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Gene: ENSG00000185479 |
Summary for KRT6B |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000185479 | Gene symbol | KRT6B |
| Gene name | keratin 6B | |
| HGNC | 6444 | |
| Entrez ID | 3854 | |
| Gene type | protein_coding | |
| Synonyms | KRT6B| | |
| UniProtAcc | P04259 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for KRT6B |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KRT6B | 2.80e+03 | -4.34e+00 | 8.05e-01 | -5.39e+00 | 7.04e-08 | 7.86e-06 | BRCA |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KRT6B | 3.39e+03 | 9.98e+00 | 1.25e+00 | 8.00e+00 | 1.23e-15 | 9.59e-14 | BLCA |
| KRT6B | 6.84e+04 | 4.47e+00 | 1.02e+00 | 4.39e+00 | 1.16e-05 | 1.74e-04 | ESCA |
| KRT6B | 3.63e+02 | 5.63e+00 | 1.12e+00 | 5.03e+00 | 4.80e-07 | 3.71e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| KRT6B | 8.45e+02 | 3.89e+00 | 9.30e-01 | 4.18e+00 | 2.91e-05 | 3.31e-04 | STAD |
| KRT6B | 3.10e+02 | 6.18e+00 | 8.83e-01 | 7.00e+00 | 2.65e-12 | 1.09e-10 | READ |
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Sex-biased somatic mutation for KRT6B |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for KRT6B |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg02068361 | chr12:52452146 | CGI:chr12:52367050-52367315 | promoter | 5.15e-01 | 7.13e-01 | -3.91e+00 | 9.07e-05 | 6.71e-04 | -1.98e-01 |
| LIHC | cg11601375 | chr12:52452289 | CGI:chr12:52367050-52367315 | promoter | 6.80e-01 | 8.61e-01 | 2.36e+00 | 1.83e-02 | 2.08e-02 | -1.81e-01 |
| LIHC | cg13221107 | chr12:52452304 | CGI:chr12:52367050-52367315 | promoter | 6.29e-01 | 8.51e-01 | 3.75e+00 | 1.79e-04 | 3.45e-04 | -2.22e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg13221107 | chr12:52452304 | CGI:chr12:52367050-52367315 | promoter | 7.95e-01 | 6.81e-01 | 2.50e+00 | 1.23e-02 | 1.37e-02 | 1.14e-01 |
| BLCA | cg13221107 | chr12:52452304 | CGI:chr12:52367050-52367315 | promoter | 5.78e-01 | 8.28e-01 | 2.31e+00 | 2.08e-02 | 2.79e-02 | -2.49e-01 |
Top |
Exon skipping events with PSI in TCGA for KRT6B |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for KRT6B |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for KRT6B |
| TFs related to KRT6B. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | ZNF594 | KRT6B | 5.78e+00 | 9.80e-01 | 5.13e+00 | 1.88e-02 | Male-biased |
| DLBC | ELF3 | KRT6B | 4.55e+00 | 3.12e-03 | 5.77e+00 | 9.96e-01 | Female-biased |
| DLBC | NR1I2 | KRT6B | 6.40e+00 | 9.90e-01 | 5.53e+00 | 9.89e-03 | Male-biased |
| DLBC | POU3F3 | KRT6B | 4.68e+00 | 1.66e-03 | 6.10e+00 | 9.98e-01 | Female-biased |
| DLBC | POU4F1 | KRT6B | 5.27e+00 | 4.17e-03 | 6.41e+00 | 9.95e-01 | Female-biased |
| DLBC | POU4F3 | KRT6B | 5.42e+00 | 6.09e-03 | 6.46e+00 | 9.93e-01 | Female-biased |
| DLBC | RUNX1 | KRT6B | 5.55e+00 | 9.85e-01 | 4.77e+00 | 1.39e-02 | Male-biased |
| DLBC | ZNF418 | KRT6B | 1.29e+00 | 3.04e-06 | 4.65e+00 | 9.95e-01 | Female-biased |
| DLBC | ZNF506 | KRT6B | 5.54e+00 | 9.97e-01 | 4.15e+00 | 1.39e-03 | Male-biased |
| DLBC | ZNF594 | KRT6B | 5.80e+00 | 9.97e-01 | 4.50e+00 | 1.95e-03 | Male-biased |
| DLBC | ZNF615 | KRT6B | 5.34e+00 | 1.66e-02 | 6.11e+00 | 9.83e-01 | Female-biased |
| DLBC | ZNF716 | KRT6B | 4.33e+00 | 3.04e-03 | 5.56e+00 | 9.96e-01 | Female-biased |
| DLBC | ZNF765 | KRT6B | 4.62e+00 | 9.92e-01 | 3.36e+00 | 2.12e-03 | Male-biased |
| ESCA | ZNF304 | KRT6B | 3.22e+00 | 8.71e-03 | 4.04e+00 | 9.81e-01 | Female-biased |
| ESCA | ZNF770 | KRT6B | 2.40e+00 | 8.51e-04 | 3.70e+00 | 9.81e-01 | Female-biased |
| LGG | ZNF304 | KRT6B | 3.64e+00 | 6.22e-03 | 4.22e+00 | 9.81e-01 | Female-biased |
| LGG | ZNF468 | KRT6B | 4.44e+00 | 6.92e-03 | 5.01e+00 | 9.90e-01 | Female-biased |
| LGG | ZNF566 | KRT6B | 4.32e+00 | 6.20e-03 | 4.91e+00 | 9.90e-01 | Female-biased |
| LGG | ZNF765 | KRT6B | 4.75e+00 | 1.24e-02 | 5.21e+00 | 9.85e-01 | Female-biased |
| LGG | ZSCAN22 | KRT6B | 4.23e+00 | 8.22e-03 | 4.76e+00 | 9.87e-01 | Female-biased |
| PAAD | ELF3 | KRT6B | 5.71e+00 | 9.89e-01 | 4.87e+00 | 9.73e-03 | Male-biased |
| PAAD | ELF4 | KRT6B | 5.05e+00 | 1.37e-02 | 5.79e+00 | 9.85e-01 | Female-biased |
| PAAD | ELF5 | KRT6B | 5.59e+00 | 9.93e-01 | 4.65e+00 | 5.81e-03 | Male-biased |
| PAAD | HAND2 | KRT6B | 5.85e+00 | 9.81e-01 | 5.13e+00 | 1.80e-02 | Male-biased |
| PAAD | POU3F3 | KRT6B | 5.92e+00 | 9.94e-01 | 4.96e+00 | 5.40e-03 | Male-biased |
| PAAD | POU4F1 | KRT6B | 6.26e+00 | 9.89e-01 | 5.43e+00 | 1.01e-02 | Male-biased |
| PAAD | POU4F3 | KRT6B | 6.40e+00 | 9.87e-01 | 5.61e+00 | 1.24e-02 | Male-biased |
| PAAD | REL | KRT6B | 5.48e+00 | 9.89e-01 | 4.62e+00 | 9.18e-03 | Male-biased |
| PAAD | ZNF615 | KRT6B | 6.02e+00 | 9.85e-01 | 5.25e+00 | 1.39e-02 | Male-biased |
| PAAD | ZNF716 | KRT6B | 5.66e+00 | 9.88e-01 | 4.84e+00 | 1.11e-02 | Male-biased |
| PCPG | NR1I2 | KRT6B | 5.90e+00 | 9.82e-01 | 5.21e+00 | 1.66e-02 | Male-biased |
| PCPG | ZNF304 | KRT6B | 4.21e+00 | 9.84e-01 | 3.23e+00 | 4.47e-03 | Male-biased |
| PCPG | ZNF468 | KRT6B | 4.70e+00 | 9.93e-01 | 3.50e+00 | 1.62e-03 | Male-biased |
| PCPG | ZNF506 | KRT6B | 5.28e+00 | 9.91e-01 | 4.40e+00 | 7.16e-03 | Male-biased |
| PCPG | ZNF566 | KRT6B | 4.30e+00 | 9.87e-01 | 3.24e+00 | 3.05e-03 | Male-biased |
| PCPG | ZNF594 | KRT6B | 5.13e+00 | 9.92e-01 | 4.18e+00 | 5.17e-03 | Male-biased |
| PCPG | ZNF765 | KRT6B | 4.92e+00 | 9.92e-01 | 3.92e+00 | 4.08e-03 | Male-biased |
| PCPG | ZSCAN22 | KRT6B | 4.35e+00 | 9.89e-01 | 3.22e+00 | 2.27e-03 | Male-biased |
| SARC | ELF3 | KRT6B | 5.10e+00 | 3.06e-03 | 5.96e+00 | 9.96e-01 | Female-biased |
| SARC | PBX4 | KRT6B | 6.42e+00 | 1.45e-02 | 7.00e+00 | 9.85e-01 | Female-biased |
| SARC | POU3F3 | KRT6B | 5.25e+00 | 2.37e-03 | 6.16e+00 | 9.97e-01 | Female-biased |
| SARC | POU4F1 | KRT6B | 5.79e+00 | 5.13e-03 | 6.56e+00 | 9.94e-01 | Female-biased |
| SARC | POU4F3 | KRT6B | 5.90e+00 | 6.84e-03 | 6.62e+00 | 9.93e-01 | Female-biased |
| SARC | ZNF304 | KRT6B | 4.68e+00 | 9.94e-01 | 3.50e+00 | 3.03e-04 | Male-biased |
| SARC | ZNF418 | KRT6B | 2.61e+00 | 1.22e-04 | 4.08e+00 | 9.87e-01 | Female-biased |
| SARC | ZNF468 | KRT6B | 5.36e+00 | 9.98e-01 | 4.12e+00 | 2.23e-04 | Male-biased |
| SARC | ZNF506 | KRT6B | 5.59e+00 | 9.97e-01 | 4.66e+00 | 1.18e-03 | Male-biased |
| SARC | ZNF566 | KRT6B | 5.48e+00 | 9.98e-01 | 4.30e+00 | 3.23e-04 | Male-biased |
| SARC | ZNF594 | KRT6B | 6.32e+00 | 9.98e-01 | 5.40e+00 | 1.25e-03 | Male-biased |
| SARC | ZNF615 | KRT6B | 5.68e+00 | 1.41e-02 | 6.27e+00 | 9.85e-01 | Female-biased |
| SARC | ZNF716 | KRT6B | 4.93e+00 | 9.65e-03 | 5.59e+00 | 9.89e-01 | Female-biased |
| SARC | ZNF765 | KRT6B | 5.27e+00 | 9.98e-01 | 4.07e+00 | 2.85e-04 | Male-biased |
| SARC | ZSCAN22 | KRT6B | 5.27e+00 | 9.97e-01 | 4.13e+00 | 3.78e-04 | Male-biased |
| THYM | ELF3 | KRT6B | 4.99e+00 | 8.48e-03 | 5.72e+00 | 9.90e-01 | Female-biased |
| THYM | POU3F3 | KRT6B | 5.08e+00 | 5.90e-03 | 5.90e+00 | 9.93e-01 | Female-biased |
| THYM | POU4F1 | KRT6B | 5.50e+00 | 7.07e-03 | 6.28e+00 | 9.92e-01 | Female-biased |
| THYM | POU4F3 | KRT6B | 5.62e+00 | 1.01e-02 | 6.31e+00 | 9.89e-01 | Female-biased |
| THYM | ZNF418 | KRT6B | 3.67e+00 | 8.65e-04 | 4.97e+00 | 9.95e-01 | Female-biased |
| THYM | ZNF615 | KRT6B | 5.46e+00 | 1.65e-02 | 6.03e+00 | 9.83e-01 | Female-biased |
| THYM | ZNF716 | KRT6B | 4.72e+00 | 7.09e-03 | 5.50e+00 | 9.91e-01 | Female-biased |
| UVM | ELF3 | KRT6B | 3.84e+00 | 2.02e-03 | 5.91e+00 | 9.96e-01 | Female-biased |
| UVM | IRX2 | KRT6B | 6.05e+00 | 1.40e-02 | 7.20e+00 | 9.86e-01 | Female-biased |
| UVM | NR1I2 | KRT6B | 6.11e+00 | 9.82e-01 | 5.06e+00 | 1.72e-02 | Male-biased |
| UVM | PBX4 | KRT6B | 5.26e+00 | 6.75e-03 | 6.79e+00 | 9.93e-01 | Female-biased |
| UVM | POU3F3 | KRT6B | 3.74e+00 | 8.27e-04 | 6.16e+00 | 9.98e-01 | Female-biased |
| UVM | POU4F1 | KRT6B | 4.35e+00 | 3.16e-03 | 6.24e+00 | 9.96e-01 | Female-biased |
| UVM | POU4F3 | KRT6B | 4.54e+00 | 4.66e-03 | 6.25e+00 | 9.94e-01 | Female-biased |
| UVM | RUNX1 | KRT6B | 5.66e+00 | 9.80e-01 | 4.61e+00 | 1.72e-02 | Male-biased |
| UVM | ZNF263 | KRT6B | 4.77e+00 | 9.84e-01 | 3.12e+00 | 4.95e-03 | Male-biased |
| UVM | ZNF304 | KRT6B | 5.08e+00 | 9.92e-01 | 2.77e+00 | 1.05e-03 | Male-biased |
| UVM | ZNF418 | KRT6B | 1.52e+00 | 1.10e-05 | 5.53e+00 | 9.97e-01 | Female-biased |
| UVM | ZNF468 | KRT6B | 5.59e+00 | 9.97e-01 | 2.89e+00 | 3.65e-04 | Male-biased |
| UVM | ZNF506 | KRT6B | 6.13e+00 | 9.98e-01 | 3.88e+00 | 1.31e-03 | Male-biased |
| UVM | ZNF566 | KRT6B | 5.17e+00 | 9.93e-01 | 2.96e+00 | 1.36e-03 | Male-biased |
| UVM | ZNF594 | KRT6B | 5.71e+00 | 9.93e-01 | 4.02e+00 | 4.71e-03 | Male-biased |
| UVM | ZNF615 | KRT6B | 4.54e+00 | 7.27e-03 | 6.03e+00 | 9.91e-01 | Female-biased |
| UVM | ZNF716 | KRT6B | 3.87e+00 | 3.55e-03 | 5.70e+00 | 9.94e-01 | Female-biased |
| UVM | ZNF765 | KRT6B | 5.82e+00 | 9.98e-01 | 3.14e+00 | 3.87e-04 | Male-biased |
| UVM | ZSCAN22 | KRT6B | 5.17e+00 | 9.93e-01 | 2.91e+00 | 1.20e-03 | Male-biased |
| KRT6B related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for KRT6B |
| RBPs related to ES in KRT6B. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| KRT6B related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs71461330 | chr12:57604939:C:T | - | 0.141406072029046 | 0.0331694989994691 | READ | Female-baised eQTL |
| rs1806652 | chr12:57605318:C:T | - | 0.141406072029046 | 0.0331694989994691 | READ | Female-baised eQTL |
| rs184301136 | chr12:57591140:C:G | - | 0.140761718763681 | 0.0356929248087662 | READ | Female-baised eQTL |
| rs11172262 | chr12:57596352:G:A | - | 0.140761718763681 | 0.0356929248087662 | READ | Female-baised eQTL |
| rs55681800 | chr12:43575106:C:T | - | 0.114807006273633 | 0.0408778891565439 | LUSC | Female-baised eQTL |
| rs1949083 | chr12:43477426:G:T | - | 0.0976191177643816 | 0.0478310551461005 | LUSC | Female-baised eQTL |
| rs73276934 | chr12:43177622:C:A | - | 0.0951770910535891 | 0.0490526283809035 | LUSC | Female-baised eQTL |
| rs73276936 | chr12:43178863:T:A | - | 0.0951770910535891 | 0.0490526283809035 | LUSC | Female-baised eQTL |
| rs61237420 | chr12:49282941:C:T | - | 0.0861586865673853 | 0.0368332442153118 | STAD | Female-baised eQTL |
| rs111883829 | chr12:49283559:C:T | - | 0.0861586865673853 | 0.0368332442153118 | STAD | Female-baised eQTL |
| rs190801170 | chr12:56784029:A:G | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs60504608 | chr12:56786972:T:C | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs367594994 | chr12:56789842:G:A | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs187390529 | chr12:56789885:C:T | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs183202132 | chr12:56789961:C:T | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs189021632 | chr12:56790012:G:A | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs61937787 | chr12:56795271:C:T | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs56858561 | chr12:56801861:T:C | - | 0.184315447060659 | 0.0368297025524006 | BLCA | Female-baised eQTL |
| rs2277381 | chr12:51912243:C:G | - | 0.118704358743051 | 0.027777929396668 | COAD | Female-baised eQTL |
| rs3782480 | chr12:51911285:G:T | - | 0.11856204676532 | 0.0280333436116213 | COAD | Female-baised eQTL |
| rs12578436 | chr12:51911916:G:A | - | 0.11856204676532 | 0.0280333436116213 | COAD | Female-baised eQTL |
| rs117487599 | chr12:51898200:G:A | - | 0.0988236685841233 | 0.0285836891788399 | COAD | Female-baised eQTL |
| rs2277383 | chr12:51920604:T:G | - | 0.111557432538746 | 0.0443182493961294 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2022528 | chr12:47587530:G:A | - | 0.0628225466554941 | 0.0270883711756239 | LUSC | Male-baised eQTL |
| rs6581226 | chr12:59043630:A:C | - | -0.0878941820596781 | 0.0111598252368376 | BLCA | Male-baised eQTL |
| rs3782471 | chr12:51362112:G:A | - | -0.0373657812838471 | 0.0257200827096852 | BLCA | Male-baised eQTL |
| rs10783433 | chr12:51361509:G:A | - | -0.0358474005656328 | 0.0336691635891754 | BLCA | Male-baised eQTL |
| rs10876167 | chr12:51372735:G:C | - | 0.0584156815606637 | 0.00838679365228802 | LUAD | Male-baised eQTL |
| rs10506397 | chr12:59641704:T:C | - | 0.043893488420176 | 0.0114430939345439 | COAD | Male-baised eQTL |
| rs1027477 | chr12:59649957:C:T | - | 0.0438297786629397 | 0.0115858041273548 | COAD | Male-baised eQTL |
| rs11173102 | chr12:59612524:G:C | - | 0.0421853181905366 | 0.0150222620544478 | COAD | Male-baised eQTL |
| rs17122775 | chr12:59644211:T:C | - | 0.0419240822547429 | 0.0167057331129692 | COAD | Male-baised eQTL |
| rs61930678 | chr12:43836918:A:G | - | 0.0619930908118764 | 0.0183697479682292 | COAD | Male-baised eQTL |
| rs17122696 | chr12:59617064:G:A | - | 0.0407312292157408 | 0.0187905015235621 | COAD | Male-baised eQTL |
| rs61567111 | chr12:43815960:C:T | - | 0.0599134838703233 | 0.0227614859224587 | COAD | Male-baised eQTL |
| rs56066688 | chr12:43912802:T:G | - | 0.0597518178073307 | 0.0232834478358869 | COAD | Male-baised eQTL |
| rs11172754 | chr12:58838962:G:A | - | 0.0377049500892191 | 0.0284533050708451 | COAD | Male-baised eQTL |
| rs10877172 | chr12:58841615:T:C | - | 0.041849964906655 | 0.0300727794277702 | COAD | Male-baised eQTL |
| rs55914098 | chr12:43915474:A:G | - | 0.0554937015160564 | 0.0327012681269867 | COAD | Male-baised eQTL |
| rs12368989 | chr12:46349563:G:C | - | 0.043755986753971 | 0.0342345969088388 | COAD | Male-baised eQTL |
| rs11532404 | chr12:58830301:G:A | - | 0.0356982528067329 | 0.0383114912880185 | COAD | Male-baised eQTL |
| rs7315476 | chr12:58832402:C:T | - | 0.0356982528067329 | 0.0383114912880185 | COAD | Male-baised eQTL |
| rs10877170 | chr12:58837592:T:G | - | 0.0356982528067329 | 0.0383114912880185 | COAD | Male-baised eQTL |
| rs10877171 | chr12:58838015:G:C | - | 0.0356982528067329 | 0.0383114912880185 | COAD | Male-baised eQTL |
| rs7488630 | chr12:58840178:T:C | - | 0.0356982528067329 | 0.0383114912880185 | COAD | Male-baised eQTL |
| rs13377809 | chr12:43809127:A:G | - | 0.0543544754831934 | 0.0390851420641421 | COAD | Male-baised eQTL |
| rs60715781 | chr12:43859794:C:T | - | 0.0537341035050718 | 0.0401986938639029 | COAD | Male-baised eQTL |
| rs56134007 | chr12:43879169:A:T | - | 0.0537341035050718 | 0.0401986938639029 | COAD | Male-baised eQTL |
| rs61930709 | chr12:43888295:A:G | - | 0.0537341035050718 | 0.0401986938639029 | COAD | Male-baised eQTL |
| rs1587254 | chr12:58828938:T:C | - | 0.0352815681172194 | 0.0410325638703972 | COAD | Male-baised eQTL |
| rs11172746 | chr12:58829000:G:A | - | 0.0352815681172194 | 0.0410325638703972 | COAD | Male-baised eQTL |
| rs7133253 | chr12:58829240:T:C | - | 0.0352815681172194 | 0.0410325638703972 | COAD | Male-baised eQTL |
| rs11531178 | chr12:58829438:C:A | - | 0.0352815681172194 | 0.0410325638703972 | COAD | Male-baised eQTL |
| rs11531179 | chr12:58829897:T:C | - | 0.0352815681172194 | 0.0410325638703972 | COAD | Male-baised eQTL |
| rs11533651 | chr12:58830086:C:T | - | 0.0352815681172194 | 0.0410325638703972 | COAD | Male-baised eQTL |
| rs56312131 | chr12:43913696:G:A | - | 0.0520449808148817 | 0.045883968442916 | COAD | Male-baised eQTL |
| rs11172758 | chr12:58844604:A:G | - | 0.0342485282064984 | 0.0471415442128078 | COAD | Male-baised eQTL |
| rs2221004 | chr12:58828595:T:C | - | 0.0344631912324391 | 0.0484567479395391 | COAD | Male-baised eQTL |
| rs1587255 | chr12:58828636:T:C | - | 0.0344028988840727 | 0.0489346168458073 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of KRT6B |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000185479 | KRT6B | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| ENSG00000185479 | KRT6B | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| ENSG00000185479 | KRT6B | C0153381 | Malignant neoplasm of mouth | 1 | CTD_human |
| ENSG00000185479 | KRT6B | C0265334 | Pachyonychia Congenita | 1 | CTD_human |
| ENSG00000185479 | KRT6B | C1706595 | Pachyonychia Congenita, Jadassohn Lewandowsky Type | 1 | CTD_human |
| ENSG00000185479 | KRT6B | C1721007 | Pachyonychia Congenita, Type 2 (disorder) | 1 | CTD_human |
