|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000185324 |
Summary for CDK10 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000185324 | Gene symbol | CDK10 |
| Gene name | cyclin dependent kinase 10 | |
| HGNC | 1770 | |
| Entrez ID | 8558 | |
| Gene type | protein_coding | |
| Synonyms | CDK10|PISSLRE | |
| UniProtAcc | Q15131 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CDK10 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CDK10 | 3.30e+03 | 1.24e+00 | 2.31e-01 | 5.36e+00 | 8.16e-08 | 8.44e-07 | BLCA |
| CDK10 | 6.81e+03 | 1.31e+00 | 1.67e-01 | 7.86e+00 | 3.77e-15 | 4.48e-14 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CDK10 | 4.58e+03 | 1.07e+00 | 1.77e-01 | 6.08e+00 | 1.23e-09 | 6.98e-09 | KIRC |
| CDK10 | 2.87e+03 | 1.56e+00 | 3.13e-01 | 4.99e+00 | 5.99e-07 | 5.55e-06 | READ |
Top |
Sex-biased somatic mutation for CDK10 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for CDK10 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for CDK10 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for CDK10 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | CDK10-202 | chr16_89689084_+ | 3.20e-01 | 2.39e-01 | 2.11e+00 | 3.46e-02 | 4.44e-02 | 8.07e-02 |
| THCA | CDK10-202 | chr16_89689021_+ | 6.09e-01 | 4.72e-01 | 2.10e+00 | 3.56e-02 | 4.91e-02 | 1.37e-01 |
| COAD | CDK10-202 | chr16_89689045_+ | 4.17e-01 | 3.18e-01 | 2.08e+00 | 3.80e-02 | 4.42e-02 | 9.96e-02 |
| STAD | CDK10-202 | chr16_89688867_+ | 3.39e-01 | 2.15e-01 | 3.01e+00 | 2.59e-03 | 4.96e-02 | 1.24e-01 |
| KIRP | CDK10-202 | chr16_89688289_+ | 7.81e-01 | 6.92e-01 | 2.01e+00 | 4.46e-02 | 4.86e-02 | 8.94e-02 |
| PAAD | CDK10-202 | chr16_89687649_+ | 1.81e-01 | 1.48e-01 | 1.98e+00 | 4.72e-02 | 4.94e-02 | 3.33e-02 |
| READ | CDK10-202 | chr16_89688980_+ | 4.89e-01 | 3.23e-01 | 2.81e+00 | 4.94e-03 | 4.67e-02 | 1.66e-01 |
| ESCA | CDK10-202 | chr16_89688289_+ | 7.01e-01 | 8.45e-01 | -2.05e+00 | 4.08e-02 | 4.99e-02 | -1.44e-01 |
| ESCA | CDK10-202 | chr16_89688343_+ | 1.89e-01 | 3.60e-01 | -2.93e+00 | 3.35e-03 | 4.99e-02 | -1.72e-01 |
| LAML | CDK10-202 | chr16_89687649_+ | 2.29e-01 | 1.69e-01 | 2.41e+00 | 1.61e-02 | 4.94e-02 | 5.94e-02 |
| CHOL | CDK10-202 | chr16_89687638_+ | 7.78e-01 | 7.09e-01 | 2.28e+00 | 2.24e-02 | 4.94e-02 | 6.90e-02 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| THCA | CDK10-202 | chr16_89687664_+ | 1.99e-01 | 1.35e-01 | 2.77e+00 | 5.69e-03 | 1.18e-02 | 6.36e-02 |
| THCA | CDK10-202 | chr16_89687689_+ | 1.87e-01 | 1.27e-01 | 2.80e+00 | 5.17e-03 | 1.10e-02 | 6.02e-02 |
| THCA | CDK10-202 | chr16_89687702_+ | 3.38e-01 | 2.65e-01 | 2.54e+00 | 1.12e-02 | 1.84e-02 | 7.27e-02 |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for CDK10 |
| TFs related to CDK10. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAG1 | CDK10 | 3.10e+00 | 7.26e-03 | 4.41e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF141 | CDK10 | 3.00e+00 | 6.37e-03 | 4.35e+00 | 9.80e-01 | Female-biased |
| BRCA | ZNF28 | CDK10 | 3.00e+00 | 6.20e-03 | 4.35e+00 | 9.81e-01 | Female-biased |
| BRCA | ZNF692 | CDK10 | 3.20e+00 | 5.16e-03 | 4.62e+00 | 9.87e-01 | Female-biased |
| CDK10 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for CDK10 |
| RBPs related to ES in CDK10. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | EIF4B | exon_skip_139697 | 1.01e+01 | 5.42e-03 | 1.06e+01 | 9.93e-01 | Female-biased |
| UVM | EIF4B | exon_skip_139697 | 1.04e+01 | 4.48e-03 | 1.07e+01 | 9.94e-01 | Female-biased |
| THYM | SAMD4A | exon_skip_139646 | 8.55e+00 | 9.83e-01 | 8.24e+00 | 1.09e-02 | Male-biased |
| LIHC | SAMD4A | exon_skip_139646 | 8.78e+00 | 9.89e-01 | 8.31e+00 | 5.47e-03 | Male-biased |
| DLBC | PTBP1 | exon_skip_139715 | 8.73e+00 | 1.33e-02 | 9.05e+00 | 9.82e-01 | Female-biased |
| CHOL | SAMD4A | exon_skip_139646 | 7.99e+00 | 4.12e-03 | 8.51e+00 | 9.89e-01 | Female-biased |
| KIRP | HNRNPH2 | exon_skip_139650 | 6.95e+00 | 9.83e-01 | 6.49e+00 | 2.63e-03 | Male-biased |
| KIRP | HNRNPH2 | exon_skip_139663 | 6.90e+00 | 9.82e-01 | 6.47e+00 | 3.46e-03 | Male-biased |
| BRCA | EIF4B | exon_skip_139697 | 1.04e+01 | 9.86e-01 | 9.87e+00 | 1.21e-02 | Male-biased |
| READ | SAMD4A | exon_skip_139646 | 8.48e+00 | 9.93e-01 | 7.91e+00 | 9.38e-04 | Male-biased |
| THCA | HNRNPH2 | exon_skip_139650 | 6.76e+00 | 4.55e-03 | 7.12e+00 | 9.83e-01 | Female-biased |
| MESO | HNRNPH2 | exon_skip_139663 | 6.78e+00 | 9.84e-01 | 6.14e+00 | 6.91e-04 | Male-biased |
| MESO | PTBP1 | exon_skip_139715 | 8.62e+00 | 1.10e-02 | 8.96e+00 | 9.84e-01 | Female-biased |
| HNSC | PTBP1 | exon_skip_139715 | 8.24e+00 | 3.70e-03 | 8.67e+00 | 9.91e-01 | Female-biased |
| CDK10 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12931598 | chr16:81769109:C:G | - | 0.0579013163781716 | 0.0366396890541826 | LGG | Female-baised eQTL |
| rs80032671 | chr16:83730633:T:A | - | 0.0723216762692101 | 0.0391260524494669 | LGG | Female-baised eQTL |
| rs16959838 | chr16:83229914:C:G | - | 0.0609037617417756 | 0.00995207726333651 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs59961458 | chr16:81997346:C:G | - | 0.161368225027912 | 0.0111057777470194 | THCA | Male-baised eQTL |
| rs177266 | chr16:86773456:T:A | - | 0.0914069654542934 | 0.0384420176515261 | KIRC | Male-baised eQTL |
| rs299970 | chr16:86773388:T:C | - | 0.0894730968317442 | 0.0416653337627998 | KIRC | Male-baised eQTL |
| rs12445534 | chr16:82284883:G:C | - | 0.0634340319122955 | 0.0421282207233418 | KIRC | Male-baised eQTL |
| rs62070788 | chr16:89307602:G:T | - | 0.0967578961941505 | 0.000304448726205588 | BLCA | Male-baised eQTL |
| rs3114916 | chr16:89295205:G:C | - | -0.0444542168548839 | 0.0115345799180426 | BLCA | Male-baised eQTL |
| rs3114917 | chr16:89294557:G:A | - | -0.0395900864066312 | 0.0431385904278952 | BLCA | Male-baised eQTL |
| rs2353028 | chr16:89286270:G:A | - | -0.0391654158904355 | 0.0474803085708339 | BLCA | Male-baised eQTL |
| rs10400998 | chr16:81054860:C:T | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs78759525 | chr16:81055653:C:T | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs57687812 | chr16:81055984:C:A | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs61438195 | chr16:81056494:A:G | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs55648346 | chr16:81056626:A:G | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs61435632 | chr16:81056652:C:T | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs57906343 | chr16:81056913:G:A | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs28469459 | chr16:81057010:T:A | - | 0.100279655503219 | 0.0227673765373967 | COAD | Male-baised eQTL |
| rs71400112 | chr16:80749732:A:T | - | 0.101538908441844 | 0.0268648611904953 | COAD | Male-baised eQTL |
| rs7191547 | chr16:86349950:A:G | - | 0.0585147765496032 | 0.0273029585045267 | COAD | Male-baised eQTL |
| rs7199054 | chr16:81593694:C:T | - | 0.10369110720516 | 0.0281782166553108 | COAD | Male-baised eQTL |
| rs6540253 | chr16:86079290:G:C | - | 0.0474773777156406 | 0.0292944728342153 | COAD | Male-baised eQTL |
| rs7185501 | chr16:82385691:T:A | - | 0.0752574768383393 | 0.0314077805293497 | COAD | Male-baised eQTL |
| rs62041058 | chr16:87145134:T:A | - | 0.0631795973268707 | 0.0339441551919573 | COAD | Male-baised eQTL |
| rs4783073 | chr16:84813267:C:T | - | 0.0563171778197155 | 0.0360618279043763 | COAD | Male-baised eQTL |
| rs9925840 | chr16:82386867:T:C | - | 0.0760918217061259 | 0.0376057916393395 | COAD | Male-baised eQTL |
| rs962682 | chr16:84812645:A:G | - | 0.0565784634535846 | 0.0385503383880109 | COAD | Male-baised eQTL |
| rs10735709 | chr16:84811912:G:C | - | 0.055343709741664 | 0.0392785036462798 | COAD | Male-baised eQTL |
| rs1532302 | chr16:84812809:T:C | - | 0.0555293210750351 | 0.0426760108309192 | COAD | Male-baised eQTL |
| rs4783070 | chr16:84812940:C:T | - | 0.0555293210750351 | 0.0426760108309192 | COAD | Male-baised eQTL |
| rs4783071 | chr16:84813208:C:T | - | 0.0555293210750351 | 0.0426760108309192 | COAD | Male-baised eQTL |
| rs4783072 | chr16:84813234:G:A | - | 0.0555293210750351 | 0.0426760108309192 | COAD | Male-baised eQTL |
| rs744838 | chr16:84741080:A:G | - | 0.0475998675372525 | 0.0435646134882283 | COAD | Male-baised eQTL |
| rs4783069 | chr16:84811428:G:A | - | 0.0552511018377935 | 0.0451202767731734 | COAD | Male-baised eQTL |
| rs7185882 | chr16:82385868:T:G | - | 0.071322183479025 | 0.0462824362767711 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000185324 |
| CpG Site: cg05714116 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.418597555438405 | |
 | Gene ID: ENSG00000185324 |
| CpG Site: cg01714440 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.27185198176216 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01714440 | chr16:89682730 | gene,promoter | -0.27185198176216 | 1.68441578168599e-07 | -0.3518370733160295 | 2.7513116840238233e-10 | BLCA |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05714116 | chr16:89686147 | gene | -0.418597555438405 | 3.18438737250839e-08 | -0.39055472847052625 | 1.0157897643790774e-10 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_139702 | chr16:89693397:89693467 | Frame-shift | rs164749 | chr16:89641816:T:G | Distant upstream | -0.0364214712104825 | 0.0484169870127088 | GBM | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of CDK10 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
