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Gene: ENSG00000185627 |
Summary for PSMD13 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000185627 | Gene symbol | PSMD13 |
| Gene name | proteasome 26S subunit, non-ATPase 13 | |
| HGNC | 9558 | |
| Entrez ID | 5719 | |
| Gene type | protein_coding | |
| Synonyms | PSMD13|p40.5|Rpn9 | |
| UniProtAcc | Q9UNM6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for PSMD13 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for PSMD13 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for PSMD13 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for PSMD13 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for PSMD13 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for PSMD13 |
| TFs related to PSMD13. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PSMD13 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for PSMD13 |
| RBPs related to ES in PSMD13. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | KHDRBS1 | exon_skip_55175 | 7.69e+00 | 9.84e-01 | 7.19e+00 | 5.56e-03 | Male-biased |
| ACC | MSI1 | exon_skip_55175 | 1.42e+01 | 9.94e-01 | 1.37e+01 | 5.79e-03 | Male-biased |
| UVM | MSI1 | exon_skip_55175 | 1.40e+01 | 1.34e-03 | 1.45e+01 | 9.99e-01 | Female-biased |
| KIRP | MSI1 | exon_skip_55175 | 1.40e+01 | 3.82e-04 | 1.46e+01 | 1.00e+00 | Female-biased |
| KIRP | MSI1 | exon_skip_55179 | 1.54e+01 | 9.17e-04 | 1.59e+01 | 9.99e-01 | Female-biased |
| BRCA | MSI1 | exon_skip_55179 | 1.53e+01 | 9.95e-01 | 1.47e+01 | 5.40e-03 | Male-biased |
| ESCA | MSI1 | exon_skip_55175 | 1.31e+01 | 4.51e-03 | 1.36e+01 | 9.95e-01 | Female-biased |
| ESCA | MSI1 | exon_skip_55179 | 1.41e+01 | 6.64e-04 | 1.49e+01 | 9.99e-01 | Female-biased |
| READ | KHDRBS1 | exon_skip_55175 | 7.33e+00 | 9.86e-01 | 6.88e+00 | 2.61e-03 | Male-biased |
| READ | MSI1 | exon_skip_55175 | 1.45e+01 | 9.99e-01 | 1.39e+01 | 1.01e-03 | Male-biased |
| THCA | MSI1 | exon_skip_55179 | 1.44e+01 | 2.35e-04 | 1.51e+01 | 1.00e+00 | Female-biased |
| MESO | MSI1 | exon_skip_55175 | 1.37e+01 | 1.82e-03 | 1.42e+01 | 9.98e-01 | Female-biased |
| LGG | SRSF1 | exon_skip_55182 | 8.54e+00 | 7.98e-03 | 8.90e+00 | 9.87e-01 | Female-biased |
| KICH | MSI1 | exon_skip_55179 | 1.47e+01 | 4.62e-04 | 1.53e+01 | 9.99e-01 | Female-biased |
| BLCA | MSI1 | exon_skip_55179 | 1.51e+01 | 1.07e-03 | 1.57e+01 | 9.99e-01 | Female-biased |
| HNSC | MSI1 | exon_skip_55179 | 1.50e+01 | 4.03e-04 | 1.56e+01 | 1.00e+00 | Female-biased |
| SARC | MSI1 | exon_skip_55179 | 1.57e+01 | 9.99e-01 | 1.50e+01 | 9.48e-04 | Male-biased |
| PSMD13 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1487878 | chr11:7292443:G:C | - | 0.0720527766250739 | 0.0493261788483116 | SARC | Female-baised eQTL |
| rs10768939 | chr11:5412932:A:G | - | -0.174512122255285 | 0.0404259981508111 | KIRP | Female-baised eQTL |
| rs1498472 | chr11:5423974:T:C | - | -0.172347899933874 | 0.0487069372504891 | KIRP | Female-baised eQTL |
| rs11023827 | chr11:2694494:A:C | - | -0.129826357729414 | 0.0165554892160513 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10839728 | chr11:7128344:T:G | - | 0.0491437917477758 | 0.0453380213073267 | LGG | Male-baised eQTL |
| rs7948662 | chr11:5379741:G:A | - | 0.0342319557333254 | 0.0474209678042208 | KIRC | Male-baised eQTL |
| rs55709035 | chr11:5367012:G:C | - | 0.0340476525730977 | 0.0480179680485788 | KIRC | Male-baised eQTL |
| rs34120424 | chr11:5367672:G:C | - | 0.0340476525730977 | 0.0480179680485788 | KIRC | Male-baised eQTL |
| rs2647607 | chr11:5364658:A:G | - | 0.0339744500597161 | 0.0486850883838462 | KIRC | Male-baised eQTL |
| rs4758176 | chr11:5897770:T:C | - | -0.0924021177182921 | 0.0438693451050191 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_55173 | chr11:244040:244075 | Frame-shift | rs2272566 | chr11:244552:A:G | Distant downstream | -0.0340974541768045 | 0.017380210093832 | PCPG | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of PSMD13 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000185627 | PSMD13 | C0019693 | HIV Infections | 1 | CTD_human |
| ENSG00000185627 | PSMD13 | C4505456 | HIV Coinfection | 1 | CTD_human |
