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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000196074

Summary for SYCP2

check button Gene summary

Gene informationEnsembl ID

ENSG00000196074

Gene symbol

SYCP2

Gene namesynaptonemal complex protein 2
HGNC

11490

Entrez ID

10388

Gene typeprotein_coding
SynonymsSYCP2|SCP2
UniProtAcc

Q9BX26


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for SYCP2

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SYCP24.58e+021.26e+002.26e-015.57e+002.51e-082.19e-06HNSC

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SYCP25.04e+023.40e+004.22e-018.06e+007.49e-169.56e-15HNSC
SYCP23.53e+022.41e+005.45e-014.42e+009.90e-065.84e-05BLCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
SYCP22.35e+031.41e+001.35e-011.05e+019.93e-264.26e-25BRCA

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Sex-biased somatic mutation for SYCP2

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for SYCP2

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg07347645chr20:59932116CGI:chr20:59932700-59934462UTR,promoter,exon,gene body6.55e-014.55e-012.30e+002.12e-023.58e-022.01e-01
BRCAcg22214414chr20:59932177CGI:chr20:59932700-59934462promoter,gene body6.88e-014.62e-012.54e+001.12e-022.79e-022.26e-01
BRCAcg12181372chr20:59933068CGI:chr20:59932700-59934462promoter,gene body7.19e-014.62e-012.17e+002.99e-024.09e-022.56e-01
LIHCcg26690949chr20:59933888CGI:chr20:59932700-59934462promoter3.16e-014.20e-01-2.88e+004.02e-039.64e-03-1.04e-01
GBMcg26690949chr20:59933888CGI:chr20:59932700-59934462promoter2.26e-021.28e-01-2.26e+002.36e-023.81e-02-1.05e-01
ESCAcg20800536chr20:59933833CGI:chr20:59932700-59934462promoter2.63e-011.61e-012.50e+001.23e-023.01e-021.03e-01
ESCAcg02801359chr20:59933867CGI:chr20:59932700-59934462promoter3.29e-012.05e-012.32e+002.01e-023.79e-021.24e-01
ESCAcg26690949chr20:59933888CGI:chr20:59932700-59934462promoter3.02e-011.70e-012.40e+001.65e-023.50e-021.32e-01
ESCAcg25183989chr20:59933531CGI:chr20:59932700-59934462promoter,gene body5.78e-014.58e-013.06e+002.22e-038.93e-031.20e-01
ESCAcg00125414chr20:59934187CGI:chr20:59932700-59934462promoter3.06e-011.76e-012.84e+004.47e-031.55e-021.30e-01
ESCAcg14536096chr20:59934243CGI:chr20:59932700-59934462promoter3.03e-011.81e-012.12e+003.41e-024.54e-021.22e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
HNSCcg07347645chr20:59932116CGI:chr20:59932700-59934462UTR,promoter,exon,gene body8.37e-019.48e-01-3.33e+008.58e-041.59e-03-1.11e-01
HNSCcg23241473chr20:59932172CGI:chr20:59932700-59934462promoter,gene body7.60e-019.07e-01-3.87e+001.07e-042.75e-04-1.47e-01
LUSCcg26690949chr20:59933888CGI:chr20:59932700-59934462promoter1.22e-011.67e-022.86e+004.19e-037.14e-031.05e-01
LUSCcg06710769chr20:59934504CGI:chr20:59932700-59934462promoter2.33e-018.49e-022.25e+002.44e-022.79e-021.48e-01
LUSCcg23241473chr20:59932172CGI:chr20:59932700-59934462promoter,gene body8.36e-019.42e-01-4.05e+005.21e-055.63e-04-1.06e-01
COADcg20800536chr20:59933833CGI:chr20:59932700-59934462promoter2.80e-011.09e-012.59e+009.47e-031.38e-021.72e-01
COADcg00125414chr20:59934187CGI:chr20:59932700-59934462promoter2.40e-016.50e-023.08e+002.04e-034.01e-031.75e-01
LIHCcg20800536chr20:59933833CGI:chr20:59932700-59934462promoter2.60e-011.19e-012.45e+001.41e-021.65e-021.42e-01
LIHCcg06710769chr20:59934504CGI:chr20:59932700-59934462promoter3.85e-012.08e-012.84e+004.56e-036.08e-031.77e-01
LIHCcg14536096chr20:59934243CGI:chr20:59932700-59934462promoter3.41e-011.74e-012.90e+003.68e-035.03e-031.67e-01
CHOLcg12181372chr20:59933068CGI:chr20:59932700-59934462promoter,gene body8.88e-016.88e-012.88e+004.04e-031.47e-022.00e-01
CHOLcg25183989chr20:59933531CGI:chr20:59932700-59934462promoter,gene body5.95e-014.73e-012.06e+003.90e-024.26e-021.22e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg21950459chr20:59933021CGI:chr20:59932700-59934462promoter,gene body7.60e-019.70e-01-5.44e+005.31e-081.11e-07-2.10e-01
BRCAcg07347645chr20:59932116CGI:chr20:59932700-59934462UTR,promoter,exon,gene body6.55e-019.32e-01-1.13e+011.54e-292.12e-28-2.76e-01
BRCAcg23241473chr20:59932172CGI:chr20:59932700-59934462promoter,gene body6.25e-019.06e-01-1.02e+012.37e-241.89e-23-2.81e-01
BRCAcg22214414chr20:59932177CGI:chr20:59932700-59934462promoter,gene body6.88e-019.22e-01-9.44e+003.68e-212.20e-20-2.35e-01
BRCAcg12181372chr20:59933068CGI:chr20:59932700-59934462promoter,gene body7.19e-018.67e-01-2.59e+009.47e-031.07e-02-1.48e-01
LIHCcg25183989chr20:59933531CGI:chr20:59932700-59934462promoter,gene body5.83e-014.54e-013.73e+001.89e-046.25e-041.29e-01

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Exon skipping events with PSI in TCGA for SYCP2

∗Please access ExonSkipDB for exon skipping annotation.
check buttonLandscape of exon skipping events across multiple cancer types.
AS event heatmap

check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for SYCP2

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for SYCP2

check buttonTFs related to SYCP2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCZNF141SYCP23.98e+009.82e-013.06e+005.89e-03Male-biased
ACCZNF28SYCP24.00e+009.85e-012.92e+003.02e-03Male-biased
PAADALX1SYCP24.28e+009.90e-012.72e+002.13e-04Male-biased
PAADBARX2SYCP24.33e+009.91e-012.77e+002.20e-04Male-biased
PAADCDC5LSYCP24.62e+009.93e-013.36e+001.11e-03Male-biased
PAADFOXF1SYCP23.89e+009.83e-012.42e+003.30e-04Male-biased
PAADFOXQ1SYCP23.94e+009.84e-012.53e+004.78e-04Male-biased
PAADGATA3SYCP24.39e+009.89e-013.31e+002.87e-03Male-biased
PAADHMX1SYCP24.19e+009.89e-012.81e+005.54e-04Male-biased
PAADHOXA9SYCP24.23e+009.89e-012.93e+008.79e-04Male-biased
PAADIRX3SYCP24.54e+009.91e-013.46e+002.88e-03Male-biased
PAADIRX5SYCP25.16e+009.90e-014.27e+007.84e-03Male-biased
PAADISXSYCP24.40e+009.92e-012.96e+004.10e-04Male-biased
PAADLHX3SYCP23.91e+009.82e-012.62e+008.80e-04Male-biased
PAADMEOX2SYCP24.01e+009.86e-012.39e+001.43e-04Male-biased
PAADMYNNSYCP24.01e+009.85e-012.49e+002.53e-04Male-biased
PAADNEUROD1SYCP24.35e+009.90e-013.15e+001.51e-03Male-biased
PAADONECUT3SYCP24.06e+009.86e-012.73e+007.25e-04Male-biased
PAADPAX3SYCP25.93e+009.91e-015.06e+008.34e-03Male-biased
PAADPHOX2BSYCP24.24e+009.90e-012.76e+003.22e-04Male-biased
PAADPOU1F1SYCP24.18e+009.86e-013.09e+002.63e-03Male-biased
PAADPOU4F1SYCP24.00e+009.85e-012.55e+003.85e-04Male-biased
PAADPOU4F2SYCP23.98e+009.85e-012.31e+001.06e-04Male-biased
PAADPOU4F3SYCP24.07e+009.86e-012.66e+004.84e-04Male-biased
PAADPRRX1SYCP24.40e+009.91e-013.08e+007.96e-04Male-biased
PAADSOX10SYCP24.08e+009.87e-012.59e+003.07e-04Male-biased
PAADSOX8SYCP24.00e+009.85e-012.56e+004.12e-04Male-biased
PAADSOX9SYCP23.96e+009.84e-012.39e+001.90e-04Male-biased
PAADTSYCP24.01e+009.80e-013.06e+005.31e-03Male-biased
PAADTWIST1SYCP23.91e+009.83e-012.34e+001.95e-04Male-biased
PAADZKSCAN2SYCP23.94e+009.84e-012.37e+001.87e-04Male-biased
PAADZNF175SYCP23.86e+009.82e-012.40e+003.59e-04Male-biased
PAADZNF232SYCP24.27e+009.86e-013.27e+004.21e-03Male-biased
PAADZNF250SYCP24.02e+009.86e-012.61e+004.59e-04Male-biased
PAADZNF334SYCP23.93e+009.84e-011.91e+001.41e-05Male-biased
PAADZNF337SYCP24.25e+009.87e-013.16e+002.54e-03Male-biased
PAADZNF45SYCP23.91e+009.82e-012.68e+001.21e-03Male-biased
PAADZNF525SYCP24.44e+009.92e-013.16e+001.01e-03Male-biased
PAADZNF580SYCP24.27e+009.90e-012.52e+007.31e-05Male-biased
PAADZNF716SYCP23.83e+009.81e-012.29e+002.25e-04Male-biased
PAADZNF79SYCP23.82e+009.81e-011.90e+002.59e-05Male-biased
PAADZNF8SYCP24.11e+009.85e-013.04e+002.89e-03Male-biased
PAADZSCAN23SYCP24.21e+009.85e-013.22e+004.49e-03Male-biased
SKCMZNF418SYCP24.52e+008.91e-035.55e+009.88e-01Female-biased

check buttonSYCP2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for SYCP2

check buttonRBPs related to ES in SYCP2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonSYCP2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs404727chr20:56890378:A:G--0.06511849290181970.00636864703630953LUADFemale-baised eQTL
rs1321864chr20:56794071:C:T-0.06638606722548280.0077600984546988LUADFemale-baised eQTL
rs6096235chr20:51033173:C:T-0.06264054439392040.0247315505431122LUADFemale-baised eQTL
rs6013211chr20:51549470:A:T-0.04636438133650950.0272241520227769LUADFemale-baised eQTL
rs7270377chr20:56886844:G:A-0.0511386243586950.0420771272252855LUADFemale-baised eQTL
rs6096186chr20:50917412:T:C-0.08197873522452140.0431671795613918LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs11905447chr20:53036314:C:T-0.08921929005254870.00791367695103126LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000196074
CpG Site: cg23241473
Position to Gene: gene,promoter
Male Effect: -0.305106624563457
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000196074
CpG Site: cg07347645
Position to Gene: gene,exon,promoter,UTR
Male Effect: -0.30489030254373
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000196074
CpG Site: cg22214414
Position to Gene: gene,promoter
Male Effect: -0.30489030254373
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000196074
CpG Site: cg12181372
Position to Gene: gene,promoter
Male Effect: -
Female Effect: -0.486632887903856
eQTM boxplot analysisGene ID: ENSG00000196074
CpG Site: cg22214414
Position to Gene: gene,promoter
Male Effect: -0.306770686099121
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000196074
CpG Site: cg25183989
Position to Gene: gene,promoter
Male Effect: -0.116691590438242
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg23241473chr20:59932172gene,promoter-0.3051066245634577.85293409076334e-05-0.33479449030337093.2498496689244313e-07LUAD
cg07347645chr20:59932116gene,exon,promoter,UTR-0.304890302543737.98635901322736e-05-0.3340855761144393.2479109200545916e-07LUAD
cg22214414chr20:59932177gene,promoter-0.304890302543737.98635901322736e-05-0.3340855761144393.2479109200545916e-07LUAD
cg22214414chr20:59932177gene,promoter-0.3067706860991218.71763211220533e-56-0.79247263651912683.905387346493121e-60LUSC
cg25183989chr20:59933531gene,promoter-0.1166915904382429.38003625062123e-17-0.52361735134071547.826116246098354e-21LUSC

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg12181372chr20:59933068gene,promoter-0.4866328879038563.65609501363785e-11-0.4406305423348071.5483528474106814e-13LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of SYCP2

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource