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Gene: ENSG00000185924 |
Summary for RTN4RL1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000185924 | Gene symbol | RTN4RL1 |
| Gene name | reticulon 4 receptor like 1 | |
| HGNC | 21329 | |
| Entrez ID | 146760 | |
| Gene type | protein_coding | |
| Synonyms | RTN4RL1|NGRH2|NgR3|DKFZp547J144 | |
| UniProtAcc | Q86UN2 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for RTN4RL1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RTN4RL1 | 2.06e+02 | -1.28e+00 | 3.48e-01 | -3.68e+00 | 2.38e-04 | 5.72e-04 | LUAD |
| RTN4RL1 | 5.66e+02 | 1.55e+00 | 6.45e-01 | 2.41e+00 | 1.61e-02 | 3.73e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| RTN4RL1 | 4.27e+02 | 1.40e+00 | 3.26e-01 | 4.28e+00 | 1.88e-05 | 7.09e-05 | LIHC |
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Sex-biased somatic mutation for RTN4RL1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for RTN4RL1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg07471768 | chr17:2023758 | CGI:chr17:2023914-2026114 | promoter,gene body | 2.64e-01 | 3.68e-01 | -2.45e+00 | 1.43e-02 | 3.06e-02 | -1.04e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg26772766 | chr17:2024888 | CGI:chr17:2023914-2026114 | UTR,promoter,exon,gene body | 2.17e-01 | 3.15e-02 | 2.74e+00 | 6.15e-03 | 9.75e-03 | 1.86e-01 |
| COAD | cg06791321 | chr17:2024238 | CGI:chr17:2023914-2026114 | promoter,gene body | 2.76e-01 | 1.23e-01 | 2.07e+00 | 3.85e-02 | 4.10e-02 | 1.52e-01 |
| COAD | cg20641798 | chr17:2024903 | CGI:chr17:2023914-2026114 | UTR,promoter,exon,gene body | 2.48e-01 | 7.02e-02 | 2.25e+00 | 2.44e-02 | 2.89e-02 | 1.78e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for RTN4RL1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for RTN4RL1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for RTN4RL1 |
| TFs related to RTN4RL1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | KLF3 | RTN4RL1 | 4.65e+00 | 9.81e-01 | 3.13e+00 | 6.52e-03 | Male-biased |
| UVM | KLF8 | RTN4RL1 | 4.60e+00 | 9.81e-01 | 3.00e+00 | 5.40e-03 | Male-biased |
| UVM | NR1H4 | RTN4RL1 | 4.61e+00 | 9.82e-01 | 2.93e+00 | 4.49e-03 | Male-biased |
| UVM | SNAI1 | RTN4RL1 | 4.57e+00 | 9.82e-01 | 2.78e+00 | 3.58e-03 | Male-biased |
| UVM | SPZ1 | RTN4RL1 | 4.69e+00 | 9.82e-01 | 3.14e+00 | 6.05e-03 | Male-biased |
| UVM | ZIC4 | RTN4RL1 | 4.60e+00 | 9.80e-01 | 3.05e+00 | 6.11e-03 | Male-biased |
| UVM | ZIC5 | RTN4RL1 | 4.64e+00 | 9.82e-01 | 3.05e+00 | 5.56e-03 | Male-biased |
| UVM | ZNF141 | RTN4RL1 | 4.79e+00 | 9.84e-01 | 3.18e+00 | 5.31e-03 | Male-biased |
| UVM | ZNF17 | RTN4RL1 | 4.69e+00 | 9.83e-01 | 3.04e+00 | 4.91e-03 | Male-biased |
| UVM | ZNF28 | RTN4RL1 | 4.90e+00 | 9.88e-01 | 3.10e+00 | 3.60e-03 | Male-biased |
| UVM | ZNF320 | RTN4RL1 | 4.75e+00 | 9.86e-01 | 2.96e+00 | 3.57e-03 | Male-biased |
| UVM | ZNF331 | RTN4RL1 | 4.89e+00 | 9.89e-01 | 2.79e+00 | 1.79e-03 | Male-biased |
| UVM | ZNF333 | RTN4RL1 | 4.80e+00 | 9.87e-01 | 2.95e+00 | 3.18e-03 | Male-biased |
| UVM | ZNF619 | RTN4RL1 | 4.66e+00 | 9.81e-01 | 3.12e+00 | 6.11e-03 | Male-biased |
| UVM | ZNF662 | RTN4RL1 | 4.71e+00 | 9.85e-01 | 2.91e+00 | 3.54e-03 | Male-biased |
| UVM | ZNF682 | RTN4RL1 | 4.64e+00 | 9.82e-01 | 2.97e+00 | 4.69e-03 | Male-biased |
| UVM | ZNF860 | RTN4RL1 | 4.74e+00 | 9.85e-01 | 2.97e+00 | 3.78e-03 | Male-biased |
| RTN4RL1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for RTN4RL1 |
| RBPs related to ES in RTN4RL1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| RTN4RL1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000185924 | KCNQ1OT1,hsa-mir-133b,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | TMEM147-AS1,hsa-mir-133b,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | KCNQ1OT1,hsa-mir-141,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | TMEM147-AS1,hsa-mir-141,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | AC232271.1,hsa-mir-141,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | KCNQ1OT1,hsa-mir-200a,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | TMEM147-AS1,hsa-mir-200a,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | AC232271.1,hsa-mir-200a,RTN4RL1 | Female-specific ceRNA | TCGA-LIHC |
| ENSG00000185924 | STRA6LP,hsa-mir-149,RTN4RL1 | Male-specific ceRNA | TCGA-LUAD |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17833890 | chr17:1542797:C:G | - | 0.146983026117171 | 0.025216339903806 | LGG | Female-baised eQTL |
| rs79875459 | chr17:5858036:G:T | - | 0.161518855368208 | 0.0345981373592665 | KIRC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs117064519 | chr17:8185072:T:C | - | 0.0650810541488294 | 0.0467481069145771 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000185924 |
| CpG Site: cg12967327 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.42372713936631 | |
 | Gene ID: ENSG00000185924 |
| CpG Site: cg23094620 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.143846871434137 | |
 | Gene ID: ENSG00000185924 |
| CpG Site: cg14571092 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.460491294063219 | |
 | Gene ID: ENSG00000185924 |
| CpG Site: cg25813630 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.252940447649765 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg12967327 | chr17:2002896 | gene | -0.42372713936631 | 2.85572393464002e-09 | -0.6787595222680188 | 4.545412228892923e-12 | PAAD |
| cg23094620 | chr17:2012242 | gene | -0.143846871434137 | 1.12393282806309e-05 | -0.3361727192531963 | 3.736822469325631e-08 | LUAD |
| cg14571092 | chr17:1967053 | gene | -0.460491294063219 | 1.18007097763944e-16 | -0.7299848484955291 | 2.1279377507736714e-21 | LIHC |
| cg25813630 | chr17:1974806 | gene | -0.252940447649765 | 4.52159105581904e-08 | -0.5647285928730363 | 1.511492138276304e-11 | LIHC |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of RTN4RL1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
