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Gene: ENSG00000184470 |
Summary for TXNRD2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000184470 | Gene symbol | TXNRD2 |
| Gene name | thioredoxin reductase 2 | |
| HGNC | 18155 | |
| Entrez ID | 10587 | |
| Gene type | protein_coding | |
| Synonyms | TXNRD2|TR|TRXR2|TR3|SELZ | |
| UniProtAcc | Q9NNW7 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TXNRD2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TXNRD2 | 2.25e+03 | -1.60e+00 | 2.88e-01 | -5.57e+00 | 2.58e-08 | 2.68e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for TXNRD2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TXNRD2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg15926585 | chr22:19940922 | CGI:chr22:19941573-19941945 | promoter,gene body | 7.62e-01 | 6.49e-01 | 2.01e+00 | 4.49e-02 | 4.72e-02 | 1.13e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg15926585 | chr22:19940922 | CGI:chr22:19941573-19941945 | promoter,gene body | 7.57e-01 | 8.80e-01 | -2.21e+00 | 2.70e-02 | 3.03e-02 | -1.23e-01 |
| LUSC | cg00107488 | chr22:19942914 | CGI:chr22:19941573-19941945 | promoter | 1.34e-01 | 3.07e-01 | -4.01e+00 | 5.99e-05 | 5.82e-04 | -1.73e-01 |
| CHOL | cg15926585 | chr22:19940922 | CGI:chr22:19941573-19941945 | promoter,gene body | 6.49e-01 | 8.54e-01 | -1.99e+00 | 4.65e-02 | 4.65e-02 | -2.05e-01 |
| CHOL | cg00107488 | chr22:19942914 | CGI:chr22:19941573-19941945 | promoter | 2.21e-01 | 7.04e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -4.83e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg07194846 | chr22:19942654 | CGI:chr22:19941573-19941945 | promoter | 4.25e-01 | 1.61e-01 | 4.29e+00 | 1.82e-05 | 2.97e-05 | 2.64e-01 |
| BRCA | cg00107488 | chr22:19942914 | CGI:chr22:19941573-19941945 | promoter | 4.25e-01 | 2.30e-01 | 7.48e+00 | 7.18e-14 | 2.40e-13 | 1.95e-01 |
| LUAD | cg00107488 | chr22:19942914 | CGI:chr22:19941573-19941945 | promoter | 1.94e-01 | 3.06e-01 | -3.29e+00 | 9.88e-04 | 3.17e-03 | -1.12e-01 |
| BLCA | cg00465975 | chr22:19942034 | CGI:chr22:19941573-19941945 | promoter | 1.84e-01 | 8.27e-02 | 3.13e+00 | 1.74e-03 | 6.31e-03 | 1.01e-01 |
| BLCA | cg07194846 | chr22:19942654 | CGI:chr22:19941573-19941945 | promoter | 2.77e-01 | 1.60e-01 | 2.13e+00 | 3.34e-02 | 3.80e-02 | 1.16e-01 |
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Exon skipping events with PSI in TCGA for TXNRD2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TXNRD2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TXNRD2 |
| TFs related to TXNRD2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TXNRD2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TXNRD2 |
| RBPs related to ES in TXNRD2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | BRUNOL6 | exon_skip_367512 | 8.79e+00 | 9.84e-01 | 8.50e+00 | 1.07e-02 | Male-biased |
| UVM | HNRNPH2 | exon_skip_367516 | 7.79e+00 | 7.01e-03 | 8.12e+00 | 9.85e-01 | Female-biased |
| THYM | BRUNOL6 | exon_skip_367500 | 8.43e+00 | 3.71e-03 | 8.84e+00 | 9.91e-01 | Female-biased |
| COAD | BRUNOL6 | exon_skip_367512 | 8.56e+00 | 5.81e-03 | 8.94e+00 | 9.90e-01 | Female-biased |
| LUAD | BRUNOL6 | exon_skip_367520 | 8.90e+00 | 9.82e-01 | 8.60e+00 | 1.33e-02 | Male-biased |
| CHOL | BRUNOL6 | exon_skip_367512 | 8.39e+00 | 1.42e-02 | 8.76e+00 | 9.80e-01 | Female-biased |
| ESCA | HNRNPH2 | exon_skip_367516 | 8.33e+00 | 9.89e-01 | 7.78e+00 | 4.54e-03 | Male-biased |
| READ | BRUNOL6 | exon_skip_367500 | 8.49e+00 | 8.09e-03 | 8.84e+00 | 9.87e-01 | Female-biased |
| THCA | HNRNPH2 | exon_skip_367516 | 7.95e+00 | 3.49e-04 | 8.57e+00 | 9.94e-01 | Female-biased |
| PCPG | SNRNP70 | exon_skip_367508 | 6.73e+00 | 3.38e-03 | 7.14e+00 | 9.84e-01 | Female-biased |
| MESO | BRUNOL6 | exon_skip_367520 | 8.49e+00 | 1.04e-02 | 8.83e+00 | 9.84e-01 | Female-biased |
| LGG | BRUNOL6 | exon_skip_367520 | 8.51e+00 | 7.66e-03 | 8.86e+00 | 9.88e-01 | Female-biased |
| GBM | BRUNOL6 | exon_skip_367520 | 8.92e+00 | 9.91e-01 | 8.50e+00 | 3.99e-03 | Male-biased |
| KIRC | BRUNOL6 | exon_skip_367512 | 8.37e+00 | 1.02e-02 | 8.68e+00 | 9.84e-01 | Female-biased |
| KICH | BRUNOL6 | exon_skip_367500 | 8.51e+00 | 8.79e-03 | 8.85e+00 | 9.86e-01 | Female-biased |
| TXNRD2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs759228 | chr22:20643899:G:A | - | 0.219313508322756 | 0.0281606248795807 | PCPG | Female-baised eQTL |
| rs587179 | chr22:26416790:A:T | - | -0.145982660791398 | 0.0288218016216996 | LIHC | Female-baised eQTL |
| rs500570 | chr22:25517754:C:T | - | 0.137479639474121 | 6.43344056131228e-05 | LUSC | Female-baised eQTL |
| rs635829 | chr22:25525786:G:A | - | 0.129105804471269 | 6.64057364601872e-05 | LUSC | Female-baised eQTL |
| rs555682 | chr22:25525816:T:C | - | 0.124178940841379 | 0.000119330425804649 | LUSC | Female-baised eQTL |
| rs28641760 | chr22:25529641:A:G | - | 0.116195988919452 | 0.000499683064885848 | LUSC | Female-baised eQTL |
| rs73167602 | chr22:24396695:A:T | - | 0.118539698170452 | 0.00245119689971161 | LUSC | Female-baised eQTL |
| rs2780695 | chr22:25513844:G:A | - | 0.103208015165341 | 0.00370319427399564 | LUSC | Female-baised eQTL |
| rs2184167 | chr22:25512989:C:T | - | 0.105104830689881 | 0.00370319427399564 | LUSC | Female-baised eQTL |
| rs17002022 | chr22:23485397:G:A | - | 0.0815473902368941 | 0.00686708678911463 | LUSC | Female-baised eQTL |
| rs4820649 | chr22:25509497:C:G | - | 0.0980653082623142 | 0.00722395119251709 | LUSC | Female-baised eQTL |
| rs682389 | chr22:25500824:A:G | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs4822634 | chr22:25501748:C:T | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs5761090 | chr22:25502520:A:G | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs5761091 | chr22:25502748:G:C | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs5752163 | chr22:25502779:C:T | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs671834 | chr22:25504640:A:G | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs694921 | chr22:25505977:A:G | - | 0.0980118352577543 | 0.00745227368862346 | LUSC | Female-baised eQTL |
| rs112060973 | chr22:25507304:T:A | - | 0.0978888811876073 | 0.00753717665829308 | LUSC | Female-baised eQTL |
| rs5761092 | chr22:25508290:A:G | - | 0.0978888811876073 | 0.00753717665829308 | LUSC | Female-baised eQTL |
| rs5761097 | chr22:25509230:A:G | - | 0.0978888811876073 | 0.00753717665829308 | LUSC | Female-baised eQTL |
| rs5761098 | chr22:25512728:A:G | - | 0.0959131533184234 | 0.00809774682268996 | LUSC | Female-baised eQTL |
| rs507715 | chr22:25511938:C:A | - | 0.0959185481635698 | 0.00816322679734148 | LUSC | Female-baised eQTL |
| rs4820650 | chr22:25529391:T:C | - | 0.0906992613481108 | 0.00991402336041014 | LUSC | Female-baised eQTL |
| rs75106793 | chr22:20396990:C:T | - | 0.105758432815813 | 0.0108645635223316 | LUSC | Female-baised eQTL |
| rs7292491 | chr22:25799473:T:G | - | -0.106389641987834 | 0.0142675557160351 | LUSC | Female-baised eQTL |
| rs910520 | chr22:25801961:C:A | - | -0.105961732357686 | 0.015243588120321 | LUSC | Female-baised eQTL |
| rs910521 | chr22:25801962:T:G | - | -0.105961732357686 | 0.015243588120321 | LUSC | Female-baised eQTL |
| rs4822658 | chr22:25802391:G:C | - | -0.105961732357686 | 0.015243588120321 | LUSC | Female-baised eQTL |
| rs16980905 | chr22:25866888:A:T | - | 0.166400155339129 | 0.016325880980697 | LUSC | Female-baised eQTL |
| rs4822638 | chr22:25529111:T:C | - | 0.0853400563693562 | 0.0177564245534569 | LUSC | Female-baised eQTL |
| rs73167582 | chr22:24299500:T:C | - | 0.0937805267346962 | 0.0214050157188363 | LUSC | Female-baised eQTL |
| rs149317771 | chr22:24301933:C:A | - | 0.0937805267346962 | 0.0214050157188363 | LUSC | Female-baised eQTL |
| rs73167588 | chr22:24327504:C:T | - | 0.0937805267346962 | 0.0214050157188363 | LUSC | Female-baised eQTL |
| rs7285057 | chr22:24426695:T:C | - | 0.0843303169342287 | 0.0214149469903556 | LUSC | Female-baised eQTL |
| rs7290879 | chr22:23484679:G:A | - | 0.0725924654565887 | 0.0228372884740512 | LUSC | Female-baised eQTL |
| rs151290801 | chr22:24511648:C:G | - | 0.0827478319497655 | 0.0236653961882763 | LUSC | Female-baised eQTL |
| rs113961307 | chr22:23483069:A:G | - | 0.0728006664104658 | 0.0248007949499926 | LUSC | Female-baised eQTL |
| rs79640023 | chr22:23481562:G:A | - | 0.0721415944115837 | 0.02494695461862 | LUSC | Female-baised eQTL |
| rs2330923 | chr22:24709865:G:C | - | 0.0900253755953391 | 0.0255451775002494 | LUSC | Female-baised eQTL |
| rs9620388 | chr22:24463699:A:C | - | 0.0817685823269358 | 0.0272657062920071 | LUSC | Female-baised eQTL |
| rs9624480 | chr22:24475974:C:T | - | 0.0817685823269358 | 0.0272657062920071 | LUSC | Female-baised eQTL |
| rs372567965 | chr22:24477183:G:C | - | 0.0817685823269358 | 0.0272657062920071 | LUSC | Female-baised eQTL |
| rs73879064 | chr22:24477558:G:A | - | 0.0817685823269358 | 0.0272657062920071 | LUSC | Female-baised eQTL |
| rs9624482 | chr22:24482238:G:A | - | 0.0817685823269358 | 0.0272657062920071 | LUSC | Female-baised eQTL |
| rs6004245 | chr22:24709254:G:A | - | 0.0881572440103404 | 0.0278622764513553 | LUSC | Female-baised eQTL |
| rs6004247 | chr22:24709380:C:T | - | 0.0881572440103404 | 0.0278622764513553 | LUSC | Female-baised eQTL |
| rs9624472 | chr22:24438763:A:G | - | 0.0815545063261942 | 0.0285564613621014 | LUSC | Female-baised eQTL |
| rs1964959 | chr22:24446947:T:C | - | 0.0815545063261942 | 0.0285564613621014 | LUSC | Female-baised eQTL |
| rs7290459 | chr22:24450021:C:A | - | 0.0815545063261942 | 0.0285564613621014 | LUSC | Female-baised eQTL |
| rs73169823 | chr22:24450509:C:T | - | 0.0815545063261942 | 0.0285564613621014 | LUSC | Female-baised eQTL |
| rs2232857 | chr22:24494977:G:T | - | 0.0807188113540632 | 0.0290888630598498 | LUSC | Female-baised eQTL |
| rs17004921 | chr22:24444708:C:T | - | 0.0765502356936005 | 0.0318486400025672 | LUSC | Female-baised eQTL |
| rs7290428 | chr22:23484399:G:A | - | 0.0736689399417646 | 0.032818411809281 | LUSC | Female-baised eQTL |
| rs74432260 | chr22:23473404:C:T | - | 0.0758234663095229 | 0.0330723306799733 | LUSC | Female-baised eQTL |
| rs5760598 | chr22:24707190:C:T | - | 0.0840903896917454 | 0.0351168260111442 | LUSC | Female-baised eQTL |
| rs5761167 | chr22:25766847:T:A | - | 0.098136594957095 | 0.0410329250782856 | LUSC | Female-baised eQTL |
| rs5751953 | chr22:24708120:T:C | - | 0.0843137861037412 | 0.0422116453047056 | LUSC | Female-baised eQTL |
| rs5751954 | chr22:24708253:A:G | - | 0.0843137861037412 | 0.0422116453047056 | LUSC | Female-baised eQTL |
| rs7285536 | chr22:24707576:A:G | - | 0.0841986434019864 | 0.0424825715980399 | LUSC | Female-baised eQTL |
| rs5751951 | chr22:24707803:C:T | - | 0.0841986434019864 | 0.0424825715980399 | LUSC | Female-baised eQTL |
| rs5751952 | chr22:24707849:C:T | - | 0.0841986434019864 | 0.0424825715980399 | LUSC | Female-baised eQTL |
| rs143777398 | chr22:23309028:A:G | - | 0.0851048440972039 | 0.0433643068101323 | LUSC | Female-baised eQTL |
| rs73169811 | chr22:24422122:G:A | - | 0.0860030242303193 | 0.0443672787981898 | LUSC | Female-baised eQTL |
| rs5763911 | chr22:20443002:T:C | - | 0.107510089352306 | 0.0460729665017132 | LUSC | Female-baised eQTL |
| rs5760597 | chr22:24707134:G:A | - | 0.0812642298642068 | 0.0464006921476807 | LUSC | Female-baised eQTL |
| rs5760599 | chr22:24707281:C:T | - | 0.0812642298642068 | 0.0464006921476807 | LUSC | Female-baised eQTL |
| rs9620303 | chr22:23663642:C:T | - | 0.0811655606719062 | 0.0489558095642284 | LUSC | Female-baised eQTL |
| rs9624285 | chr22:23679763:G:A | - | 0.0811655606719062 | 0.0489558095642284 | LUSC | Female-baised eQTL |
| rs28367128 | chr22:23681009:C:T | - | 0.0811655606719062 | 0.0489558095642284 | LUSC | Female-baised eQTL |
| rs9624286 | chr22:23681016:G:A | - | 0.0811655606719062 | 0.0489558095642284 | LUSC | Female-baised eQTL |
| rs9620314 | chr22:23681109:C:T | - | 0.0811655606719062 | 0.0489558095642284 | LUSC | Female-baised eQTL |
| rs5761205 | chr22:25798275:T:G | - | 0.0816210775515955 | 0.0496943032259111 | LUSC | Female-baised eQTL |
| rs12171223 | chr22:22187515:C:T | - | 0.123485625198179 | 0.0145318638070178 | KIRC | Female-baised eQTL |
| rs5997412 | chr22:28880759:G:A | - | 0.0664721206317428 | 0.03442291802095 | KIRC | Female-baised eQTL |
| rs469991 | chr22:28911871:G:C | - | -0.0666154359927674 | 0.0346930761692707 | KIRC | Female-baised eQTL |
| rs132536 | chr22:28906918:A:G | - | -0.0662891512273778 | 0.0365026789863422 | KIRC | Female-baised eQTL |
| rs11504959 | chr22:22188764:G:T | - | 0.117263466625617 | 0.0368642565076197 | KIRC | Female-baised eQTL |
| rs12169557 | chr22:22193707:C:T | - | 0.117263466625617 | 0.0368642565076197 | KIRC | Female-baised eQTL |
| rs132528 | chr22:28899910:C:T | - | -0.0654273898220264 | 0.0402959784127321 | KIRC | Female-baised eQTL |
| rs132531 | chr22:28901377:C:T | - | -0.0654273898220264 | 0.0402959784127321 | KIRC | Female-baised eQTL |
| rs4822726 | chr22:26490736:T:G | - | -0.0594672771849508 | 0.0340864371120153 | LUAD | Female-baised eQTL |
| rs763258 | chr22:26445211:G:A | - | -0.0613738973779628 | 0.0366797370683483 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2518754 | chr22:17464790:T:C | - | 0.0768387734140217 | 0.00502180186135502 | LGG | Male-baised eQTL |
| rs112369041 | chr22:17464992:T:C | - | 0.0768387734140217 | 0.00502180186135502 | LGG | Male-baised eQTL |
| rs113632723 | chr22:17465155:C:T | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs113259551 | chr22:17465186:C:T | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs180855003 | chr22:17465232:G:A | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs186205699 | chr22:17465233:T:C | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs66526912 | chr22:17465486:G:A | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs113910237 | chr22:17465587:C:T | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs2522287 | chr22:17465925:G:T | - | 0.0756342674258887 | 0.00839503250896492 | LGG | Male-baised eQTL |
| rs2518760 | chr22:17474528:A:G | - | 0.0731404887440347 | 0.0105423930388652 | LGG | Male-baised eQTL |
| rs2522292 | chr22:17474946:T:C | - | 0.0718183022306931 | 0.0129695961023946 | LGG | Male-baised eQTL |
| rs2522293 | chr22:17475068:G:T | - | 0.0718183022306931 | 0.0129695961023946 | LGG | Male-baised eQTL |
| rs2522295 | chr22:17475935:T:C | - | 0.0718183022306931 | 0.0129695961023946 | LGG | Male-baised eQTL |
| rs2097596 | chr22:17473581:A:T | - | 0.0693877982757593 | 0.017608942679661 | LGG | Male-baised eQTL |
| rs2522294 | chr22:17475697:G:C | - | 0.0695931169939731 | 0.0178252113042166 | LGG | Male-baised eQTL |
| rs2522296 | chr22:17476920:G:C | - | 0.0679957656569833 | 0.0218150036184374 | LGG | Male-baised eQTL |
| rs5759845 | chr22:23475979:G:A | - | 0.0490532768147617 | 0.0397749600725946 | LUAD | Male-baised eQTL |
| rs5996554 | chr22:23477142:C:T | - | 0.0491021443125775 | 0.0411176668574205 | LUAD | Male-baised eQTL |
| rs5759844 | chr22:23475704:G:A | - | 0.0486264072391847 | 0.0444518524602903 | LUAD | Male-baised eQTL |
| rs1974652 | chr22:20146624:A:G | - | 0.0532820109525455 | 0.0450747985202849 | COAD | Male-baised eQTL |
| rs5996807 | chr22:24998774:G:A | - | -0.0539187183092112 | 0.0461120778575993 | COAD | Male-baised eQTL |
| rs4821955 | chr22:22360055:T:C | - | -0.0559222327719498 | 0.0499503160438232 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000184470 |
| CpG Site: cg15926585 | |
| Position to Gene: gene,promoter | |
| Male Effect: -0.411416346541583 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15926585 | chr22:19940922 | gene,promoter | -0.411416346541583 | 6.72502314191391e-11 | -0.484958492107648 | 1.4805627779911465e-14 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TXNRD2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000184470 | TXNRD2 | C0017612 | Glaucoma, Open-Angle | 1 | CTD_human |
| ENSG00000184470 | TXNRD2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000184470 | TXNRD2 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
| ENSG00000184470 | TXNRD2 | C0271148 | Secondary Open Angle Glaucoma | 1 | CTD_human |
| ENSG00000184470 | TXNRD2 | C0339573 | Glaucoma, Primary Open Angle | 1 | CTD_human |
| ENSG00000184470 | TXNRD2 | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
