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Gene: ENSG00000184349 |
Summary for EFNA5 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000184349 | Gene symbol | EFNA5 |
| Gene name | ephrin A5 | |
| HGNC | 3225 | |
| Entrez ID | 1946 | |
| Gene type | protein_coding | |
| Synonyms | EFNA5|AF1|LERK7 | |
| UniProtAcc | P52803 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for EFNA5 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| EFNA5 | 9.76e+02 | -1.00e+00 | 2.02e-01 | -4.95e+00 | 7.28e-07 | 2.76e-06 | HNSC |
| EFNA5 | 5.05e+02 | 3.14e+00 | 5.86e-01 | 5.36e+00 | 8.14e-08 | 7.49e-07 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for EFNA5 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for EFNA5 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg18449021 | chr5:107669115 | CGI:chr5:107669429-107672490 | promoter,gene body | 2.15e-01 | 3.76e-01 | -2.77e+00 | 5.61e-03 | 8.92e-03 | -1.61e-01 |
| LIHC | cg22834126 | chr5:107672318 | CGI:chr5:107669429-107672490 | promoter | 1.36e-01 | 3.23e-02 | 2.47e+00 | 1.34e-02 | 1.57e-02 | 1.03e-01 |
| LIHC | cg11474250 | chr5:107671425 | CGI:chr5:107669429-107672490 | promoter | 3.00e-01 | 4.56e-02 | 2.83e+00 | 4.60e-03 | 6.13e-03 | 2.54e-01 |
| LIHC | cg03685346 | chr5:107670298 | CGI:chr5:107669429-107672490 | promoter,gene body | 2.75e-01 | 1.31e-01 | 2.45e+00 | 1.42e-02 | 1.66e-02 | 1.44e-01 |
| KIRP | cg18449021 | chr5:107669115 | CGI:chr5:107669429-107672490 | promoter,gene body | 4.79e-01 | 3.44e-01 | 2.29e+00 | 2.18e-02 | 2.48e-02 | 1.35e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg01100912 | chr5:107669689 | CGI:chr5:107669429-107672490 | promoter,gene body | 1.30e-01 | 2.38e-02 | 2.20e+00 | 2.77e-02 | 3.12e-02 | 1.06e-01 |
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Exon skipping events with PSI in TCGA for EFNA5 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for EFNA5 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | EFNA5-003 | chr5_107590491_- | 5.37e-01 | 6.74e-01 | -2.22e+00 | 2.64e-02 | 4.18e-02 | -1.37e-01 |
| LUAD | EFNA5-003 | chr5_107626357_- | 3.51e-01 | 4.82e-01 | -2.40e+00 | 1.63e-02 | 3.51e-02 | -1.31e-01 |
| LUAD | EFNA5-003 | chr5_107627584_- | 5.53e-01 | 3.21e-01 | 2.01e+00 | 4.45e-02 | 4.83e-02 | 2.33e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for EFNA5 |
| TFs related to EFNA5. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | ZNF418 | EFNA5 | 2.89e+00 | 3.33e-03 | 4.09e+00 | 9.86e-01 | Female-biased |
| MESO | ALX1 | EFNA5 | 3.34e+00 | 6.46e-03 | 4.76e+00 | 9.89e-01 | Female-biased |
| MESO | ISX | EFNA5 | 3.54e+00 | 6.32e-03 | 4.96e+00 | 9.90e-01 | Female-biased |
| MESO | LHX3 | EFNA5 | 3.14e+00 | 8.73e-03 | 4.45e+00 | 9.83e-01 | Female-biased |
| MESO | NKX2-2 | EFNA5 | 3.22e+00 | 5.41e-03 | 4.68e+00 | 9.89e-01 | Female-biased |
| MESO | PHOX2A | EFNA5 | 3.63e+00 | 6.77e-03 | 5.04e+00 | 9.90e-01 | Female-biased |
| MESO | PHOX2B | EFNA5 | 3.25e+00 | 4.21e-03 | 4.79e+00 | 9.91e-01 | Female-biased |
| MESO | PRDM1 | EFNA5 | 2.62e+00 | 5.25e-03 | 4.07e+00 | 9.81e-01 | Female-biased |
| MESO | PRRX1 | EFNA5 | 3.51e+00 | 7.67e-03 | 4.88e+00 | 9.88e-01 | Female-biased |
| MESO | ZNF250 | EFNA5 | 3.21e+00 | 1.11e-02 | 4.45e+00 | 9.81e-01 | Female-biased |
| MESO | ZNF33B | EFNA5 | 2.83e+00 | 2.32e-03 | 4.53e+00 | 9.91e-01 | Female-biased |
| MESO | ZNF418 | EFNA5 | 2.39e+00 | 9.35e-05 | 4.88e+00 | 9.96e-01 | Female-biased |
| MESO | ZNF570 | EFNA5 | 2.44e+00 | 2.11e-03 | 4.16e+00 | 9.86e-01 | Female-biased |
| MESO | ZNF85 | EFNA5 | 2.99e+00 | 6.11e-03 | 4.41e+00 | 9.86e-01 | Female-biased |
| EFNA5 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for EFNA5 |
| RBPs related to ES in EFNA5. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| EFNA5 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs60569410 | chr5:108125984:A:C | - | 0.312877651733508 | 0.0289424940327818 | KIRP | Female-baised eQTL |
| rs58652615 | chr5:108127804:G:T | - | 0.312877651733508 | 0.0289424940327818 | KIRP | Female-baised eQTL |
| rs77751798 | chr5:109440130:C:A | - | 0.150135961895664 | 0.00605654770710562 | KIRC | Female-baised eQTL |
| rs6876920 | chr5:109446409:C:T | - | 0.150135961895664 | 0.00605654770710562 | KIRC | Female-baised eQTL |
| rs113982851 | chr5:109447584:C:T | - | 0.150135961895664 | 0.00605654770710562 | KIRC | Female-baised eQTL |
| rs112386187 | chr5:109448783:A:T | - | 0.150135961895664 | 0.00605654770710562 | KIRC | Female-baised eQTL |
| rs10037359 | chr5:115477942:C:T | - | 0.048521239331882 | 0.0306021950751091 | LUAD | Female-baised eQTL |
| rs10037405 | chr5:115478106:C:G | - | 0.0467835711146888 | 0.0434711793681954 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs142037001 | chr5:101602288:T:C | - | 0.142244677902972 | 0.0330448981472349 | SARC | Male-baised eQTL |
| rs115480753 | chr5:101608166:C:T | - | 0.142244677902972 | 0.0330448981472349 | SARC | Male-baised eQTL |
| rs4703159 | chr5:101605158:C:T | - | 0.138041158768051 | 0.0367440480571945 | SARC | Male-baised eQTL |
| rs11241407 | chr5:100111052:T:C | - | 0.0876249986773376 | 0.0335948393834407 | LUAD | Male-baised eQTL |
| rs10054703 | chr5:100095615:A:G | - | 0.0847079604788168 | 0.0471300561196398 | LUAD | Male-baised eQTL |
| rs66903361 | chr5:100095667:C:T | - | 0.0845734578152459 | 0.0482074531635311 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000184349 |
| CpG Site: cg00230715 | |
| Position to Gene: gene | |
| Male Effect: -0.472026689507278 | |
| Female Effect: - | |
 | Gene ID: ENSG00000184349 |
| CpG Site: cg24728949 | |
| Position to Gene: gene | |
| Male Effect: -0.414296668745837 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg00230715 | chr5:107518566 | gene | -0.472026689507278 | 1.97640875201027e-11 | -0.4755553870762984 | 9.746493335762253e-13 | KIRP |
| cg24728949 | chr5:107484468 | gene | -0.414296668745837 | 5.77124098334559e-06 | -0.36051205412185716 | 3.011183956551546e-08 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of EFNA5 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000184349 | EFNA5 | C0035126 | Reperfusion Injury | 1 | CTD_human |
