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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000181830

Summary for SLC35C1

check button Gene summary

Gene informationEnsembl ID

ENSG00000181830

Gene symbol

SLC35C1

Gene namesolute carrier family 35 member C1
HGNC

20197

Entrez ID

55343

Gene typeprotein_coding
SynonymsSLC35C1|FUCT1|FLJ11320
UniProtAcc

Q96A29


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for SLC35C1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for SLC35C1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for SLC35C1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
ACCcg05151185chr11:45805720CGI:chr11:45804064-45805426UTR,promoter,exon,gene body3.67e-014.87e-01-2.03e+004.25e-024.68e-02-1.20e-01
DLBCcg08794544chr11:45803967CGI:chr11:45804064-45805426promoter4.63e-015.70e-01-2.40e+001.64e-023.12e-02-1.08e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BLCAcg19527995chr11:45803805CGI:chr11:45804064-45805426promoter7.18e-018.74e-01-3.06e+002.24e-034.29e-03-1.56e-01
BLCAcg01838971chr11:45803897CGI:chr11:45804064-45805426promoter5.33e-016.36e-01-2.48e+001.32e-021.76e-02-1.04e-01
LIHCcg02176725chr11:45803101CGI:chr11:45804064-45805426promoter8.02e-019.39e-01-5.47e+004.38e-082.65e-07-1.38e-01
LIHCcg19527995chr11:45803805CGI:chr11:45804064-45805426promoter6.34e-018.52e-01-4.17e+003.08e-057.31e-05-2.18e-01
LIHCcg01838971chr11:45803897CGI:chr11:45804064-45805426promoter4.97e-016.15e-01-3.63e+002.83e-045.18e-04-1.18e-01
LIHCcg27363529chr11:45803918CGI:chr11:45804064-45805426promoter5.05e-016.23e-01-3.61e+003.05e-045.53e-04-1.18e-01
LIHCcg09452027chr11:45803932CGI:chr11:45804064-45805426promoter5.74e-017.34e-01-3.83e+001.27e-042.55e-04-1.59e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg00927035chr11:45803894CGI:chr11:45804064-45805426promoter5.42e-014.41e-017.92e+002.35e-158.79e-151.01e-01
BRCAcg27363529chr11:45803918CGI:chr11:45804064-45805426promoter6.67e-015.58e-018.25e+001.56e-166.40e-161.09e-01
BRCAcg17695841chr11:45803934CGI:chr11:45804064-45805426promoter7.18e-015.72e-019.42e+004.48e-212.66e-201.46e-01
BRCAcg08794544chr11:45803967CGI:chr11:45804064-45805426promoter4.29e-012.25e-011.12e+014.31e-295.64e-282.03e-01
BRCAcg24303076chr11:45805709CGI:chr11:45804064-45805426UTR,promoter,exon,gene body2.81e-011.47e-019.91e+003.73e-232.66e-221.34e-01
BRCAcg05151185chr11:45805720CGI:chr11:45804064-45805426UTR,promoter,exon,gene body3.65e-011.87e-011.13e+012.03e-292.76e-281.78e-01
LUADcg09452027chr11:45803932CGI:chr11:45804064-45805426promoter5.96e-016.99e-01-2.16e+003.09e-023.53e-02-1.02e-01
COADcg08794544chr11:45803967CGI:chr11:45804064-45805426promoter2.37e-013.71e-01-4.29e+001.75e-053.21e-04-1.34e-01
KIRPcg00927035chr11:45803894CGI:chr11:45804064-45805426promoter5.32e-013.89e-012.68e+007.47e-031.39e-021.43e-01
KIRPcg27363529chr11:45803918CGI:chr11:45804064-45805426promoter6.62e-015.55e-012.58e+009.87e-031.67e-021.07e-01
KIRPcg17695841chr11:45803934CGI:chr11:45804064-45805426promoter7.06e-015.94e-012.53e+001.13e-021.83e-021.12e-01

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Exon skipping events with PSI in TCGA for SLC35C1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for SLC35C1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for SLC35C1

check buttonTFs related to SLC35C1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
BLCAKLF7SLC35C14.10e+009.86e-012.30e+003.26e-04Male-biased
BLCAKLF9SLC35C14.00e+009.83e-012.42e+006.77e-04Male-biased
BLCAZNF30SLC35C13.94e+009.81e-012.27e+005.12e-04Male-biased
BLCAZNF311SLC35C13.94e+009.81e-012.30e+005.64e-04Male-biased
BLCAZNF441SLC35C13.99e+009.83e-012.26e+004.02e-04Male-biased
BLCAZNF543SLC35C14.04e+009.84e-012.51e+008.10e-04Male-biased
CHOLZNF418SLC35C13.77e+009.83e-012.07e+004.09e-04Male-biased
DLBCMYCNSLC35C14.26e+009.88e-012.99e+002.06e-03Male-biased
DLBCZNF141SLC35C13.92e+009.81e-012.57e+001.45e-03Male-biased
DLBCZNF157SLC35C13.95e+009.82e-012.59e+001.39e-03Male-biased
DLBCZNF235SLC35C14.86e-012.04e-063.90e+009.83e-01Female-biased
DLBCZNF287SLC35C16.13e-014.00e-063.91e+009.83e-01Female-biased
DLBCZNF423SLC35C14.45e+009.89e-013.28e+003.05e-03Male-biased
DLBCZNF692SLC35C14.06e+009.85e-012.44e+005.64e-04Male-biased
MESOZNF418SLC35C11.52e+001.27e-043.94e+009.84e-01Female-biased

check buttonSLC35C1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for SLC35C1

check buttonRBPs related to ES in SLC35C1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonSLC35C1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10768247chr11:37115800:C:T-0.1001895760910140.0111019049166721LGGFemale-baised eQTL
rs59443529chr11:44409662:T:A-0.05775307780132190.0231527725169656LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs1566261chr11:39287280:C:T-0.0928628235527170.000211130622959906STADMale-baised eQTL
rs17726019chr11:39288872:G:A-0.0928628235527170.000211130622959906STADMale-baised eQTL
rs7108039chr11:39291964:C:T-0.0928628235527170.000211130622959906STADMale-baised eQTL
rs75038711chr11:39297108:A:T-0.09587218482240730.000211545478065994STADMale-baised eQTL
rs11035209chr11:39297903:C:G-0.09587218482240730.000211545478065994STADMale-baised eQTL
rs78190940chr11:39260704:A:T-0.09242210888784650.000310813306514229STADMale-baised eQTL
rs34779584chr11:39279399:C:T-0.0710470136357770.00985096550665857STADMale-baised eQTL
rs1603771chr11:39265443:A:G-0.07116211049054970.012402942379897STADMale-baised eQTL
rs372870730chr11:39265479:A:T-0.07116211049054970.012402942379897STADMale-baised eQTL
rs76004501chr11:39266481:G:C-0.07116211049054970.012402942379897STADMale-baised eQTL
rs138455426chr11:39271205:A:G-0.07088029351512780.0133394304123781STADMale-baised eQTL
rs34506955chr11:39271534:G:A-0.07088029351512780.0133394304123781STADMale-baised eQTL
rs36065824chr11:39272822:C:T-0.07088029351512780.0133394304123781STADMale-baised eQTL
rs142541218chr11:39271282:C:T-0.07072867616515640.0139249089912635STADMale-baised eQTL
rs4540819chr11:45639588:C:A-0.08834490748643810.000434430339620906KIRCMale-baised eQTL
rs11038595chr11:45636402:A:G-0.08806060212450730.00299165767083505KIRCMale-baised eQTL
rs1992849chr11:45642938:C:T-0.08444841806499240.00421447096277552KIRCMale-baised eQTL
rs56153401chr11:45549386:G:A-0.0651825360287340.00472983346925771KIRCMale-baised eQTL
rs60359792chr11:45634189:T:A-0.0851381073070860.00479895617959986KIRCMale-baised eQTL
rs11038593chr11:45634790:A:G-0.0851381073070860.00479895617959986KIRCMale-baised eQTL
rs75499904chr11:45632590:T:G-0.08508471611575310.00486816326915139KIRCMale-baised eQTL
rs72896778chr11:45647456:T:A-0.08313089005601710.00489956815866739KIRCMale-baised eQTL
rs17195718chr11:45549561:T:C-0.06428392121648060.00563203879656896KIRCMale-baised eQTL
rs11038604chr11:45648399:C:T-0.08176059555555370.00576435651346358KIRCMale-baised eQTL
rs3740702chr11:45648845:C:T-0.07914261176527830.0121220293220507KIRCMale-baised eQTL
rs72895277chr11:45559611:T:C-0.06180550818352850.0163637385040305KIRCMale-baised eQTL
rs34312154chr11:47448793:G:A-0.07149949225067780.0214109239384633LUADMale-baised eQTL
rs74385561chr11:47449501:C:T-0.07149949225067780.0214109239384633LUADMale-baised eQTL
rs113459934chr11:47543170:G:A-0.06997068646238270.0256359370426031LUADMale-baised eQTL
rs112396704chr11:47910185:G:A-0.06554755824467070.049496671176705LUADMale-baised eQTL
rs11034587chr11:38107085:T:C--0.1003049386635040.000518873406066853COADMale-baised eQTL
rs1115491chr11:43477902:T:G-0.06768143343109640.00457260015988136COADMale-baised eQTL
rs73456363chr11:39479140:T:C-0.09090808087377080.00592728694497052COADMale-baised eQTL
rs113126066chr11:39481888:T:C-0.09090808087377080.00592728694497052COADMale-baised eQTL
rs73456368chr11:39482438:A:C-0.09090808087377080.00592728694497052COADMale-baised eQTL
rs113504549chr11:39488522:T:C-0.09020246918644250.00634403421658988COADMale-baised eQTL
rs4755712chr11:43502536:T:A--0.07394306042698640.0069091352804688COADMale-baised eQTL
rs748172chr11:43474580:C:T-0.06093542568203770.0296036336176614COADMale-baised eQTL
rs11037456chr11:43503302:T:C-0.06176849864771370.034954228740524COADMale-baised eQTL
rs56261311chr11:39511995:G:C-0.06464575374820360.0366440902276102COADMale-baised eQTL
rs11824373chr11:39513999:A:C-0.06464575374820360.0366440902276102COADMale-baised eQTL
rs2851565chr11:49046816:A:G-0.08565234058296840.0372971822604275COADMale-baised eQTL
rs2955192chr11:49086024:A:G-0.08598612396730820.0375092326922444COADMale-baised eQTL
rs7121532chr11:43482800:G:A-0.0580364142558080.0428265549653373COADMale-baised eQTL
rs78419815chr11:39515443:T:G-0.06352364935687920.0431693219887729COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000181830
CpG Site: cg19527995
Position to Gene: promoter
Male Effect: -
Female Effect: -0.437015039951724
eQTM boxplot analysisGene ID: ENSG00000181830
CpG Site: cg17066254
Position to Gene: promoter
Male Effect: -0.435477281214414
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000181830
CpG Site: cg02176725
Position to Gene: promoter
Male Effect: -0.435477281214414
Female Effect: -
eQTM boxplot analysisGene ID: ENSG00000181830
CpG Site: cg01838971
Position to Gene: promoter
Male Effect: -0.145574613033652
Female Effect: -

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg17066254chr11:45803096promoter-0.4354772812144147.53632092334609e-20-0.60915161679663879.821551129291342e-24STAD
cg02176725chr11:45803101promoter-0.4354772812144147.53632092334609e-20-0.60915161679663879.821551129291342e-24STAD
cg01838971chr11:45803897promoter-0.1455746130336522.48120264951097e-05-0.358649342050916364.437949423217867e-08STAD

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg19527995chr11:45803805promoter-0.4370150399517242.2149596246412e-19-0.56598101598787015.357374958293429e-23LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of SLC35C1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000181830SLC35C1C0398739Congenital disorder of glycosylation, type 2C1CTD_human