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Gene: ENSG00000180611 |
Summary for MB21D2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000180611 | Gene symbol | MB21D2 |
| Gene name | Mab-21 domain containing 2 | |
| HGNC | 30438 | |
| Entrez ID | 151963 | |
| Gene type | protein_coding | |
| Synonyms | MB21D2| | |
| UniProtAcc | Q8IYB1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MB21D2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MB21D2 | 3.38e+02 | -1.11e+00 | 2.94e-01 | -3.78e+00 | 1.58e-04 | 4.05e-04 | KICH |
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Sex-biased somatic mutation for MB21D2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MB21D2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| MESO | cg07163456 | chr3:192918635 | CGI:chr3:192916520-192918178 | promoter | 4.75e-01 | 5.89e-01 | -2.65e+00 | 8.15e-03 | 2.50e-02 | -1.14e-01 |
| ACC | cg07908870 | chr3:192916575 | CGI:chr3:192916520-192918178 | promoter,gene body | 2.07e-01 | 3.23e-01 | -1.98e+00 | 4.79e-02 | 4.87e-02 | -1.16e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg23344395 | chr3:192916213 | CGI:chr3:192916520-192918178 | promoter,gene body | 7.27e-01 | 6.03e-01 | 3.79e+00 | 1.48e-04 | 3.90e-04 | 1.24e-01 |
| LUSC | cg07163456 | chr3:192918635 | CGI:chr3:192916520-192918178 | promoter | 4.31e-01 | 5.79e-01 | -2.87e+00 | 4.06e-03 | 6.99e-03 | -1.48e-01 |
| BLCA | cg23344395 | chr3:192916213 | CGI:chr3:192916520-192918178 | promoter,gene body | 5.44e-01 | 7.53e-01 | -2.60e+00 | 9.37e-03 | 1.34e-02 | -2.09e-01 |
| BLCA | cg07163456 | chr3:192918635 | CGI:chr3:192916520-192918178 | promoter | 5.41e-01 | 6.94e-01 | -3.00e+00 | 2.73e-03 | 5.02e-03 | -1.52e-01 |
| KIRP | cg23344395 | chr3:192916213 | CGI:chr3:192916520-192918178 | promoter,gene body | 3.85e-01 | 5.85e-01 | -3.83e+00 | 1.28e-04 | 3.18e-04 | -2.00e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg23344395 | chr3:192916213 | CGI:chr3:192916520-192918178 | promoter,gene body | 7.33e-01 | 5.96e-01 | 2.23e+00 | 2.59e-02 | 3.23e-02 | 1.38e-01 |
| HNSC | cg07163456 | chr3:192918635 | CGI:chr3:192916520-192918178 | promoter | 5.62e-01 | 3.73e-01 | 2.48e+00 | 1.32e-02 | 2.17e-02 | 1.89e-01 |
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Exon skipping events with PSI in TCGA for MB21D2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MB21D2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MB21D2 |
| TFs related to MB21D2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | MBD2 | MB21D2 | 4.16e+00 | 9.84e-01 | 2.52e+00 | 2.89e-03 | Male-biased |
| BRCA | ZNF141 | MB21D2 | 4.16e+00 | 9.87e-01 | 1.92e+00 | 4.53e-04 | Male-biased |
| BRCA | ZNF23 | MB21D2 | 4.09e+00 | 9.84e-01 | 2.24e+00 | 1.50e-03 | Male-biased |
| BRCA | ZNF28 | MB21D2 | 4.08e+00 | 9.85e-01 | 1.76e+00 | 3.54e-04 | Male-biased |
| BRCA | ZNF418 | MB21D2 | 2.15e+00 | 1.16e-04 | 4.68e+00 | 9.93e-01 | Female-biased |
| BRCA | ZNF460 | MB21D2 | 4.10e+00 | 9.83e-01 | 2.39e+00 | 2.38e-03 | Male-biased |
| BRCA | ZNF486 | MB21D2 | 4.18e+00 | 9.80e-01 | 2.83e+00 | 6.70e-03 | Male-biased |
| BRCA | ZNF530 | MB21D2 | 3.96e+00 | 9.81e-01 | 2.02e+00 | 1.18e-03 | Male-biased |
| BRCA | ZNF543 | MB21D2 | 4.08e+00 | 9.83e-01 | 2.37e+00 | 2.30e-03 | Male-biased |
| BRCA | ZNF682 | MB21D2 | 4.05e+00 | 9.83e-01 | 2.06e+00 | 9.92e-04 | Male-biased |
| BRCA | ZNF879 | MB21D2 | 2.11e+00 | 7.18e-04 | 4.15e+00 | 9.80e-01 | Female-biased |
| BRCA | ZNF891 | MB21D2 | 3.94e+00 | 9.81e-01 | 1.80e+00 | 6.20e-04 | Male-biased |
| DLBC | ZNF418 | MB21D2 | 2.98e+00 | 2.81e-03 | 4.22e+00 | 9.87e-01 | Female-biased |
| LGG | MBD2 | MB21D2 | 3.44e+00 | 3.91e-03 | 4.10e+00 | 9.80e-01 | Female-biased |
| LGG | PHF1 | MB21D2 | 4.03e+00 | 1.16e-02 | 4.50e+00 | 9.81e-01 | Female-biased |
| LGG | ZNF460 | MB21D2 | 3.41e+00 | 2.60e-03 | 4.15e+00 | 9.83e-01 | Female-biased |
| READ | ZNF225 | MB21D2 | 2.92e+00 | 2.01e-04 | 4.89e+00 | 9.96e-01 | Female-biased |
| READ | ZNF418 | MB21D2 | 2.87e+00 | 1.01e-05 | 5.72e+00 | 9.99e-01 | Female-biased |
| READ | ZNF879 | MB21D2 | 2.91e+00 | 7.74e-05 | 5.17e+00 | 9.98e-01 | Female-biased |
| MB21D2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MB21D2 |
| RBPs related to ES in MB21D2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MB21D2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000180611 | AP002957.1,hsa-mir-1224,MB21D2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000180611 | LINC01537,hsa-mir-1224,MB21D2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000180611 | AC103740.2,hsa-mir-1224,MB21D2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000180611 | LINC02783,hsa-mir-1224,MB21D2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000180611 | AP003119.3,hsa-mir-1224,MB21D2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000180611 | LOXL1-AS1,hsa-mir-1224,MB21D2 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000180611 | AL136526.1,hsa-mir-301a,MB21D2 | Female-specific ceRNA | TCGA-KICH |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs13091309 | chr3:189815295:T:C | - | 0.141452987356355 | 0.0196426828256759 | BLCA | Female-baised eQTL |
| rs4687417 | chr3:193376592:T:A | - | -0.0899970955573456 | 0.00836850816248359 | LUAD | Female-baised eQTL |
| rs77141367 | chr3:194337597:C:T | - | 0.0781934753354597 | 0.0172798133176973 | LUAD | Female-baised eQTL |
| rs58315618 | chr3:194337741:T:C | - | 0.0781934753354597 | 0.0172798133176973 | LUAD | Female-baised eQTL |
| rs59839945 | chr3:194337881:G:A | - | 0.0699632183602288 | 0.0364547729791377 | LUAD | Female-baised eQTL |
| rs57954364 | chr3:194337888:G:C | - | 0.0699632183602288 | 0.0364547729791377 | LUAD | Female-baised eQTL |
| rs6782581 | chr3:197252235:C:G | - | 0.0359647362529097 | 0.0380065375870416 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs972460 | chr3:192137772:G:T | - | -0.0590601074932154 | 0.0273075625298137 | KIRC | Male-baised eQTL |
| rs73189802 | chr3:187208865:T:C | - | 0.0833523348907124 | 0.0161641063335877 | BLCA | Male-baised eQTL |
| rs73055531 | chr3:188360560:C:T | - | 0.0528154044275872 | 0.0431960778598951 | BLCA | Male-baised eQTL |
| rs16863249 | chr3:188360854:G:T | - | 0.0528154044275872 | 0.0431960778598951 | BLCA | Male-baised eQTL |
| rs1568669 | chr3:188749374:A:T | - | -0.0878222531493481 | 0.0103023676621466 | COAD | Male-baised eQTL |
| rs16863574 | chr3:188744436:A:G | - | 0.0910272599689963 | 0.0136121537768223 | COAD | Male-baised eQTL |
| rs16863577 | chr3:188747929:T:C | - | 0.0914415590898525 | 0.0217237462142805 | COAD | Male-baised eQTL |
| rs16848791 | chr3:188752775:T:G | - | 0.0914415590898525 | 0.0217237462142805 | COAD | Male-baised eQTL |
| rs6778396 | chr3:194692513:G:A | - | 0.117301568410124 | 0.0223760333140302 | COAD | Male-baised eQTL |
| rs62289462 | chr3:184932893:A:T | - | 0.110069086347906 | 0.0246860822516492 | COAD | Male-baised eQTL |
| rs62289463 | chr3:184947156:A:G | - | 0.110069086347906 | 0.0246860822516492 | COAD | Male-baised eQTL |
| rs71310874 | chr3:190640662:T:C | - | 0.106606527692134 | 0.0259951540357957 | COAD | Male-baised eQTL |
| rs1105911 | chr3:187699607:C:G | - | -0.055837365175517 | 0.0380714601184799 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000180611 |
| CpG Site: cg23344395 | |
| Position to Gene: gene,promoter | |
| Male Effect: - | |
| Female Effect: -0.391834556731156 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg23344395 | chr3:192916213 | gene,promoter | -0.391834556731156 | 3.8312506836055e-05 | -0.32368967947093646 | 1.2466369335753624e-07 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MB21D2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
