SexAnnoDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structure and Gene expression level

leaf

Sex-biased somatic mutation

leaf

DNA methylation with beta values in gene

leaf

Exon skipping events with PSI in TCGA

leaf

RNA A-to-I editing events in TCGA

leaf

Sex-biased TF-Gene network of gene

leaf

Sex-biased RBP-ES network of gene

leaf

Sex-biased CeRNA regulation of gene

leaf

Sex-biased eQTL regulation of gene

leaf

Sex-biased eQTM regulation of gene

leaf

Sex-biased sQTL regulation of gene

leaf

Sex-biased sQTM regulation of gene

leaf

Related disease information of gene

Gene: ENSG00000197043

Summary for ANXA6

check button Gene summary

Gene informationEnsembl ID

ENSG00000197043

Gene symbol

ANXA6

Gene nameannexin A6
HGNC

544

Entrez ID

309

Gene typeprotein_coding
SynonymsANXA6|
UniProtAcc

P08133


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

Top

Structure and expression level for ANXA6

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
ANXA64.73e+03-1.07e+002.11e-01-5.06e+004.30e-071.69e-06HNSC
ANXA63.81e+03-1.04e+003.56e-01-2.91e+003.58e-031.70e-02ESCA
ANXA67.80e+03-1.59e+005.01e-01-3.18e+001.47e-034.76e-03CHOL

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

Top

Sex-biased somatic mutation for ANXA6

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

Top

DNA methylation with beta values for ANXA6

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
CHOLcg21623671chr5:151157290CGI:chr5:151157530-151157857promoter,gene body4.72e-013.12e-011.97e+004.84e-024.84e-021.60e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUSCcg03208031chr5:151158317CGI:chr5:151157530-151157857promoter1.88e-017.95e-023.22e+001.30e-033.09e-031.09e-01
LUSCcg00407659chr5:151158853CGI:chr5:151157530-151157857promoter6.36e-017.66e-01-3.22e+001.27e-033.06e-03-1.30e-01
BLCAcg00407659chr5:151158853CGI:chr5:151157530-151157857promoter6.05e-017.71e-01-3.91e+009.10e-053.74e-04-1.66e-01
CHOLcg21623671chr5:151157290CGI:chr5:151157530-151157857promoter,gene body3.12e-015.77e-022.65e+007.96e-031.92e-022.54e-01
CHOLcg03208031chr5:151158317CGI:chr5:151157530-151157857promoter1.75e-016.48e-022.21e+002.70e-023.50e-021.10e-01
CHOLcg19057001chr5:151158604CGI:chr5:151157530-151157857promoter3.80e-015.62e-01-2.21e+002.70e-023.50e-02-1.82e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta

Top

Exon skipping events with PSI in TCGA for ANXA6

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI
BRCAexon_skip_4456334.92e-016.79e-01-1.15e+018.70e-315.13e-29-1.87e-01
READexon_skip_4456335.57e-018.22e-01-3.94e+008.00e-053.54e-03-2.65e-01

Top

RNA A-to-I editing events in TCGA for ANXA6

∗Please access CAeditome for RNA editing annotation.
check buttonLandscape of RNA editing events across multiple cancer types.
ED heatmap

check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre
STADANXA6-004chr5_151111913_-5.60e-013.65e-012.22e+002.64e-024.96e-021.95e-01

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

Top

Sex-biased TF-Gene network for ANXA6

check buttonTFs related to ANXA6.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonANXA6 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

Top

Sex-biased RBP-ES network for ANXA6

check buttonRBPs related to ES in ANXA6.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
RBP ES
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCZCRB1exon_skip_4456351.26e+013.24e-031.32e+019.96e-01Female-biased
UVMPABPN1exon_skip_4456119.02e+001.25e-039.51e+009.96e-01Female-biased
THYMESRP2exon_skip_4456168.38e+002.55e-038.82e+009.92e-01Female-biased
THYMZCRB1exon_skip_4456351.31e+019.96e-011.27e+013.27e-03Male-biased
COADPABPN1exon_skip_4456119.07e+001.08e-029.40e+009.86e-01Female-biased
DLBCZC3H10exon_skip_4456389.49e+009.92e-019.09e+005.40e-03Male-biased
LUADZCRB1exon_skip_4456351.29e+019.97e-011.25e+012.86e-03Male-biased
KIRPPABPN1exon_skip_4456119.16e+001.41e-029.46e+009.83e-01Female-biased
KIRPZC3H10exon_skip_4456389.46e+009.93e-019.04e+003.91e-03Male-biased
KIRPZCRB1exon_skip_4456351.32e+019.99e-011.25e+013.74e-04Male-biased
BRCAZCRB1exon_skip_4456351.27e+019.84e-011.22e+011.53e-02Male-biased
ESCAZC3H10exon_skip_4456388.91e+004.06e-039.47e+009.93e-01Female-biased
READPABPN1exon_skip_4456118.99e+004.04e-039.40e+009.93e-01Female-biased
READZC3H10exon_skip_4456389.18e+005.09e-039.58e+009.92e-01Female-biased
PCPGZC3H10exon_skip_4456389.08e+006.63e-039.43e+009.90e-01Female-biased
MESOZC3H10exon_skip_4456389.44e+009.93e-018.99e+003.91e-03Male-biased
GBMPABPN1exon_skip_4456119.46e+009.82e-019.15e+001.50e-02Male-biased
GBMZCRB1exon_skip_4456351.25e+019.74e-041.31e+019.99e-01Female-biased
PAADZC3H10exon_skip_4456389.10e+004.22e-039.47e+009.93e-01Female-biased
PAADZCRB1exon_skip_4456351.26e+012.35e-031.30e+019.97e-01Female-biased
KIRCPABPN1exon_skip_4456119.03e+006.09e-039.39e+009.91e-01Female-biased
KICHZC3H10exon_skip_4456389.11e+003.34e-039.53e+009.94e-01Female-biased
HNSCPABPN1exon_skip_4456119.08e+001.31e-029.39e+009.84e-01Female-biased
HNSCZC3H10exon_skip_4456389.01e+005.61e-039.39e+009.91e-01Female-biased

check buttonANXA6 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

Top

Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

Top

Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs1422964chr5:144640917:C:T-0.05958298212567540.017064899520503LUADFemale-baised eQTL
rs17702948chr5:144598447:T:C-0.05951321775384350.0178298478325643LUADFemale-baised eQTL
rs1368290chr5:144654314:T:C-0.05822108007445940.0209828437976893LUADFemale-baised eQTL
rs35087376chr5:144600663:T:C-0.05848508520560990.0212542946228515LUADFemale-baised eQTL
rs35216411chr5:144617013:G:C-0.05848508520560990.0212542946228515LUADFemale-baised eQTL
rs6873273chr5:144594406:T:G-0.05423443790914520.021391604173688LUADFemale-baised eQTL
rs150790895chr5:144625365:C:T-0.05778590629064620.0242281267294179LUADFemale-baised eQTL
rs79051645chr5:144626243:C:T-0.05778590629064620.0242281267294179LUADFemale-baised eQTL
rs149836147chr5:144628488:A:G-0.05778590629064620.0242281267294179LUADFemale-baised eQTL
rs13181387chr5:144631414:C:T-0.05778590629064620.0242281267294179LUADFemale-baised eQTL
rs35987098chr5:144631658:G:A-0.05778590629064620.0242281267294179LUADFemale-baised eQTL
rs34130847chr5:144632857:C:T-0.05778590629064620.0242281267294179LUADFemale-baised eQTL
rs17451641chr5:144651025:A:G-0.05616343949434630.0297650629693816LUADFemale-baised eQTL
rs17451662chr5:144651191:C:A-0.05616343949434630.0297650629693816LUADFemale-baised eQTL
rs72804441chr5:144652292:A:G-0.05616343949434630.0297650629693816LUADFemale-baised eQTL
rs2217634chr5:144653053:G:T-0.05616343949434630.0297650629693816LUADFemale-baised eQTL
rs35833913chr5:144645916:T:C-0.05528888139933880.0342214458918273LUADFemale-baised eQTL
rs72804427chr5:144642489:C:T-0.05736873283236460.0348370734220102LUADFemale-baised eQTL
rs35319417chr5:144647127:T:A-0.05516450980768630.0353292420474325LUADFemale-baised eQTL
rs28565988chr5:154507894:C:T-0.06033464190363310.0357278434394258LUADFemale-baised eQTL
rs66755232chr5:144607332:T:G-0.05722776897818170.0360847009208053LUADFemale-baised eQTL
rs34435175chr5:144609791:T:C-0.05722776897818170.0360847009208053LUADFemale-baised eQTL
rs35575909chr5:144586575:G:T-0.05493749380935970.0362774250218836LUADFemale-baised eQTL
rs1432671chr5:144587705:G:C-0.05493749380935970.0362774250218836LUADFemale-baised eQTL
rs13176800chr5:144588301:G:A-0.05493749380935970.0362774250218836LUADFemale-baised eQTL
rs3861859chr5:144599470:C:T-0.05695999808424230.0381622939033621LUADFemale-baised eQTL
rs17450961chr5:144584606:G:C-0.05495454911170340.0385548178094225LUADFemale-baised eQTL
rs17385203chr5:144584129:G:A-0.05476039838628870.0393076298682202LUADFemale-baised eQTL
rs13161148chr5:144586868:G:C-0.05435123117669260.0406768973712409LUADFemale-baised eQTL
rs2081032chr5:144614427:C:T-0.05497047039976140.0418476383709591LUADFemale-baised eQTL
rs144854522chr5:144588777:G:A-0.05417345212025230.0419841358139731LUADFemale-baised eQTL
rs7737144chr5:144656427:G:A-0.0585923506287250.0420523360001739LUADFemale-baised eQTL
rs11957385chr5:144535702:G:A-0.05008353500324510.0431547717369171LUADFemale-baised eQTL
rs1549234chr5:144639961:G:T-0.055951662844390.043758911705462LUADFemale-baised eQTL
rs13181693chr5:144586750:A:G-0.05230284866905010.0477287913345794LUADFemale-baised eQTL
rs929751chr5:144621504:C:T-0.0554379142461420.0481084788594148LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs12173156chr5:158295049:C:T--0.08832939550059540.0233059052836805THCAMale-baised eQTL
rs3792837chr5:147394119:G:A-0.06890724397152360.0325092971999436LIHCMale-baised eQTL
rs17106606chr5:147383526:C:G-0.06744792817601370.0479476612469193LIHCMale-baised eQTL
rs17595504chr5:155254380:A:G-0.1365145232877720.000413023522725764LGGMale-baised eQTL
rs17654424chr5:155255063:G:A-0.1365145232877720.000413023522725764LGGMale-baised eQTL
rs12518515chr5:155249181:G:T-0.1227438955884460.00291372086039513LGGMale-baised eQTL
rs112403687chr5:155250053:G:T-0.1227438955884460.00291372086039513LGGMale-baised eQTL
rs112451302chr5:155236816:G:A-0.1140406201762090.00513463467746186LGGMale-baised eQTL
rs56947465chr5:155239584:G:A-0.1147302678235970.00681407767755789LGGMale-baised eQTL
rs113027398chr5:155244633:G:C-0.1145908901463210.00699476416252596LGGMale-baised eQTL
rs73291994chr5:155228596:C:T-0.1096461930711080.0124785241688688LGGMale-baised eQTL
rs17653878chr5:155229520:G:A-0.1096461930711080.0124785241688688LGGMale-baised eQTL
rs76253066chr5:155229248:C:T-0.1084563338500110.0151783998520223LGGMale-baised eQTL
rs58858647chr5:155234055:G:C-0.1084563338500110.0151783998520223LGGMale-baised eQTL
rs58883939chr5:155234102:A:C-0.1084563338500110.0151783998520223LGGMale-baised eQTL
rs17575789chr5:155228079:A:C-0.09764433498626910.0293443660085851LGGMale-baised eQTL
rs78883938chr5:145104775:G:A-0.1048827522718710.0111786596255378BLCAMale-baised eQTL
rs1981626chr5:145148892:T:C--0.08232611228240750.0208362784286771BLCAMale-baised eQTL
rs1347145chr5:151279716:A:T-0.06978968183391880.00871605027717203COADMale-baised eQTL
rs10071465chr5:151091816:G:A-0.0587572425337690.0154272999416624COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

Top

Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000197043
CpG Site: cg15892650
Position to Gene: gene
Male Effect: -0.423448365110143
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000197043
CpG Site: cg14870539
Position to Gene: gene,exon,UTR
Male Effect: -0.33240875710543
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000197043
CpG Site: cg18643093
Position to Gene: gene
Male Effect: -0.402795578257348
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg15892650chr5:151145074gene-0.4234483651101431.7420850884741e-09-0.429172117612527559.252298806523695e-13LIHC
cg14870539chr5:151151191gene,exon,UTR-0.332408757105433.08093041342426e-10-0.398063486670692632.058994439580406e-12LGG
cg18643093chr5:151141696gene-0.4027955782573482.49894526223456e-07-0.332698386345668736.737358054939743e-09LGG

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

Top

Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_445633chr5:151110626:151110644In-framers11750722chr5:151508364:A:GDistant upstream0.07146374910518350.00912988649232164COADFemale-baised sQTL

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type
exon_skip_445633chr5:151110626:151110644In-framers6896664chr5:151885713:A:GDistant upstream-0.03347431153103190.0102841921107147LUSCMale-baised sQTL
exon_skip_445633chr5:151110626:151110644In-framers6892117chr5:151885424:A:GDistant upstream-0.03247158644340030.0188968078919609LUSCMale-baised sQTL
exon_skip_445633chr5:151110626:151110644In-framers3763011chr5:151025142:G:ADistant downstream0.03414996626932050.0486604038495686LUSCMale-baised sQTL

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

Top

Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

Top

Related disease information of ANXA6

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000197043ANXA6C0019193Hepatitis, Toxic1CTD_human
ENSG00000197043ANXA6C0023467Leukemia, Myelocytic, Acute1CTD_human
ENSG00000197043ANXA6C0026998Acute Myeloid Leukemia, M11CTD_human
ENSG00000197043ANXA6C0860207Drug-Induced Liver Disease1CTD_human
ENSG00000197043ANXA6C1262760Hepatitis, Drug-Induced1CTD_human
ENSG00000197043ANXA6C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
ENSG00000197043ANXA6C3658290Drug-Induced Acute Liver Injury1CTD_human
ENSG00000197043ANXA6C4277682Chemical and Drug Induced Liver Injury1CTD_human
ENSG00000197043ANXA6C4279912Chemically-Induced Liver Toxicity1CTD_human