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Gene: ENSG00000182979 |
Summary for MTA1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000182979 | Gene symbol | MTA1 |
| Gene name | metastasis associated 1 | |
| HGNC | 7410 | |
| Entrez ID | 9112 | |
| Gene type | protein_coding | |
| Synonyms | MTA1| | |
| UniProtAcc | Q13330 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for MTA1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MTA1 | 3.88e+03 | 1.10e+00 | 1.16e-01 | 9.52e+00 | 1.75e-21 | 9.09e-21 | LUSC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MTA1 | 2.26e+03 | 1.06e+00 | 2.76e-01 | 3.84e+00 | 1.23e-04 | 5.73e-04 | READ |
Top |
Sex-biased somatic mutation for MTA1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MTA1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg01318265 | chr14:105418384 | CGI:chr14:105419676-105420248 | promoter | 7.08e-01 | 8.95e-01 | -4.42e+00 | 9.74e-06 | 5.26e-04 | -1.87e-01 |
| BLCA | cg01318265 | chr14:105418384 | CGI:chr14:105419676-105420248 | promoter | 6.87e-01 | 8.35e-01 | -3.02e+00 | 2.50e-03 | 4.69e-03 | -1.48e-01 |
| ESCA | cg21517792 | chr14:105419194 | CGI:chr14:105419676-105420248 | promoter | 6.65e-01 | 5.26e-01 | 2.39e+00 | 1.67e-02 | 3.90e-02 | 1.39e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for MTA1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| ESCA | exon_skip_110809 | 5.91e-01 | 8.32e-01 | -4.21e+00 | 2.54e-05 | 6.20e-03 | -2.41e-01 |
| CHOL | exon_skip_110809 | 7.80e-01 | 9.36e-01 | -2.45e+00 | 1.42e-02 | 2.78e-02 | -1.56e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| READ | exon_skip_110809 | 6.10e-01 | 8.58e-01 | -3.82e+00 | 1.31e-04 | 3.84e-03 | -2.48e-01 |
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RNA A-to-I editing events in TCGA for MTA1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MTA1 |
| TFs related to MTA1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | PLAGL2 | MTA1 | 3.62e+00 | 8.73e-03 | 4.88e+00 | 9.86e-01 | Female-biased |
| GBM | ZNF141 | MTA1 | 4.55e+00 | 9.81e-01 | 3.52e+00 | 1.25e-02 | Male-biased |
| MTA1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MTA1 |
| RBPs related to ES in MTA1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | HNRNPH2 | exon_skip_110811 | 6.75e+00 | 9.81e-01 | 6.29e+00 | 3.83e-03 | Male-biased |
| STAD | HNRNPH2 | exon_skip_110814 | 7.75e+00 | 1.68e-03 | 8.29e+00 | 9.91e-01 | Female-biased |
| ACC | CNOT4 | exon_skip_110816 | 1.08e+01 | 9.92e-01 | 1.03e+01 | 6.84e-03 | Male-biased |
| UVM | KHDRBS3 | exon_skip_110810 | 9.05e+00 | 2.68e-03 | 9.47e+00 | 9.94e-01 | Female-biased |
| UVM | MBNL1 | exon_skip_110807 | 8.22e+00 | 1.27e-02 | 8.50e+00 | 9.81e-01 | Female-biased |
| LIHC | SNRPA | exon_skip_110811 | 7.11e+00 | 9.82e-01 | 6.63e+00 | 4.93e-03 | Male-biased |
| COAD | HNRNPH2 | exon_skip_110811 | 6.81e+00 | 9.82e-01 | 6.36e+00 | 3.18e-03 | Male-biased |
| COAD | HNRNPH2 | exon_skip_110814 | 7.95e+00 | 3.78e-03 | 8.37e+00 | 9.89e-01 | Female-biased |
| DLBC | KHDRBS3 | exon_skip_110810 | 9.21e+00 | 8.74e-03 | 9.55e+00 | 9.88e-01 | Female-biased |
| CHOL | HNRNPH2 | exon_skip_110811 | 7.08e+00 | 9.86e-01 | 6.31e+00 | 7.14e-04 | Male-biased |
| KIRP | HNRNPH2 | exon_skip_110814 | 7.79e+00 | 2.98e-03 | 8.22e+00 | 9.89e-01 | Female-biased |
| READ | HNRNPH2 | exon_skip_110814 | 8.37e+00 | 9.83e-01 | 8.04e+00 | 9.66e-03 | Male-biased |
| PCPG | KHDRBS3 | exon_skip_110810 | 9.33e+00 | 9.83e-01 | 9.04e+00 | 1.40e-02 | Male-biased |
| MESO | CNOT4 | exon_skip_110816 | 1.01e+01 | 1.34e-02 | 1.05e+01 | 9.85e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_110821 | 6.11e+00 | 7.74e-04 | 6.70e+00 | 9.83e-01 | Female-biased |
| PAAD | HNRNPH2 | exon_skip_110811 | 6.25e+00 | 2.28e-03 | 6.67e+00 | 9.81e-01 | Female-biased |
| KICH | CNOT4 | exon_skip_110816 | 1.03e+01 | 5.87e-03 | 1.07e+01 | 9.93e-01 | Female-biased |
| KICH | KHDRBS3 | exon_skip_110810 | 8.85e+00 | 6.49e-03 | 9.21e+00 | 9.90e-01 | Female-biased |
| HNSC | RBM4 | exon_skip_110818 | 8.74e+00 | 9.91e-01 | 8.30e+00 | 3.95e-03 | Male-biased |
| SARC | HNRNPH2 | exon_skip_110811 | 6.02e+00 | 1.39e-03 | 6.61e+00 | 9.82e-01 | Female-biased |
| SARC | KHDRBS3 | exon_skip_110810 | 9.33e+00 | 9.83e-01 | 9.00e+00 | 1.41e-02 | Male-biased |
| MTA1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000182979 | AC144548.1,hsa-mir-543,MTA1 | Male-specific ceRNA | TCGA-LUSC |
| ENSG00000182979 | AC093752.2,hsa-mir-559,MTA1 | Male-specific ceRNA | TCGA-LUSC |
| ENSG00000182979 | AL355488.1,hsa-mir-559,MTA1 | Male-specific ceRNA | TCGA-LUSC |
| ENSG00000182979 | AP003352.1,hsa-mir-559,MTA1 | Male-specific ceRNA | TCGA-LUSC |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10129884 | chr14:97652481:G:A | - | 0.0584869629137444 | 0.0270357148899036 | KIRC | Male-baised eQTL |
| rs2754061 | chr14:99313098:A:G | - | -0.0451727957618444 | 0.04958388240488 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs8012258 | chr14:104524791:C:T | Distant upstream | 0.0669792957644154 | 0.0146849204089922 | STAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10135029 | chr14:104651473:G:A | Distant upstream | 0.0693868220623337 | 0.034140439747061 | COAD | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10143022 | chr14:104995721:A:G | Distant upstream | -0.0449221089394923 | 0.00187853437123862 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10143079 | chr14:104995732:C:T | Distant upstream | -0.0449221089394923 | 0.00187853437123862 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10136586 | chr14:104993780:C:T | Distant upstream | -0.0443929008839126 | 0.00218121894404075 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs7159328 | chr14:104994092:G:A | Distant upstream | -0.0443929008839126 | 0.00218121894404075 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10162501 | chr14:105020412:G:A | Distant upstream | -0.0445323082467382 | 0.0022121697100157 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs3803294 | chr14:105011765:G:A | Distant upstream | -0.0450378245929544 | 0.00222794911501051 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs9324080 | chr14:105017363:T:C | Distant upstream | -0.0446283628474976 | 0.00260797354479292 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs7159532 | chr14:104994202:G:A | Distant upstream | -0.0441316089768602 | 0.00263235375461905 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs12431580 | chr14:105012544:T:G | Distant upstream | -0.0440340514485022 | 0.00315614635196803 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs3923888 | chr14:105014250:C:T | Distant upstream | -0.0440340514485022 | 0.00315614635196803 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs28391579 | chr14:105004126:T:G | Distant upstream | -0.0429388380337069 | 0.00435670937784114 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs61996057 | chr14:105003031:G:T | Distant upstream | -0.0428706748535868 | 0.0046680362457174 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs74629810 | chr14:105002999:T:A | Distant upstream | -0.0427160348998399 | 0.00497552592748308 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs4075085 | chr14:105013204:T:G | Distant upstream | -0.0432045255216244 | 0.00501130729996065 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs4075087 | chr14:105013318:C:T | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs7146925 | chr14:105013688:G:A | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs6576069 | chr14:105013793:T:C | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs4577017 | chr14:105013900:G:A | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs4577018 | chr14:105013903:G:A | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs11628967 | chr14:105015742:G:A | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs11160831 | chr14:105015939:C:T | Distant upstream | -0.0422256579191735 | 0.00575937088768462 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs61997770 | chr14:105029032:C:T | Distant upstream | -0.042412600460987 | 0.00585059589905432 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10144833 | chr14:105008503:A:G | Distant upstream | -0.0419407978251429 | 0.0064432486894879 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs4570772 | chr14:105013913:T:G | Distant upstream | -0.0424189282996666 | 0.00652238476367866 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs10147672 | chr14:105014849:G:A | Distant upstream | -0.0412642236057301 | 0.00747346211036179 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs6576071 | chr14:105029549:T:C | Distant upstream | -0.0416432002136927 | 0.00771714864255981 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs6576072 | chr14:105029808:G:A | Distant upstream | -0.0416432002136927 | 0.00771714864255981 | KIRP | Male-baised sQTL |
| exon_skip_110809 | chr14:105449358:105449409 | In-frame | rs61997771 | chr14:105031574:C:T | Distant upstream | -0.0421267765843174 | 0.00822720264532552 | KIRP | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
 | EX ID: exon_skip_110823 |
| CpG Site: cg02263377 | |
| Position to EX: Distant upstream | |
| Male Effect: - | |
| Female Effect: 0.0606710395875493 |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| exon_skip_110823 | chr14:105466706:105466742 | cg02263377 | chr14:104729479 | Distant upstream | 0.0606710395875493 | 7.84303996420098e-08 | 0.3583805625871464 | 1.2715919071150806e-08 | In-frame | LUAD |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of MTA1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000182979 | MTA1 | C0014175 | Endometriosis | 1 | CTD_human |
| ENSG00000182979 | MTA1 | C0030567 | Parkinson Disease | 1 | CTD_human |
| ENSG00000182979 | MTA1 | C0269102 | Endometrioma | 1 | CTD_human |
