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Gene: ENSG00000185437 |
Summary for SH3BGR |
Gene summary |
| Gene information | Ensembl ID | ENSG00000185437 | Gene symbol | SH3BGR |
| Gene name | SH3 domain binding glutamate rich protein | |
| HGNC | 10822 | |
| Entrez ID | 6450 | |
| Gene type | protein_coding | |
| Synonyms | SH3BGR|21-GARP | |
| UniProtAcc | P55822 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SH3BGR |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SH3BGR | 1.32e+02 | -1.68e+00 | 3.64e-01 | -4.61e+00 | 4.06e-06 | 7.62e-05 | ESCA |
| SH3BGR | 1.69e+02 | -1.03e+00 | 3.96e-01 | -2.61e+00 | 9.06e-03 | 2.29e-02 | CHOL |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SH3BGR | 1.13e+02 | -2.96e+00 | 3.92e-01 | -7.57e+00 | 3.87e-14 | 2.58e-12 | READ |
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Sex-biased somatic mutation for SH3BGR |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SH3BGR |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg19946699 | chr21:39445719 | CGI:chr21:39445376-39446047 | promoter | 1.46e-01 | 2.52e-01 | -3.11e+00 | 1.86e-03 | 3.70e-03 | -1.06e-01 |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg12638745 | chr21:39444538 | CGI:chr21:39445376-39446047 | promoter | 5.98e-01 | 4.90e-01 | 2.65e+00 | 8.15e-03 | 1.53e-02 | 1.09e-01 |
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Exon skipping events with PSI in TCGA for SH3BGR |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Landscape of exon skipping events across multiple cancer types. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SH3BGR |
| ∗Please access CAeditome for RNA editing annotation. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SH3BGR |
TFs related to SH3BGR.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | NRF1 | SH3BGR | 3.92e+00 | 9.86e-01 | 2.35e+00 | 7.16e-05 | Male-biased |
| SKCM | CDX2 | SH3BGR | 4.42e+00 | 9.84e-01 | 2.89e+00 | 2.31e-03 | Male-biased |
| SKCM | DUX4 | SH3BGR | 4.97e+00 | 9.86e-01 | 3.83e+00 | 7.53e-03 | Male-biased |
| SKCM | EMX1 | SH3BGR | 5.01e+00 | 9.86e-01 | 3.89e+00 | 8.21e-03 | Male-biased |
| SKCM | EMX2 | SH3BGR | 4.87e+00 | 9.87e-01 | 3.61e+00 | 5.37e-03 | Male-biased |
| SKCM | EN1 | SH3BGR | 5.03e+00 | 9.86e-01 | 3.92e+00 | 8.42e-03 | Male-biased |
| SKCM | FOXG1 | SH3BGR | 4.54e+00 | 9.88e-01 | 2.71e+00 | 8.70e-04 | Male-biased |
| SKCM | FOXL1 | SH3BGR | 4.61e+00 | 9.89e-01 | 2.83e+00 | 1.03e-03 | Male-biased |
| SKCM | FOXP3 | SH3BGR | 4.83e+00 | 9.89e-01 | 3.43e+00 | 3.51e-03 | Male-biased |
| SKCM | GBX2 | SH3BGR | 5.24e+00 | 9.81e-01 | 4.31e+00 | 1.45e-02 | Male-biased |
| SKCM | IRX3 | SH3BGR | 5.20e+00 | 9.87e-01 | 4.10e+00 | 8.63e-03 | Male-biased |
| SKCM | LHX3 | SH3BGR | 4.81e+00 | 9.90e-01 | 3.23e+00 | 2.03e-03 | Male-biased |
| SKCM | POU3F2 | SH3BGR | 4.61e+00 | 9.89e-01 | 2.77e+00 | 8.22e-04 | Male-biased |
| SKCM | POU6F2 | SH3BGR | 5.10e+00 | 9.90e-01 | 3.78e+00 | 4.54e-03 | Male-biased |
| SKCM | ZFP82 | SH3BGR | 4.43e+00 | 9.85e-01 | 2.76e+00 | 1.49e-03 | Male-biased |
| SKCM | ZNF250 | SH3BGR | 4.54e+00 | 9.83e-01 | 3.28e+00 | 5.29e-03 | Male-biased |
| SKCM | ZNF334 | SH3BGR | 4.96e+00 | 9.94e-01 | 2.74e+00 | 2.10e-04 | Male-biased |
| SKCM | ZNF418 | SH3BGR | 5.29e+00 | 9.96e-01 | 2.86e+00 | 1.00e-04 | Male-biased |
| SKCM | ZNF879 | SH3BGR | 4.72e+00 | 9.90e-01 | 2.87e+00 | 8.01e-04 | Male-biased |
SH3BGR related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SH3BGR |
RBPs related to ES in SH3BGR.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LGG | PABPN1 | exon_skip_359892 | 9.28e+00 | 9.83e-01 | 8.98e+00 | 1.42e-02 | Male-biased |
SH3BGR related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Gene ID: ENSG00000185437 | |
| SNP ID: rs596289 | |
| Position to Gene: gene | |
| Male Effect: 0.1288210761485 | |
| Female Effect: - |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4818244 | chr21:41522634:T:C | - | -0.143589065527699 | 0.0328900096233151 | READ | Female-baised eQTL |
| rs77477690 | chr21:30980522:T:G | - | 0.151141180850235 | 0.0390218160439041 | HNSC | Female-baised eQTL |
| rs111812774 | chr21:42418121:A:G | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs112141973 | chr21:42418360:A:G | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs111598256 | chr21:42419304:C:A | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs117346108 | chr21:42420224:T:G | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs55675850 | chr21:42424472:T:C | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs113862835 | chr21:42426498:A:G | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs79268926 | chr21:42429521:G:A | - | 0.317283268750569 | 0.0399081734606378 | GBM | Female-baised eQTL |
| rs36014071 | chr21:41054539:T:G | - | 0.132137018356128 | 3.52647193228151e-05 | KIRC | Female-baised eQTL |
| rs8130241 | chr21:41664668:C:T | - | 0.0955272067788993 | 0.00905570953417138 | KIRC | Female-baised eQTL |
| rs2835529 | chr21:36895193:C:T | - | 0.104460864619462 | 0.0119895069920662 | KIRC | Female-baised eQTL |
| rs17371034 | chr21:30055262:T:C | - | 0.100264337201467 | 0.0180069537106258 | KIRC | Female-baised eQTL |
| rs6516945 | chr21:30056447:A:G | - | 0.100264337201467 | 0.0180069537106258 | KIRC | Female-baised eQTL |
| rs7276462 | chr21:30057318:C:T | - | 0.100264337201467 | 0.0180069537106258 | KIRC | Female-baised eQTL |
| rs17114242 | chr21:42057929:T:C | - | 0.0931217370720787 | 0.0260938004762651 | KIRC | Female-baised eQTL |
| rs57212550 | chr21:38255287:C:T | - | 0.0865516225451301 | 0.0306796960756155 | KIRC | Female-baised eQTL |
| rs147461878 | chr21:30049517:A:C | - | 0.0944106360335345 | 0.0351328284492843 | KIRC | Female-baised eQTL |
| rs75450420 | chr21:30137694:C:G | - | 0.104685219684402 | 0.0381131767943477 | KIRC | Female-baised eQTL |
| rs11910292 | chr21:44625568:A:T | - | 0.0716714267033065 | 0.0456293551577426 | KIRC | Female-baised eQTL |
| rs59683906 | chr21:36963115:T:A | - | 0.0920998833162561 | 0.0477017192554531 | KIRC | Female-baised eQTL |
| rs112090345 | chr21:36970925:C:T | - | 0.0919884041977419 | 0.0482770450588883 | KIRC | Female-baised eQTL |
| rs228108 | chr21:42585465:T:G | - | 0.216361954191086 | 0.000174285312879405 | BLCA | Female-baised eQTL |
| rs13052694 | chr21:42605502:A:C | - | 0.161801577102312 | 0.000682052467179127 | BLCA | Female-baised eQTL |
| rs13046013 | chr21:42605757:G:A | - | 0.161801577102312 | 0.000682052467179127 | BLCA | Female-baised eQTL |
| rs13048709 | chr21:42605776:A:G | - | 0.151448111284407 | 0.00170295195279191 | BLCA | Female-baised eQTL |
| rs2837091 | chr21:39575690:G:C | - | 0.147310330225833 | 0.0127057676120706 | BLCA | Female-baised eQTL |
| rs17751811 | chr21:39576934:T:C | - | 0.147310330225833 | 0.0127057676120706 | BLCA | Female-baised eQTL |
| rs117106633 | chr21:39579617:C:G | - | 0.14701106876364 | 0.0129089520293899 | BLCA | Female-baised eQTL |
| rs117206787 | chr21:39591402:T:G | - | 0.14701106876364 | 0.0129089520293899 | BLCA | Female-baised eQTL |
| rs77889953 | chr21:39573489:T:G | - | 0.146586621112582 | 0.0136626768445268 | BLCA | Female-baised eQTL |
| rs17824785 | chr21:39575425:G:A | - | 0.146586621112582 | 0.0136626768445268 | BLCA | Female-baised eQTL |
| rs7282821 | chr21:39572741:C:T | - | 0.146095995662407 | 0.014422041255667 | BLCA | Female-baised eQTL |
| rs74902297 | chr21:39583263:G:A | - | 0.13385613667368 | 0.0330199710001324 | BLCA | Female-baised eQTL |
| rs79219884 | chr21:39528054:A:T | - | 0.0803314361158933 | 0.0356836969351944 | LUAD | Female-baised eQTL |
| rs142967832 | chr21:39528543:T:C | - | 0.0803314361158933 | 0.0356836969351944 | LUAD | Female-baised eQTL |
| rs75477292 | chr21:39528681:G:A | - | 0.0803314361158933 | 0.0356836969351944 | LUAD | Female-baised eQTL |
| rs79874412 | chr21:39528934:G:A | - | 0.0803314361158933 | 0.0356836969351944 | LUAD | Female-baised eQTL |
| rs117114519 | chr21:39529245:T:C | - | 0.0803314361158933 | 0.0356836969351944 | LUAD | Female-baised eQTL |
| rs117465668 | chr21:39529256:C:G | - | 0.0803314361158933 | 0.0356836969351944 | LUAD | Female-baised eQTL |
| rs74813064 | chr21:39529636:T:C | - | 0.0801892745464863 | 0.0362491991589339 | LUAD | Female-baised eQTL |
| rs12627674 | chr21:39529859:G:C | - | 0.0801892745464863 | 0.0362491991589339 | LUAD | Female-baised eQTL |
| rs12627733 | chr21:39530279:C:T | - | 0.0801892745464863 | 0.0362491991589339 | LUAD | Female-baised eQTL |
| rs75510200 | chr21:39530536:C:T | - | 0.0801892745464863 | 0.0362491991589339 | LUAD | Female-baised eQTL |
| rs76727406 | chr21:39530686:T:C | - | 0.0801892745464863 | 0.0362491991589339 | LUAD | Female-baised eQTL |
| rs145226413 | chr21:39536154:A:G | - | 0.0800778883925037 | 0.0369159014707162 | LUAD | Female-baised eQTL |
| rs58548854 | chr21:43427940:C:A | - | 0.0675585106559334 | 0.0409867097526828 | LUAD | Female-baised eQTL |
| rs4818048 | chr21:39537025:C:G | - | 0.0767694802025257 | 0.0448329449370686 | LUAD | Female-baised eQTL |
| rs4818054 | chr21:39543698:C:G | - | 0.0761089811993769 | 0.0485539172900042 | LUAD | Female-baised eQTL |
| rs200887836 | chr21:39543965:A:T | - | 0.0761089811993769 | 0.0485539172900042 | LUAD | Female-baised eQTL |
| rs77804635 | chr21:39546384:C:G | - | 0.0761089811993769 | 0.0485539172900042 | LUAD | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10439624 | chr21:41111535:T:C | - | 0.0484766334522202 | 0.0110923317760697 | HNSC | Male-baised eQTL |
| rs13047759 | chr21:41112922:T:C | - | 0.0481817872812507 | 0.0123967294280007 | HNSC | Male-baised eQTL |
| rs2154547 | chr21:37592877:C:T | - | 0.0440252285225249 | 0.014866080188873 | HNSC | Male-baised eQTL |
| rs2154548 | chr21:37592981:G:A | - | 0.0440252285225249 | 0.014866080188873 | HNSC | Male-baised eQTL |
| rs12483512 | chr21:41114278:A:C | - | 0.0472272031911846 | 0.0153599169894256 | HNSC | Male-baised eQTL |
| rs9979131 | chr21:37593239:T:C | - | 0.0437298793637865 | 0.0175685958718711 | HNSC | Male-baised eQTL |
| rs9981372 | chr21:37593899:C:T | - | 0.043238016199057 | 0.0178531338739089 | HNSC | Male-baised eQTL |
| rs9305743 | chr21:41393021:G:A | - | 0.083552327721158 | 0.000552470038468225 | KIRC | Male-baised eQTL |
| rs73228024 | chr21:41388906:A:G | - | 0.0668116788957248 | 0.00876863322275533 | KIRC | Male-baised eQTL |
| rs218629 | chr21:36410045:A:C | - | -0.0652608808699626 | 0.0116911965024537 | KIRC | Male-baised eQTL |
| rs2837037 | chr21:39452235:C:T | gene | 0.0405552774015555 | 0.0127668162880168 | KIRC | Male-baised eQTL |
| rs9305740 | chr21:41387089:C:T | - | 0.057068257003711 | 0.0170746334682796 | KIRC | Male-baised eQTL |
| rs111666410 | chr21:31127473:C:T | - | 0.069792113020121 | 0.0203712606481364 | KIRC | Male-baised eQTL |
| rs9305739 | chr21:41386783:T:C | - | 0.0541626427074145 | 0.0265986002000483 | KIRC | Male-baised eQTL |
| rs13049605 | chr21:36400540:C:T | - | 0.0592363476989307 | 0.0297338095727364 | KIRC | Male-baised eQTL |
| rs35705526 | chr21:36402978:T:C | - | 0.0585803371649165 | 0.0306825692127256 | KIRC | Male-baised eQTL |
| rs8127355 | chr21:42591915:G:C | - | 0.0405337794479198 | 0.0306913788885651 | KIRC | Male-baised eQTL |
| rs8130703 | chr21:42591977:A:G | - | 0.0405337794479198 | 0.0306913788885651 | KIRC | Male-baised eQTL |
| rs138148812 | chr21:36392308:C:G | - | 0.059025911539803 | 0.0311187066488296 | KIRC | Male-baised eQTL |
| rs2226371 | chr21:38318457:T:C | - | -0.0373938439664816 | 0.0319410142984793 | KIRC | Male-baised eQTL |
| rs13046430 | chr21:36400292:C:G | - | 0.0587778428542393 | 0.0326759725276865 | KIRC | Male-baised eQTL |
| rs71330676 | chr21:36388694:T:C | - | 0.0582610075959362 | 0.0328241204883297 | KIRC | Male-baised eQTL |
| rs59627355 | chr21:36385172:T:A | - | 0.0567818235806226 | 0.0398424703703216 | KIRC | Male-baised eQTL |
| rs2833286 | chr21:31127259:A:G | - | 0.0613271784150724 | 0.0476103654976101 | KIRC | Male-baised eQTL |
| rs73191630 | chr21:31127408:C:T | - | 0.0613271784150724 | 0.0476103654976101 | KIRC | Male-baised eQTL |
| rs2835902 | chr21:37704615:A:G | - | 0.0558178511874518 | 0.0490411187264732 | KIRC | Male-baised eQTL |
| rs2096497 | chr21:37280477:T:A | - | -0.0461490779394774 | 0.023874391936393 | BLCA | Male-baised eQTL |
| rs9984898 | chr21:37266188:T:G | - | -0.0431105413597306 | 0.0394941653322008 | BLCA | Male-baised eQTL |
| rs73906034 | chr21:39416201:G:A | - | 0.112650462365107 | 2.92345781845225e-05 | LUAD | Male-baised eQTL |
| rs596289 | chr21:39502806:C:T | gene | 0.1288210761485 | 4.13808269151828e-05 | LUAD | Male-baised eQTL |
| rs2837022 | chr21:39424825:T:C | - | 0.125012880349455 | 0.000168337894902413 | LUAD | Male-baised eQTL |
| rs4281987 | chr21:39445823:G:A | promoter | 0.094322769803928 | 0.000872646209793587 | LUAD | Male-baised eQTL |
| rs940625 | chr21:39475270:A:G | gene | 0.105172312088182 | 0.00181326376427459 | LUAD | Male-baised eQTL |
| rs874221 | chr21:39475085:T:C | gene | 0.0758364464299362 | 0.00300377490929358 | LUAD | Male-baised eQTL |
| rs73906033 | chr21:39414393:G:A | - | 0.0839766852521024 | 0.00323402712012111 | LUAD | Male-baised eQTL |
| rs76503256 | chr21:39409603:A:T | - | 0.0837355973746975 | 0.00357495430230547 | LUAD | Male-baised eQTL |
| rs73906032 | chr21:39412314:G:A | - | 0.0810457595073448 | 0.00485385903943322 | LUAD | Male-baised eQTL |
| rs75822208 | chr21:39464544:G:A | gene | 0.114510121860248 | 0.00631039078112216 | LUAD | Male-baised eQTL |
| rs7279753 | chr21:39415474:C:G | - | 0.078634006154999 | 0.00853645912347712 | LUAD | Male-baised eQTL |
| rs2837017 | chr21:39416157:G:A | - | 0.078634006154999 | 0.00853645912347712 | LUAD | Male-baised eQTL |
| rs7276575 | chr21:39416294:T:C | - | 0.078634006154999 | 0.00853645912347712 | LUAD | Male-baised eQTL |
| rs143400985 | chr21:39469858:G:A | gene | 0.117000039051642 | 0.00861941341040161 | LUAD | Male-baised eQTL |
| rs2837015 | chr21:39414489:T:A | - | 0.0782721460378298 | 0.00933004588023348 | LUAD | Male-baised eQTL |
| rs78367934 | chr21:39414902:T:G | - | 0.0782721460378298 | 0.00933004588023348 | LUAD | Male-baised eQTL |
| rs77199433 | chr21:39440623:G:A | - | 0.0838620482633175 | 0.01002284811815 | LUAD | Male-baised eQTL |
| rs76141934 | chr21:39440709:T:C | - | 0.0838620482633175 | 0.01002284811815 | LUAD | Male-baised eQTL |
| rs2837009 | chr21:39407306:T:C | - | 0.0779501022618758 | 0.0101016618288312 | LUAD | Male-baised eQTL |
| rs7275686 | chr21:39416429:C:A | - | 0.0778000889458177 | 0.0104413510702905 | LUAD | Male-baised eQTL |
| rs76966447 | chr21:39441722:T:G | - | 0.0815761299413221 | 0.015775920720874 | LUAD | Male-baised eQTL |
| rs1624691 | chr21:39744021:T:C | - | -0.0849175759607666 | 0.021143109998371 | LUAD | Male-baised eQTL |
| rs2837039 | chr21:39453629:T:C | gene | 0.0819942058269873 | 0.0228594880937272 | LUAD | Male-baised eQTL |
| rs2837037 | chr21:39452235:C:T | gene | 0.0811854745063836 | 0.024270666849446 | LUAD | Male-baised eQTL |
| rs432185 | chr21:39741194:A:G | - | -0.0848249063831168 | 0.0337250751939828 | LUAD | Male-baised eQTL |
| rs75152729 | chr21:45383686:G:T | - | 0.120072005880499 | 0.0368953827002548 | LUAD | Male-baised eQTL |
| rs392232 | chr21:39750510:G:A | - | -0.0888389787854215 | 0.0378502700747766 | LUAD | Male-baised eQTL |
| rs1734853 | chr21:39742156:A:G | - | -0.0830979223051717 | 0.0403488553702163 | LUAD | Male-baised eQTL |
| rs1735138 | chr21:39476741:T:C | gene | 0.0586813330093182 | 0.0420238799074971 | LUAD | Male-baised eQTL |
| rs7283910 | chr21:39470534:T:C | gene | 0.0659585212127304 | 0.042259838593478 | LUAD | Male-baised eQTL |
| rs2837040 | chr21:39454689:T:C | gene | 0.0784743873476467 | 0.0428580366418492 | LUAD | Male-baised eQTL |
| rs7278892 | chr21:39471308:G:A | gene | 0.0584245124238876 | 0.0430163370421959 | LUAD | Male-baised eQTL |
| rs7279038 | chr21:39471379:G:A | gene | 0.0584245124238876 | 0.0430163370421959 | LUAD | Male-baised eQTL |
| rs386856 | chr21:39741367:A:G | - | -0.0824118288030189 | 0.0444683354023443 | LUAD | Male-baised eQTL |
| rs75751409 | chr21:39451507:A:T | gene | 0.0754356836896342 | 0.0461892931609785 | LUAD | Male-baised eQTL |
| rs8130027 | chr21:32819999:A:G | - | 0.109928724042946 | 0.0468963974881523 | LUAD | Male-baised eQTL |
| rs2837036 | chr21:39450562:A:G | gene,enhancer | 0.075348506089459 | 0.0471815749019272 | LUAD | Male-baised eQTL |
| rs11575939 | chr21:39451976:C:G | gene,CDS,exon | 0.075348506089459 | 0.0471815749019272 | LUAD | Male-baised eQTL |
| rs79459980 | chr21:39448275:T:C | gene,enhancer | 0.0748895357631784 | 0.0483837007542919 | LUAD | Male-baised eQTL |
| rs75546017 | chr21:39460439:T:C | gene | 0.0777272610805757 | 0.0490548341372516 | LUAD | Male-baised eQTL |
| rs56138563 | chr21:42904850:G:A | - | 0.0629678497258416 | 0.0265806294288399 | COAD | Male-baised eQTL |
| rs35665440 | chr21:42912748:C:T | - | 0.0629678497258416 | 0.0265806294288399 | COAD | Male-baised eQTL |
| rs79467049 | chr21:32774335:A:G | - | 0.0827775876714632 | 0.0334637061899004 | COAD | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs1474384 | chr21:39497344:G:A | Proximal upstream | 0.0216614413990714 | 4.96719587244838e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs13049203 | chr21:39499260:G:A | Proximal upstream | 0.0216614413990714 | 4.96719587244838e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837053 | chr21:39500335:G:C | Proximal downstream | 0.0216614413990714 | 4.96719587244838e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837055 | chr21:39502259:C:T | Proximal downstream | 0.0216614413990714 | 4.96719587244838e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs11088478 | chr21:39481206:T:C | Proximal upstream | 0.0215965128605397 | 5.34336869726362e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs28634277 | chr21:39482313:A:G | Proximal upstream | 0.0215965128605397 | 5.34336869726362e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7278885 | chr21:39485978:A:G | Proximal upstream | 0.0215965128605397 | 5.34336869726362e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs13050145 | chr21:39486830:G:C | Proximal upstream | 0.0215965128605397 | 5.34336869726362e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs4818041 | chr21:39500202:T:C | Proximal downstream | 0.0214812337475097 | 5.4268703197161e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs3787927 | chr21:39488584:T:C | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7280971 | chr21:39489750:A:G | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs11702769 | chr21:39491235:C:T | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs28728311 | chr21:39491297:G:T | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9976202 | chr21:39491788:C:T | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9976208 | chr21:39491809:C:T | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs8126715 | chr21:39495654:A:T | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs8126860 | chr21:39495707:C:T | Proximal upstream | 0.021417846472272 | 5.81732329039327e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837047 | chr21:39485597:G:C | Proximal upstream | 0.0216118131954 | 6.15577789709973e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837046 | chr21:39483331:A:G | Proximal upstream | 0.0212012590289801 | 8.15305229032147e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2026268 | chr21:39484471:G:A | Proximal upstream | 0.0212012590289801 | 8.15305229032147e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837048 | chr21:39487782:G:A | Proximal upstream | 0.0211498516480471 | 8.3888784717967e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs12482418 | chr21:39480411:A:G | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9984540 | chr21:39482574:G:C | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9983297 | chr21:39485427:T:C | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs8128795 | chr21:39490318:T:A | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837049 | chr21:39490386:G:A | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs8128567 | chr21:39490653:G:T | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7277107 | chr21:39490834:A:G | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837050 | chr21:39491075:A:G | Proximal upstream | 0.0211136710376776 | 8.68151866464449e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs1524929 | chr21:39508248:G:T | Proximal downstream | 0.0211897021043558 | 9.34564673807677e-05 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7281076 | chr21:39489601:G:C | Proximal upstream | 0.0205669443954657 | 0.000185495580718964 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs1475593 | chr21:39505879:G:T | Proximal downstream | 0.0205056513641805 | 0.000209837510743238 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs6517553 | chr21:39490796:A:G | Proximal upstream | 0.0203007660467924 | 0.000247669701048043 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs874221 | chr21:39475085:T:C | Distant upstream | -0.0209289823291871 | 0.00053148431214584 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7283910 | chr21:39470534:T:C | Distant upstream | -0.0201888554224203 | 0.00172423758426546 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs8127748 | chr21:39490407:A:G | Proximal upstream | 0.0182350867674506 | 0.00209794829634405 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs13046275 | chr21:39471777:A:G | Distant upstream | 0.0180419161958561 | 0.00301127535250768 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs1007351 | chr21:39528852:C:T | Distant downstream | 0.0164443533061559 | 0.00651686597947965 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs11088481 | chr21:39530165:C:G | Distant downstream | 0.0160579331227339 | 0.00952387754095082 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs1735138 | chr21:39476741:T:C | Proximal upstream | -0.0165414590637638 | 0.0233928644947588 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7278892 | chr21:39471308:G:A | Distant upstream | -0.0165029610878909 | 0.0245030479224859 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7279038 | chr21:39471379:G:A | Distant upstream | -0.0165029610878909 | 0.0245030479224859 | THCA | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs994003 | chr21:38665626:C:T | Distant upstream | 0.0676894793344729 | 0.0166167955781006 | KIRP | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9975531 | chr21:38661111:C:G | Distant upstream | 0.0654472368701108 | 0.0290079753455377 | KIRP | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2836619 | chr21:38679523:A:G | Distant upstream | 0.0640327820573018 | 0.0387344317248755 | KIRP | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs6517476 | chr21:38681534:A:C | Distant upstream | 0.0636678749504517 | 0.040292477922904 | KIRP | Female-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs461592 | chr21:38647412:C:A | Distant upstream | 0.0656935379567556 | 0.0486902356914792 | KIRP | Female-baised sQTL |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2836990 | chr21:39362723:C:T | Distant upstream | -0.0418791017735024 | 0.000451068420765824 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2735313 | chr21:39349685:A:C | Distant upstream | -0.0413319916406287 | 0.000504830952865752 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs13433458 | chr21:39356662:C:T | Distant upstream | -0.0412411966744174 | 0.000506482269862949 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9980725 | chr21:39358047:G:C | Distant upstream | -0.041113426611992 | 0.000516996247576226 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs7279434 | chr21:39350807:A:G | Distant upstream | -0.041080207609202 | 0.000565155980823408 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs28629334 | chr21:39352729:G:C | Distant upstream | -0.041080207609202 | 0.000565155980823408 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9983270 | chr21:39365873:C:T | Distant upstream | -0.0414734887744275 | 0.000580639198960323 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs9983594 | chr21:39366070:G:A | Distant upstream | -0.0414734887744275 | 0.000580639198960323 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs76174438 | chr21:39367636:C:T | Distant upstream | -0.0411147015853956 | 0.000712754683790679 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs28550626 | chr21:39368980:A:G | Distant upstream | -0.0403171689454475 | 0.000968688645050523 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs79523630 | chr21:39369504:C:T | Distant upstream | -0.0403171689454475 | 0.000968688645050523 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs78990292 | chr21:39369533:T:C | Distant upstream | -0.0381763531803326 | 0.00312933097090983 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs614610 | chr21:39571120:A:G | Distant downstream | -0.0319602631877778 | 0.00766235424295991 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs510750 | chr21:39571179:T:C | Distant downstream | -0.0319602631877778 | 0.00766235424295991 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs486465 | chr21:39564221:C:G | Distant downstream | -0.0313632753975819 | 0.00882724407473356 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2239384 | chr21:39350144:T:A | Distant upstream | -0.0279901911484673 | 0.0172661877146101 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs4818027 | chr21:39351231:G:A | Distant upstream | -0.0279901911484673 | 0.0172661877146101 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs630315 | chr21:39569920:C:T | Distant downstream | -0.0292812917997181 | 0.0198712147178804 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs484678 | chr21:39570606:T:G | Distant downstream | -0.0292812917997181 | 0.0198712147178804 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2836995 | chr21:39376875:A:G | Distant upstream | -0.0288376223899365 | 0.0223690119695687 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs628045 | chr21:39570448:C:T | Distant downstream | -0.0302204132402148 | 0.0250855780996027 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837025 | chr21:39427013:T:C | Distant upstream | -0.0338747321768715 | 0.0274959077953608 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs613758 | chr21:39564709:C:A | Distant downstream | -0.0291490464476842 | 0.0305410343799779 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs74693568 | chr21:39419536:G:A | Distant upstream | -0.0328478103933841 | 0.0321475877056795 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs617260 | chr21:39570563:T:C | Distant downstream | -0.0273626313240136 | 0.0378544449044678 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2178836 | chr21:39127318:G:A | Distant upstream | 0.0244060717081233 | 0.0445039076488407 | KIRC | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837182 | chr21:39763399:G:A | Distant downstream | -0.0402657712690557 | 0.0413262233157027 | THCA | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs73217271 | chr21:39763679:C:T | Distant downstream | -0.0402657712690557 | 0.0413262233157027 | THCA | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs2837045 | chr21:39479858:C:T | Proximal upstream | 0.0283934255763717 | 0.0182441945865312 | KIRP | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs76770676 | chr21:39524231:A:G | Distant downstream | -0.0792677288235294 | 0.0220592002340908 | PCPG | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs74351703 | chr21:39524258:C:T | Distant downstream | -0.0783037422248804 | 0.0273486866132675 | PCPG | Male-baised sQTL |
| exon_skip_359881 | chr21:39499822:39499915 | In-frame | rs75196868 | chr21:39524457:C:A | Distant downstream | -0.0783037422248804 | 0.0273486866132675 | PCPG | Male-baised sQTL |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SH3BGR |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |