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Gene: ENSG00000182742

Summary for HOXB4

Gene summary

Gene information	Ensembl ID	ENSG00000182742
	Gene symbol	HOXB4
	Gene name	homeobox B4
	HGNC	5115
	Entrez ID	3214
	Gene type	protein_coding
	Synonyms	HOXB4\|
	UniProtAcc	P17483

Drugs associated with this gene(DrugBank).

Gene ID

Gene Symbol

Drug ID

Drug Name

Drug Type

Cancer therapeutic drugs associated with this gene(NCI).

Gene ID

Gene Name

Drug ID

Drug Name

Drug Type

Cancer

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Structure and expression level for HOXB4

AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.

Landscape of gene expressions across multiple cancer types.

Differentially expressed gene analysis between tumor male and tumor female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Differentially expressed gene analysis between tumor male and normal male samples.

Coding Name	Base Mean	log2FoldChange	lfcSE	Stat	P value	P.adjust Value	Cancer Type
HOXB4	4.74e+02	1.52e+00	3.70e-01	4.12e+00	3.78e-05	1.92e-04	BLCA

Differentially expressed gene analysis between tumor female and normal female samples.

Coding Name

Base Mean

log2FoldChange

lfcSE

Stat

P value

P.adjust Value

Cancer Type

Top

Sex-biased somatic mutation for HOXB4

∗For more information on exon skipping events please check the ExonskipDB database.

Gene ID

Cancer Type

Hugo Symbol

Male

Female

pval

ci.up

ci.low

adjPval

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DNA methylation with beta values for HOXB4

Landscape of DNA methylation across multiple cancer types.

Differentially expressed CpG sites between male tumor and female tumor patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg07015911	chr17:48578218	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.69e-01	4.42e-01	-2.32e+00	2.04e-02	3.52e-02	-1.73e-01
BRCA	cg21460081	chr17:48578650	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.59e-01	4.43e-01	-3.08e+00	2.09e-03	1.39e-02	-1.83e-01
BRCA	cg15565065	chr17:48578114	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.15e-01	3.56e-01	-1.97e+00	4.92e-02	4.96e-02	-1.41e-01
BRCA	cg08089301	chr17:48578199	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.84e-01	4.40e-01	-2.29e+00	2.18e-02	3.62e-02	-1.56e-01
BRCA	cg26327071	chr17:48578456	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.75e-01	5.77e-01	-3.09e+00	1.98e-03	1.35e-02	-3.01e-01
BRCA	cg13789775	chr17:48578362	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.24e-01	4.05e-01	-2.94e+00	3.25e-03	1.71e-02	-1.81e-01
BRCA	cg04609859	chr17:48578374	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.05e-01	3.53e-01	-2.89e+00	3.88e-03	1.84e-02	-1.48e-01
BRCA	cg02422694	chr17:48578428	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.05e-01	3.83e-01	-2.87e+00	4.10e-03	1.88e-02	-1.78e-01
BRCA	cg19081437	chr17:48578434	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.13e-01	4.26e-01	-3.32e+00	9.12e-04	8.92e-03	-2.13e-01
BRCA	cg24114154	chr17:48578467	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.51e-01	6.52e-01	-3.22e+00	1.27e-03	1.08e-02	-3.01e-01
BRCA	cg12806763	chr17:48578474	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.54e-01	6.21e-01	-2.86e+00	4.18e-03	1.89e-02	-2.66e-01
BRCA	cg26072749	chr17:48579912	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	5.50e-01	1.79e-01	2.70e+00	6.96e-03	2.32e-02	3.71e-01
BRCA	cg14884929	chr17:48580294	CGI:chr17:48581586-48582641	promoter	4.84e-01	3.40e-01	2.35e+00	1.88e-02	3.41e-02	1.43e-01
BRCA	cg04514255	chr17:48580808	CGI:chr17:48581586-48582641	promoter	5.41e-01	3.76e-01	2.76e+00	5.80e-03	2.16e-02	1.66e-01
LUAD	cg26072749	chr17:48579912	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	4.28e-01	2.90e-01	1.49e+01	2.36e-50	6.30e-49	1.38e-01
HNSC	cg26072749	chr17:48579912	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	5.11e-01	6.27e-01	5.05e+00	4.38e-07	5.16e-06	-1.16e-01
SARC	cg21460081	chr17:48578650	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.48e-01	1.20e-01	4.33e+00	1.48e-05	9.01e-05	1.28e-01
SARC	cg22660147	chr17:48578731	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.19e-01	9.01e-02	4.48e+00	7.56e-06	4.83e-05	1.29e-01
PAAD	cg26072749	chr17:48579912	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	5.46e-01	2.24e-01	8.90e+00	5.67e-19	7.76e-18	3.22e-01
LAML	cg26072749	chr17:48579912	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	4.08e-01	5.39e-01	4.79e+00	1.70e-06	6.28e-06	-1.31e-01
MESO	cg26916621	chr17:48579984	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	7.02e-01	8.03e-01	-2.52e+00	1.17e-02	3.07e-02	-1.00e-01
MESO	cg04514255	chr17:48580808	CGI:chr17:48581586-48582641	promoter	4.71e-01	6.18e-01	-2.40e+00	1.66e-02	3.60e-02	-1.48e-01
CHOL	cg26072749	chr17:48579912	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	2.17e-01	3.23e-01	3.22e+00	1.30e-03	4.58e-03	-1.05e-01

Differentially expressed CpG sites between male tumor and male normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
KIRC	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	3.31e-01	1.68e-01	3.85e+00	1.19e-04	2.38e-04	1.63e-01
KIRC	cg17144149	chr17:48579210	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	4.35e-01	3.34e-01	2.56e+00	1.06e-02	1.25e-02	1.02e-01
THCA	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	2.44e-01	1.39e-01	3.42e+00	6.18e-04	2.21e-03	1.05e-01
THCA	cg01572694	chr17:48580193	CGI:chr17:48581586-48582641	promoter	5.93e-01	4.93e-01	2.19e+00	2.86e-02	3.44e-02	1.00e-01
LUSC	cg07015911	chr17:48578218	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	3.95e-01	7.92e-02	2.64e+00	8.23e-03	1.19e-02	3.16e-01
LUSC	cg21460081	chr17:48578650	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.87e-01	5.70e-02	2.98e+00	2.87e-03	5.41e-03	2.30e-01
LUSC	cg15565065	chr17:48578114	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	3.98e-01	1.56e-02	4.05e+00	5.21e-05	5.63e-04	3.82e-01
LUSC	cg08089301	chr17:48578199	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	4.03e-01	1.74e-02	3.08e+00	2.07e-03	4.28e-03	3.85e-01
LUSC	cg26327071	chr17:48578456	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.89e-01	4.14e-02	2.60e+00	9.19e-03	1.30e-02	3.48e-01
LUSC	cg22660147	chr17:48578731	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.20e-01	4.29e-02	3.38e+00	7.32e-04	2.12e-03	2.78e-01
LUSC	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	6.56e-01	1.27e-01	4.31e+00	1.60e-05	5.26e-04	5.29e-01
LUSC	cg09194159	chr17:48578226	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	4.34e-01	1.11e-01	2.58e+00	9.98e-03	1.38e-02	3.23e-01
LUSC	cg13789775	chr17:48578362	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.27e-01	6.48e-02	2.88e+00	4.00e-03	6.91e-03	2.63e-01
LUSC	cg04609859	chr17:48578374	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.84e-01	9.67e-02	2.99e+00	2.78e-03	5.29e-03	1.87e-01
LUSC	cg02422694	chr17:48578428	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.20e-01	9.66e-02	2.27e+00	2.32e-02	2.69e-02	2.23e-01
LUSC	cg19081437	chr17:48578434	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.17e-01	9.08e-02	2.51e+00	1.21e-02	1.60e-02	2.26e-01
LUSC	cg24114154	chr17:48578467	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	4.44e-01	1.13e-01	2.62e+00	8.82e-03	1.26e-02	3.31e-01
LUSC	cg12806763	chr17:48578474	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	4.41e-01	1.46e-01	2.47e+00	1.36e-02	1.76e-02	2.96e-01
LUSC	cg05527785	chr17:48579181	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	5.33e-01	1.44e-01	3.91e+00	9.25e-05	6.75e-04	3.90e-01
LUSC	cg17144149	chr17:48579210	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	6.81e-01	3.16e-01	3.86e+00	1.12e-04	7.33e-04	3.65e-01
LUSC	cg10953655	chr17:48579302	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	4.43e-01	2.05e-01	3.96e+00	7.60e-05	6.28e-04	2.38e-01
LUSC	cg26916621	chr17:48579984	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	7.49e-01	5.38e-01	3.52e+00	4.34e-04	1.52e-03	2.11e-01
LUSC	cg15649236	chr17:48580142	CGI:chr17:48581586-48582641	promoter	6.71e-01	3.39e-01	3.96e+00	7.45e-05	6.23e-04	3.33e-01
LUSC	cg01572694	chr17:48580193	CGI:chr17:48581586-48582641	promoter	6.92e-01	4.95e-01	3.52e+00	4.34e-04	1.52e-03	1.97e-01
LUSC	cg14884929	chr17:48580294	CGI:chr17:48581586-48582641	promoter	5.21e-01	2.08e-01	3.99e+00	6.62e-05	6.00e-04	3.14e-01
LUSC	cg04514255	chr17:48580808	CGI:chr17:48581586-48582641	promoter	5.43e-01	3.56e-01	3.27e+00	1.06e-03	2.70e-03	1.87e-01
COAD	cg07015911	chr17:48578218	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	1.38e-01	2.60e-02	2.54e+00	1.11e-02	1.56e-02	1.12e-01
COAD	cg09194159	chr17:48578226	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	1.45e-01	4.37e-02	2.88e+00	3.92e-03	6.79e-03	1.01e-01
BLCA	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	2.41e-01	3.51e-01	-2.34e+00	1.94e-02	2.39e-02	-1.10e-01
BLCA	cg05527785	chr17:48579181	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.17e-01	4.00e-01	-3.39e+00	7.04e-04	1.73e-03	-1.83e-01
BLCA	cg17144149	chr17:48579210	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.42e-01	5.63e-01	-3.16e+00	1.55e-03	3.21e-03	-2.21e-01
BLCA	cg10953655	chr17:48579302	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	2.23e-01	3.44e-01	-2.68e+00	7.44e-03	1.12e-02	-1.21e-01
KIRP	cg26916621	chr17:48579984	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	6.41e-01	5.19e-01	2.16e+00	3.04e-02	3.28e-02	1.22e-01
CHOL	cg07015911	chr17:48578218	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	4.50e-01	8.20e-02	3.02e+00	2.51e-03	1.19e-02	3.68e-01
CHOL	cg21460081	chr17:48578650	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.35e-01	6.08e-02	3.39e+00	6.96e-04	9.20e-03	2.74e-01
CHOL	cg15565065	chr17:48578114	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	4.59e-01	2.03e-02	3.54e+00	4.02e-04	8.32e-03	4.39e-01
CHOL	cg08089301	chr17:48578199	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	4.70e-01	2.34e-02	3.39e+00	6.96e-04	9.20e-03	4.47e-01
CHOL	cg26327071	chr17:48578456	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	4.98e-01	4.41e-02	3.24e+00	1.18e-03	1.07e-02	4.54e-01
CHOL	cg22660147	chr17:48578731	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.47e-01	8.18e-02	2.21e+00	2.70e-02	3.50e-02	2.65e-01
CHOL	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	6.45e-01	1.84e-01	2.36e+00	1.83e-02	2.92e-02	4.61e-01
CHOL	cg09194159	chr17:48578226	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	4.84e-01	1.24e-01	3.02e+00	2.51e-03	1.19e-02	3.61e-01
CHOL	cg13789775	chr17:48578362	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.61e-01	1.10e-01	1.99e+00	4.65e-02	4.65e-02	1.52e-01
CHOL	cg04609859	chr17:48578374	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.46e-01	5.23e-02	2.88e+00	4.04e-03	1.47e-02	1.93e-01
CHOL	cg02422694	chr17:48578428	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.78e-01	8.75e-02	1.99e+00	4.65e-02	4.65e-02	2.91e-01
CHOL	cg19081437	chr17:48578434	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.67e-01	7.45e-02	2.80e+00	5.09e-03	1.63e-02	2.92e-01
CHOL	cg24114154	chr17:48578467	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	5.12e-01	1.17e-01	3.24e+00	1.18e-03	1.07e-02	3.94e-01
CHOL	cg12806763	chr17:48578474	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	5.26e-01	1.29e-01	3.24e+00	1.18e-03	1.07e-02	3.97e-01
CHOL	cg10953655	chr17:48579302	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	4.44e-01	1.67e-01	2.73e+00	6.38e-03	1.82e-02	2.78e-01
CHOL	cg26916621	chr17:48579984	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	6.69e-01	3.72e-01	3.10e+00	1.96e-03	1.07e-02	2.97e-01
CHOL	cg15649236	chr17:48580142	CGI:chr17:48581586-48582641	promoter	6.60e-01	3.24e-01	3.02e+00	2.51e-03	1.19e-02	3.36e-01
CHOL	cg01572694	chr17:48580193	CGI:chr17:48581586-48582641	promoter	6.79e-01	4.51e-01	2.43e+00	1.50e-02	2.65e-02	2.28e-01

Differentially expressed CpG sites between female tumor and female normal patients.

Cancer Type	CpG Site	Position	CpG Island	Position to Gene	ave1	ave2	wilcoxon.w	wilcoxon.p	padj	dBeta
BRCA	cg07015911	chr17:48578218	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.69e-01	7.49e-02	5.10e+00	3.43e-07	6.66e-07	1.94e-01
BRCA	cg21460081	chr17:48578650	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.59e-01	9.09e-02	7.80e+00	6.03e-15	2.19e-14	1.68e-01
BRCA	cg15565065	chr17:48578114	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.15e-01	2.54e-02	7.47e+00	7.80e-14	2.60e-13	1.90e-01
BRCA	cg08089301	chr17:48578199	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.84e-01	5.73e-02	5.80e+00	6.58e-09	1.49e-08	2.26e-01
BRCA	cg26327071	chr17:48578456	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.75e-01	4.75e-02	6.44e+00	1.22e-10	3.17e-10	2.28e-01
BRCA	cg22660147	chr17:48578731	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.46e-01	7.37e-02	7.07e+00	1.54e-12	4.65e-12	1.72e-01
BRCA	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	6.25e-01	4.72e-01	-2.01e+00	4.48e-02	4.52e-02	1.53e-01
BRCA	cg09194159	chr17:48578226	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.87e-01	9.53e-02	4.65e+00	3.25e-06	5.74e-06	1.91e-01
BRCA	cg13789775	chr17:48578362	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.24e-01	9.49e-02	3.99e+00	6.66e-05	1.02e-04	1.29e-01
BRCA	cg02422694	chr17:48578428	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.05e-01	8.67e-02	3.65e+00	2.61e-04	3.71e-04	1.19e-01
BRCA	cg19081437	chr17:48578434	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.13e-01	8.50e-02	4.85e+00	1.21e-06	2.22e-06	1.28e-01
BRCA	cg24114154	chr17:48578467	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.51e-01	1.20e-01	3.81e+00	1.40e-04	2.05e-04	2.31e-01
BRCA	cg12806763	chr17:48578474	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	3.54e-01	1.33e-01	5.94e+00	2.85e-09	6.67e-09	2.22e-01
LUAD	cg04514255	chr17:48580808	CGI:chr17:48581586-48582641	promoter	4.60e-01	3.54e-01	2.06e+00	3.93e-02	4.20e-02	1.06e-01
COAD	cg22660147	chr17:48578731	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.01e-01	3.31e-01	-2.24e+00	2.51e-02	3.06e-02	-1.31e-01
LIHC	cg08089301	chr17:48578199	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.25e-01	1.94e-02	2.85e+00	4.31e-03	7.14e-03	2.05e-01
LIHC	cg22660147	chr17:48578731	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.05e-01	6.69e-02	2.95e+00	3.13e-03	5.54e-03	1.38e-01
LIHC	cg02132714	chr17:48579328	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	3.20e-01	1.25e-01	2.54e+00	1.11e-02	1.51e-02	1.95e-01
LIHC	cg09194159	chr17:48578226	CGI:chr17:48576691-48577007	promoter,exon,CDS,gene body	2.53e-01	8.51e-02	2.30e+00	2.17e-02	2.57e-02	1.68e-01
LIHC	cg05527785	chr17:48579181	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	2.78e-01	1.29e-01	2.38e+00	1.74e-02	2.16e-02	1.49e-01
LIHC	cg17144149	chr17:48579210	CGI:chr17:48576691-48577007	UTR,promoter,exon,gene body	4.27e-01	3.02e-01	2.46e+00	1.39e-02	1.81e-02	1.24e-01
LIHC	cg26916621	chr17:48579984	CGI:chr17:48581586-48582641	UTR,promoter,exon,gene body	5.50e-01	3.80e-01	2.20e+00	2.77e-02	3.12e-02	1.70e-01
LIHC	cg01572694	chr17:48580193	CGI:chr17:48581586-48582641	promoter	5.74e-01	4.36e-01	2.77e+00	5.56e-03	8.73e-03	1.38e-01
LIHC	cg14884929	chr17:48580294	CGI:chr17:48581586-48582641	promoter	2.77e-01	1.64e-01	2.16e+00	3.04e-02	3.37e-02	1.12e-01

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Exon skipping events with PSI in TCGA for HOXB4

∗Please access ExonSkipDB for exon skipping annotation.

Differentially expressed exon skipping events between male tumor and female tumor patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between male tumor and male normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

Differentially expressed exon skipping events between female tumor and female normal patients.

Cancer Type

Exon Skipping

ave.female_T

ave.female_N

wilcoxon.w

wilcoxon.p

padj

dPSI

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RNA A-to-I editing events in TCGA for HOXB4

∗Please access CAeditome for RNA editing annotation.

Differentially expressed RNA editing events between male tumor and female tumor patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between male tumor and male normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Differentially expressed RNA editing events between female tumor and female normal patients.

Cancer Type

Transcript

Editing

ave.male_T

ave.female_T

wilcoxon.w

wilcoxon.p

p_adj

dFre

Protein coding RNA editing(s).

Editing Position

Variant Type

Gene Symbol

Transcript ID

NTchange

AAchange

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Sex-biased TF-Gene network for HOXB4

TFs related to HOXB4.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type	TF	Target Gene	Male Edge Score	Male Edge Threshold	Female Edge Score	Female Edge Threshold	Type
ESCA	HKR1	HOXB4	3.94e+00	9.84e-01	2.97e+00	2.36e-03	Male-biased
ESCA	KLF17	HOXB4	3.79e+00	9.81e-01	2.69e+00	1.13e-03	Male-biased
ESCA	ZNF101	HOXB4	3.84e+00	9.81e-01	2.93e+00	3.13e-03	Male-biased
ESCA	ZNF141	HOXB4	3.96e+00	9.86e-01	2.72e+00	5.00e-04	Male-biased
ESCA	ZNF23	HOXB4	4.06e+00	9.88e-01	2.87e+00	6.47e-04	Male-biased
ESCA	ZNF28	HOXB4	4.02e+00	9.88e-01	2.74e+00	3.97e-04	Male-biased
ESCA	ZNF300	HOXB4	3.93e+00	9.85e-01	2.78e+00	8.53e-04	Male-biased
ESCA	ZNF320	HOXB4	3.86e+00	9.84e-01	2.70e+00	7.71e-04	Male-biased
ESCA	ZNF468	HOXB4	4.02e+00	9.87e-01	2.96e+00	1.39e-03	Male-biased
ESCA	ZNF487	HOXB4	2.88e+00	1.61e-03	4.06e+00	9.89e-01	Female-biased
ESCA	ZNF506	HOXB4	3.91e+00	9.82e-01	3.01e+00	3.45e-03	Male-biased
ESCA	ZNF530	HOXB4	3.88e+00	9.83e-01	2.87e+00	1.74e-03	Male-biased
ESCA	ZNF534	HOXB4	4.06e+00	9.85e-01	3.17e+00	3.66e-03	Male-biased
ESCA	ZNF587	HOXB4	3.94e+00	9.80e-01	3.14e+00	5.89e-03	Male-biased
ESCA	ZNF682	HOXB4	3.86e+00	9.84e-01	2.68e+00	6.85e-04	Male-biased
ESCA	ZNF707	HOXB4	3.87e+00	9.83e-01	2.86e+00	1.83e-03	Male-biased
ESCA	ZNF793	HOXB4	3.99e+00	9.81e-01	3.19e+00	6.27e-03	Male-biased
ESCA	ZNF816	HOXB4	4.12e+00	9.89e-01	3.05e+00	1.32e-03	Male-biased
ESCA	ZSCAN22	HOXB4	3.90e+00	9.82e-01	3.03e+00	3.92e-03	Male-biased
MESO	HSFY2	HOXB4	4.56e+00	1.54e-02	5.70e+00	9.83e-01	Female-biased
MESO	MYNN	HOXB4	3.67e+00	5.19e-03	5.16e+00	9.92e-01	Female-biased
MESO	TEAD3	HOXB4	3.93e+00	1.11e-02	5.18e+00	9.86e-01	Female-biased
MESO	ZNF136	HOXB4	3.81e+00	8.91e-03	5.13e+00	9.88e-01	Female-biased
SARC	ZNF793	HOXB4	3.44e+00	7.85e-03	4.13e+00	9.80e-01	Female-biased

HOXB4 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for HOXB4

RBPs related to ES in HOXB4.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.

Cancer Type

RBP

Target ES

Male Edge Score

Male Edge Threshold

Female Edge Score

Female Edge Threshold

Type

HOXB4 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

Sex-biased CeRNA regulation of gene.

Gene ID

ceRNA(lncRNA-miRNA-mRNA)

Group

Cancer Type

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Sex-biased eQTL regulation of gene

Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

eQTL

Description

Male-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs76983130	chr17:40889353:T:C	-	0.199179634530113	0.0325986881645158	LUSC	Female-baised eQTL
rs9635728	chr17:41047203:G:C	-	0.112598274213045	0.0449087723447796	LUSC	Female-baised eQTL
rs11079928	chr17:50792397:T:C	-	0.137337224133419	0.0382054745440189	STAD	Female-baised eQTL
rs2671637	chr17:49463641:G:A	-	0.0880825453446231	7.68078216041136e-05	LUAD	Female-baised eQTL
rs35585925	chr17:39741957:T:C	-	0.0748867045203248	0.000765175001017841	LUAD	Female-baised eQTL
rs9904491	chr17:49462699:C:T	-	0.0726543395159747	0.00710059849438389	LUAD	Female-baised eQTL
rs1316865	chr17:49463292:T:G	-	0.0726543395159747	0.00710059849438389	LUAD	Female-baised eQTL
rs9906836	chr17:49459639:G:C	-	0.0647878575067752	0.0175373271212111	LUAD	Female-baised eQTL

Female-specific eQTL regulation.

SNP ID	SNP Info	Position to Gene	Effect Score	FDR	Cancer Type	Biased Type
rs12452082	chr17:47866635:G:A	-	0.152656821467605	0.00218457098682663	SARC	Male-baised eQTL
rs2109086	chr17:51476741:C:T	-	0.0874816847785709	0.0115109559370905	KIRC	Male-baised eQTL
rs8074148	chr17:51477672:A:G	-	0.0874816847785709	0.0115109559370905	KIRC	Male-baised eQTL
rs8078799	chr17:43349580:G:A	-	0.0944332816876135	0.0306556352203318	KIRC	Male-baised eQTL
rs4606754	chr17:43353822:A:G	-	0.0943622490896873	0.0307619101416499	KIRC	Male-baised eQTL
rs72840953	chr17:54890902:C:T	-	0.0933834495237776	0.0239407920454849	COAD	Male-baised eQTL
rs72840955	chr17:54891377:C:T	-	0.092008562658843	0.0323871278544084	COAD	Male-baised eQTL
rs34575880	chr17:54139041:A:T	-	0.101447262864713	0.0378985372477766	COAD	Male-baised eQTL

Opposite sex-biased eQTL regulation.

SNP ID

SNP Info

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Sex-biased Gene in Cancer

Cancer Type

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Sex-biased eQTM regulation of gene

Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).

eQTM	Description
	Gene ID: ENSG00000182742
	CpG Site: cg26916621
	Position to Gene: gene,exon,promoter,UTR
	Male Effect: -
	Female Effect: -0.245375164716928

Male-specific eQTM regulation.

CpG Site

CpG Postion

Position to Gene

Effect Score

FDR

Cor.r

Cor.Pvalue

Cancer Type

Female-specific eQTM regulation.

CpG Site	CpG Postion	Position to Gene	Effect Score	FDR	Cor.r	Cor.Pvalue	Cancer Type
cg26916621	chr17:48579984	gene,exon,promoter,UTR	-0.245375164716928	3.22976753579682e-16	-0.5314515481855231	5.448409580090919e-20	LUAD

Opposite sex-biased eQTM regulation.

CpG Site

CpG Postion

CpG Island

Position to Gene

Male Effect

Male FDR

Female Effect

Female FDR

Male Cor

Male P-value

Female Cor

Female P-value

Sex-biased Coding Gene

Cancer Type

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Sex-biased sQTL regulation of gene

Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTL

Description

Male-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Female-specific sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Effect Score

FDR

Cancer Type

Biased Type

Opposite sex-biased sQTL regulation.

ES ID

Skipped Exon

ORF Anno

SNP ID

SNP Info

SNP Position to ES

Male Effect

Male FDR

Female Effect

Female FDR

Cancer Type

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Sex-biased sQTM regulation of gene

Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).

sQTM

Description

Male-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Female-specific sQTM regulation.

EX ID

Skipped Exon

CPG Site

CPG Position

Position to EX Events

Effect Score

FDR

Cor.r

Cor.Pvalue

ORF_anno

Cancer Type

Opposite sex-biased sQTM regulation.

EX ID

EX Info

Skipped Exon

CPG Site

CPG Position

CPG Island

Position to EX Events

Male Effect

Male FDR

Female Effect

Female FDR

Male Correlation

Male P-value

Female Correlation

Female P-value

ORF_anno

Cancer Type

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Related disease information of HOXB4

Diseases associated with this gene (DisGeNET).

Gene ID

Gene Symbol

Disease ID

Disease Name

Number of PMID

Source

	Gene summary
	Gene structure and Gene expression level
	Sex-biased somatic mutation
	DNA methylation with beta values in gene
	Exon skipping events with PSI in TCGA
	RNA A-to-I editing events in TCGA
	Sex-biased TF-Gene network of gene
	Sex-biased RBP-ES network of gene
	Sex-biased CeRNA regulation of gene
	Sex-biased eQTL regulation of gene
	Sex-biased eQTM regulation of gene
	Sex-biased sQTL regulation of gene
	Sex-biased sQTM regulation of gene
	Related disease information of gene