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Gene: ENSG00000183722 |
Summary for LHFP |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000183722 | Gene symbol | LHFP |
| Gene name | LHFPL tetraspan subfamily member 6 | |
| HGNC | 6586 | |
| Entrez ID | 10186 | |
| Gene type | protein_coding | |
| Synonyms | LHFPL6|MGC22429 | |
| UniProtAcc | Q9Y693 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for LHFP |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LHFP | 1.15e+03 | -2.09e+00 | 3.76e-01 | -5.57e+00 | 2.58e-08 | 3.01e-07 | BLCA |
| LHFP | 8.62e+02 | -1.53e+00 | 2.44e-01 | -6.27e+00 | 3.68e-10 | 2.22e-09 | KIRP |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| LHFP | 1.85e+03 | -1.49e+00 | 2.93e-01 | -5.10e+00 | 3.35e-07 | 1.35e-06 | KICH |
| LHFP | 2.75e+03 | -2.04e+00 | 8.81e-02 | -2.32e+01 | 3.12e-119 | 1.87e-117 | BRCA |
| LHFP | 6.07e+02 | -1.06e+00 | 3.56e-01 | -2.97e+00 | 2.94e-03 | 8.77e-03 | READ |
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Sex-biased somatic mutation for LHFP |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for LHFP |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg08228917 | chr13:39602925 | CGI:chr13:39602712-39603439 | UTR,promoter,exon,gene body | 1.84e-01 | 4.89e-02 | 3.46e+00 | 5.37e-04 | 1.93e-03 | 1.35e-01 |
| COAD | cg21284880 | chr13:39603603 | CGI:chr13:39602712-39603439 | promoter | 1.83e-01 | 5.23e-02 | 2.15e+00 | 3.15e-02 | 3.59e-02 | 1.31e-01 |
Top |
Exon skipping events with PSI in TCGA for LHFP |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for LHFP |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for LHFP |
| TFs related to LHFP. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LAML | NHLH1 | LHFP | 3.19e+00 | 5.15e-03 | 4.26e+00 | 9.83e-01 | Female-biased |
| LAML | PLAG1 | LHFP | 3.28e+00 | 7.38e-03 | 4.25e+00 | 9.80e-01 | Female-biased |
| LAML | ZNF141 | LHFP | 3.64e+00 | 1.05e-02 | 4.52e+00 | 9.81e-01 | Female-biased |
| LAML | ZNF16 | LHFP | 3.38e+00 | 6.32e-03 | 4.40e+00 | 9.84e-01 | Female-biased |
| LAML | ZNF28 | LHFP | 3.53e+00 | 6.25e-03 | 4.55e+00 | 9.86e-01 | Female-biased |
| LAML | ZNF320 | LHFP | 3.40e+00 | 5.51e-03 | 4.45e+00 | 9.85e-01 | Female-biased |
| LAML | ZNF454 | LHFP | 3.55e+00 | 8.35e-03 | 4.49e+00 | 9.83e-01 | Female-biased |
| LAML | ZNF530 | LHFP | 3.31e+00 | 7.70e-03 | 4.27e+00 | 9.80e-01 | Female-biased |
| LAML | ZNF891 | LHFP | 3.43e+00 | 6.68e-03 | 4.43e+00 | 9.84e-01 | Female-biased |
| LHFP related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for LHFP |
| RBPs related to ES in LHFP. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LHFP related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7997142 | chr13:30462228:T:C | - | 0.371095565697862 | 2.06350885614788e-05 | KIRP | Female-baised eQTL |
| rs969248 | chr13:30463076:A:G | - | 0.371095565697862 | 2.06350885614788e-05 | KIRP | Female-baised eQTL |
| rs983723 | chr13:30463308:T:C | - | 0.371095565697862 | 2.06350885614788e-05 | KIRP | Female-baised eQTL |
| rs112688675 | chr13:30464141:C:T | - | 0.371095565697862 | 2.06350885614788e-05 | KIRP | Female-baised eQTL |
| rs73451924 | chr13:30464211:A:G | - | 0.371095565697862 | 2.06350885614788e-05 | KIRP | Female-baised eQTL |
| rs2388545 | chr13:30466806:T:C | - | 0.311201014736316 | 0.00071917490233924 | KIRP | Female-baised eQTL |
| rs6490464 | chr13:30472168:A:C | - | 0.311201014736316 | 0.00071917490233924 | KIRP | Female-baised eQTL |
| rs7325616 | chr13:30473580:T:C | - | 0.311201014736316 | 0.00071917490233924 | KIRP | Female-baised eQTL |
| rs2388547 | chr13:30469671:A:G | - | 0.267134111660734 | 0.00657590201577648 | KIRP | Female-baised eQTL |
| rs112224045 | chr13:30470748:A:G | - | 0.293814654781116 | 0.0132374350669761 | KIRP | Female-baised eQTL |
| rs6563505 | chr13:31458811:T:G | - | 0.223224446330198 | 0.0280633362772543 | KIRP | Female-baised eQTL |
| rs73449172 | chr13:31455572:C:A | - | 0.212554904277611 | 0.0319946672090235 | KIRP | Female-baised eQTL |
| rs9533253 | chr13:42828297:G:A | - | 0.254882205741073 | 0.000489619000325329 | BLCA | Female-baised eQTL |
| rs9525676 | chr13:42758617:G:A | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs35396262 | chr13:42759882:T:C | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs9533236 | chr13:42765210:A:G | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs10507516 | chr13:42767972:G:A | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs9525678 | chr13:42770721:A:T | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs12871717 | chr13:42774032:T:C | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs9533239 | chr13:42774542:C:A | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs34847025 | chr13:42775776:C:T | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs9525680 | chr13:42778859:G:A | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs35817545 | chr13:42800193:G:A | - | 0.236304253693128 | 0.00123255822245139 | BLCA | Female-baised eQTL |
| rs9525682 | chr13:42783407:A:G | - | 0.234831318527064 | 0.00147415523325727 | BLCA | Female-baised eQTL |
| rs12876418 | chr13:42828489:C:T | - | 0.210603157503959 | 0.00572883738014198 | BLCA | Female-baised eQTL |
| rs12877687 | chr13:42784759:G:A | - | 0.195448206912044 | 0.0119784536533864 | BLCA | Female-baised eQTL |
| rs2875496 | chr13:42785845:C:T | - | 0.195448206912044 | 0.0119784536533864 | BLCA | Female-baised eQTL |
| rs11619487 | chr13:42786103:A:G | - | 0.195448206912044 | 0.0119784536533864 | BLCA | Female-baised eQTL |
| rs2296244 | chr13:42790684:G:A | - | 0.195448206912044 | 0.0119784536533864 | BLCA | Female-baised eQTL |
| rs9533245 | chr13:42787133:G:T | - | 0.193553884783112 | 0.0144281215903733 | BLCA | Female-baised eQTL |
| rs9533249 | chr13:42793524:C:G | - | 0.191815283839888 | 0.0200211202162491 | BLCA | Female-baised eQTL |
| rs9533234 | chr13:42748641:A:G | - | 0.196907261968969 | 0.0203738686515416 | BLCA | Female-baised eQTL |
| rs117109354 | chr13:46537706:C:T | - | 0.291196555837868 | 0.0325217558668045 | BLCA | Female-baised eQTL |
| rs9525681 | chr13:42781102:T:A | - | 0.171580176916086 | 0.0394827330773352 | BLCA | Female-baised eQTL |
| rs9525683 | chr13:42788118:C:A | - | 0.168916739169314 | 0.0455566611724965 | BLCA | Female-baised eQTL |
| rs9533246 | chr13:42788340:A:G | - | 0.168916739169314 | 0.0455566611724965 | BLCA | Female-baised eQTL |
| rs9525684 | chr13:42788387:C:T | - | 0.168916739169314 | 0.0455566611724965 | BLCA | Female-baised eQTL |
| rs7334276 | chr13:42825427:T:C | - | 0.176607631845631 | 0.0480860081046145 | BLCA | Female-baised eQTL |
| rs622085 | chr13:36871971:C:T | - | 0.0501817415463552 | 0.0330793926164062 | LUAD | Female-baised eQTL |
| rs7999818 | chr13:36114751:T:C | - | 0.0726267695241052 | 0.0342265855014821 | LUAD | Female-baised eQTL |
| rs495972 | chr13:36871261:T:A | - | 0.0489811427241459 | 0.0473746170652995 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs73157147 | chr13:29782209:T:G | - | 0.0760145811239285 | 0.00835644083674946 | HNSC | Male-baised eQTL |
| rs35884932 | chr13:29810286:A:T | - | 0.0679218239015904 | 0.0458156876643203 | HNSC | Male-baised eQTL |
| rs9595995 | chr13:48766489:T:G | - | 0.162951844947541 | 0.0394779519850815 | GBM | Male-baised eQTL |
| rs73480227 | chr13:48768413:C:T | - | 0.162951844947541 | 0.0394779519850815 | GBM | Male-baised eQTL |
| rs959353 | chr13:48770526:G:C | - | 0.162951844947541 | 0.0394779519850815 | GBM | Male-baised eQTL |
| rs9595997 | chr13:48773067:G:A | - | 0.162951844947541 | 0.0394779519850815 | GBM | Male-baised eQTL |
| rs732769 | chr13:48773821:T:C | - | 0.162951844947541 | 0.0394779519850815 | GBM | Male-baised eQTL |
| rs73185370 | chr13:41997463:T:C | - | 0.0949571105687976 | 0.0275041666413158 | LUSC | Male-baised eQTL |
| rs73172203 | chr13:42216229:A:G | - | 0.0614052679993811 | 0.0447650351210166 | KIRC | Male-baised eQTL |
| rs190682 | chr13:31575229:T:C | - | -0.0383010944491946 | 0.048177345357913 | BLCA | Male-baised eQTL |
| rs17573850 | chr13:44311453:A:G | - | 0.0542875219847802 | 0.00304164906548697 | COAD | Male-baised eQTL |
| rs9595104 | chr13:44325971:T:C | - | 0.0862346861739665 | 0.00653938464264829 | COAD | Male-baised eQTL |
| rs4942281 | chr13:44133990:C:T | - | -0.0610985800733505 | 0.0207343941634565 | COAD | Male-baised eQTL |
| rs4942282 | chr13:44134280:G:A | - | -0.0610985800733505 | 0.0207343941634565 | COAD | Male-baised eQTL |
| rs7317685 | chr13:48141617:A:G | - | -0.0697496626047866 | 0.0213592085133153 | COAD | Male-baised eQTL |
| rs3809350 | chr13:44162043:T:C | - | -0.0564731732791857 | 0.0294873770576803 | COAD | Male-baised eQTL |
| rs11147924 | chr13:43700141:C:T | - | 0.0897562307326401 | 0.0312734352863766 | COAD | Male-baised eQTL |
| rs7339205 | chr13:44149115:G:C | - | -0.052490156188881 | 0.0330171749806361 | COAD | Male-baised eQTL |
| rs1969885 | chr13:45521845:T:C | - | -0.0602754428567071 | 0.0346937740269344 | COAD | Male-baised eQTL |
| rs999252 | chr13:45522726:G:A | - | -0.0602754428567071 | 0.0346937740269344 | COAD | Male-baised eQTL |
| rs17075266 | chr13:30997316:G:T | - | 0.045208732105893 | 0.0387729221171355 | COAD | Male-baised eQTL |
| rs4942290 | chr13:44183203:C:T | - | -0.0565980107513408 | 0.0394738221045641 | COAD | Male-baised eQTL |
| rs59757139 | chr13:44149478:A:C | - | -0.0555294587709016 | 0.0402432296235767 | COAD | Male-baised eQTL |
| rs9562537 | chr13:44181651:G:A | - | -0.055673832712653 | 0.041436412514146 | COAD | Male-baised eQTL |
| rs1230473 | chr13:46202712:T:G | - | 0.0701884446330731 | 0.046959465672415 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000183722 |
| CpG Site: cg15617023 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.406962499553931 | |
 | Gene ID: ENSG00000183722 |
| CpG Site: cg03094555 | |
| Position to Gene: gene | |
| Male Effect: -0.204094392498372 | |
| Female Effect: - | |
 | Gene ID: ENSG00000183722 |
| CpG Site: cg03173528 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.155938218317308 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg03094555 | chr13:39385561 | gene | -0.204094392498372 | 1.21554363691449e-10 | -0.4155084048036515 | 1.2884972421532369e-13 | SKCM |
| cg03173528 | chr13:39601084 | gene,exon,CDS | -0.155938218317308 | 8.08255837380036e-08 | -0.3521412824616439 | 5.977980940455304e-10 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15617023 | chr13:39539111 | gene | -0.406962499553931 | 3.39736841072231e-06 | -0.3704672299728403 | 1.8303437218166695e-08 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of LHFP |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
