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Gene: ENSG00000183269 |
Summary for OR52E8 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000183269 | Gene symbol | OR52E8 |
| Gene name | olfactory receptor family 52 subfamily E member 8 | |
| HGNC | 15217 | |
| Entrez ID | 390079 | |
| Gene type | protein_coding | |
| Synonyms | OR52E8| | |
| UniProtAcc | Q6IFG1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for OR52E8 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for OR52E8 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for OR52E8 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg26762873 | chr11:5858569 | CGI:chr11:6234538-6234892 | promoter | 6.54e-01 | 5.41e-01 | 2.23e+00 | 2.58e-02 | 3.92e-02 | 1.14e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg07833852 | chr11:5857725 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 7.98e-01 | 9.40e-01 | -4.28e+00 | 1.91e-05 | 7.13e-05 | -1.41e-01 |
| LUAD | cg22957613 | chr11:5857728 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 7.60e-01 | 8.83e-01 | -3.60e+00 | 3.24e-04 | 7.53e-04 | -1.23e-01 |
| LUAD | cg26762873 | chr11:5858569 | CGI:chr11:6234538-6234892 | promoter | 8.07e-01 | 9.11e-01 | -3.15e+00 | 1.62e-03 | 2.92e-03 | -1.04e-01 |
| LUSC | cg25100880 | chr11:5856789 | CGI:chr11:6234538-6234892 | promoter,exon,CDS,gene body | 4.38e-01 | 7.31e-01 | -2.81e+00 | 5.00e-03 | 8.15e-03 | -2.93e-01 |
| LUSC | cg07833852 | chr11:5857725 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 7.17e-01 | 9.43e-01 | -4.08e+00 | 4.43e-05 | 5.44e-04 | -2.26e-01 |
| LUSC | cg22957613 | chr11:5857728 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 6.88e-01 | 8.94e-01 | -3.82e+00 | 1.36e-04 | 8.00e-04 | -2.06e-01 |
| LUSC | cg26762873 | chr11:5858569 | CGI:chr11:6234538-6234892 | promoter | 7.30e-01 | 9.24e-01 | -2.69e+00 | 7.05e-03 | 1.06e-02 | -1.94e-01 |
| COAD | cg26762873 | chr11:5858569 | CGI:chr11:6234538-6234892 | promoter | 7.17e-01 | 9.07e-01 | -2.85e+00 | 4.31e-03 | 7.33e-03 | -1.90e-01 |
| BLCA | cg25100880 | chr11:5856789 | CGI:chr11:6234538-6234892 | promoter,exon,CDS,gene body | 3.94e-01 | 7.68e-01 | -2.46e+00 | 1.39e-02 | 1.83e-02 | -3.75e-01 |
| ESCA | cg22957613 | chr11:5857728 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 6.81e-01 | 8.38e-01 | -2.29e+00 | 2.18e-02 | 4.10e-02 | -1.57e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg25100880 | chr11:5856789 | CGI:chr11:6234538-6234892 | promoter,exon,CDS,gene body | 4.37e-01 | 6.71e-01 | -6.84e+00 | 8.00e-12 | 2.29e-11 | -2.34e-01 |
| BRCA | cg07833852 | chr11:5857725 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 7.52e-01 | 9.26e-01 | -9.12e+00 | 7.75e-20 | 4.13e-19 | -1.74e-01 |
| BRCA | cg22957613 | chr11:5857728 | CGI:chr11:6234538-6234892 | UTR,promoter,exon,gene body | 7.08e-01 | 8.72e-01 | -8.60e+00 | 8.03e-18 | 3.64e-17 | -1.64e-01 |
| BRCA | cg26762873 | chr11:5858569 | CGI:chr11:6234538-6234892 | promoter | 7.36e-01 | 8.92e-01 | -4.64e+00 | 3.55e-06 | 6.23e-06 | -1.55e-01 |
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Exon skipping events with PSI in TCGA for OR52E8 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for OR52E8 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for OR52E8 |
| TFs related to OR52E8. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | ZFP28 | OR52E8 | 6.41e+00 | 6.41e-03 | 7.47e+00 | 9.93e-01 | Female-biased |
| CHOL | ZNF418 | OR52E8 | 7.61e+00 | 3.08e-03 | 8.85e+00 | 9.97e-01 | Female-biased |
| MESO | ZNF35 | OR52E8 | 6.95e+00 | 1.55e-02 | 8.09e+00 | 9.84e-01 | Female-biased |
| MESO | ZNF418 | OR52E8 | 5.47e+00 | 6.10e-03 | 6.92e+00 | 9.94e-01 | Female-biased |
| SARC | ZNF418 | OR52E8 | 8.38e+00 | 9.92e-01 | 7.78e+00 | 7.58e-03 | Male-biased |
| THYM | BCL11A | OR52E8 | 7.91e+00 | 9.98e-01 | 6.76e+00 | 1.48e-03 | Male-biased |
| THYM | LHX2 | OR52E8 | 1.00e+01 | 9.99e-01 | 8.69e+00 | 6.38e-04 | Male-biased |
| THYM | SPI1 | OR52E8 | 8.30e+00 | 9.99e-01 | 7.05e+00 | 9.79e-04 | Male-biased |
| THYM | SPIB | OR52E8 | 8.42e+00 | 9.98e-01 | 7.33e+00 | 1.88e-03 | Male-biased |
| THYM | ZFP28 | OR52E8 | 7.33e+00 | 9.99e-01 | 5.94e+00 | 5.44e-04 | Male-biased |
| THYM | ZNF124 | OR52E8 | 7.46e+00 | 9.81e-01 | 6.92e+00 | 1.92e-02 | Male-biased |
| THYM | ZNF35 | OR52E8 | 8.96e+00 | 1.00e+00 | 6.80e+00 | 3.13e-05 | Male-biased |
| THYM | ZNF418 | OR52E8 | 8.36e+00 | 1.00e+00 | 4.70e+00 | 3.59e-07 | Male-biased |
| UVM | ZNF35 | OR52E8 | 7.63e+00 | 9.86e-01 | 6.47e+00 | 1.39e-02 | Male-biased |
| UVM | ZNF418 | OR52E8 | 6.25e+00 | 9.95e-01 | 4.45e+00 | 3.87e-03 | Male-biased |
| OR52E8 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for OR52E8 |
| RBPs related to ES in OR52E8. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| OR52E8 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of OR52E8 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
