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Gene: ENSG00000187260 |
Summary for WDR86 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000187260 | Gene symbol | WDR86 |
| Gene name | WD repeat domain 86 | |
| HGNC | 28020 | |
| Entrez ID | 349136 | |
| Gene type | protein_coding | |
| Synonyms | WDR86| | |
| UniProtAcc | Q86TI4 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for WDR86 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| WDR86 | 2.43e+02 | -2.05e+00 | 1.31e-01 | -1.57e+01 | 1.27e-55 | 1.52e-54 | BRCA |
Top |
Sex-biased somatic mutation for WDR86 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for WDR86 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| PAAD | cg17362861 | chr7:151410171 | CGI:chr7:151409290-151410722 | promoter,gene body | 2.10e-01 | 3.16e-01 | -3.12e+00 | 1.83e-03 | 7.72e-03 | -1.06e-01 |
| MESO | cg17881007 | chr7:151408936 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 5.66e-01 | 3.97e-01 | 2.59e+00 | 9.62e-03 | 2.75e-02 | 1.69e-01 |
| KICH | cg03693105 | chr7:151411254 | CGI:chr7:151409290-151410722 | promoter | 3.29e-01 | 4.91e-01 | -2.95e+00 | 3.22e-03 | 1.33e-02 | -1.62e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg10770742 | chr7:151410199 | CGI:chr7:151409290-151410722 | promoter,gene body | 3.40e-01 | 7.46e-02 | 2.71e+00 | 6.72e-03 | 1.03e-02 | 2.66e-01 |
| BLCA | cg21532325 | chr7:151410314 | CGI:chr7:151409290-151410722 | promoter,gene body | 2.90e-01 | 5.61e-02 | 2.75e+00 | 5.87e-03 | 9.26e-03 | 2.34e-01 |
| BLCA | cg17362861 | chr7:151410171 | CGI:chr7:151409290-151410722 | promoter,gene body | 2.49e-01 | 2.55e-02 | 2.64e+00 | 8.31e-03 | 1.22e-02 | 2.23e-01 |
| BLCA | cg16482474 | chr7:151410551 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 2.29e-01 | 5.41e-02 | 2.38e+00 | 1.72e-02 | 2.17e-02 | 1.75e-01 |
| BLCA | cg00234261 | chr7:151408996 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 1.40e-01 | 2.92e-01 | -3.75e+00 | 1.75e-04 | 5.99e-04 | -1.52e-01 |
| BLCA | cg12433277 | chr7:151409904 | CGI:chr7:151409290-151410722 | UTR,promoter,exon,gene body | 3.21e-01 | 1.23e-01 | 2.96e+00 | 3.12e-03 | 5.58e-03 | 1.98e-01 |
| BLCA | cg24068372 | chr7:151410175 | CGI:chr7:151409290-151410722 | promoter,gene body | 2.54e-01 | 7.78e-02 | 2.68e+00 | 7.44e-03 | 1.12e-02 | 1.76e-01 |
| LIHC | cg17881007 | chr7:151408936 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 4.85e-01 | 3.39e-01 | 2.89e+00 | 3.88e-03 | 5.26e-03 | 1.46e-01 |
| CHOL | cg03693105 | chr7:151411254 | CGI:chr7:151409290-151410722 | promoter | 5.52e-01 | 3.81e-01 | 1.99e+00 | 4.65e-02 | 4.65e-02 | 1.71e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg10770742 | chr7:151410199 | CGI:chr7:151409290-151410722 | promoter,gene body | 1.90e-01 | 3.59e-02 | 8.51e+00 | 1.76e-17 | 7.74e-17 | 1.54e-01 |
| BRCA | cg21532325 | chr7:151410314 | CGI:chr7:151409290-151410722 | promoter,gene body | 1.54e-01 | 2.93e-02 | 7.45e+00 | 9.41e-14 | 3.12e-13 | 1.24e-01 |
| BRCA | cg17881007 | chr7:151408936 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 3.67e-01 | 6.54e-02 | 1.14e+01 | 3.54e-30 | 5.27e-29 | 3.01e-01 |
| BRCA | cg23476065 | chr7:151408957 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 5.63e-01 | 3.39e-01 | 1.06e+01 | 2.15e-26 | 2.09e-25 | 2.23e-01 |
| BRCA | cg00234261 | chr7:151408996 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 3.08e-01 | 1.24e-01 | 1.01e+01 | 8.16e-24 | 6.20e-23 | 1.84e-01 |
| BRCA | cg12433277 | chr7:151409904 | CGI:chr7:151409290-151410722 | UTR,promoter,exon,gene body | 2.88e-01 | 1.05e-01 | 1.07e+01 | 1.11e-26 | 1.11e-25 | 1.83e-01 |
| BRCA | cg19831077 | chr7:151410838 | CGI:chr7:151409290-151410722 | promoter | 4.03e-01 | 2.73e-01 | 8.99e+00 | 2.54e-19 | 1.30e-18 | 1.30e-01 |
| KIRC | cg23476065 | chr7:151408957 | CGI:chr7:151409290-151410722 | promoter,exon,gene body | 3.47e-01 | 2.21e-01 | 2.81e+00 | 5.03e-03 | 1.10e-02 | 1.26e-01 |
| LIHC | cg12433277 | chr7:151409904 | CGI:chr7:151409290-151410722 | UTR,promoter,exon,gene body | 3.44e-01 | 1.77e-01 | 3.04e+00 | 2.35e-03 | 4.41e-03 | 1.67e-01 |
| LIHC | cg19831077 | chr7:151410838 | CGI:chr7:151409290-151410722 | promoter | 5.18e-01 | 3.91e-01 | 2.82e+00 | 4.85e-03 | 7.84e-03 | 1.26e-01 |
| LIHC | cg03693105 | chr7:151411254 | CGI:chr7:151409290-151410722 | promoter | 5.88e-01 | 3.84e-01 | 4.01e+00 | 5.95e-05 | 2.60e-04 | 2.04e-01 |
| KIRP | cg19831077 | chr7:151410838 | CGI:chr7:151409290-151410722 | promoter | 4.05e-01 | 3.01e-01 | 2.15e+00 | 3.13e-02 | 3.63e-02 | 1.04e-01 |
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Exon skipping events with PSI in TCGA for WDR86 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for WDR86 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | WDR86-202 | chr7_151383374_- | 2.82e-01 | 4.17e-01 | -2.55e+00 | 1.06e-02 | 2.93e-02 | -1.34e-01 |
| LUAD | WDR86-202 | chr7_151383516_- | 3.58e-01 | 3.03e-01 | 2.16e+00 | 3.06e-02 | 4.32e-02 | 5.48e-02 |
| LGG | WDR86-202 | chr7_151408493_- | 3.28e-01 | 2.50e-01 | 2.67e+00 | 7.51e-03 | 4.34e-02 | 7.77e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| THCA | WDR86-202 | chr7_151407622_- | 1.92e-01 | 1.50e-01 | 2.02e+00 | 4.38e-02 | 4.53e-02 | 4.24e-02 |
| THCA | WDR86-202 | chr7_151408493_- | 2.72e-01 | 2.17e-01 | 2.38e+00 | 1.73e-02 | 2.62e-02 | 5.41e-02 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| BRCA | WDR86-202 | chr7_151383516_- | 4.07e-01 | 2.72e-01 | 2.23e+00 | 2.61e-02 | 3.01e-02 | 1.34e-01 |
| THCA | WDR86-202 | chr7_151383589_- | 5.07e-01 | 3.27e-01 | 3.71e+00 | 2.03e-04 | 1.06e-03 | 1.80e-01 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for WDR86 |
| TFs related to WDR86. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PLAGL2 | WDR86 | 4.27e+00 | 9.83e-01 | 3.32e+00 | 6.85e-03 | Male-biased |
| LGG | PLAGL2 | WDR86 | 3.38e+00 | 2.06e-03 | 4.17e+00 | 9.84e-01 | Female-biased |
| LGG | ZNF460 | WDR86 | 3.48e+00 | 3.37e-03 | 4.18e+00 | 9.83e-01 | Female-biased |
| LGG | ZNF740 | WDR86 | 3.39e+00 | 2.60e-03 | 4.13e+00 | 9.83e-01 | Female-biased |
| WDR86 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for WDR86 |
| RBPs related to ES in WDR86. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| WDR86 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4726097 | chr7:151800882:G:C | - | -0.0664190462000213 | 0.0310769269785878 | THCA | Female-baised eQTL |
| rs1371821 | chr7:155073591:A:G | - | -0.07917993446667 | 0.00181342396160329 | LUAD | Female-baised eQTL |
| rs4466312 | chr7:153554098:G:A | - | 0.0751494498945215 | 0.00645433054858872 | LUAD | Female-baised eQTL |
| rs4416745 | chr7:153205808:C:T | - | -0.0658702046240464 | 0.00911888189179602 | LUAD | Female-baised eQTL |
| rs10247334 | chr7:153583918:T:C | - | 0.0521110134258454 | 0.0110561365227614 | LUAD | Female-baised eQTL |
| rs28844732 | chr7:153576848:T:C | - | 0.0525988823425778 | 0.0111609054224695 | LUAD | Female-baised eQTL |
| rs17170051 | chr7:146348645:C:G | - | 0.074051842364267 | 0.0113819961849172 | LUAD | Female-baised eQTL |
| rs4374904 | chr7:153574495:A:G | - | 0.0525137972196417 | 0.011499907697589 | LUAD | Female-baised eQTL |
| rs4380847 | chr7:153575547:A:G | - | 0.0525137972196417 | 0.011499907697589 | LUAD | Female-baised eQTL |
| rs10224556 | chr7:153582679:G:C | - | 0.0523253709373271 | 0.0121693945563818 | LUAD | Female-baised eQTL |
| rs10227913 | chr7:153583086:G:A | - | 0.0522631126747699 | 0.0156897847426405 | LUAD | Female-baised eQTL |
| rs28410640 | chr7:146338990:G:C | - | 0.0714174578975335 | 0.0166323628635554 | LUAD | Female-baised eQTL |
| rs11977983 | chr7:146339152:T:C | - | 0.0714174578975335 | 0.0166323628635554 | LUAD | Female-baised eQTL |
| rs11978155 | chr7:146339671:T:C | - | 0.0714174578975335 | 0.0166323628635554 | LUAD | Female-baised eQTL |
| rs17170042 | chr7:146339807:C:T | - | 0.0714174578975335 | 0.0166323628635554 | LUAD | Female-baised eQTL |
| rs10952399 | chr7:153210399:A:C | - | -0.0631965642447997 | 0.0205173778142731 | LUAD | Female-baised eQTL |
| rs10231672 | chr7:146345521:G:A | - | 0.0695628795338122 | 0.0208571945018603 | LUAD | Female-baised eQTL |
| rs10233678 | chr7:153213774:C:T | - | -0.0710533720864731 | 0.0233311801438503 | LUAD | Female-baised eQTL |
| rs4440542 | chr7:153205869:C:T | - | -0.0623211041844389 | 0.0308281756906258 | LUAD | Female-baised eQTL |
| rs11535217 | chr7:153216754:G:A | - | -0.0615398533704619 | 0.0313267978929339 | LUAD | Female-baised eQTL |
| rs10260495 | chr7:146341521:A:G | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs10248899 | chr7:146341974:C:A | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs28478892 | chr7:146342159:T:C | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs10275558 | chr7:146343927:T:C | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs28687551 | chr7:146344503:A:G | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs10273261 | chr7:146344679:A:G | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs10227977 | chr7:146344858:G:A | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs10280011 | chr7:146345232:T:C | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs10231549 | chr7:146345403:G:A | - | 0.0648512657604593 | 0.0338304939786288 | LUAD | Female-baised eQTL |
| rs78744332 | chr7:146339897:A:G | - | 0.0647057649326369 | 0.034725377177465 | LUAD | Female-baised eQTL |
| rs10255602 | chr7:146339954:A:G | - | 0.0647057649326369 | 0.034725377177465 | LUAD | Female-baised eQTL |
| rs10269314 | chr7:146340120:G:A | - | 0.0647057649326369 | 0.034725377177465 | LUAD | Female-baised eQTL |
| rs10269331 | chr7:146340164:G:A | - | 0.0647057649326369 | 0.034725377177465 | LUAD | Female-baised eQTL |
| rs10245727 | chr7:146341735:C:A | - | 0.0646491886513679 | 0.0350352167876108 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000187260 |
| CpG Site: cg19831077 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.284180778138128 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19831077 | chr7:151410838 | promoter | -0.284180778138128 | 7.47246589804936e-10 | -0.4513570193302218 | 3.3389972123127463e-14 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of WDR86 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
