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Gene: ENSG00000182580 |
Summary for EPHB3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000182580 | Gene symbol | EPHB3 |
| Gene name | EPH receptor B3 | |
| HGNC | 3394 | |
| Entrez ID | 2049 | |
| Gene type | protein_coding | |
| Synonyms | EPHB3|Hek2|Tyro6 | |
| UniProtAcc | P54753 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for EPHB3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| EPHB3 | 2.71e+03 | -1.26e+00 | 3.39e-01 | -3.73e+00 | 1.95e-04 | 1.56e-02 | MESO |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| EPHB3 | 1.43e+03 | 1.27e+00 | 4.36e-01 | 2.92e+00 | 3.51e-03 | 9.78e-03 | BLCA |
| EPHB3 | 1.54e+03 | 4.08e+00 | 9.07e-01 | 4.50e+00 | 6.89e-06 | 4.04e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| EPHB3 | 3.99e+02 | -1.64e+00 | 4.56e-01 | -3.59e+00 | 3.29e-04 | 7.94e-04 | KICH |
| EPHB3 | 9.21e+03 | 2.58e+00 | 5.16e-01 | 5.01e+00 | 5.46e-07 | 5.15e-06 | READ |
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Sex-biased somatic mutation for EPHB3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for EPHB3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg02565842 | chr3:184560480 | CGI:chr3:184561406-184562933 | promoter | 8.31e-01 | 9.35e-01 | -4.07e+00 | 4.78e-05 | 1.07e-04 | -1.04e-01 |
| LUSC | cg02565842 | chr3:184560480 | CGI:chr3:184561406-184562933 | promoter | 7.73e-01 | 9.39e-01 | -4.04e+00 | 5.42e-05 | 5.68e-04 | -1.66e-01 |
| LIHC | cg00229368 | chr3:184561833 | CGI:chr3:184561406-184562933 | UTR,promoter,exon,gene body | 1.78e-01 | 3.61e-02 | 2.32e+00 | 2.06e-02 | 2.30e-02 | 1.41e-01 |
| LIHC | cg16382256 | chr3:184561869 | CGI:chr3:184561406-184562933 | UTR,promoter,exon,gene body | 1.39e-01 | 1.63e-02 | 3.25e+00 | 1.14e-03 | 1.78e-03 | 1.23e-01 |
| LIHC | cg02565842 | chr3:184560480 | CGI:chr3:184561406-184562933 | promoter | 3.96e-01 | 6.10e-01 | -4.21e+00 | 2.54e-05 | 6.17e-05 | -2.14e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for EPHB3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for EPHB3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for EPHB3 |
| TFs related to EPHB3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| EPHB3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for EPHB3 |
| RBPs related to ES in EPHB3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| EPHB3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000182580 | AL138828.1,hsa-mir-149,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | GNAS-AS1,hsa-mir-149,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | ADAMTSL4-AS1,hsa-mir-149,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | AL139246.3,hsa-mir-518c,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | NIFK-AS1,hsa-mir-518c,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | FOXD2-AS1,hsa-mir-518c,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | LINC01121,hsa-mir-518c,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | AC093916.1,hsa-mir-518c,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | PEF1-AS1,hsa-mir-518c,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | CYP1B1-AS1,hsa-mir-760,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | FOXD2-AS1,hsa-mir-760,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | LINC01816,hsa-mir-760,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | AC019205.1,hsa-mir-760,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | ZNF232-AS1,hsa-mir-760,EPHB3 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000182580 | ARHGAP27P1-BPTFP1-KPNA2P3,hsa-mir-760,EPHB3 | Female-specific ceRNA | TCGA-KICH |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9854831 | chr3:184766389:G:A | - | 0.260131318098627 | 0.019759232839857 | GBM | Female-baised eQTL |
| rs940909 | chr3:191556247:T:C | - | -0.155464269091465 | 0.0293997715557664 | GBM | Female-baised eQTL |
| rs2710935 | chr3:182529291:C:T | - | -0.143533411334295 | 0.0260025416950804 | STAD | Female-baised eQTL |
| rs3101057 | chr3:182536509:T:C | - | -0.14703667043924 | 0.0264573901397379 | STAD | Female-baised eQTL |
| rs11389365 | chr3:179717671:G:C | - | -0.138360712937016 | 0.0141629981944689 | LGG | Female-baised eQTL |
| rs74766110 | chr3:187885132:A:G | - | 0.125232714056388 | 0.00106180960763105 | BLCA | Female-baised eQTL |
| rs73049520 | chr3:187885265:A:G | - | 0.125232714056388 | 0.00106180960763105 | BLCA | Female-baised eQTL |
| rs73049523 | chr3:187885434:C:G | - | 0.125232714056388 | 0.00106180960763105 | BLCA | Female-baised eQTL |
| rs73049525 | chr3:187885630:T:C | - | 0.125232714056388 | 0.00106180960763105 | BLCA | Female-baised eQTL |
| rs112102329 | chr3:187884113:T:C | - | 0.128275850721545 | 0.0083536158613519 | BLCA | Female-baised eQTL |
| rs4358320 | chr3:183133653:G:A | - | 0.139747726172782 | 0.00888078161904468 | BLCA | Female-baised eQTL |
| rs56881250 | chr3:187884747:T:C | - | 0.119634401539838 | 0.0172665102650218 | BLCA | Female-baised eQTL |
| rs2630247 | chr3:193926950:A:G | - | -0.105947101359891 | 0.0462310413849869 | BLCA | Female-baised eQTL |
| rs5022475 | chr3:177990085:A:T | - | 0.0369526248189911 | 0.0384026846014261 | LUAD | Female-baised eQTL |
| rs76570584 | chr3:185311616:G:A | - | 0.0596451776499323 | 0.0435014787954526 | LUAD | Female-baised eQTL |
| rs77471256 | chr3:179984706:T:C | - | 0.0341154351927341 | 0.0485186709295756 | LUAD | Female-baised eQTL |
| rs546852 | chr3:191425951:T:G | - | -0.0877658034948668 | 0.0175492362170635 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs13325300 | chr3:186281614:T:A | - | 0.0770428131565798 | 0.0419541644296528 | STAD | Male-baised eQTL |
| rs4686820 | chr3:186963484:G:A | - | -0.0679919507965805 | 0.0237476858930049 | LGG | Male-baised eQTL |
| rs9833074 | chr3:179701387:T:C | - | -0.138089418082552 | 4.78616632452954e-05 | LUAD | Male-baised eQTL |
| rs4854948 | chr3:179700188:C:T | - | -0.146659542221739 | 0.000220106989565323 | LUAD | Male-baised eQTL |
| rs9834881 | chr3:179698514:A:T | - | -0.134323585675144 | 0.000329763763519718 | LUAD | Male-baised eQTL |
| rs4854947 | chr3:179696917:G:A | - | -0.132409312175082 | 0.000370631045077642 | LUAD | Male-baised eQTL |
| rs6805646 | chr3:179706270:A:C | - | -0.156601529497891 | 0.00061034572044943 | LUAD | Male-baised eQTL |
| rs9838020 | chr3:179702173:T:C | - | -0.127768029709946 | 0.00254919464945814 | LUAD | Male-baised eQTL |
| rs9838032 | chr3:179702186:T:A | - | -0.111762261823581 | 0.00273647720930359 | LUAD | Male-baised eQTL |
| rs2111392 | chr3:179705847:T:C | - | -0.124432536795423 | 0.00431022828687691 | LUAD | Male-baised eQTL |
| rs11389365 | chr3:179717671:G:C | - | -0.121968155962046 | 0.00789820163826661 | LUAD | Male-baised eQTL |
| rs7650812 | chr3:194440935:A:G | - | 0.107369057007274 | 0.00921846307761153 | LUAD | Male-baised eQTL |
| rs800368 | chr3:179713153:G:A | - | -0.114908072878346 | 0.0162668571033759 | LUAD | Male-baised eQTL |
| rs266722 | chr3:186710473:A:G | - | -0.0626961121325592 | 0.00866078787432554 | COAD | Male-baised eQTL |
| rs35557208 | chr3:186710490:C:T | - | 0.0626961121325592 | 0.00866078787432554 | COAD | Male-baised eQTL |
| rs13062356 | chr3:186710594:G:T | - | 0.0626961121325592 | 0.00866078787432554 | COAD | Male-baised eQTL |
| rs6444164 | chr3:186709584:G:A | - | 0.0568638746038422 | 0.0309590107634127 | COAD | Male-baised eQTL |
| rs73039238 | chr3:175103683:A:T | - | 0.117535733318861 | 0.0436432269850676 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000182580 |
| CpG Site: cg13694876 | |
| Position to Gene: gene,enhancer | |
| Male Effect: -0.42105915108823 | |
| Female Effect: - | |
 | Gene ID: ENSG00000182580 |
| CpG Site: cg02565842 | |
| Position to Gene: promoter | |
| Male Effect: -0.440084214558875 | |
| Female Effect: - | |
 | Gene ID: ENSG00000182580 |
| CpG Site: cg12612213 | |
| Position to Gene: gene | |
| Male Effect: -0.436247801084884 | |
| Female Effect: - | |
 | Gene ID: ENSG00000182580 |
| CpG Site: cg03867377 | |
| Position to Gene: gene,exon,CDS | |
| Male Effect: -0.429841685216021 | |
| Female Effect: - | |
 | Gene ID: ENSG00000182580 |
| CpG Site: cg13694876 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.477072291131197 | |
 | Gene ID: ENSG00000182580 |
| CpG Site: cg13694876 | |
| Position to Gene: gene,enhancer | |
| Male Effect: - | |
| Female Effect: -0.455826696104955 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13694876 | chr3:184564932 | gene,enhancer | -0.42105915108823 | 2.70804273728568e-27 | -0.8605374342582615 | 7.07905502867831e-30 | PAAD |
| cg02565842 | chr3:184560480 | promoter | -0.440084214558875 | 3.2371610904869e-10 | -0.7858433178743703 | 2.4954592280805634e-21 | PAAD |
| cg12612213 | chr3:184568115 | gene | -0.436247801084884 | 5.55964897347022e-10 | -0.634659801129641 | 2.2635039058054314e-12 | PAAD |
| cg03867377 | chr3:184571357 | gene,exon,CDS | -0.429841685216021 | 8.43552016807415e-07 | -0.45581054428012885 | 6.023934915401347e-10 | COAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13694876 | chr3:184564932 | gene,enhancer | -0.477072291131197 | 2.72957953815725e-57 | -0.8168181183174227 | 2.210633735144403e-62 | LUAD |
| cg13694876 | chr3:184564932 | gene,enhancer | -0.455826696104955 | 4.33402850864982e-29 | -0.7519293683184766 | 7.420865309384048e-34 | SKCM |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of EPHB3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
