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Gene: ENSG00000186462

Summary for NAP1L2

Gene summary

Gene information	Ensembl ID	ENSG00000186462
	Gene symbol	NAP1L2
	Gene name	nucleosome assembly protein 1 like 2
	HGNC	7638
	Entrez ID	4674
	Gene type	protein_coding
	Synonyms	NAP1L2\|BPX\|MGC26243
	UniProtAcc	Q9ULW6

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for NAP1L2

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
NAP1L2	1.30e+02	-1.45e+00	2.88e-01	-5.04e+00	4.77e-07	2.90e-05	SARC

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
NAP1L2	1.80e+02	-1.59e+00	1.48e-01	-1.07e+01	6.37e-27	2.86e-26	BRCA

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Sex-biased somatic mutation for NAP1L2

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for NAP1L2

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.32e-01	5.80e-02	4.77e+00	1.81e-06	4.81e-05	2.74e-01
BRCA	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.21e-01	6.22e-02	3.99e+00	6.74e-05	1.21e-03	2.59e-01
LUAD	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	3.97e-01	1.49e-01	3.07e+00	2.16e-03	5.53e-03	2.48e-01
LUAD	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.52e-01	1.88e-01	1.97e+00	4.89e-02	4.93e-02	3.64e-01
LGG	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.39e-01	5.08e-02	1.92e+01	2.89e-82	6.95e-81	2.88e-01
LGG	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.37e-01	1.20e-01	7.20e+00	6.03e-13	3.65e-12	2.17e-01
LGG	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.40e-01	1.96e-01	3.31e+00	9.26e-04	3.62e-03	3.44e-01
LGG	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.65e-01	6.32e-02	1.94e+01	5.63e-84	1.51e-82	3.02e-01
THCA	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	4.81e-01	2.53e-01	5.97e+00	2.37e-09	1.19e-08	2.28e-01
HNSC	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.71e-01	2.36e-01	-3.48e+00	5.07e-04	2.39e-03	3.35e-01
LUSC	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.16e-01	6.39e-02	1.33e+01	3.20e-40	5.25e-39	2.52e-01
LUSC	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	2.87e-01	1.34e-01	2.65e+00	8.07e-03	2.25e-02	1.53e-01
LUSC	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.60e-01	1.15e-01	1.04e+01	1.68e-25	1.98e-24	2.46e-01
LUSC	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	4.89e-01	1.87e-01	-2.07e+00	3.80e-02	4.53e-02	3.02e-01
LUSC	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.18e-01	7.56e-02	1.36e+01	6.06e-42	1.05e-40	2.43e-01
LUSC	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	2.69e-01	1.05e-01	7.61e+00	2.73e-14	2.49e-13	1.64e-01
SKCM	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	2.28e-01	5.59e-02	1.57e+01	2.99e-55	4.81e-54	1.72e-01
SKCM	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	2.85e-01	1.26e-01	1.14e+01	4.38e-30	4.23e-29	1.59e-01
SKCM	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	2.66e-01	7.71e-02	1.65e+01	5.77e-61	1.06e-59	1.89e-01
SKCM	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	2.34e-01	1.28e-01	6.14e+00	8.03e-10	4.72e-09	1.06e-01
COAD	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	7.25e-01	5.71e-01	-5.02e+00	5.11e-07	3.71e-06	1.54e-01
BLCA	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.77e-01	1.50e-01	6.12e+00	9.62e-10	8.71e-09	2.27e-01
STAD	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.22e-01	4.09e-01	3.64e+00	2.69e-04	1.27e-03	1.14e-01
STAD	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	4.36e-01	2.16e-01	-4.40e+00	1.11e-05	6.05e-05	2.20e-01
STAD	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	7.01e-01	5.57e-01	-4.31e+00	1.61e-05	8.69e-05	1.44e-01
STAD	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	4.58e-01	2.79e-01	7.47e+00	7.88e-14	6.94e-13	1.79e-01
SARC	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	2.43e-01	7.14e-02	1.07e+01	1.25e-26	2.58e-25	1.71e-01
SARC	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.32e-01	1.49e-01	2.18e+00	2.91e-02	3.63e-02	1.83e-01
SARC	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.90e-01	2.25e-01	9.80e+00	1.15e-22	1.84e-21	3.65e-01
SARC	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.10e-01	8.92e-02	1.18e+01	2.93e-32	8.66e-31	2.21e-01
SARC	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	2.71e-01	1.25e-01	-2.49e+00	1.26e-02	2.15e-02	1.46e-01
PCPG	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.51e-01	1.30e-01	8.59e+00	9.00e-18	7.43e-17	2.21e-01
PCPG	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.09e-01	5.99e-02	1.15e+01	8.40e-31	2.64e-29	2.49e-01
PCPG	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	2.60e-01	1.27e-01	4.03e+00	5.47e-05	2.37e-04	1.33e-01
PAAD	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.86e-01	2.07e-01	5.84e+00	5.32e-09	4.08e-08	1.78e-01
PAAD	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	4.54e-01	2.12e-01	2.03e+00	4.27e-02	4.72e-02	2.42e-01
PAAD	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	6.00e-01	2.31e-01	2.96e+00	3.11e-03	1.17e-02	3.69e-01
PAAD	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	4.26e-01	1.76e-01	8.85e+00	9.10e-19	1.23e-17	2.50e-01
PAAD	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	4.34e-01	2.27e-01	-3.12e+00	1.79e-03	7.60e-03	2.07e-01
READ	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.65e-01	3.22e-01	4.06e+00	4.97e-05	2.45e-04	2.43e-01
READ	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	4.43e-01	2.97e-01	3.19e+00	1.41e-03	5.38e-03	1.46e-01
READ	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	4.33e-01	2.21e-01	4.76e+00	1.97e-06	1.13e-05	2.12e-01
READ	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	3.51e-01	2.50e-01	2.73e+00	6.36e-03	1.84e-02	1.01e-01
GBM	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.84e-01	1.02e-01	5.39e+00	7.09e-08	5.51e-07	2.82e-01
GBM	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.61e-01	1.31e-01	2.28e+00	2.27e-02	3.75e-02	2.29e-01
GBM	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.58e-01	5.70e-02	6.69e+00	2.16e-11	3.26e-10	3.01e-01
ESCA	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	4.61e-01	2.83e-01	3.27e+00	1.07e-03	4.80e-03	1.78e-01
ESCA	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	4.24e-01	2.24e-01	4.06e+00	4.86e-05	2.73e-04	2.00e-01
LAML	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.35e-01	2.24e-01	6.64e+00	3.03e-11	1.44e-10	3.11e-01
LAML	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	5.30e-01	1.87e-01	6.23e+00	4.80e-10	2.13e-09	3.43e-01
LAML	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	5.32e-01	1.78e-01	7.41e+00	1.29e-13	7.05e-13	3.54e-01
LAML	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	6.88e-01	5.71e-01	-4.93e+00	8.44e-07	3.17e-06	1.17e-01
LAML	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	5.00e-01	1.86e-01	8.66e+00	4.83e-18	3.43e-17	3.14e-01
LAML	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	4.70e-01	1.71e-01	5.05e+00	4.46e-07	1.70e-06	2.98e-01
THYM	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.46e-01	6.97e-02	8.76e+00	1.93e-18	1.68e-17	2.76e-01
THYM	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	3.74e-01	1.40e-01	3.39e+00	6.89e-04	1.91e-03	2.33e-01
THYM	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	5.18e-01	1.37e-01	2.73e+00	6.25e-03	1.36e-02	3.82e-01
THYM	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.89e-01	2.58e-01	5.23e+00	1.66e-07	6.18e-07	3.32e-01
THYM	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.81e-01	7.54e-02	8.75e+00	2.23e-18	1.93e-17	3.06e-01
THYM	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	4.88e-01	1.09e-01	-3.35e+00	8.20e-04	2.24e-03	3.79e-01
MESO	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	2.46e-01	6.82e-02	5.55e+00	2.89e-08	2.89e-07	1.77e-01
MESO	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	4.27e-01	1.51e-01	-3.07e+00	2.16e-03	9.70e-03	2.76e-01
MESO	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.05e-01	8.68e-02	5.90e+00	3.62e-09	4.77e-08	2.18e-01
MESO	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	3.36e-01	1.38e-01	-3.10e+00	1.93e-03	8.81e-03	1.98e-01
UVM	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	2.37e-01	5.16e-02	6.71e+00	1.99e-11	1.73e-10	1.86e-01
UVM	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	4.02e-01	1.36e-01	3.20e+00	1.40e-03	4.13e-03	2.66e-01
UVM	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.21e-01	1.57e-01	2.81e+00	4.99e-03	1.26e-02	3.64e-01
UVM	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.19e-01	6.15e-02	6.85e+00	7.28e-12	6.72e-11	2.57e-01
ACC	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.02e-01	5.73e-02	7.23e+00	4.87e-13	9.29e-12	2.44e-01
ACC	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	2.98e-01	1.53e-01	3.27e+00	1.06e-03	5.56e-03	1.45e-01
ACC	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	4.58e-01	2.69e-01	4.80e+00	1.59e-06	1.31e-05	1.89e-01
ACC	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	2.91e-01	3.92e-02	6.60e+00	4.21e-11	5.46e-10	2.52e-01
KICH	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	1.42e-01	3.82e-02	5.45e+00	5.04e-08	5.25e-07	1.04e-01
KICH	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	2.58e-01	8.24e-02	5.81e+00	6.19e-09	7.39e-08	1.75e-01
KICH	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	2.08e-01	5.67e-02	6.41e+00	1.42e-10	2.83e-09	1.51e-01
KICH	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	2.66e-01	9.54e-02	4.19e+00	2.77e-05	2.13e-04	1.71e-01
CHOL	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	4.34e-01	6.58e-02	3.98e+00	6.91e-05	3.67e-04	3.68e-01
CHOL	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.28e-01	1.58e-01	3.50e+00	4.62e-04	1.99e-03	1.70e-01
CHOL	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	4.10e-01	1.25e-01	4.04e+00	5.27e-05	2.87e-04	2.85e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
HNSC	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	1.52e-01	3.15e-02	4.01e+00	6.09e-05	1.71e-04	1.21e-01
COAD	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	3.01e-01	1.42e-01	2.91e+00	3.56e-03	6.28e-03	1.59e-01
COAD	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	4.31e-01	1.09e-01	3.47e+00	5.19e-04	1.32e-03	3.23e-01
COAD	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.68e-01	5.52e-02	4.62e+00	3.76e-06	2.88e-05	3.13e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg07693661	chrX:73215171	CGI:chrX:73079542-73080064	promoter	2.98e-01	4.18e-01	-4.24e+00	2.21e-05	3.57e-05	-1.20e-01
BRCA	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.62e-01	5.22e-01	-8.91e+00	4.93e-19	2.46e-18	-1.60e-01
BRCA	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	3.21e-01	4.37e-01	-9.53e+00	1.64e-21	1.01e-20	-1.16e-01
BRCA	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	2.57e-01	4.04e-01	-8.57e+00	1.01e-17	4.53e-17	-1.46e-01
KIRC	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	3.51e-01	2.43e-01	2.47e+00	1.33e-02	2.06e-02	1.08e-01
KIRC	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	5.77e-01	4.58e-01	2.82e+00	4.84e-03	1.08e-02	1.19e-01
LUAD	cg23483095	chrX:73214718	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	4.16e-01	3.01e-01	2.64e+00	8.25e-03	1.37e-02	1.16e-01
LUAD	cg02379437	chrX:73215281	CGI:chrX:73079542-73080064	promoter	3.37e-01	4.98e-01	-2.66e+00	7.76e-03	1.31e-02	-1.61e-01
BLCA	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	3.77e-01	5.12e-01	-1.99e+00	4.69e-02	4.77e-02	-1.34e-01
LIHC	cg16371598	chrX:73214161	CGI:chrX:73079542-73080064	promoter,exon,CDS,gene body	2.91e-01	4.47e-01	-2.51e+00	1.21e-02	1.62e-02	-1.56e-01
LIHC	cg20001978	chrX:73214825	CGI:chrX:73079542-73080064	UTR,promoter,exon,gene body	4.23e-01	5.55e-01	2.18e+00	2.90e-02	3.24e-02	-1.32e-01
LIHC	cg04297329	chrX:73214884	CGI:chrX:73079542-73080064	promoter	2.66e-01	4.01e-01	-3.91e+00	9.30e-05	3.64e-04	-1.35e-01

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Exon skipping events with PSI in TCGA for NAP1L2

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for NAP1L2

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for NAP1L2

TFs related to NAP1L2.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
BLCA	FOXR2	NAP1L2	4.97e+00	9.88e-01	4.15e+00	9.29e-03	Male-biased
BLCA	ZNF418	NAP1L2	5.21e+00	9.94e-01	4.14e+00	3.99e-03	Male-biased
BLCA	ZNF879	NAP1L2	4.94e+00	9.92e-01	3.94e+00	5.08e-03	Male-biased
BRCA	FOXR2	NAP1L2	3.37e+00	2.04e-03	5.10e+00	9.95e-01	Female-biased
BRCA	PATZ1	NAP1L2	4.91e+00	9.88e-01	3.61e+00	8.16e-03	Male-biased
BRCA	ZNF175	NAP1L2	4.16e+00	1.36e-02	5.28e+00	9.84e-01	Female-biased
BRCA	ZNF28	NAP1L2	4.96e+00	9.92e-01	3.45e+00	4.43e-03	Male-biased
BRCA	ZNF320	NAP1L2	4.54e+00	9.84e-01	3.26e+00	8.32e-03	Male-biased
BRCA	ZNF418	NAP1L2	2.32e+00	1.04e-04	4.88e+00	9.95e-01	Female-biased
BRCA	ZNF879	NAP1L2	2.24e+00	1.83e-04	4.66e+00	9.93e-01	Female-biased
BRCA	ZNF891	NAP1L2	4.91e+00	9.88e-01	3.59e+00	7.74e-03	Male-biased
CHOL	ZNF418	NAP1L2	4.83e+00	1.47e-02	5.68e+00	9.84e-01	Female-biased
LAML	BARHL2	NAP1L2	6.28e+00	9.88e-01	5.38e+00	1.08e-02	Male-biased
LAML	FOXR2	NAP1L2	5.15e+00	9.96e-01	3.62e+00	9.56e-04	Male-biased
LAML	LHX6	NAP1L2	6.41e+00	9.86e-01	5.56e+00	1.34e-02	Male-biased
LAML	MECOM	NAP1L2	5.67e+00	9.93e-01	4.61e+00	5.85e-03	Male-biased
LAML	NFE2L2	NAP1L2	5.09e+00	9.86e-01	4.19e+00	1.09e-02	Male-biased
LAML	PDX1	NAP1L2	5.97e+00	9.86e-01	5.12e+00	1.29e-02	Male-biased
LAML	ZNF136	NAP1L2	5.57e+00	9.93e-01	4.47e+00	5.11e-03	Male-biased
LAML	ZNF154	NAP1L2	5.74e+00	9.82e-01	4.96e+00	1.71e-02	Male-biased
LAML	ZNF175	NAP1L2	5.29e+00	9.90e-01	4.29e+00	7.31e-03	Male-biased
LAML	ZNF180	NAP1L2	2.57e+00	8.79e-04	4.07e+00	9.83e-01	Female-biased
LAML	ZNF24	NAP1L2	4.71e+00	9.83e-01	3.82e+00	1.09e-02	Male-biased
LAML	ZNF3	NAP1L2	4.90e+00	9.89e-01	3.86e+00	6.34e-03	Male-biased
LAML	ZNF320	NAP1L2	2.83e+00	2.32e-03	4.10e+00	9.82e-01	Female-biased
LAML	ZNF341	NAP1L2	2.72e+00	1.94e-03	4.03e+00	9.80e-01	Female-biased
LAML	ZNF418	NAP1L2	4.97e+00	9.95e-01	3.40e+00	8.10e-04	Male-biased
LAML	ZNF444	NAP1L2	3.00e+00	4.27e-03	4.11e+00	9.80e-01	Female-biased
LAML	ZNF467	NAP1L2	2.65e+00	1.25e-03	4.07e+00	9.82e-01	Female-biased
LAML	ZNF879	NAP1L2	4.69e+00	9.89e-01	3.55e+00	4.24e-03	Male-biased
LAML	ZNF880	NAP1L2	2.93e+00	3.23e-03	4.11e+00	9.81e-01	Female-biased
MESO	FOXR2	NAP1L2	4.17e+00	7.15e-03	5.56e+00	9.91e-01	Female-biased
MESO	ZNF175	NAP1L2	4.58e+00	1.81e-02	5.67e+00	9.81e-01	Female-biased
MESO	ZNF418	NAP1L2	4.03e+00	2.17e-03	5.77e+00	9.97e-01	Female-biased
MESO	ZNF879	NAP1L2	3.86e+00	5.11e-03	5.36e+00	9.93e-01	Female-biased
SARC	FOXR2	NAP1L2	3.86e+00	4.66e-03	4.64e+00	9.90e-01	Female-biased
SARC	ZNF418	NAP1L2	2.64e+00	3.30e-04	3.92e+00	9.83e-01	Female-biased
THYM	FOXR2	NAP1L2	5.35e+00	1.33e-02	5.97e+00	9.86e-01	Female-biased
THYM	ZNF235	NAP1L2	4.03e+00	1.29e-02	4.65e+00	9.81e-01	Female-biased
THYM	ZNF418	NAP1L2	5.62e+00	4.74e-03	6.50e+00	9.95e-01	Female-biased
THYM	ZNF879	NAP1L2	5.08e+00	7.93e-03	5.83e+00	9.91e-01	Female-biased

NAP1L2 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for NAP1L2

RBPs related to ES in NAP1L2.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

NAP1L2 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Female-specific eQTL regulation.

SNP ID

SNP Info

Position to Gene

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM

Description

Male-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Female-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

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Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

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Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

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Related disease information of NAP1L2

Diseases associated with this gene (DisGeNET).

Gene ID

Gene Symbol

Disease ID

Disease Name

Number of PMID

Source

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene