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Gene: ENSG00000182809 |
Summary for CRIP2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000182809 | Gene symbol | CRIP2 |
| Gene name | cysteine rich protein 2 | |
| HGNC | 2361 | |
| Entrez ID | 1397 | |
| Gene type | protein_coding | |
| Synonyms | CRIP2|CRP2|ESP1 | |
| UniProtAcc | P52943 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CRIP2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| CRIP2 | 5.09e+03 | 1.08e+00 | 4.37e-01 | 2.47e+00 | 1.34e-02 | 3.19e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for CRIP2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CRIP2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 5.77e-01 | 7.21e-01 | -3.19e+00 | 1.41e-03 | 6.97e-03 | -1.45e-01 |
| ACC | cg27082076 | chr14:105471797 | CGI:chr14:105469927-105470207 | promoter | 6.39e-01 | 7.50e-01 | -2.51e+00 | 1.21e-02 | 2.81e-02 | -1.11e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 5.30e-01 | 4.11e-01 | 4.12e+00 | 3.71e-05 | 8.55e-05 | 1.19e-01 |
| KIRC | cg15532667 | chr14:105473335 | CGI:chr14:105474251-105475563 | promoter,exon,CDS,gene body | 3.52e-01 | 2.39e-01 | 4.41e+00 | 1.04e-05 | 2.80e-05 | 1.13e-01 |
| LUSC | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 6.97e-01 | 5.79e-01 | 2.98e+00 | 2.91e-03 | 5.47e-03 | 1.18e-01 |
| BLCA | cg27082076 | chr14:105471797 | CGI:chr14:105469927-105470207 | promoter | 8.68e-01 | 7.64e-01 | 2.79e+00 | 5.30e-03 | 8.53e-03 | 1.04e-01 |
| LIHC | cg03451296 | chr14:105474054 | CGI:chr14:105474251-105475563 | promoter,gene body | 3.29e-01 | 1.73e-01 | 2.74e+00 | 6.08e-03 | 7.84e-03 | 1.56e-01 |
| ESCA | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 6.85e-01 | 4.38e-01 | 3.16e+00 | 1.59e-03 | 3.37e-02 | 2.47e-01 |
| CHOL | cg03451296 | chr14:105474054 | CGI:chr14:105474251-105475563 | promoter,gene body | 6.48e-02 | 1.96e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -1.31e-01 |
| CHOL | cg02155796 | chr14:105473842 | CGI:chr14:105474251-105475563 | promoter,gene body | 9.00e-02 | 3.40e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -2.50e-01 |
| CHOL | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 5.71e-01 | 3.97e-01 | 1.99e+00 | 4.65e-02 | 4.65e-02 | 1.74e-01 |
| CHOL | cg15532667 | chr14:105473335 | CGI:chr14:105474251-105475563 | promoter,exon,CDS,gene body | 4.18e-01 | 6.46e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -2.28e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19509076 | chr14:105472110 | CGI:chr14:105469927-105470207 | promoter | 5.38e-01 | 6.83e-01 | -9.64e+00 | 5.57e-22 | 3.57e-21 | -1.45e-01 |
| BRCA | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 5.21e-01 | 6.77e-01 | -9.75e+00 | 1.83e-22 | 1.23e-21 | -1.55e-01 |
| BRCA | cg15532667 | chr14:105473335 | CGI:chr14:105474251-105475563 | promoter,exon,CDS,gene body | 3.34e-01 | 4.36e-01 | -7.26e+00 | 3.90e-13 | 1.24e-12 | -1.02e-01 |
| THCA | cg19509076 | chr14:105472110 | CGI:chr14:105469927-105470207 | promoter | 6.29e-01 | 7.30e-01 | -6.59e+00 | 4.53e-11 | 1.16e-09 | -1.02e-01 |
| HNSC | cg15532667 | chr14:105473335 | CGI:chr14:105474251-105475563 | promoter,exon,CDS,gene body | 4.45e-01 | 3.20e-01 | 2.38e+00 | 1.75e-02 | 2.55e-02 | 1.25e-01 |
| LIHC | cg10750828 | chr14:105472690 | CGI:chr14:105474251-105475563 | promoter | 5.13e-01 | 4.10e-01 | 2.40e+00 | 1.63e-02 | 2.05e-02 | 1.03e-01 |
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Exon skipping events with PSI in TCGA for CRIP2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CRIP2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CRIP2 |
| TFs related to CRIP2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CRIP2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CRIP2 |
| RBPs related to ES in CRIP2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| STAD | RBM4 | exon_skip_110851 | 1.12e+01 | 9.95e-01 | 1.07e+01 | 4.02e-03 | Male-biased |
| UVM | RBM4 | exon_skip_110851 | 1.10e+01 | 9.95e-01 | 1.06e+01 | 3.99e-03 | Male-biased |
| THYM | ZC3H10 | exon_skip_110842 | 6.61e+00 | 9.81e-01 | 6.14e+00 | 2.06e-03 | Male-biased |
| LIHC | RBM4 | exon_skip_110851 | 1.10e+01 | 3.72e-03 | 1.15e+01 | 9.95e-01 | Female-biased |
| COAD | RBM4 | exon_skip_110851 | 1.11e+01 | 4.63e-03 | 1.15e+01 | 9.95e-01 | Female-biased |
| COAD | ZC3H10 | exon_skip_110842 | 6.61e+00 | 9.81e-01 | 6.11e+00 | 1.91e-03 | Male-biased |
| CHOL | RBM4 | exon_skip_110851 | 1.12e+01 | 1.29e-02 | 1.15e+01 | 9.86e-01 | Female-biased |
| KIRP | RBM4 | exon_skip_110851 | 1.08e+01 | 1.91e-03 | 1.12e+01 | 9.97e-01 | Female-biased |
| BRCA | ZC3H10 | exon_skip_110842 | 6.15e+00 | 9.16e-04 | 7.60e+00 | 9.89e-01 | Female-biased |
| ESCA | RBM4 | exon_skip_110851 | 1.08e+01 | 1.73e-02 | 1.12e+01 | 9.82e-01 | Female-biased |
| THCA | RBM4 | exon_skip_110851 | 1.14e+01 | 9.95e-01 | 1.10e+01 | 3.71e-03 | Male-biased |
| PCPG | SAMD4A | exon_skip_110867 | 6.62e+00 | 9.81e-01 | 6.13e+00 | 1.45e-03 | Male-biased |
| MESO | ZC3H10 | exon_skip_110842 | 6.86e+00 | 9.85e-01 | 6.19e+00 | 5.25e-04 | Male-biased |
| PAAD | SAMD4A | exon_skip_110867 | 6.34e+00 | 1.28e-03 | 6.82e+00 | 9.84e-01 | Female-biased |
| PAAD | SNRPA | exon_skip_110867 | 6.56e+00 | 1.25e-03 | 7.04e+00 | 9.85e-01 | Female-biased |
| SKCM | ZC3H10 | exon_skip_110842 | 7.12e+00 | 9.83e-01 | 6.68e+00 | 4.09e-03 | Male-biased |
| HNSC | SAMD4A | exon_skip_110867 | 6.89e+00 | 9.85e-01 | 6.25e+00 | 7.47e-04 | Male-biased |
| HNSC | SNRPA | exon_skip_110867 | 7.00e+00 | 9.83e-01 | 6.53e+00 | 3.09e-03 | Male-biased |
| SARC | SAMD4A | exon_skip_110867 | 6.66e+00 | 9.80e-01 | 6.16e+00 | 2.99e-03 | Male-biased |
| SARC | ZC3H10 | exon_skip_110842 | 6.98e+00 | 9.81e-01 | 6.54e+00 | 4.62e-03 | Male-biased |
| CRIP2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11622717 | chr14:99470610:C:G | - | 0.172960126571481 | 0.0402595489440535 | GBM | Female-baised eQTL |
| rs1981266 | chr14:101213181:C:T | - | 0.0974842668005337 | 0.00547435886407948 | LGG | Female-baised eQTL |
| rs857054 | chr14:98058487:A:G | - | 0.113489320662904 | 0.0339021980805118 | KIRC | Female-baised eQTL |
| rs8022459 | chr14:98058619:T:A | - | 0.113489320662904 | 0.0339021980805118 | KIRC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs8009773 | chr14:98725293:A:T | - | 0.103107141722328 | 0.0223875186661419 | KIRP | Male-baised eQTL |
| rs8008208 | chr14:98731630:A:C | - | 0.106646470662682 | 0.0413025406024179 | KIRP | Male-baised eQTL |
| rs149497738 | chr14:100177909:G:T | - | 0.100926017397311 | 0.0104241537789136 | LGG | Male-baised eQTL |
| rs77885563 | chr14:100171488:T:C | - | 0.0906704903353575 | 0.0254866513392672 | LGG | Male-baised eQTL |
| rs143154883 | chr14:100174440:G:A | - | 0.0906704903353575 | 0.0254866513392672 | LGG | Male-baised eQTL |
| rs80350312 | chr14:100175910:G:A | - | 0.0906704903353575 | 0.0254866513392672 | LGG | Male-baised eQTL |
| rs75644274 | chr14:100176677:T:C | - | 0.0884846930414155 | 0.0359328393081119 | LGG | Male-baised eQTL |
| rs944122 | chr14:99011693:C:G | - | -0.076812799559994 | 0.0413653799841246 | KIRC | Male-baised eQTL |
| rs12435943 | chr14:98039131:G:T | - | 0.064654289331625 | 0.0476550226093588 | KIRC | Male-baised eQTL |
| rs9919939 | chr14:98039564:C:A | - | 0.064654289331625 | 0.0476550226093588 | KIRC | Male-baised eQTL |
| rs12433370 | chr14:98043466:C:T | - | 0.064654289331625 | 0.0476550226093588 | KIRC | Male-baised eQTL |
| rs12433407 | chr14:98043605:C:A | - | 0.064654289331625 | 0.0476550226093588 | KIRC | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000182809 |
| CpG Site: cg15532667 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: -0.102879525858816 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg15532667 | chr14:105473335 | gene,exon,CDS,promoter | -0.102879525858816 | 5.21445008329354e-05 | -0.3359451835431035 | 2.766970902968465e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CRIP2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
