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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000182636

Summary for NDN

check button Gene summary

Gene informationEnsembl ID

ENSG00000182636

Gene symbol

NDN

Gene namenecdin, MAGE family member
HGNC

7675

Entrez ID

4692

Gene typeprotein_coding
SynonymsNDN|HsT16328|PWCR
UniProtAcc

Q99608


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for NDN

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
NDN7.33e+02-1.10e+001.94e-01-5.67e+001.39e-086.47e-08LUAD
NDN8.26e+02-1.60e+004.58e-01-3.50e+004.69e-041.71e-03BLCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
NDN1.00e+03-1.86e+001.00e-01-1.86e+017.27e-771.56e-75BRCA
NDN4.39e+02-1.74e+003.97e-01-4.38e+001.17e-057.43e-05READ

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Sex-biased somatic mutation for NDN

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for NDN

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg12138102chr15:23688413CGI:chr15:23686412-23687451promoter4.01e-012.97e-012.44e+001.48e-023.11e-021.04e-01
BRCAcg25061289chr15:23688473CGI:chr15:23686412-23687451promoter3.63e-012.33e-012.91e+003.64e-031.79e-021.30e-01
GBMcg25061289chr15:23688473CGI:chr15:23686412-23687451promoter3.62e-014.68e-01-2.03e+004.26e-024.70e-02-1.06e-01
ACCcg12138102chr15:23688413CGI:chr15:23686412-23687451promoter6.62e-015.00e-012.93e+003.37e-031.32e-021.62e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
LUADcg08325271chr15:23687855CGI:chr15:23686412-23687451promoter7.11e-018.65e-01-2.83e+004.60e-036.98e-03-1.54e-01
THCAcg12138102chr15:23688413CGI:chr15:23686412-23687451promoter6.74e-017.94e-01-3.08e+002.10e-035.37e-03-1.20e-01
THCAcg25061289chr15:23688473CGI:chr15:23686412-23687451promoter6.36e-017.64e-01-3.95e+007.66e-054.94e-04-1.28e-01
HNSCcg25061289chr15:23688473CGI:chr15:23686412-23687451promoter3.73e-014.77e-01-3.30e+009.50e-041.74e-03-1.04e-01
LUSCcg01989224chr15:23687611CGI:chr15:23686412-23687451promoter3.98e-015.00e-01-2.50e+001.24e-021.64e-02-1.03e-01
LUSCcg16591875chr15:23687717CGI:chr15:23686412-23687451promoter6.53e-017.57e-01-2.12e+003.36e-023.62e-02-1.04e-01
LUSCcg11872504chr15:23687932CGI:chr15:23686412-23687451promoter6.91e-019.04e-01-3.17e+001.50e-033.42e-03-2.13e-01
COADcg11872504chr15:23687932CGI:chr15:23686412-23687451promoter7.17e-018.53e-01-2.11e+003.47e-023.79e-02-1.36e-01
BLCAcg26740481chr15:23685864CGI:chr15:23686412-23687451UTR,promoter,exon,gene body6.40e-017.83e-01-2.16e+003.12e-023.46e-02-1.43e-01
LIHCcg24137567chr15:23685805CGI:chr15:23686412-23687451UTR,promoter,exon,gene body3.60e-014.76e-01-5.10e+003.48e-071.51e-06-1.16e-01
LIHCcg06743811chr15:23686304CGI:chr15:23686412-23687451promoter,exon,CDS,gene body4.30e-015.75e-01-4.32e+001.58e-054.07e-05-1.45e-01
CHOLcg22694067chr15:23687250CGI:chr15:23686412-23687451UTR,promoter,exon,gene body4.82e-013.56e-012.73e+006.38e-031.82e-021.26e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg26740481chr15:23685864CGI:chr15:23686412-23687451UTR,promoter,exon,gene body6.77e-018.60e-01-7.95e+001.87e-157.04e-15-1.83e-01
BRCAcg01989224chr15:23687611CGI:chr15:23686412-23687451promoter3.79e-014.80e-01-7.48e+007.59e-142.53e-13-1.01e-01
BRCAcg16591875chr15:23687717CGI:chr15:23686412-23687451promoter6.94e-018.01e-01-4.50e+006.84e-061.17e-05-1.08e-01
BRCAcg11872504chr15:23687932CGI:chr15:23686412-23687451promoter6.35e-018.81e-01-1.07e+011.17e-261.17e-25-2.45e-01
BRCAcg12138102chr15:23688413CGI:chr15:23686412-23687451promoter4.01e-016.13e-01-1.22e+012.15e-345.72e-33-2.12e-01
BRCAcg25061289chr15:23688473CGI:chr15:23686412-23687451promoter3.63e-016.30e-01-1.27e+016.55e-372.68e-35-2.66e-01
KIRCcg24137567chr15:23685805CGI:chr15:23686412-23687451UTR,promoter,exon,gene body4.25e-015.27e-01-2.55e+001.08e-021.80e-02-1.02e-01
LUADcg01989224chr15:23687611CGI:chr15:23686412-23687451promoter4.52e-015.57e-01-3.04e+002.37e-035.73e-03-1.05e-01
COADcg01989224chr15:23687611CGI:chr15:23686412-23687451promoter5.44e-014.31e-012.27e+002.30e-022.88e-021.12e-01
BLCAcg16591875chr15:23687717CGI:chr15:23686412-23687451promoter6.40e-017.59e-01-2.20e+002.76e-023.35e-02-1.19e-01
KIRPcg25061289chr15:23688473CGI:chr15:23686412-23687451promoter5.48e-016.88e-01-2.31e+002.08e-022.75e-02-1.40e-01

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Exon skipping events with PSI in TCGA for NDN

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for NDN

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for NDN

check buttonTFs related to NDN.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
CHOLZNF571NDN3.07e+004.71e-034.19e+009.86e-01Female-biased
MESOZNF418NDN3.33e+001.44e-035.18e+009.96e-01Female-biased

check buttonNDN related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for NDN

check buttonRBPs related to ES in NDN.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonNDN related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs74005944chr15:33665923:C:G-0.1572898300500380.0449979934740275HNSCFemale-baised eQTL
rs73365884chr15:29471760:C:T-0.3597121309427080.000143759586614372GBMFemale-baised eQTL
rs74008480chr15:29473811:G:A-0.3597121309427080.000143759586614372GBMFemale-baised eQTL
rs73365895chr15:29474064:T:C-0.3597121309427080.000143759586614372GBMFemale-baised eQTL
rs7175986chr15:32740906:A:G-0.3047886578268850.000254316783034832GBMFemale-baised eQTL
rs28436730chr15:32743909:C:T-0.3047886578268850.000254316783034832GBMFemale-baised eQTL
rs1655656chr15:29392930:T:A-0.2970086239745850.00402099591857233GBMFemale-baised eQTL
rs533554chr15:29393136:G:T-0.2970086239745850.00402099591857233GBMFemale-baised eQTL
rs17115228chr15:25103709:C:G-0.2473443682780580.0131619743703381GBMFemale-baised eQTL
rs8025274chr15:28990643:T:G-0.2001006878299090.0315791911794039GBMFemale-baised eQTL
rs58959759chr15:28955936:A:G-0.2000584736950890.0317007344498224GBMFemale-baised eQTL
rs8033952chr15:28136577:C:A--0.1976987619173410.0383365756251247GBMFemale-baised eQTL
rs8040272chr15:24578869:A:G-0.1496198872721680.0425101233231854GBMFemale-baised eQTL
rs76699450chr15:24041641:G:A-0.1887577056010270.0446888742303238GBMFemale-baised eQTL
rs60251681chr15:24042365:G:A-0.1887577056010270.0446888742303238GBMFemale-baised eQTL
rs139170165chr15:24046788:C:G-0.1887577056010270.0446888742303238GBMFemale-baised eQTL
rs149001760chr15:24047422:T:C-0.1887577056010270.0446888742303238GBMFemale-baised eQTL
rs143843965chr15:24047426:A:G-0.1887577056010270.0446888742303238GBMFemale-baised eQTL
rs10519646chr15:29310799:C:T-0.199417596857760.0488939899393913GBMFemale-baised eQTL
rs11638932chr15:24828607:A:G-0.09973097112241490.0352451226657753LUSCFemale-baised eQTL
rs75243807chr15:24829114:A:C-0.09867297335745330.0462725681001926LUSCFemale-baised eQTL
rs75066798chr15:24830781:G:C-0.09834402117697080.0488825370284566LUSCFemale-baised eQTL
rs140984085chr15:24837625:A:T-0.09663262324152530.0496119318420555LUSCFemale-baised eQTL
rs140958366chr15:24838016:C:T-0.09663262324152530.0496119318420555LUSCFemale-baised eQTL
rs11629898chr15:24843988:G:A-0.09663262324152530.0496119318420555LUSCFemale-baised eQTL
rs11634286chr15:24846619:C:G-0.09663262324152530.0496119318420555LUSCFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs114484885chr15:26075643:T:C-0.07832421196591790.0398667075309238LIHCMale-baised eQTL
rs78649218chr15:26076450:C:T-0.07832421196591790.0398667075309238LIHCMale-baised eQTL
rs79496313chr15:26076787:T:C-0.0777380318829480.0456655355249182LIHCMale-baised eQTL
rs77993860chr15:26076855:G:A-0.0777380318829480.0456655355249182LIHCMale-baised eQTL
rs3897710chr15:26077831:G:A-0.0777380318829480.0456655355249182LIHCMale-baised eQTL
rs12905276chr15:29155009:G:A-0.0651189815196330.031138377564175LUADMale-baised eQTL
rs7174078chr15:29154944:A:G-0.06422354944263670.0373042360779884LUADMale-baised eQTL
rs17604644chr15:31838818:T:G-0.06967103871501050.030755325393989COADMale-baised eQTL
rs7178899chr15:31247694:C:T-0.0953840796884020.0324982169740545COADMale-baised eQTL
rs17604629chr15:31820466:T:C-0.06924528193344350.033915724881186COADMale-baised eQTL
rs35575383chr15:31808848:T:C-0.0684257451747740.0426899949472214COADMale-baised eQTL
rs11638384chr15:31812939:G:A-0.06804991143810890.0433566546466814COADMale-baised eQTL
rs12904569chr15:31811143:A:C-0.0667571872766780.049898781837382COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000182636
CpG Site: cg06743811
Position to Gene: gene,exon,CDS,promoter
Male Effect: -
Female Effect: -0.42708576486846
eQTM boxplot analysisGene ID: ENSG00000182636
CpG Site: cg08325271
Position to Gene: promoter
Male Effect: -
Female Effect: -0.42212117784657
eQTM boxplot analysisGene ID: ENSG00000182636
CpG Site: cg13828758
Position to Gene: gene,exon,promoter,UTR
Male Effect: -0.435314812793382
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000182636
CpG Site: cg13828758
Position to Gene: gene,exon,promoter,UTR
Male Effect: -0.447719999463829
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000182636
CpG Site: cg22694067
Position to Gene: gene,exon,promoter,UTR
Male Effect: -0.267555638016573
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg13828758chr15:23687226gene,exon,promoter,UTR-0.4353148127933823.2925329406582e-13-0.51644148484282761.330101797394543e-16LUAD
cg13828758chr15:23687226gene,exon,promoter,UTR-0.4477199994638291.03203478821881e-08-0.373648337409334451.42575508425783e-10LUSC
cg22694067chr15:23687250gene,exon,promoter,UTR-0.2675556380165735.2126019216807e-06-0.31818536399451386.547177994980591e-08LUSC

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg06743811chr15:23686304gene,exon,CDS,promoter-0.427085764868461.72327016691315e-09-0.69401422190770089.496933696403657e-13PAAD
cg08325271chr15:23687855promoter-0.422121177846573.15096247336501e-09-0.70804501475280715.007433698139581e-12PAAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of NDN

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000182636NDNC0007097Carcinoma1CTD_human
ENSG00000182636NDNC0024667Animal Mammary Neoplasms1CTD_human
ENSG00000182636NDNC0032897Prader-Willi Syndrome1CTD_human
ENSG00000182636NDNC0205696Anaplastic carcinoma1CTD_human
ENSG00000182636NDNC0205697Carcinoma, Spindle-Cell1CTD_human
ENSG00000182636NDNC0205698Undifferentiated carcinoma1CTD_human
ENSG00000182636NDNC0205699Carcinomatosis1CTD_human
ENSG00000182636NDNC0265222Royer Syndrome1CTD_human
ENSG00000182636NDNC1257925Mammary Carcinoma, Animal1CTD_human