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Gene: ENSG00000187531 |
Summary for SIRT7 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000187531 | Gene symbol | SIRT7 |
| Gene name | sirtuin 7 | |
| HGNC | 14935 | |
| Entrez ID | 51547 | |
| Gene type | protein_coding | |
| Synonyms | SIRT7| | |
| UniProtAcc | Q9NRC8 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SIRT7 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SIRT7 | 2.30e+03 | 1.60e+00 | 2.04e-01 | 7.85e+00 | 4.29e-15 | 2.89e-13 | BLCA |
| SIRT7 | 9.90e+02 | 1.05e+00 | 1.42e-01 | 7.37e+00 | 1.69e-13 | 2.86e-12 | LIHC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for SIRT7 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SIRT7 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg07855221 | chr17:81919438 | CGI:chr17:81917549-81918248 | promoter,gene body | 7.71e-01 | 6.43e-01 | 1.97e+00 | 4.84e-02 | 4.84e-02 | 1.27e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg09489844 | chr17:81922771 | CGI:chr17:81922573-81922996 | promoter | 7.71e-01 | 9.87e-01 | -2.36e+00 | 1.81e-02 | 2.20e-02 | -2.16e-01 |
| LUSC | cg07855221 | chr17:81919438 | CGI:chr17:81917549-81918248 | promoter,gene body | 6.24e-01 | 7.31e-01 | -3.17e+00 | 1.52e-03 | 3.46e-03 | -1.07e-01 |
| LUSC | cg03168447 | chr17:81922574 | CGI:chr17:81922573-81922996 | promoter | 8.09e-01 | 9.24e-01 | -3.33e+00 | 8.53e-04 | 2.34e-03 | -1.15e-01 |
| CHOL | cg09253473 | chr17:81919513 | CGI:chr17:81917549-81918248 | promoter,gene body | 6.80e-01 | 8.29e-01 | -2.43e+00 | 1.50e-02 | 2.65e-02 | -1.48e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for SIRT7 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SIRT7 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SIRT7 |
| TFs related to SIRT7. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SIRT7 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SIRT7 |
| RBPs related to ES in SIRT7. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | RBM46 | exon_skip_294664 | 1.01e+01 | 9.84e-01 | 9.77e+00 | 1.42e-02 | Male-biased |
| ESCA | RBM4 | exon_skip_294665 | 8.93e+00 | 9.83e-01 | 8.52e+00 | 1.28e-02 | Male-biased |
| READ | RBM46 | exon_skip_294664 | 9.86e+00 | 9.81e-01 | 9.57e+00 | 1.69e-02 | Male-biased |
| READ | RBM8A | exon_skip_294665 | 1.16e+01 | 9.89e-01 | 1.13e+01 | 1.06e-02 | Male-biased |
| THCA | RBM46 | exon_skip_294664 | 9.70e+00 | 1.45e-02 | 9.97e+00 | 9.84e-01 | Female-biased |
| KICH | RBM4 | exon_skip_294665 | 8.59e+00 | 8.55e-03 | 8.93e+00 | 9.87e-01 | Female-biased |
| KICH | RBM8A | exon_skip_294665 | 1.14e+01 | 5.56e-03 | 1.17e+01 | 9.94e-01 | Female-biased |
| BLCA | RBM4 | exon_skip_294672 | 8.19e+00 | 9.80e-01 | 7.84e+00 | 1.17e-02 | Male-biased |
| SIRT7 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000187531 | AC105339.2,hsa-mir-142,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | RUSC1-AS1,hsa-mir-142,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | AC025178.1,hsa-mir-142,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | AC104825.1,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | AC145423.1,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | LINC00663,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | AL162431.1,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | SNHG4,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | LINC01089,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
| ENSG00000187531 | ZKSCAN2-DT,hsa-mir-152,SIRT7 | Male-specific ceRNA | TCGA-BLCA |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7221278 | chr17:73790495:G:A | - | 0.240953466196385 | 2.2234890309083e-05 | STAD | Female-baised eQTL |
| rs17249803 | chr17:73785938:G:A | - | 0.189307070467486 | 0.000169486954577175 | STAD | Female-baised eQTL |
| rs148043040 | chr17:73808146:C:A | - | 0.188027089662055 | 0.00021086956122664 | STAD | Female-baised eQTL |
| rs151133475 | chr17:73811130:G:A | - | 0.188027089662055 | 0.00021086956122664 | STAD | Female-baised eQTL |
| rs79546944 | chr17:73811460:C:T | - | 0.188027089662055 | 0.00021086956122664 | STAD | Female-baised eQTL |
| rs80342780 | chr17:73813110:G:A | - | 0.188027089662055 | 0.00021086956122664 | STAD | Female-baised eQTL |
| rs117025579 | chr17:73799927:C:G | - | 0.187639172669588 | 0.00022350568142399 | STAD | Female-baised eQTL |
| rs73345608 | chr17:73800157:A:G | - | 0.187639172669588 | 0.00022350568142399 | STAD | Female-baised eQTL |
| rs8070752 | chr17:73801418:G:A | - | 0.187639172669588 | 0.00022350568142399 | STAD | Female-baised eQTL |
| rs76912347 | chr17:73802054:C:T | - | 0.187639172669588 | 0.00022350568142399 | STAD | Female-baised eQTL |
| rs2883087 | chr17:73788577:C:T | - | 0.166553345777877 | 0.000288423595271256 | STAD | Female-baised eQTL |
| rs12601555 | chr17:73540863:C:T | - | 0.158902854556324 | 0.019167993519334 | BLCA | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11652820 | chr17:72190888:C:T | - | -0.0659643347495075 | 0.0177123882091345 | LIHC | Male-baised eQTL |
| rs7209901 | chr17:76805793:A:G | - | -0.128038801782618 | 0.0274253512895922 | LGG | Male-baised eQTL |
| rs8081515 | chr17:76807920:T:C | - | -0.119372623274786 | 0.0365856561958163 | LGG | Male-baised eQTL |
| rs7224332 | chr17:76805142:A:G | - | -0.11631397387587 | 0.0463880967570927 | LGG | Male-baised eQTL |
| rs7210079 | chr17:76805911:A:G | - | -0.11631397387587 | 0.0463880967570927 | LGG | Male-baised eQTL |
| rs2172213 | chr17:76806177:T:C | - | -0.11631397387587 | 0.0463880967570927 | LGG | Male-baised eQTL |
| rs2131030 | chr17:76806263:G:A | - | -0.116016022549457 | 0.0480006731036728 | LGG | Male-baised eQTL |
| rs7208733 | chr17:76804917:T:C | - | -0.114842245619339 | 0.0495383793178383 | LGG | Male-baised eQTL |
| rs2681122 | chr17:82817139:T:C | - | -0.0505096600067863 | 0.0157546398608904 | KIRC | Male-baised eQTL |
| rs681228 | chr17:82818940:C:T | - | -0.0496847008779809 | 0.0164380657016969 | KIRC | Male-baised eQTL |
| rs2459714 | chr17:82816675:C:G | - | -0.050475225273674 | 0.0177900839308986 | KIRC | Male-baised eQTL |
| rs2677930 | chr17:82817204:C:T | - | -0.049786986060978 | 0.0184633102064209 | KIRC | Male-baised eQTL |
| rs11653084 | chr17:82834000:C:A | - | -0.0460913455665127 | 0.0417587089158693 | KIRC | Male-baised eQTL |
| rs11657931 | chr17:82834001:A:G | - | -0.0460913455665127 | 0.0417587089158693 | KIRC | Male-baised eQTL |
| rs9893321 | chr17:72506726:T:C | - | 0.0858700092037676 | 0.0264838260505722 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000187531 |
| CpG Site: cg01618928 | |
| Position to Gene: gene,exon | |
| Male Effect: -0.377145160072155 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01618928 | chr17:81912886 | gene,exon | -0.377145160072155 | 2.54029384083122e-06 | -0.37597896649819895 | 6.746613868253725e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of SIRT7 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000187531 | SIRT7 | C0015695 | Fatty Liver | 1 | CTD_human |
| ENSG00000187531 | SIRT7 | C0035126 | Reperfusion Injury | 1 | CTD_human |
| ENSG00000187531 | SIRT7 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
| ENSG00000187531 | SIRT7 | C2711227 | Steatohepatitis | 1 | CTD_human |
