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Gene: ENSG00000196141 |
Summary for SPATS2L |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000196141 | Gene symbol | SPATS2L |
| Gene name | spermatogenesis associated serine rich 2 like | |
| HGNC | 24574 | |
| Entrez ID | 26010 | |
| Gene type | protein_coding | |
| Synonyms | SPATS2L|DNAPTP6|SGNP | |
| UniProtAcc | Q9NUQ6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SPATS2L |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for SPATS2L |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SPATS2L |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg06905367 | chr2:200305661 | CGI:chr2:200306477-200307769 | promoter | 7.72e-01 | 6.03e-01 | 2.48e+00 | 1.30e-02 | 2.54e-02 | 1.69e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg25099087 | chr2:200307758 | CGI:chr2:200306477-200307769 | promoter,gene body | 1.94e-01 | 7.68e-02 | 5.86e+00 | 4.75e-09 | 1.09e-08 | 1.17e-01 |
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Exon skipping events with PSI in TCGA for SPATS2L |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SPATS2L |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SPATS2L |
| TFs related to SPATS2L. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MESO | FOXD2 | SPATS2L | 2.37e+00 | 1.41e-03 | 4.19e+00 | 9.88e-01 | Female-biased |
| MESO | FOXF1 | SPATS2L | 2.64e+00 | 3.49e-03 | 4.21e+00 | 9.86e-01 | Female-biased |
| MESO | FOXI1 | SPATS2L | 3.01e+00 | 8.51e-03 | 4.32e+00 | 9.82e-01 | Female-biased |
| MESO | FOXL1 | SPATS2L | 2.01e+00 | 1.04e-03 | 3.91e+00 | 9.83e-01 | Female-biased |
| MESO | FOXQ1 | SPATS2L | 2.49e+00 | 3.02e-03 | 4.11e+00 | 9.84e-01 | Female-biased |
| MESO | HESX1 | SPATS2L | 3.19e+00 | 7.19e-03 | 4.56e+00 | 9.86e-01 | Female-biased |
| MESO | HNF1B | SPATS2L | 3.22e+00 | 9.97e-03 | 4.49e+00 | 9.83e-01 | Female-biased |
| MESO | LHX9 | SPATS2L | 3.24e+00 | 6.39e-03 | 4.65e+00 | 9.88e-01 | Female-biased |
| MESO | NANOG | SPATS2L | 2.81e+00 | 4.67e-03 | 4.30e+00 | 9.86e-01 | Female-biased |
| MESO | POU2F2 | SPATS2L | 2.76e+00 | 6.81e-03 | 4.14e+00 | 9.81e-01 | Female-biased |
| MESO | POU3F3 | SPATS2L | 2.47e+00 | 1.43e-03 | 4.29e+00 | 9.89e-01 | Female-biased |
| MESO | POU5F1 | SPATS2L | 2.98e+00 | 8.32e-03 | 4.30e+00 | 9.82e-01 | Female-biased |
| MESO | POU6F2 | SPATS2L | 3.13e+00 | 5.09e-03 | 4.62e+00 | 9.89e-01 | Female-biased |
| MESO | PRRX1 | SPATS2L | 3.29e+00 | 9.74e-03 | 4.57e+00 | 9.84e-01 | Female-biased |
| MESO | SOX10 | SPATS2L | 2.92e+00 | 6.27e-03 | 4.33e+00 | 9.84e-01 | Female-biased |
| MESO | SOX14 | SPATS2L | 3.15e+00 | 9.09e-03 | 4.45e+00 | 9.83e-01 | Female-biased |
| MESO | SOX17 | SPATS2L | 3.00e+00 | 8.44e-03 | 4.32e+00 | 9.82e-01 | Female-biased |
| MESO | SOX18 | SPATS2L | 3.08e+00 | 9.88e-03 | 4.35e+00 | 9.81e-01 | Female-biased |
| MESO | SOX6 | SPATS2L | 3.08e+00 | 8.23e-03 | 4.41e+00 | 9.83e-01 | Female-biased |
| MESO | ZKSCAN2 | SPATS2L | 2.40e+00 | 2.56e-03 | 4.07e+00 | 9.84e-01 | Female-biased |
| MESO | ZNF25 | SPATS2L | 1.98e+00 | 7.79e-04 | 3.95e+00 | 9.84e-01 | Female-biased |
| MESO | ZNF334 | SPATS2L | 1.84e+00 | 1.70e-04 | 4.19e+00 | 9.89e-01 | Female-biased |
| MESO | ZNF33B | SPATS2L | 2.46e+00 | 3.35e-03 | 4.05e+00 | 9.83e-01 | Female-biased |
| MESO | ZNF354B | SPATS2L | 2.70e+00 | 6.36e-03 | 4.10e+00 | 9.80e-01 | Female-biased |
| MESO | ZNF418 | SPATS2L | 1.25e+00 | 2.81e-05 | 4.06e+00 | 9.87e-01 | Female-biased |
| READ | ZNF418 | SPATS2L | 2.89e+00 | 2.16e-03 | 4.11e+00 | 9.84e-01 | Female-biased |
| SARC | FOXD2 | SPATS2L | 4.17e+00 | 9.82e-01 | 3.51e+00 | 5.37e-03 | Male-biased |
| SARC | FOXF1 | SPATS2L | 4.19e+00 | 9.81e-01 | 3.58e+00 | 7.21e-03 | Male-biased |
| SARC | FOXQ1 | SPATS2L | 4.07e+00 | 9.81e-01 | 3.39e+00 | 4.50e-03 | Male-biased |
| SARC | HESX1 | SPATS2L | 4.56e+00 | 9.82e-01 | 4.03e+00 | 1.16e-02 | Male-biased |
| SARC | HNF1B | SPATS2L | 4.54e+00 | 9.82e-01 | 4.01e+00 | 1.16e-02 | Male-biased |
| SARC | LHX9 | SPATS2L | 4.61e+00 | 9.81e-01 | 4.08e+00 | 1.28e-02 | Male-biased |
| SARC | MIXL1 | SPATS2L | 5.02e+00 | 9.83e-01 | 4.50e+00 | 1.34e-02 | Male-biased |
| SARC | POU3F3 | SPATS2L | 4.32e+00 | 9.88e-01 | 3.53e+00 | 2.53e-03 | Male-biased |
| SARC | POU5F1 | SPATS2L | 4.35e+00 | 9.82e-01 | 3.77e+00 | 8.87e-03 | Male-biased |
| SARC | POU6F2 | SPATS2L | 4.63e+00 | 9.87e-01 | 4.01e+00 | 7.15e-03 | Male-biased |
| SARC | PRRX1 | SPATS2L | 4.65e+00 | 9.83e-01 | 4.11e+00 | 1.13e-02 | Male-biased |
| SARC | SOX18 | SPATS2L | 4.48e+00 | 9.82e-01 | 3.92e+00 | 1.03e-02 | Male-biased |
| SARC | ZNF25 | SPATS2L | 3.93e+00 | 9.80e-01 | 3.06e+00 | 1.55e-03 | Male-biased |
| SARC | ZNF334 | SPATS2L | 4.11e+00 | 9.86e-01 | 3.07e+00 | 6.13e-04 | Male-biased |
| SPATS2L related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SPATS2L |
| RBPs related to ES in SPATS2L. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | SAMD4A | exon_skip_332252 | 8.40e+00 | 7.22e-03 | 8.78e+00 | 9.88e-01 | Female-biased |
| ACC | KHDRBS3 | exon_skip_332230 | 1.13e+01 | 9.88e-01 | 1.09e+01 | 1.08e-02 | Male-biased |
| ACC | SAMD4A | exon_skip_332252 | 9.02e+00 | 9.93e-01 | 8.40e+00 | 2.59e-03 | Male-biased |
| LUSC | ESRP2 | exon_skip_332255 | 6.99e+00 | 9.81e-01 | 6.55e+00 | 5.41e-03 | Male-biased |
| LUSC | SAMD4A | exon_skip_332252 | 7.97e+00 | 3.05e-03 | 8.45e+00 | 9.90e-01 | Female-biased |
| COAD | SAMD4A | exon_skip_332252 | 8.14e+00 | 1.45e-03 | 8.67e+00 | 9.93e-01 | Female-biased |
| COAD | STAR-PAP | exon_skip_332240 | 1.29e+01 | 9.98e-01 | 1.24e+01 | 1.55e-03 | Male-biased |
| CHOL | STAR-PAP | exon_skip_332240 | 1.27e+01 | 9.97e-01 | 1.21e+01 | 2.62e-03 | Male-biased |
| KIRP | SAMD4A | exon_skip_332252 | 8.24e+00 | 7.13e-03 | 8.60e+00 | 9.87e-01 | Female-biased |
| BRCA | MSI1 | exon_skip_332243 | 1.54e+01 | 9.87e-01 | 1.48e+01 | 1.30e-02 | Male-biased |
| ESCA | SAMD4A | exon_skip_332252 | 8.46e+00 | 9.84e-01 | 8.01e+00 | 9.17e-03 | Male-biased |
| ESCA | STAR-PAP | exon_skip_332240 | 1.21e+01 | 5.41e-03 | 1.26e+01 | 9.94e-01 | Female-biased |
| READ | MSI1 | exon_skip_332243 | 1.58e+01 | 1.00e+00 | 1.51e+01 | 2.51e-04 | Male-biased |
| READ | STAR-PAP | exon_skip_332240 | 1.26e+01 | 9.95e-01 | 1.22e+01 | 4.31e-03 | Male-biased |
| THCA | MSI1 | exon_skip_332243 | 1.51e+01 | 1.00e+00 | 1.44e+01 | 5.45e-05 | Male-biased |
| MESO | KHDRBS3 | exon_skip_332230 | 1.09e+01 | 2.24e-03 | 1.14e+01 | 9.97e-01 | Female-biased |
| MESO | STAR-PAP | exon_skip_332240 | 1.22e+01 | 1.48e-03 | 1.28e+01 | 9.98e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_332252 | 8.55e+00 | 9.81e-01 | 8.24e+00 | 1.30e-02 | Male-biased |
| GBM | STAR-PAP | exon_skip_332240 | 1.22e+01 | 3.63e-03 | 1.26e+01 | 9.96e-01 | Female-biased |
| PAAD | SAMD4A | exon_skip_332252 | 8.11e+00 | 1.30e-04 | 8.79e+00 | 9.95e-01 | Female-biased |
| PAAD | STAR-PAP | exon_skip_332240 | 1.32e+01 | 9.99e-01 | 1.26e+01 | 3.52e-04 | Male-biased |
| KICH | KHDRBS3 | exon_skip_332230 | 1.12e+01 | 9.95e-01 | 1.08e+01 | 4.17e-03 | Male-biased |
| KICH | SAMD4A | exon_skip_332252 | 8.16e+00 | 4.26e-03 | 8.55e+00 | 9.89e-01 | Female-biased |
| BLCA | KHDRBS3 | exon_skip_332230 | 1.11e+01 | 7.83e-03 | 1.14e+01 | 9.91e-01 | Female-biased |
| SKCM | MSI1 | exon_skip_332243 | 1.50e+01 | 2.49e-03 | 1.55e+01 | 9.97e-01 | Female-biased |
| HNSC | SRSF2 | exon_skip_332197 | 9.05e+00 | 9.83e-01 | 8.73e+00 | 1.34e-02 | Male-biased |
| HNSC | STAR-PAP | exon_skip_332240 | 1.24e+01 | 8.20e-03 | 1.28e+01 | 9.91e-01 | Female-biased |
| SARC | KHDRBS1 | exon_skip_332240 | 6.42e+00 | 3.19e-03 | 6.91e+00 | 9.82e-01 | Female-biased |
| SARC | STAR-PAP | exon_skip_332240 | 1.22e+01 | 2.78e-03 | 1.27e+01 | 9.97e-01 | Female-biased |
| SPATS2L related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs13022612 | chr2:194372393:G:A | - | 0.166434197684436 | 0.0205104420678642 | HNSC | Female-baised eQTL |
| rs12622555 | chr2:194372582:C:T | - | 0.151641770214819 | 0.040421011109058 | HNSC | Female-baised eQTL |
| rs140650062 | chr2:205969499:G:C | - | 0.13957019906723 | 0.0180547241595569 | BLCA | Female-baised eQTL |
| rs112490174 | chr2:205973611:G:A | - | 0.147085576117656 | 0.0239923475467881 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs6756895 | chr2:196950458:C:T | - | 0.056894583417737 | 0.0383867993433818 | COAD | Male-baised eQTL |
| rs6434891 | chr2:196950758:T:A | - | 0.056894583417737 | 0.0383867993433818 | COAD | Male-baised eQTL |
| rs1025694 | chr2:196950345:G:C | - | 0.0561122830748867 | 0.0429314485721043 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_332241 | chr2:200439121:200439328 | In-frame | rs2348128 | chr2:200769438:A:G | Distant downstream | -0.0786162861247525 | 0.0043650508377351 | PAAD | Male-baised sQTL |
| exon_skip_332241 | chr2:200439121:200439328 | In-frame | rs7575806 | chr2:200767789:G:C | Distant downstream | -0.0705486286392921 | 0.0363939594634193 | PAAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SPATS2L |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000196141 | SPATS2L | C0004238 | Atrial Fibrillation | 2 | CTD_human |
| ENSG00000196141 | SPATS2L | C0235480 | Paroxysmal atrial fibrillation | 2 | CTD_human |
| ENSG00000196141 | SPATS2L | C2585653 | Persistent atrial fibrillation | 2 | CTD_human |
| ENSG00000196141 | SPATS2L | C3468561 | familial atrial fibrillation | 2 | CTD_human |
