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Gene: ENSG00000183495 |
Summary for EP400 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000183495 | Gene symbol | EP400 |
| Gene name | E1A binding protein p400 | |
| HGNC | 11958 | |
| Entrez ID | 57634 | |
| Gene type | protein_coding | |
| Synonyms | EP400|CAGH32|KIAA1498|P400|KIAA1818|DKFZP434I225 | |
| UniProtAcc | Q96L91 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for EP400 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for EP400 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for EP400 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| UVM | cg26147845 | chr12:131949293 | CGI:chr12:131949605-131950696 | promoter | 3.98e-01 | 1.26e-01 | 3.01e+00 | 2.60e-03 | 7.21e-03 | 2.73e-01 |
| CHOL | cg26147845 | chr12:131949293 | CGI:chr12:131949605-131950696 | promoter | 6.60e-01 | 3.55e-01 | 2.96e+00 | 3.07e-03 | 8.81e-03 | 3.05e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg26147845 | chr12:131949293 | CGI:chr12:131949605-131950696 | promoter | 1.15e-01 | 2.18e-01 | -3.01e+00 | 2.61e-03 | 5.06e-03 | -1.03e-01 |
| LUSC | cg12488585 | chr12:131949505 | CGI:chr12:131949605-131950696 | promoter | 4.60e-01 | 7.56e-01 | -4.34e+00 | 1.41e-05 | 5.26e-04 | -2.96e-01 |
| BLCA | cg26147845 | chr12:131949293 | CGI:chr12:131949605-131950696 | promoter | 8.62e-02 | 2.06e-01 | -3.68e+00 | 2.34e-04 | 7.45e-04 | -1.20e-01 |
| LIHC | cg26147845 | chr12:131949293 | CGI:chr12:131949605-131950696 | promoter | 1.12e-01 | 2.28e-01 | -3.42e+00 | 6.32e-04 | 1.05e-03 | -1.16e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg12488585 | chr12:131949505 | CGI:chr12:131949605-131950696 | promoter | 5.11e-01 | 6.99e-01 | -1.04e+01 | 1.57e-25 | 1.41e-24 | -1.88e-01 |
| KIRP | cg12488585 | chr12:131949505 | CGI:chr12:131949605-131950696 | promoter | 7.10e-01 | 8.17e-01 | -2.30e+00 | 2.17e-02 | 2.83e-02 | -1.06e-01 |
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Exon skipping events with PSI in TCGA for EP400 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for EP400 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for EP400 |
| TFs related to EP400. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| PAAD | ZNF418 | EP400 | 3.82e+00 | 9.80e-01 | 2.51e+00 | 7.87e-04 | Male-biased |
| EP400 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for EP400 |
| RBPs related to ES in EP400. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | FXR2 | exon_skip_88758 | 7.72e+00 | 7.31e-03 | 8.11e+00 | 9.85e-01 | Female-biased |
| CHOL | PPRC1 | exon_skip_88766 | 1.20e+01 | 5.51e-03 | 1.25e+01 | 9.94e-01 | Female-biased |
| CHOL | RBM4 | exon_skip_88766 | 9.42e+00 | 5.32e-03 | 9.91e+00 | 9.92e-01 | Female-biased |
| ESCA | BRUNOL6 | exon_skip_88754 | 8.85e+00 | 9.86e-01 | 8.40e+00 | 9.20e-03 | Male-biased |
| ESCA | FXR2 | exon_skip_88758 | 7.62e+00 | 6.72e-03 | 8.10e+00 | 9.85e-01 | Female-biased |
| READ | PTBP1 | exon_skip_88755 | 7.22e+00 | 9.85e-01 | 6.80e+00 | 3.49e-03 | Male-biased |
| EP400 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4765062 | chr12:124122055:C:A | - | 0.0494447684539882 | 0.0103869228984599 | KIRC | Male-baised eQTL |
| rs11057457 | chr12:124120540:T:C | - | 0.0481198229877735 | 0.0195675849493231 | KIRC | Male-baised eQTL |
| rs28699369 | chr12:125072934:T:G | - | -0.101566588299154 | 0.0406284978009245 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000183495 |
| CpG Site: cg05573322 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.383932454259979 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg05573322 | chr12:132030313 | gene | -0.383932454259979 | 3.19388067382951e-08 | -0.39271006839886746 | 9.319046653709615e-11 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of EP400 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
