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Gene: ENSG00000187608 |
Summary for ISG15 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000187608 | Gene symbol | ISG15 |
| Gene name | ISG15 ubiquitin like modifier | |
| HGNC | 4053 | |
| Entrez ID | 9636 | |
| Gene type | protein_coding | |
| Synonyms | ISG15|IFI15|UCRP | |
| UniProtAcc | P05161 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ISG15 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ISG15 | 1.17e+03 | 1.06e+00 | 2.43e-01 | 4.35e+00 | 1.34e-05 | 3.96e-05 | KIRP |
| ISG15 | 6.07e+03 | 3.09e+00 | 4.72e-01 | 6.53e+00 | 6.48e-11 | 7.53e-09 | ESCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ISG15 | 5.04e+03 | 1.47e+00 | 4.14e-01 | 3.56e+00 | 3.67e-04 | 2.54e-03 | STAD |
| ISG15 | 7.08e+03 | 3.52e+00 | 1.70e-01 | 2.07e+01 | 1.85e-95 | 6.47e-94 | BRCA |
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Sex-biased somatic mutation for ISG15 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ISG15 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for ISG15 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for ISG15 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ISG15 |
| TFs related to ISG15. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ISG15 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ISG15 |
| RBPs related to ES in ISG15. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ISG15 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs76474919 | chr1:6776738:C:T | - | 0.0545876715601701 | 0.0470899806102484 | LGG | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4313364 | chr1:4035035:C:T | - | 0.19204165754434 | 0.0366573627866816 | PAAD | Male-baised eQTL |
| rs10864294 | chr1:7333260:C:T | - | 0.0540310433537701 | 0.00326372803586525 | LIHC | Male-baised eQTL |
| rs11121524 | chr1:10172476:C:G | - | 0.0439935828271842 | 0.0358495219154618 | LIHC | Male-baised eQTL |
| rs55958200 | chr1:2808685:C:T | - | 0.0651235699605693 | 0.0400916963664687 | LIHC | Male-baised eQTL |
| rs80245464 | chr1:5101257:T:C | - | 0.112955368412034 | 1.70353079356013e-05 | LGG | Male-baised eQTL |
| rs74953321 | chr1:5095503:T:A | - | 0.11005682972879 | 2.84999804132605e-05 | LGG | Male-baised eQTL |
| rs75180336 | chr1:5089993:T:C | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs75651808 | chr1:5090946:T:C | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs112465603 | chr1:5091154:A:C | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs111458522 | chr1:5091710:G:T | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs6668597 | chr1:5093363:C:G | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs112203030 | chr1:5094043:A:T | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs13374259 | chr1:5094527:T:G | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs13374190 | chr1:5094822:A:G | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs13374274 | chr1:5094914:T:A | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs2169087 | chr1:5095249:G:A | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs2334262 | chr1:5096960:C:A | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs115481549 | chr1:5097606:G:A | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs77029010 | chr1:5098314:G:A | - | 0.109895941126894 | 3.05518452187834e-05 | LGG | Male-baised eQTL |
| rs13374176 | chr1:5094505:A:G | - | 0.107272227617858 | 4.94112367143262e-05 | LGG | Male-baised eQTL |
| rs115070454 | chr1:5088783:T:C | - | 0.107150010947555 | 4.95956047708719e-05 | LGG | Male-baised eQTL |
| rs74622687 | chr1:5087199:C:G | - | 0.0969601374476142 | 0.000276815615762736 | LGG | Male-baised eQTL |
| rs112536368 | chr1:5086278:C:T | - | 0.0968866701828018 | 0.000284550412155328 | LGG | Male-baised eQTL |
| rs10799171 | chr1:4055516:T:C | - | -0.0461195218120453 | 0.0136745083865406 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000187608 |
| CpG Site: cg20062691 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.462301726387199 | |
| Female Effect: - | |
 | Gene ID: ENSG00000187608 |
| CpG Site: cg03811829 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.462301726387199 | |
| Female Effect: - | |
 | Gene ID: ENSG00000187608 |
| CpG Site: cg25350899 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.44214399747186 | |
| Female Effect: - | |
 | Gene ID: ENSG00000187608 |
| CpG Site: cg16526047 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: -0.289494765731988 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20062691 | chr1:1014012 | gene,exon,CDS | -0.462301726387199 | 2.42094658152113e-28 | -0.7073695098685332 | 8.233340464362258e-32 | KIRP |
| cg03811829 | chr1:1014069 | gene,exon,CDS | -0.462301726387199 | 2.42094658152113e-28 | -0.7073695098685332 | 8.233340464362258e-32 | KIRP |
| cg25350899 | chr1:1006002 | gene,enhancer | -0.44214399747186 | 2.50517868929596e-08 | -0.4353298177548076 | 9.976151510289891e-12 | LUAD |
| cg16526047 | chr1:1014513 | gene,exon,UTR | -0.289494765731988 | 4.13377390221184e-11 | -0.4239390069854859 | 4.919806592461471e-14 | LGG |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ISG15 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000187608 | ISG15 | C0011574 | Involutional Depression | 1 | CTD_human |
| ENSG00000187608 | ISG15 | C0021400 | Influenza | 1 | CTD_human |
| ENSG00000187608 | ISG15 | C1269683 | Major Depressive Disorder | 1 | CTD_human |
| ENSG00000187608 | ISG15 | C1571983 | Involutional paraphrenia | 1 | CTD_human |
| ENSG00000187608 | ISG15 | C1571984 | Psychosis, Involutional | 1 | CTD_human |
| ENSG00000187608 | ISG15 | C2239176 | Liver carcinoma | 1 | CTD_human |
| ENSG00000187608 | ISG15 | C4015293 | IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION | 1 | CTD_human |
