05	-2.06e-01
COAD	cg05498681	chr20:37344915	CGI:chr20:37345774-37346445	promoter,gene body	3.41e-01	5.14e-01	-4.18e+00	2.87e-05	1.32e-04	-1.73e-01
BLCA	cg24384816	chr20:37343909	CGI:chr20:37345774-37346445	promoter	2.31e-01	4.72e-01	-4.79e+00	1.68e-06	6.20e-05	-2.41e-01
BLCA	cg11210813	chr20:37343982	CGI:chr20:37345774-37346445	promoter	3.37e-01	5.45e-01	-4.35e+00	1.34e-05	1.11e-04	-2.08e-01
BLCA	cg22437284	chr20:37344133	CGI:chr20:37345774-37346445	promoter	7.62e-01	9.12e-01	-3.85e+00	1.20e-04	4.55e-04	-1.50e-01
KIRP	cg11210813	chr20:37343982	CGI:chr20:37345774-37346445	promoter	3.43e-01	4.91e-01	-4.31e+00	1.66e-05	5.71e-05	-1.48e-01
KIRP	cg24055525	chr20:37344639	CGI:chr20:37345774-37346445	promoter	3.03e-01	4.13e-01	-3.60e+00	3.24e-04	7.01e-04	-1.10e-01
CHOL	cg10865498	chr20:37346619	CGI:chr20:37345774-37346445	promoter,gene body	3.31e-01	7.12e-01	-3.54e+00	4.02e-04	8.32e-03	-3.81e-01
CHOL	cg24384816	chr20:37343909	CGI:chr20:37345774-37346445	promoter	3.84e-01	6.68e-01	-2.51e+00	1.22e-02	2.39e-02	-2.84e-01
CHOL	cg11210813	chr20:37343982	CGI:chr20:37345774-37346445	promoter	4.38e-01	6.54e-01	-2.36e+00	1.83e-02	2.92e-02	-2.16e-01
CHOL	cg18858144	chr20:37344554	CGI:chr20:37345774-37346445	promoter	3.39e-01	5.23e-01	-2.51e+00	1.22e-02	2.39e-02	-1.84e-01
CHOL	cg24055525	chr20:37344639	CGI:chr20:37345774-37346445	promoter	3.65e-01	5.14e-01	-2.06e+00	3.90e-02	4.26e-02	-1.49e-01
CHOL	cg07474022	chr20:37346509	CGI:chr20:37345774-37346445	promoter,gene body	9.69e-02	3.43e-01	-3.54e+00	4.02e-04	8.32e-03	-2.46e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg22437284	chr20:37344133	CGI:chr20:37345774-37346445	promoter	8.41e-01	7.29e-01	7.80e+00	6.14e-15	2.22e-14	1.13e-01
BRCA	cg18858144	chr20:37344554	CGI:chr20:37345774-37346445	promoter	4.40e-01	5.66e-01	-6.67e+00	2.63e-11	7.24e-11	-1.26e-01
BRCA	cg24055525	chr20:37344639	CGI:chr20:37345774-37346445	promoter	5.67e-01	7.04e-01	-6.31e+00	2.87e-10	7.29e-10	-1.37e-01
BRCA	cg19757422	chr20:37344661	CGI:chr20:37345774-37346445	promoter	6.17e-01	7.55e-01	-6.12e+00	9.28e-10	2.26e-09	-1.38e-01
BRCA	cg05498681	chr20:37344915	CGI:chr20:37345774-37346445	promoter,gene body	5.55e-01	7.08e-01	-8.49e+00	2.10e-17	9.19e-17	-1.54e-01
LUAD	cg24384816	chr20:37343909	CGI:chr20:37345774-37346445	promoter	2.15e-01	3.43e-01	-4.07e+00	4.63e-05	6.73e-04	-1.28e-01
LUAD	cg11210813	chr20:37343982	CGI:chr20:37345774-37346445	promoter	3.34e-01	4.64e-01	-4.03e+00	5.51e-05	7.02e-04	-1.30e-01
HNSC	cg24384816	chr20:37343909	CGI:chr20:37345774-37346445	promoter	3.28e-01	1.90e-01	2.59e+00	9.59e-03	1.82e-02	1.38e-01
BLCA	cg10865498	chr20:37346619	CGI:chr20:37345774-37346445	promoter,gene body	2.59e-01	4.04e-01	-3.06e+00	2.24e-03	7.22e-03	-1.45e-01
LIHC	cg18858144	chr20:37344554	CGI:chr20:37345774-37346445	promoter	4.15e-01	5.24e-01	-2.90e+00	3.68e-03	6.30e-03	-1.09e-01
KIRP	cg19757422	chr20:37344661	CGI:chr20:37345774-37346445	promoter	3.81e-01	4.94e-01	-2.50e+00	1.24e-02	1.94e-02	-1.13e-01

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Exon skipping events with PSI in TCGA for SRC

∗Please access ExonSkipDB for exon skipping annotation.

Landscape of exon skipping events across multiple cancer types.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for SRC

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for SRC

TFs related to SRC.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
BRCA	PLAGL2	SRC	3.01e+00	5.90e-03	4.39e+00	9.82e-01	Female-biased

SRC related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for SRC

RBPs related to ES in SRC.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	RBP	Target ES	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
STAD	SAMD4A	exon_skip_351622	9.31e+00	9.96e-01	8.69e+00	1.25e-03	Male-biased
UVM	SAMD4A	exon_skip_351622	8.14e+00	9.62e-03	8.45e+00	9.84e-01	Female-biased
LUSC	SAMD4A	exon_skip_351622	9.26e+00	9.94e-01	8.74e+00	2.94e-03	Male-biased
LUAD	SAMD4A	exon_skip_351622	8.70e+00	9.90e-01	8.30e+00	4.73e-03	Male-biased
LUAD	ZC3H10	exon_skip_351610	6.35e+00	1.79e-03	6.86e+00	9.83e-01	Female-biased
BRCA	SAMD4A	exon_skip_351622	7.94e+00	7.48e-04	9.47e+00	9.96e-01	Female-biased
ESCA	SAMD4A	exon_skip_351622	9.14e+00	9.95e-01	8.37e+00	1.27e-03	Male-biased
THCA	SAMD4A	exon_skip_351622	8.22e+00	8.12e-03	8.53e+00	9.86e-01	Female-biased
LGG	RBM4	exon_skip_351610	7.87e+00	8.38e-03	8.22e+00	9.84e-01	Female-biased
GBM	SAMD4A	exon_skip_351622	8.85e+00	9.93e-01	8.34e+00	1.63e-03	Male-biased
PAAD	RBM4	exon_skip_351610	8.21e+00	9.90e-01	7.80e+00	2.50e-03	Male-biased
KIRC	SAMD4A	exon_skip_351622	8.51e+00	3.28e-03	8.93e+00	9.92e-01	Female-biased
HNSC	SAMD4A	exon_skip_351622	8.88e+00	9.82e-01	8.56e+00	1.28e-02	Male-biased
SARC	SAMD4A	exon_skip_351622	8.89e+00	9.95e-01	8.03e+00	2.30e-04	Male-biased

SRC related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID	ceRNA(lncRNA-miRNA-mRNA)	Group	Cancer Type
ENSG00000197122	KCNQ1OT1,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC105339.2,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC048341.1,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	Z95331.1,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	THBS3-AS1,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC010168.2,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	TMEM147-AS1,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC232271.1,hsa-mir-141,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	KCNQ1OT1,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC105339.2,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC048341.1,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	Z95331.1,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AL008723.2,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	THBS3-AS1,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	GARS1-DT,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC010168.2,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	TMEM147-AS1,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC
ENSG00000197122	AC232271.1,hsa-mir-200a,SRC	Female-specific ceRNA	TCGA-LIHC

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs36104651	chr20:32819057:A:T	-	0.110289782297382	0.0256216987966514	HNSC	Female-baised eQTL
rs56047717	chr20:31279756:C:A	-	0.0921989638163311	0.027222887252311	HNSC	Female-baised eQTL
rs35065789	chr20:32817316:G:A	-	0.10283546369594	0.0487527823056427	HNSC	Female-baised eQTL
rs4911381	chr20:33962539:G:C	-	0.107449048157205	0.0304253533090633	LIHC	Female-baised eQTL
rs9753679	chr20:33953054:G:A	-	0.107306827979613	0.0313713541792319	LIHC	Female-baised eQTL
rs6142050	chr20:33939322:G:A	-	0.104387301975803	0.0342960100317121	LIHC	Female-baised eQTL
rs6142051	chr20:33945212:T:C	-	0.106561333382457	0.0346608190683887	LIHC	Female-baised eQTL
rs9753690	chr20:33952995:C:G	-	0.105657521392412	0.0360322727947886	LIHC	Female-baised eQTL
rs7263727	chr20:33953133:T:C	-	0.105657521392412	0.0360322727947886	LIHC	Female-baised eQTL
rs6142056	chr20:33953349:T:C	-	0.105657521392412	0.0360322727947886	LIHC	Female-baised eQTL
rs4911137	chr20:33947657:C:T	-	0.106039511482917	0.037217984163112	LIHC	Female-baised eQTL
rs6141434	chr20:33963441:T:G	-	0.104597380192289	0.0409700569760753	LIHC	Female-baised eQTL
rs6141435	chr20:33963473:G:A	-	0.104597380192289	0.0409700569760753	LIHC	Female-baised eQTL
rs8119076	chr20:33937909:A:G	-	0.104077265449904	0.0409776895692151	LIHC	Female-baised eQTL
rs4911136	chr20:33938066:C:T	-	0.104077265449904	0.0409776895692151	LIHC	Female-baised eQTL
rs6059577	chr20:33939880:T:C	-	0.104077265449904	0.0409776895692151	LIHC	Female-baised eQTL
rs6142046	chr20:33926255:C:T	-	0.101370532269362	0.0499235087535761	LIHC	Female-baised eQTL
rs1998112	chr20:33026982:A:C	-	-0.193854037799316	0.0187220926273261	LUSC	Female-baised eQTL
rs34182218	chr20:40056725:T:G	-	0.125233967233417	0.012681833888021	LGG	Female-baised eQTL
rs2207221	chr20:42042098:A:C	-	0.0439210404064065	0.0261329491139199	LUAD	Female-baised eQTL
rs875791	chr20:41979968:C:T	-	0.0456437122241173	0.0310819654181157	LUAD	Female-baised eQTL
rs2144003	chr20:42049063:G:A	-	0.0429903956971474	0.031136186710663	LUAD	Female-baised eQTL

Female-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs13041173	chr20:33955008:A:G	-	-0.0664065862067547	0.0393149605686173	LUAD	Male-baised eQTL
rs6094057	chr20:44937163:G:A	-	-0.0907889211081	0.00253741823008662	COAD	Male-baised eQTL
rs34727007	chr20:44869371:C:T	-	-0.0771140953941056	0.0107442706092512	COAD	Male-baised eQTL
rs2425661	chr20:44878836:A:G	-	-0.0741857885330055	0.0178646904737081	COAD	Male-baised eQTL
rs2425662	chr20:44878960:G:A	-	-0.0741857885330055	0.0178646904737081	COAD	Male-baised eQTL
rs3092149	chr20:44879187:A:G	-	-0.0741857885330055	0.0178646904737081	COAD	Male-baised eQTL
rs3092288	chr20:44879207:G:A	-	-0.0741857885330055	0.0178646904737081	COAD	Male-baised eQTL
rs2868163	chr20:44879313:A:G	-	-0.0741857885330055	0.0178646904737081	COAD	Male-baised eQTL
rs2868164	chr20:44879370:G:C	-	-0.0741857885330055	0.0178646904737081	COAD	Male-baised eQTL
rs2425675	chr20:44906293:G:A	-	-0.0746953108935657	0.0189394501636533	COAD	Male-baised eQTL
rs2425669	chr20:44892929:C:G	-	-0.0747445332975532	0.0197739307349446	COAD	Male-baised eQTL
rs2425671	chr20:44893414:A:G	-	-0.0747445332975532	0.0197739307349446	COAD	Male-baised eQTL
rs2425673	chr20:44898289:T:A	-	-0.0747445332975532	0.0197739307349446	COAD	Male-baised eQTL
rs3091803	chr20:44899729:A:G	-	-0.0747445332975532	0.0197739307349446	COAD	Male-baised eQTL
rs6103902	chr20:44871524:G:A	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2425651	chr20:44874616:G:A	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs11086945	chr20:44876024:A:G	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2425652	chr20:44876216:G:C	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2425653	chr20:44877037:G:A	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2425654	chr20:44877152:G:A	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2425655	chr20:44877464:G:A	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2425658	chr20:44877933:T:C	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs2142564	chr20:44878554:G:T	-	-0.0735437586802204	0.0198501664854964	COAD	Male-baised eQTL
rs3746584	chr20:44936981:G:A	-	-0.0751399455741626	0.0210389717798065	COAD	Male-baised eQTL
rs2867443	chr20:42459026:A:G	-	0.148095797329355	0.022555139754574	COAD	Male-baised eQTL
rs3091776	chr20:44882302:C:A	-	-0.072411887943647	0.0232047362209106	COAD	Male-baised eQTL
rs3091452	chr20:44882703:T:C	-	-0.072411887943647	0.0232047362209106	COAD	Male-baised eQTL
rs2253712	chr20:44895123:T:C	-	-0.0733200544139046	0.0235728137766423	COAD	Male-baised eQTL
rs2267849	chr20:44895728:A:G	-	-0.0733200544139046	0.0235728137766423	COAD	Male-baised eQTL
rs3092229	chr20:44898987:A:G	-	-0.0733200544139046	0.0235728137766423	COAD	Male-baised eQTL
rs3091709	chr20:44899629:A:G	-	-0.0733200544139046	0.0235728137766423	COAD	Male-baised eQTL
rs13043332	chr20:44869024:T:G	-	-0.0700350339385684	0.0257860122108304	COAD	Male-baised eQTL
rs7508820	chr20:44869182:A:G	-	-0.0700350339385684	0.0257860122108304	COAD	Male-baised eQTL
rs34430472	chr20:44869248:T:C	-	-0.0700350339385684	0.0257860122108304	COAD	Male-baised eQTL
rs34014890	chr20:44869256:G:C	-	-0.0700350339385684	0.0257860122108304	COAD	Male-baised eQTL
rs2179068	chr20:44869522:G:A	-	-0.0700350339385684	0.0257860122108304	COAD	Male-baised eQTL
rs2142562	chr20:44869595:G:A	-	-0.0700350339385684	0.0257860122108304	COAD	Male-baised eQTL
rs2142563	chr20:44869741:G:T	-	-0.0704249572585164	0.0264618125105616	COAD	Male-baised eQTL
rs2425664	chr20:44880463:G:A	-	-0.0710100675111426	0.0274962565254704	COAD	Male-baised eQTL
rs3092652	chr20:44880875:G:A	-	-0.0710100675111426	0.0274962565254704	COAD	Male-baised eQTL
rs2425665	chr20:44880956:C:A	-	-0.0710100675111426	0.0274962565254704	COAD	Male-baised eQTL
rs2425666	chr20:44881235:A:C	-	-0.0710100675111426	0.0274962565254704	COAD	Male-baised eQTL
rs2425667	chr20:44881438:G:T	-	-0.0710100675111426	0.0274962565254704	COAD	Male-baised eQTL
rs2425668	chr20:44881695:G:T	-	-0.0710100675111426	0.0274962565254704	COAD	Male-baised eQTL
rs2075960	chr20:44919036:T:G	-	-0.0717897779460789	0.0321505009356018	COAD	Male-baised eQTL
rs13043468	chr20:44869046:T:C	-	-0.0684945823638889	0.0323600897617418	COAD	Male-baised eQTL
rs3091409	chr20:44884973:T:G	-	-0.0697956318023571	0.035326482747015	COAD	Male-baised eQTL
rs11699415	chr20:44867511:T:C	-	-0.0666212448067683	0.0353424148489061	COAD	Male-baised eQTL
rs3795121	chr20:46354358:C:T	-	0.123523733431488	0.037695717342946	COAD	Male-baised eQTL
rs11698130	chr20:44921274:G:A	-	-0.0702243452379984	0.0397123226371907	COAD	Male-baised eQTL
rs6103901	chr20:44868544:G:A	-	-0.0650444532100706	0.0401088902027738	COAD	Male-baised eQTL
rs6103923	chr20:44916244:C:T	-	-0.0705358692295275	0.0410209638862985	COAD	Male-baised eQTL
rs6060578	chr20:35717523:C:T	-	-0.0917501811068882	0.0445939151190317	COAD	Male-baised eQTL
rs6102831	chr20:42434198:C:A	-	-0.0619571973540099	0.0453056156041887	COAD	Male-baised eQTL
rs6094048	chr20:44867968:T:C	-	-0.0648275367781424	0.0455333261579663	COAD	Male-baised eQTL
rs6129439	chr20:39901547:T:C	-	-0.0905095168343523	0.0471859212420259	COAD	Male-baised eQTL
rs6513951	chr20:44865133:T:C	-	-0.0642843596220203	0.0471955154592239	COAD	Male-baised eQTL
rs13040998	chr20:44866359:G:A	-	-0.0642843596220203	0.0471955154592239	COAD	Male-baised eQTL
rs6031840	chr20:44869212:A:G	-	-0.0642843596220203	0.0471955154592239	COAD	Male-baised eQTL

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

Top

Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000197122
	CpG Site: cg01141721
	Position to Gene: gene
	Male Effect: -
	Female Effect: -0.384940636411185
	Gene ID: ENSG00000197122
	CpG Site: cg02142074
	Position to Gene: gene,exon,CDS
	Male Effect: -
	Female Effect: -0.384851320645719
	Gene ID: ENSG00000197122
	CpG Site: cg24956391
	Position to Gene: gene
	Male Effect: -0.279419792497444
	Female Effect: -

Male-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg24956391	chr20:37383596	gene	-0.279419792497444	9.75642241258973e-08	-0.3829722060400475	2.9131406130804086e-10	LIHC

Female-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg01141721	chr20:37382216	gene	-0.384940636411185	2.86393264621917e-06	-0.35497932574427304	5.878320529412421e-09	LUAD
cg02142074	chr20:37384193	gene,exon,CDS	-0.384851320645719	2.88328607039288e-06	-0.35484105268199756	5.565682870368238e-09	LUAD

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

Top

Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

Top

Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

Top

Related disease information of SRC

Diseases associated with this gene (DisGeNET).

Gene ID	Gene Symbol	Disease ID	Disease Name	Number of PMID	Source
ENSG00000197122	SRC	C0005684	Malignant neoplasm of urinary bladder	2	CTD_human
ENSG00000197122	SRC	C0005695	Bladder Neoplasm	2	CTD_human
ENSG00000197122	SRC	C0006142	Malignant neoplasm of breast	1	CTD_human
ENSG00000197122	SRC	C0007102	Malignant tumor of colon	1	CTD_human
ENSG00000197122	SRC	C0009319	Colitis	1	CTD_human
ENSG00000197122	SRC	C0009375	Colonic Neoplasms	1	CTD_human
ENSG00000197122	SRC	C0009402	Colorectal Carcinoma	1	CTD_human
ENSG00000197122	SRC	C0009404	Colorectal Neoplasms	1	CTD_human
ENSG00000197122	SRC	C0018800	Cardiomegaly	1	CTD_human
ENSG00000197122	SRC	C0027626	Neoplasm Invasiveness	2	CTD_human
ENSG00000197122	SRC	C0038220	Status Epilepticus	1	CTD_human
ENSG00000197122	SRC	C0085548	Autosomal Recessive Polycystic Kidney Disease	1	CTD_human
ENSG00000197122	SRC	C0270823	Petit mal status	1	CTD_human
ENSG00000197122	SRC	C0311335	Grand Mal Status Epilepticus	1	CTD_human
ENSG00000197122	SRC	C0393734	Complex Partial Status Epilepticus	1	CTD_human
ENSG00000197122	SRC	C0678222	Breast Carcinoma	1	CTD_human
ENSG00000197122	SRC	C0751522	Status Epilepticus, Subclinical	1	CTD_human
ENSG00000197122	SRC	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
ENSG00000197122	SRC	C0751524	Simple Partial Status Epilepticus	1	CTD_human
ENSG00000197122	SRC	C1257931	Mammary Neoplasms, Human	1	CTD_human
ENSG00000197122	SRC	C1383860	Cardiac Hypertrophy	1	CTD_human
ENSG00000197122	SRC	C1458155	Mammary Neoplasms	1	CTD_human
ENSG00000197122	SRC	C4310789	THROMBOCYTOPENIA 6	1	CTD_human
ENSG00000197122	SRC	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene