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Gene: ENSG00000181830 |
Summary for SLC35C1 |
Gene summary |
| Gene information | Ensembl ID | ENSG00000181830 | Gene symbol | SLC35C1 |
| Gene name | solute carrier family 35 member C1 | |
| HGNC | 20197 | |
| Entrez ID | 55343 | |
| Gene type | protein_coding | |
| Synonyms | SLC35C1|FUCT1|FLJ11320 | |
| UniProtAcc | Q96A29 |
Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for SLC35C1 |
AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
Landscape of gene expressions across multiple cancer types. |
Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for SLC35C1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for SLC35C1 |
Landscape of DNA methylation across multiple cancer types. |
Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ACC | cg05151185 | chr11:45805720 | CGI:chr11:45804064-45805426 | UTR,promoter,exon,gene body | 3.67e-01 | 4.87e-01 | -2.03e+00 | 4.25e-02 | 4.68e-02 | -1.20e-01 |
| DLBC | cg08794544 | chr11:45803967 | CGI:chr11:45804064-45805426 | promoter | 4.63e-01 | 5.70e-01 | -2.40e+00 | 1.64e-02 | 3.12e-02 | -1.08e-01 |
Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg19527995 | chr11:45803805 | CGI:chr11:45804064-45805426 | promoter | 7.18e-01 | 8.74e-01 | -3.06e+00 | 2.24e-03 | 4.29e-03 | -1.56e-01 |
| BLCA | cg01838971 | chr11:45803897 | CGI:chr11:45804064-45805426 | promoter | 5.33e-01 | 6.36e-01 | -2.48e+00 | 1.32e-02 | 1.76e-02 | -1.04e-01 |
| LIHC | cg02176725 | chr11:45803101 | CGI:chr11:45804064-45805426 | promoter | 8.02e-01 | 9.39e-01 | -5.47e+00 | 4.38e-08 | 2.65e-07 | -1.38e-01 |
| LIHC | cg19527995 | chr11:45803805 | CGI:chr11:45804064-45805426 | promoter | 6.34e-01 | 8.52e-01 | -4.17e+00 | 3.08e-05 | 7.31e-05 | -2.18e-01 |
| LIHC | cg01838971 | chr11:45803897 | CGI:chr11:45804064-45805426 | promoter | 4.97e-01 | 6.15e-01 | -3.63e+00 | 2.83e-04 | 5.18e-04 | -1.18e-01 |
| LIHC | cg27363529 | chr11:45803918 | CGI:chr11:45804064-45805426 | promoter | 5.05e-01 | 6.23e-01 | -3.61e+00 | 3.05e-04 | 5.53e-04 | -1.18e-01 |
| LIHC | cg09452027 | chr11:45803932 | CGI:chr11:45804064-45805426 | promoter | 5.74e-01 | 7.34e-01 | -3.83e+00 | 1.27e-04 | 2.55e-04 | -1.59e-01 |
Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg00927035 | chr11:45803894 | CGI:chr11:45804064-45805426 | promoter | 5.42e-01 | 4.41e-01 | 7.92e+00 | 2.35e-15 | 8.79e-15 | 1.01e-01 |
| BRCA | cg27363529 | chr11:45803918 | CGI:chr11:45804064-45805426 | promoter | 6.67e-01 | 5.58e-01 | 8.25e+00 | 1.56e-16 | 6.40e-16 | 1.09e-01 |
| BRCA | cg17695841 | chr11:45803934 | CGI:chr11:45804064-45805426 | promoter | 7.18e-01 | 5.72e-01 | 9.42e+00 | 4.48e-21 | 2.66e-20 | 1.46e-01 |
| BRCA | cg08794544 | chr11:45803967 | CGI:chr11:45804064-45805426 | promoter | 4.29e-01 | 2.25e-01 | 1.12e+01 | 4.31e-29 | 5.64e-28 | 2.03e-01 |
| BRCA | cg24303076 | chr11:45805709 | CGI:chr11:45804064-45805426 | UTR,promoter,exon,gene body | 2.81e-01 | 1.47e-01 | 9.91e+00 | 3.73e-23 | 2.66e-22 | 1.34e-01 |
| BRCA | cg05151185 | chr11:45805720 | CGI:chr11:45804064-45805426 | UTR,promoter,exon,gene body | 3.65e-01 | 1.87e-01 | 1.13e+01 | 2.03e-29 | 2.76e-28 | 1.78e-01 |
| LUAD | cg09452027 | chr11:45803932 | CGI:chr11:45804064-45805426 | promoter | 5.96e-01 | 6.99e-01 | -2.16e+00 | 3.09e-02 | 3.53e-02 | -1.02e-01 |
| COAD | cg08794544 | chr11:45803967 | CGI:chr11:45804064-45805426 | promoter | 2.37e-01 | 3.71e-01 | -4.29e+00 | 1.75e-05 | 3.21e-04 | -1.34e-01 |
| KIRP | cg00927035 | chr11:45803894 | CGI:chr11:45804064-45805426 | promoter | 5.32e-01 | 3.89e-01 | 2.68e+00 | 7.47e-03 | 1.39e-02 | 1.43e-01 |
| KIRP | cg27363529 | chr11:45803918 | CGI:chr11:45804064-45805426 | promoter | 6.62e-01 | 5.55e-01 | 2.58e+00 | 9.87e-03 | 1.67e-02 | 1.07e-01 |
| KIRP | cg17695841 | chr11:45803934 | CGI:chr11:45804064-45805426 | promoter | 7.06e-01 | 5.94e-01 | 2.53e+00 | 1.13e-02 | 1.83e-02 | 1.12e-01 |
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Exon skipping events with PSI in TCGA for SLC35C1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for SLC35C1 |
| ∗Please access CAeditome for RNA editing annotation. |
Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for SLC35C1 |
TFs related to SLC35C1.∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | KLF7 | SLC35C1 | 4.10e+00 | 9.86e-01 | 2.30e+00 | 3.26e-04 | Male-biased |
| BLCA | KLF9 | SLC35C1 | 4.00e+00 | 9.83e-01 | 2.42e+00 | 6.77e-04 | Male-biased |
| BLCA | ZNF30 | SLC35C1 | 3.94e+00 | 9.81e-01 | 2.27e+00 | 5.12e-04 | Male-biased |
| BLCA | ZNF311 | SLC35C1 | 3.94e+00 | 9.81e-01 | 2.30e+00 | 5.64e-04 | Male-biased |
| BLCA | ZNF441 | SLC35C1 | 3.99e+00 | 9.83e-01 | 2.26e+00 | 4.02e-04 | Male-biased |
| BLCA | ZNF543 | SLC35C1 | 4.04e+00 | 9.84e-01 | 2.51e+00 | 8.10e-04 | Male-biased |
| CHOL | ZNF418 | SLC35C1 | 3.77e+00 | 9.83e-01 | 2.07e+00 | 4.09e-04 | Male-biased |
| DLBC | MYCN | SLC35C1 | 4.26e+00 | 9.88e-01 | 2.99e+00 | 2.06e-03 | Male-biased |
| DLBC | ZNF141 | SLC35C1 | 3.92e+00 | 9.81e-01 | 2.57e+00 | 1.45e-03 | Male-biased |
| DLBC | ZNF157 | SLC35C1 | 3.95e+00 | 9.82e-01 | 2.59e+00 | 1.39e-03 | Male-biased |
| DLBC | ZNF235 | SLC35C1 | 4.86e-01 | 2.04e-06 | 3.90e+00 | 9.83e-01 | Female-biased |
| DLBC | ZNF287 | SLC35C1 | 6.13e-01 | 4.00e-06 | 3.91e+00 | 9.83e-01 | Female-biased |
| DLBC | ZNF423 | SLC35C1 | 4.45e+00 | 9.89e-01 | 3.28e+00 | 3.05e-03 | Male-biased |
| DLBC | ZNF692 | SLC35C1 | 4.06e+00 | 9.85e-01 | 2.44e+00 | 5.64e-04 | Male-biased |
| MESO | ZNF418 | SLC35C1 | 1.52e+00 | 1.27e-04 | 3.94e+00 | 9.84e-01 | Female-biased |
SLC35C1 related gene.∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for SLC35C1 |
RBPs related to ES in SLC35C1.∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
SLC35C1 related ES.∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs10768247 | chr11:37115800:C:T | - | 0.100189576091014 | 0.0111019049166721 | LGG | Female-baised eQTL |
| rs59443529 | chr11:44409662:T:A | - | 0.0577530778013219 | 0.0231527725169656 | LUAD | Female-baised eQTL |
Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1566261 | chr11:39287280:C:T | - | 0.092862823552717 | 0.000211130622959906 | STAD | Male-baised eQTL |
| rs17726019 | chr11:39288872:G:A | - | 0.092862823552717 | 0.000211130622959906 | STAD | Male-baised eQTL |
| rs7108039 | chr11:39291964:C:T | - | 0.092862823552717 | 0.000211130622959906 | STAD | Male-baised eQTL |
| rs75038711 | chr11:39297108:A:T | - | 0.0958721848224073 | 0.000211545478065994 | STAD | Male-baised eQTL |
| rs11035209 | chr11:39297903:C:G | - | 0.0958721848224073 | 0.000211545478065994 | STAD | Male-baised eQTL |
| rs78190940 | chr11:39260704:A:T | - | 0.0924221088878465 | 0.000310813306514229 | STAD | Male-baised eQTL |
| rs34779584 | chr11:39279399:C:T | - | 0.071047013635777 | 0.00985096550665857 | STAD | Male-baised eQTL |
| rs1603771 | chr11:39265443:A:G | - | 0.0711621104905497 | 0.012402942379897 | STAD | Male-baised eQTL |
| rs372870730 | chr11:39265479:A:T | - | 0.0711621104905497 | 0.012402942379897 | STAD | Male-baised eQTL |
| rs76004501 | chr11:39266481:G:C | - | 0.0711621104905497 | 0.012402942379897 | STAD | Male-baised eQTL |
| rs138455426 | chr11:39271205:A:G | - | 0.0708802935151278 | 0.0133394304123781 | STAD | Male-baised eQTL |
| rs34506955 | chr11:39271534:G:A | - | 0.0708802935151278 | 0.0133394304123781 | STAD | Male-baised eQTL |
| rs36065824 | chr11:39272822:C:T | - | 0.0708802935151278 | 0.0133394304123781 | STAD | Male-baised eQTL |
| rs142541218 | chr11:39271282:C:T | - | 0.0707286761651564 | 0.0139249089912635 | STAD | Male-baised eQTL |
| rs4540819 | chr11:45639588:C:A | - | 0.0883449074864381 | 0.000434430339620906 | KIRC | Male-baised eQTL |
| rs11038595 | chr11:45636402:A:G | - | 0.0880606021245073 | 0.00299165767083505 | KIRC | Male-baised eQTL |
| rs1992849 | chr11:45642938:C:T | - | 0.0844484180649924 | 0.00421447096277552 | KIRC | Male-baised eQTL |
| rs56153401 | chr11:45549386:G:A | - | 0.065182536028734 | 0.00472983346925771 | KIRC | Male-baised eQTL |
| rs60359792 | chr11:45634189:T:A | - | 0.085138107307086 | 0.00479895617959986 | KIRC | Male-baised eQTL |
| rs11038593 | chr11:45634790:A:G | - | 0.085138107307086 | 0.00479895617959986 | KIRC | Male-baised eQTL |
| rs75499904 | chr11:45632590:T:G | - | 0.0850847161157531 | 0.00486816326915139 | KIRC | Male-baised eQTL |
| rs72896778 | chr11:45647456:T:A | - | 0.0831308900560171 | 0.00489956815866739 | KIRC | Male-baised eQTL |
| rs17195718 | chr11:45549561:T:C | - | 0.0642839212164806 | 0.00563203879656896 | KIRC | Male-baised eQTL |
| rs11038604 | chr11:45648399:C:T | - | 0.0817605955555537 | 0.00576435651346358 | KIRC | Male-baised eQTL |
| rs3740702 | chr11:45648845:C:T | - | 0.0791426117652783 | 0.0121220293220507 | KIRC | Male-baised eQTL |
| rs72895277 | chr11:45559611:T:C | - | 0.0618055081835285 | 0.0163637385040305 | KIRC | Male-baised eQTL |
| rs34312154 | chr11:47448793:G:A | - | 0.0714994922506778 | 0.0214109239384633 | LUAD | Male-baised eQTL |
| rs74385561 | chr11:47449501:C:T | - | 0.0714994922506778 | 0.0214109239384633 | LUAD | Male-baised eQTL |
| rs113459934 | chr11:47543170:G:A | - | 0.0699706864623827 | 0.0256359370426031 | LUAD | Male-baised eQTL |
| rs112396704 | chr11:47910185:G:A | - | 0.0655475582446707 | 0.049496671176705 | LUAD | Male-baised eQTL |
| rs11034587 | chr11:38107085:T:C | - | -0.100304938663504 | 0.000518873406066853 | COAD | Male-baised eQTL |
| rs1115491 | chr11:43477902:T:G | - | 0.0676814334310964 | 0.00457260015988136 | COAD | Male-baised eQTL |
| rs73456363 | chr11:39479140:T:C | - | 0.0909080808737708 | 0.00592728694497052 | COAD | Male-baised eQTL |
| rs113126066 | chr11:39481888:T:C | - | 0.0909080808737708 | 0.00592728694497052 | COAD | Male-baised eQTL |
| rs73456368 | chr11:39482438:A:C | - | 0.0909080808737708 | 0.00592728694497052 | COAD | Male-baised eQTL |
| rs113504549 | chr11:39488522:T:C | - | 0.0902024691864425 | 0.00634403421658988 | COAD | Male-baised eQTL |
| rs4755712 | chr11:43502536:T:A | - | -0.0739430604269864 | 0.0069091352804688 | COAD | Male-baised eQTL |
| rs748172 | chr11:43474580:C:T | - | 0.0609354256820377 | 0.0296036336176614 | COAD | Male-baised eQTL |
| rs11037456 | chr11:43503302:T:C | - | 0.0617684986477137 | 0.034954228740524 | COAD | Male-baised eQTL |
| rs56261311 | chr11:39511995:G:C | - | 0.0646457537482036 | 0.0366440902276102 | COAD | Male-baised eQTL |
| rs11824373 | chr11:39513999:A:C | - | 0.0646457537482036 | 0.0366440902276102 | COAD | Male-baised eQTL |
| rs2851565 | chr11:49046816:A:G | - | 0.0856523405829684 | 0.0372971822604275 | COAD | Male-baised eQTL |
| rs2955192 | chr11:49086024:A:G | - | 0.0859861239673082 | 0.0375092326922444 | COAD | Male-baised eQTL |
| rs7121532 | chr11:43482800:G:A | - | 0.058036414255808 | 0.0428265549653373 | COAD | Male-baised eQTL |
| rs78419815 | chr11:39515443:T:G | - | 0.0635236493568792 | 0.0431693219887729 | COAD | Male-baised eQTL |
Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg17066254 | chr11:45803096 | promoter | -0.435477281214414 | 7.53632092334609e-20 | -0.6091516167966387 | 9.821551129291342e-24 | STAD |
| cg02176725 | chr11:45803101 | promoter | -0.435477281214414 | 7.53632092334609e-20 | -0.6091516167966387 | 9.821551129291342e-24 | STAD |
| cg01838971 | chr11:45803897 | promoter | -0.145574613033652 | 2.48120264951097e-05 | -0.35864934205091636 | 4.437949423217867e-08 | STAD |
Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg19527995 | chr11:45803805 | promoter | -0.437015039951724 | 2.2149596246412e-19 | -0.5659810159878701 | 5.357374958293429e-23 | LUAD |
Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SLC35C1 |
Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000181830 | SLC35C1 | C0398739 | Congenital disorder of glycosylation, type 2C | 1 | CTD_human |