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Gene: ENSG00000180340 |
Summary for FZD2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000180340 | Gene symbol | FZD2 |
| Gene name | frizzled class receptor 2 | |
| HGNC | 4040 | |
| Entrez ID | 2535 | |
| Gene type | protein_coding | |
| Synonyms | FZD2| | |
| UniProtAcc | Q14332 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for FZD2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| FZD2 | 6.49e+02 | 1.54e+00 | 2.47e-01 | 6.25e+00 | 4.22e-10 | 5.25e-09 | STAD |
| FZD2 | 7.19e+02 | 2.42e+00 | 4.30e-01 | 5.63e+00 | 1.81e-08 | 8.89e-07 | ESCA |
| FZD2 | 1.83e+02 | 3.11e+00 | 7.23e-01 | 4.30e+00 | 1.72e-05 | 9.10e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| FZD2 | 4.44e+02 | 1.36e+00 | 9.37e-02 | 1.45e+01 | 2.16e-47 | 2.03e-46 | BRCA |
| FZD2 | 1.45e+02 | 1.17e+00 | 4.19e-01 | 2.80e+00 | 5.07e-03 | 1.39e-02 | READ |
Top |
Sex-biased somatic mutation for FZD2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for FZD2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LIHC | cg18800827 | chr17:44556415 | CGI:chr17:44557465-44559483 | promoter | 2.08e-01 | 9.26e-02 | 4.76e+00 | 1.89e-06 | 2.49e-05 | 1.16e-01 |
| LIHC | cg04354879 | chr17:44557587 | CGI:chr17:44557465-44559483 | UTR,promoter,exon,gene body | 8.98e-02 | 1.90e-01 | -2.55e+00 | 1.08e-02 | 1.86e-02 | -1.00e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| THCA | cg09339219 | chr17:44558421 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.39e-01 | 4.38e-01 | 2.85e+00 | 4.32e-03 | 9.05e-03 | 1.01e-01 |
| LUSC | cg17049621 | chr17:44558410 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 3.33e-01 | 1.79e-01 | 4.08e+00 | 4.52e-05 | 5.47e-04 | 1.54e-01 |
| LUSC | cg09339219 | chr17:44558421 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.63e-01 | 3.01e-01 | 4.23e+00 | 2.29e-05 | 5.26e-04 | 2.62e-01 |
| LUSC | cg10624665 | chr17:44559202 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.44e-01 | 3.23e-01 | 4.42e+00 | 9.95e-06 | 5.26e-04 | 2.21e-01 |
| COAD | cg17049621 | chr17:44558410 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 3.55e-01 | 2.50e-01 | 4.35e+00 | 1.38e-05 | 7.52e-05 | 1.04e-01 |
| BLCA | cg17049621 | chr17:44558410 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 3.93e-01 | 2.49e-01 | 4.00e+00 | 6.46e-05 | 2.94e-04 | 1.44e-01 |
| CHOL | cg17049621 | chr17:44558410 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 3.06e-01 | 1.41e-01 | 2.51e+00 | 1.22e-02 | 2.39e-02 | 1.65e-01 |
| CHOL | cg09339219 | chr17:44558421 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.16e-01 | 2.88e-01 | 2.88e+00 | 4.04e-03 | 1.47e-02 | 2.28e-01 |
| CHOL | cg10624665 | chr17:44559202 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.29e-01 | 3.42e-01 | 2.95e+00 | 3.19e-03 | 1.32e-02 | 1.87e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg09339219 | chr17:44558421 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 6.35e-01 | 5.28e-01 | 7.98e+00 | 1.41e-15 | 5.37e-15 | 1.07e-01 |
| BRCA | cg10624665 | chr17:44559202 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.80e-01 | 4.62e-01 | 1.01e+01 | 8.62e-24 | 6.53e-23 | 1.18e-01 |
| KIRC | cg09339219 | chr17:44558421 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 3.45e-01 | 4.49e-01 | -2.50e+00 | 1.25e-02 | 1.97e-02 | -1.04e-01 |
| LIHC | cg17049621 | chr17:44558410 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 2.64e-01 | 1.40e-01 | 3.19e+00 | 1.41e-03 | 2.95e-03 | 1.24e-01 |
| LIHC | cg09339219 | chr17:44558421 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 4.17e-01 | 2.61e-01 | 3.05e+00 | 2.30e-03 | 4.34e-03 | 1.56e-01 |
| KIRP | cg10624665 | chr17:44559202 | CGI:chr17:44557465-44559483 | promoter,exon,CDS,gene body | 5.09e-01 | 3.74e-01 | 2.56e+00 | 1.03e-02 | 1.72e-02 | 1.35e-01 |
Top |
Exon skipping events with PSI in TCGA for FZD2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for FZD2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for FZD2 |
| TFs related to FZD2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | PLAGL2 | FZD2 | 4.58e+00 | 9.92e-01 | 3.27e+00 | 1.79e-03 | Male-biased |
| DLBC | ZNF331 | FZD2 | 4.35e+00 | 9.87e-01 | 3.29e+00 | 4.45e-03 | Male-biased |
| ESCA | DNMT1 | FZD2 | 4.62e+00 | 9.95e-01 | 3.37e+00 | 4.95e-04 | Male-biased |
| ESCA | HKR1 | FZD2 | 4.32e+00 | 9.80e-01 | 3.64e+00 | 1.24e-02 | Male-biased |
| ESCA | KLF10 | FZD2 | 4.33e+00 | 9.85e-01 | 3.57e+00 | 8.20e-03 | Male-biased |
| ESCA | KLF11 | FZD2 | 4.28e+00 | 9.83e-01 | 3.54e+00 | 8.93e-03 | Male-biased |
| ESCA | KLF16 | FZD2 | 4.29e+00 | 9.81e-01 | 3.59e+00 | 1.09e-02 | Male-biased |
| ESCA | KLF7 | FZD2 | 4.30e+00 | 9.84e-01 | 3.54e+00 | 8.15e-03 | Male-biased |
| ESCA | KLF9 | FZD2 | 4.35e+00 | 9.87e-01 | 3.54e+00 | 6.03e-03 | Male-biased |
| ESCA | PATZ1 | FZD2 | 4.37e+00 | 9.90e-01 | 3.47e+00 | 3.42e-03 | Male-biased |
| ESCA | RBAK | FZD2 | 4.18e+00 | 9.84e-01 | 3.39e+00 | 6.78e-03 | Male-biased |
| ESCA | ZNF394 | FZD2 | 4.22e+00 | 9.83e-01 | 3.47e+00 | 8.31e-03 | Male-biased |
| ESCA | ZNF44 | FZD2 | 4.55e+00 | 9.93e-01 | 3.49e+00 | 1.48e-03 | Male-biased |
| ESCA | ZNF454 | FZD2 | 4.34e+00 | 9.83e-01 | 3.62e+00 | 9.92e-03 | Male-biased |
| ESCA | ZNF468 | FZD2 | 4.33e+00 | 9.82e-01 | 3.63e+00 | 1.10e-02 | Male-biased |
| ESCA | ZNF484 | FZD2 | 4.20e+00 | 9.80e-01 | 3.50e+00 | 1.09e-02 | Male-biased |
| ESCA | ZNF530 | FZD2 | 4.37e+00 | 9.84e-01 | 3.63e+00 | 9.25e-03 | Male-biased |
| ESCA | ZNF543 | FZD2 | 4.63e+00 | 9.93e-01 | 3.62e+00 | 1.98e-03 | Male-biased |
| ESCA | ZNF548 | FZD2 | 4.40e+00 | 9.86e-01 | 3.64e+00 | 7.71e-03 | Male-biased |
| ESCA | ZNF611 | FZD2 | 4.79e+00 | 9.96e-01 | 3.60e+00 | 7.17e-04 | Male-biased |
| ESCA | ZNF682 | FZD2 | 4.47e+00 | 9.90e-01 | 3.60e+00 | 4.24e-03 | Male-biased |
| ESCA | ZNF740 | FZD2 | 4.61e+00 | 9.92e-01 | 3.69e+00 | 3.25e-03 | Male-biased |
| ESCA | ZNF776 | FZD2 | 4.38e+00 | 9.88e-01 | 3.56e+00 | 5.53e-03 | Male-biased |
| ESCA | ZNF816 | FZD2 | 4.33e+00 | 9.82e-01 | 3.62e+00 | 1.06e-02 | Male-biased |
| ESCA | ZSCAN22 | FZD2 | 4.37e+00 | 9.90e-01 | 3.47e+00 | 3.49e-03 | Male-biased |
| FZD2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for FZD2 |
| RBPs related to ES in FZD2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| FZD2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000180340 | LINC02570,hsa-mir-455,FZD2 | Male-specific ceRNA | TCGA-STAD |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12945862 | chr17:40234452:C:A | - | 0.255965796984226 | 0.0108518041817118 | GBM | Female-baised eQTL |
| rs11650531 | chr17:46796629:T:C | - | 0.188508163614599 | 0.0404602463748719 | GBM | Female-baised eQTL |
| rs111424690 | chr17:40125591:C:T | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs28526298 | chr17:40126371:C:T | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9900154 | chr17:40126946:T:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs74939788 | chr17:40133166:T:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs79777572 | chr17:40141072:A:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs16965669 | chr17:40148103:C:A | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9910373 | chr17:40151989:A:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9909777 | chr17:40152090:C:T | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs111862124 | chr17:40157029:T:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9894364 | chr17:40157408:C:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs111638687 | chr17:40159537:A:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9909811 | chr17:40169690:G:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9894807 | chr17:40173925:T:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs9889905 | chr17:40174352:A:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs78262563 | chr17:40179864:A:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs12103533 | chr17:40180564:G:A | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs192552894 | chr17:40182882:A:T | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs184191800 | chr17:40182883:T:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs8071687 | chr17:40183744:T:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs8067519 | chr17:40184035:C:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs113286899 | chr17:40185683:G:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs140695349 | chr17:40186131:A:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs78852644 | chr17:40187236:T:C | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs113416862 | chr17:40187704:A:G | - | 0.21107756938592 | 0.041127784832361 | GBM | Female-baised eQTL |
| rs17547180 | chr17:44974024:C:A | - | 0.109455303636639 | 4.18728913975135e-06 | LGG | Female-baised eQTL |
| rs111731734 | chr17:38610972:T:G | - | 0.0894060215359481 | 8.30379696806316e-05 | LGG | Female-baised eQTL |
| rs7215884 | chr17:38609145:C:T | - | 0.0865559595826037 | 0.000150776186900668 | LGG | Female-baised eQTL |
| rs7210925 | chr17:38609650:C:T | - | 0.0783593363303205 | 0.000468757135357232 | LGG | Female-baised eQTL |
| rs1809832 | chr17:41138540:C:A | - | 0.135717152432434 | 0.00151339197546553 | LGG | Female-baised eQTL |
| rs139894014 | chr17:41144445:G:T | - | 0.135717152432434 | 0.00151339197546553 | LGG | Female-baised eQTL |
| rs77897033 | chr17:53784534:T:C | - | 0.0695123653500759 | 0.00443979893828271 | LGG | Female-baised eQTL |
| rs11867476 | chr17:53786136:A:G | - | 0.0692036726832935 | 0.00465057721898762 | LGG | Female-baised eQTL |
| rs62072266 | chr17:53786665:G:A | - | 0.0692036726832935 | 0.00465057721898762 | LGG | Female-baised eQTL |
| rs139875071 | chr17:54265647:C:T | - | 0.136545692688732 | 0.00586664501346769 | LGG | Female-baised eQTL |
| rs6503708 | chr17:38561046:T:C | - | 0.0640187393854862 | 0.00627327295485922 | LGG | Female-baised eQTL |
| rs7224597 | chr17:53785442:G:T | - | 0.0662697650073441 | 0.00634851670711642 | LGG | Female-baised eQTL |
| rs4794462 | chr17:53788672:T:A | - | 0.0660141711026231 | 0.00672022020730122 | LGG | Female-baised eQTL |
| rs16941684 | chr17:47225320:A:T | - | 0.0624886014253167 | 0.0142837643458461 | LGG | Female-baised eQTL |
| rs72825958 | chr17:35363600:G:T | - | 0.0692487384040777 | 0.014628046592182 | LGG | Female-baised eQTL |
| rs2103273 | chr17:50213325:C:T | - | 0.0667421205431456 | 0.0169034814877163 | LGG | Female-baised eQTL |
| rs16951169 | chr17:52240714:A:G | - | 0.0809310810086718 | 0.0177095502674204 | LGG | Female-baised eQTL |
| rs77622276 | chr17:52240683:G:A | - | 0.0808743213974578 | 0.0180214314129455 | LGG | Female-baised eQTL |
| rs16951178 | chr17:52243443:G:A | - | 0.0801415590840567 | 0.0186961284413605 | LGG | Female-baised eQTL |
| rs77808986 | chr17:52246006:C:A | - | 0.0801415590840567 | 0.0186961284413605 | LGG | Female-baised eQTL |
| rs74429746 | chr17:52247045:T:C | - | 0.0801415590840567 | 0.0186961284413605 | LGG | Female-baised eQTL |
| rs79258995 | chr17:52247452:G:A | - | 0.0801415590840567 | 0.0186961284413605 | LGG | Female-baised eQTL |
| rs57407776 | chr17:52256118:G:A | - | 0.0801415590840567 | 0.0186961284413605 | LGG | Female-baised eQTL |
| rs12051652 | chr17:50218087:C:G | - | 0.0662250337381804 | 0.0191214979144898 | LGG | Female-baised eQTL |
| rs74406467 | chr17:52245952:C:A | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs1386267 | chr17:52246161:T:C | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs12452972 | chr17:52246536:T:C | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs79401059 | chr17:52247282:T:C | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs77337571 | chr17:52247874:A:G | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs75779114 | chr17:52247918:T:C | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs75431541 | chr17:52248196:C:A | - | 0.0790868541260883 | 0.0208514246111865 | LGG | Female-baised eQTL |
| rs12945422 | chr17:50223465:C:G | - | 0.064354672602501 | 0.0239876920237313 | LGG | Female-baised eQTL |
| rs12945815 | chr17:50230847:C:T | - | 0.0641665106005016 | 0.0242848441722629 | LGG | Female-baised eQTL |
| rs76433298 | chr17:54261379:T:C | - | 0.120159016454779 | 0.0244103381576278 | LGG | Female-baised eQTL |
| rs10515001 | chr17:52251097:C:T | - | 0.0779130524501549 | 0.0256855357972952 | LGG | Female-baised eQTL |
| rs2017664 | chr17:54274265:A:G | - | 0.119665573864395 | 0.025708721465568 | LGG | Female-baised eQTL |
| rs7210808 | chr17:54275554:C:T | - | 0.119665573864395 | 0.025708721465568 | LGG | Female-baised eQTL |
| rs149392971 | chr17:54277132:G:A | - | 0.119665573864395 | 0.025708721465568 | LGG | Female-baised eQTL |
| rs80007513 | chr17:54278377:T:C | - | 0.119665573864395 | 0.025708721465568 | LGG | Female-baised eQTL |
| rs8071669 | chr17:54288287:T:C | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs16954384 | chr17:54294369:T:C | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs79203078 | chr17:54296474:C:T | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs75993709 | chr17:54305006:T:G | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs78924047 | chr17:54307068:T:C | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs117025437 | chr17:54314462:T:G | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs147872634 | chr17:54320058:A:C | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs117395122 | chr17:54323063:A:G | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs76249931 | chr17:54323349:A:G | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs80037140 | chr17:54325141:C:G | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs116185015 | chr17:54329449:C:T | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs114948042 | chr17:54331786:G:C | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs116280219 | chr17:54332214:C:T | - | 0.119467066075779 | 0.0263730045625762 | LGG | Female-baised eQTL |
| rs1865424 | chr17:54261367:A:C | - | 0.119388898672054 | 0.0266102581230773 | LGG | Female-baised eQTL |
| rs118176320 | chr17:54266759:T:C | - | 0.119388898672054 | 0.0266102581230773 | LGG | Female-baised eQTL |
| rs114643518 | chr17:54267891:T:C | - | 0.119388898672054 | 0.0266102581230773 | LGG | Female-baised eQTL |
| rs4794114 | chr17:50225729:C:A | - | 0.0627030086731872 | 0.0316015137781438 | LGG | Female-baised eQTL |
| rs4793643 | chr17:50226299:C:A | - | 0.0627030086731872 | 0.0316015137781438 | LGG | Female-baised eQTL |
| rs11654352 | chr17:50230304:G:T | - | 0.0629217171156378 | 0.0322955087750638 | LGG | Female-baised eQTL |
| rs8066605 | chr17:37687498:G:A | - | 0.0954126557442066 | 0.0332624236442156 | LGG | Female-baised eQTL |
| rs11079899 | chr17:50232082:G:A | - | 0.0624279453850282 | 0.0334772912881879 | LGG | Female-baised eQTL |
| rs12600690 | chr17:50228607:C:G | - | 0.0622577134833334 | 0.0342404893573168 | LGG | Female-baised eQTL |
| rs35374775 | chr17:50234194:C:T | - | 0.0607202298437228 | 0.039352112318403 | LGG | Female-baised eQTL |
| rs16951154 | chr17:52235411:C:A | - | 0.0853821082815922 | 0.0402629801972144 | LGG | Female-baised eQTL |
| rs16951156 | chr17:52235711:A:G | - | 0.0853821082815922 | 0.0402629801972144 | LGG | Female-baised eQTL |
| rs16951165 | chr17:52237481:G:A | - | 0.0853821082815922 | 0.0402629801972144 | LGG | Female-baised eQTL |
| rs1986817 | chr17:47180148:C:T | - | 0.0880068210354046 | 0.0405888127342846 | LGG | Female-baised eQTL |
| rs16941635 | chr17:47184589:G:A | - | 0.0880068210354046 | 0.0405888127342846 | LGG | Female-baised eQTL |
| rs8077250 | chr17:54274425:C:A | - | 0.101203750327814 | 0.0410330786493729 | LGG | Female-baised eQTL |
| rs9903239 | chr17:54273316:T:C | - | 0.101179768644888 | 0.0414398384080077 | LGG | Female-baised eQTL |
| rs28421271 | chr17:54269664:C:T | - | 0.10094418473682 | 0.0425850830560851 | LGG | Female-baised eQTL |
| rs7213499 | chr17:54271860:T:A | - | 0.10094418473682 | 0.0425850830560851 | LGG | Female-baised eQTL |
| rs9902731 | chr17:54273091:T:A | - | 0.10094418473682 | 0.0425850830560851 | LGG | Female-baised eQTL |
| rs117279442 | chr17:54334040:A:G | - | 0.112408598753308 | 0.0442724916463889 | LGG | Female-baised eQTL |
| rs116029685 | chr17:54334789:T:A | - | 0.112408598753308 | 0.0442724916463889 | LGG | Female-baised eQTL |
| rs79816416 | chr17:54339366:G:T | - | 0.112408598753308 | 0.0442724916463889 | LGG | Female-baised eQTL |
| rs76084712 | chr17:54341169:A:G | - | 0.112408598753308 | 0.0442724916463889 | LGG | Female-baised eQTL |
| rs17659536 | chr17:54257620:T:C | - | 0.112324483053116 | 0.044878896182961 | LGG | Female-baised eQTL |
| rs79290416 | chr17:54258702:A:G | - | 0.112324483053116 | 0.044878896182961 | LGG | Female-baised eQTL |
| rs11570481 | chr17:47158054:G:A | - | 0.0880183717149649 | 0.0460520406677067 | LGG | Female-baised eQTL |
| rs2429994 | chr17:38555819:A:G | - | 0.054802189440205 | 0.0460738485822094 | LGG | Female-baised eQTL |
| rs11570548 | chr17:47131353:G:A | - | 0.0869858090367043 | 0.0466325484823014 | LGG | Female-baised eQTL |
| rs78096575 | chr17:47148806:G:A | - | 0.0869858090367043 | 0.0466325484823014 | LGG | Female-baised eQTL |
| rs77144621 | chr17:47168245:G:A | - | 0.0869858090367043 | 0.0466325484823014 | LGG | Female-baised eQTL |
| rs76621174 | chr17:47132654:C:T | - | 0.087020507189653 | 0.0466430587306615 | LGG | Female-baised eQTL |
| rs149486294 | chr17:47147153:C:A | - | 0.087020507189653 | 0.0466430587306615 | LGG | Female-baised eQTL |
| rs11570495 | chr17:47153598:A:G | - | 0.087020507189653 | 0.0466430587306615 | LGG | Female-baised eQTL |
| rs78943400 | chr17:47166540:A:G | - | 0.087020507189653 | 0.0466430587306615 | LGG | Female-baised eQTL |
| rs16941671 | chr17:47218137:C:G | - | 0.0870003902122334 | 0.0472801026937286 | LGG | Female-baised eQTL |
| rs9303586 | chr17:51493861:A:G | - | 0.0800446865382941 | 0.00190537571430167 | KIRC | Female-baised eQTL |
| rs4374211 | chr17:51498383:C:T | - | 0.0800446865382941 | 0.00190537571430167 | KIRC | Female-baised eQTL |
| rs4092050 | chr17:40506501:C:T | - | -0.0925021952259189 | 0.00207688795206647 | KIRC | Female-baised eQTL |
| rs349971 | chr17:52565394:G:A | - | 0.0876167626134687 | 0.00460813896119224 | KIRC | Female-baised eQTL |
| rs921394 | chr17:40499967:C:T | - | -0.0863783344202726 | 0.00639815084704353 | KIRC | Female-baised eQTL |
| rs2521421 | chr17:47101811:G:T | - | -0.0747519901985084 | 0.00648634556148304 | KIRC | Female-baised eQTL |
| rs349973 | chr17:52564929:T:C | - | 0.0816281299350792 | 0.01003886689898 | KIRC | Female-baised eQTL |
| rs349972 | chr17:52565322:A:G | - | 0.0816281299350792 | 0.01003886689898 | KIRC | Female-baised eQTL |
| rs475298 | chr17:40498540:G:A | - | -0.0810596671336495 | 0.0114739290368412 | KIRC | Female-baised eQTL |
| rs61422252 | chr17:38809283:T:C | - | 0.0715807699854022 | 0.014338021714977 | KIRC | Female-baised eQTL |
| rs349907 | chr17:52536139:C:G | - | 0.0821387356453627 | 0.0149384354300534 | KIRC | Female-baised eQTL |
| rs6503543 | chr17:40496592:A:G | - | -0.0785615647756051 | 0.0152715284268217 | KIRC | Female-baised eQTL |
| rs9901908 | chr17:40499463:C:T | - | -0.0748921728611326 | 0.0188181499120799 | KIRC | Female-baised eQTL |
| rs3760144 | chr17:38801179:G:A | - | 0.0692807822292864 | 0.0199825415113456 | KIRC | Female-baised eQTL |
| rs9674674 | chr17:48757379:G:C | - | 0.079377822296113 | 0.0208794900438838 | KIRC | Female-baised eQTL |
| rs73390791 | chr17:54015210:A:G | - | 0.0692905889392037 | 0.0227862164585237 | KIRC | Female-baised eQTL |
| rs62073778 | chr17:47040546:T:C | - | -0.0814027767951676 | 0.0233451387653464 | KIRC | Female-baised eQTL |
| rs199592383 | chr17:47040547:C:T | - | -0.0814027767951676 | 0.0233451387653464 | KIRC | Female-baised eQTL |
| rs113488063 | chr17:54017656:C:A | - | 0.0690765844670035 | 0.0236118840400576 | KIRC | Female-baised eQTL |
| rs2242308 | chr17:36505464:G:A | - | 0.0703114475615267 | 0.0288771273532496 | KIRC | Female-baised eQTL |
| rs143978586 | chr17:52616283:G:A | - | -0.0831185683184962 | 0.0325974633225248 | KIRC | Female-baised eQTL |
| rs9914031 | chr17:52241854:G:A | - | 0.0464716858720236 | 0.0333103938661714 | KIRC | Female-baised eQTL |
| rs72818340 | chr17:36500678:G:A | - | 0.0686407544191454 | 0.0340768905013374 | KIRC | Female-baised eQTL |
| rs16954039 | chr17:54019882:A:G | - | 0.0638625014364734 | 0.0460462382799648 | KIRC | Female-baised eQTL |
| rs1542611 | chr17:36492592:G:T | - | 0.0643563236567561 | 0.0465960583750786 | KIRC | Female-baised eQTL |
| rs1870115 | chr17:54022473:C:T | - | 0.0633510493379086 | 0.0469023255647647 | KIRC | Female-baised eQTL |
| rs11871780 | chr17:52764702:G:A | - | 0.0699600963316224 | 0.047890815413647 | KIRC | Female-baised eQTL |
| rs7222007 | chr17:44586995:G:A | - | 0.0699628649725172 | 0.0491815863473149 | KIRC | Female-baised eQTL |
| rs17551103 | chr17:49968074:T:C | - | 0.183801075012312 | 0.00956611254920153 | BLCA | Female-baised eQTL |
| rs72839167 | chr17:49968153:G:C | - | 0.183801075012312 | 0.00956611254920153 | BLCA | Female-baised eQTL |
| rs72839166 | chr17:49968140:C:T | - | 0.182856159921176 | 0.010553678347729 | BLCA | Female-baised eQTL |
| rs56132909 | chr17:49969107:G:A | - | 0.182856159921176 | 0.010553678347729 | BLCA | Female-baised eQTL |
| rs61749026 | chr17:49969599:A:G | - | 0.182856159921176 | 0.010553678347729 | BLCA | Female-baised eQTL |
| rs9890089 | chr17:50608431:G:A | - | 0.123167676009718 | 0.0115400335347394 | BLCA | Female-baised eQTL |
| rs985626 | chr17:49962977:T:C | - | -0.110889406804821 | 0.0404839936058003 | BLCA | Female-baised eQTL |
| rs8067696 | chr17:37762968:A:G | - | 0.0534091396364005 | 0.000533286339179731 | LUAD | Female-baised eQTL |
| rs1006512 | chr17:53421240:G:A | - | -0.0543332210871324 | 0.00383909079210125 | LUAD | Female-baised eQTL |
| rs4794269 | chr17:51585773:A:T | - | 0.0453190467845058 | 0.00826165040221603 | LUAD | Female-baised eQTL |
| rs16950076 | chr17:51560350:T:G | - | 0.048810396343745 | 0.00952015709821596 | LUAD | Female-baised eQTL |
| rs12603334 | chr17:51599922:C:T | - | 0.0435711001873919 | 0.0117079833840314 | LUAD | Female-baised eQTL |
| rs77672831 | chr17:51609235:G:T | - | 0.0435145390203746 | 0.0119640689655364 | LUAD | Female-baised eQTL |
| rs4794271 | chr17:51590733:C:G | - | 0.0438156342069572 | 0.0120746911887369 | LUAD | Female-baised eQTL |
| rs4399573 | chr17:51601555:C:A | - | 0.0415184674058898 | 0.0183636572146053 | LUAD | Female-baised eQTL |
| rs60241356 | chr17:51591478:G:A | - | 0.0417230110802505 | 0.0189679543074426 | LUAD | Female-baised eQTL |
| rs4239171 | chr17:51581561:G:A | - | 0.0416799590753163 | 0.0191198491990947 | LUAD | Female-baised eQTL |
| rs4239174 | chr17:51588560:C:T | - | 0.0416799590753163 | 0.0191198491990947 | LUAD | Female-baised eQTL |
| rs188753761 | chr17:51589525:C:T | - | 0.0416504163159035 | 0.0193509146202477 | LUAD | Female-baised eQTL |
| rs4239172 | chr17:51581917:G:A | - | 0.04122393456647 | 0.0201936218810497 | LUAD | Female-baised eQTL |
| rs57187326 | chr17:51554351:C:T | - | 0.0442762660758407 | 0.0238089147530064 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs28826664 | chr17:53760975:G:A | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs140444552 | chr17:53761313:C:T | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs149972660 | chr17:53761838:G:A | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs117431055 | chr17:53762295:A:T | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs76009415 | chr17:53764177:A:G | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs76866407 | chr17:53766045:C:T | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs75690805 | chr17:53766879:A:T | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs113525936 | chr17:53767963:T:C | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs117327513 | chr17:53769461:T:C | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs117347631 | chr17:53770995:G:C | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs76555547 | chr17:53770996:T:C | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs12325940 | chr17:53774691:T:C | - | 0.0612655799514577 | 0.0484536246817816 | LGG | Male-baised eQTL |
| rs117079275 | chr17:39940825:T:C | - | 0.0639818296384861 | 0.011368239312001 | KIRC | Male-baised eQTL |
| rs150985855 | chr17:39940940:C:T | - | 0.0639079107002487 | 0.011528447309825 | KIRC | Male-baised eQTL |
| rs80320567 | chr17:39941789:C:T | - | 0.0639079107002487 | 0.011528447309825 | KIRC | Male-baised eQTL |
| rs79057213 | chr17:39935305:C:G | - | 0.063786258025858 | 0.0138196365506449 | KIRC | Male-baised eQTL |
| rs16965456 | chr17:39950842:T:G | - | 0.061379295074175 | 0.0154483394253424 | KIRC | Male-baised eQTL |
| rs138971063 | chr17:39951681:C:G | - | 0.0613040787224144 | 0.0156790304008063 | KIRC | Male-baised eQTL |
| rs116705564 | chr17:39954836:G:C | - | 0.0632241170688679 | 0.0158986195990875 | KIRC | Male-baised eQTL |
| rs75481677 | chr17:39951977:A:T | - | 0.0589785352156806 | 0.041282203415734 | KIRC | Male-baised eQTL |
| rs66482609 | chr17:39623346:T:C | - | 0.0485680960506943 | 0.0439399690563467 | BLCA | Male-baised eQTL |
| rs142009207 | chr17:42394393:G:C | - | 0.125664472886918 | 0.0308123700083067 | LUAD | Male-baised eQTL |
| rs16967738 | chr17:42394249:T:C | - | 0.12019094216552 | 0.0358586024763712 | LUAD | Male-baised eQTL |
| rs199506 | chr17:46781665:A:G | - | -0.0783975838901374 | 0.00420349881270193 | COAD | Male-baised eQTL |
| rs199504 | chr17:46783637:C:T | - | -0.0785190045155613 | 0.00444442060988645 | COAD | Male-baised eQTL |
| rs199512 | chr17:46779986:T:C | - | -0.077417137518819 | 0.00477180046930512 | COAD | Male-baised eQTL |
| rs199510 | chr17:46780563:A:C | - | -0.077417137518819 | 0.00477180046930512 | COAD | Male-baised eQTL |
| rs199509 | chr17:46781362:G:A | - | -0.077417137518819 | 0.00477180046930512 | COAD | Male-baised eQTL |
| rs199507 | chr17:46781489:A:G | - | -0.077417137518819 | 0.00477180046930512 | COAD | Male-baised eQTL |
| rs199505 | chr17:46782044:A:G | - | -0.077417137518819 | 0.00477180046930512 | COAD | Male-baised eQTL |
| rs70602 | chr17:46782349:T:C | - | -0.077417137518819 | 0.00477180046930512 | COAD | Male-baised eQTL |
| rs199514 | chr17:46779515:G:A | - | -0.0787680638304659 | 0.00514034332468638 | COAD | Male-baised eQTL |
| rs199516 | chr17:46779119:C:T | - | -0.0759098733675989 | 0.00614642452210253 | COAD | Male-baised eQTL |
| rs199515 | chr17:46779275:G:C | - | -0.0712229266686184 | 0.011068076278226 | COAD | Male-baised eQTL |
| rs1378358 | chr17:46709946:C:T | - | 0.0710381472071004 | 0.0145033048558265 | COAD | Male-baised eQTL |
| rs199448 | chr17:46731635:A:G | - | 0.0690667477578589 | 0.019458223983921 | COAD | Male-baised eQTL |
| rs2458218 | chr17:46284017:T:C | - | 0.0663360307137499 | 0.0293059097953202 | COAD | Male-baised eQTL |
| rs369158541 | chr17:46334710:A:G | - | 0.0672307110927068 | 0.030733319146981 | COAD | Male-baised eQTL |
| rs2877581 | chr17:54263625:G:A | - | 0.0434662693508349 | 0.0313105496907689 | COAD | Male-baised eQTL |
| rs2732704 | chr17:46275748:T:C | - | 0.066985189462897 | 0.0323403836046936 | COAD | Male-baised eQTL |
| rs2668626 | chr17:46275809:T:C | - | 0.066985189462897 | 0.0323403836046936 | COAD | Male-baised eQTL |
| rs2458217 | chr17:46275840:T:C | - | 0.066985189462897 | 0.0323403836046936 | COAD | Male-baised eQTL |
| rs2957297 | chr17:46290846:C:A | - | 0.0679192369009566 | 0.0338704350903275 | COAD | Male-baised eQTL |
| rs199513 | chr17:46779566:A:G | - | -0.0603312494063332 | 0.0392790843015476 | COAD | Male-baised eQTL |
| rs1508008 | chr17:54260652:C:T | - | 0.0424256042900808 | 0.0402035766737333 | COAD | Male-baised eQTL |
| rs11655583 | chr17:54288205:T:A | - | 0.0432488410282792 | 0.0415696528185333 | COAD | Male-baised eQTL |
| rs1508009 | chr17:54261977:G:A | - | 0.0420437416108411 | 0.0438773320276866 | COAD | Male-baised eQTL |
| rs12936374 | chr17:54290837:G:T | - | 0.0424998143586526 | 0.0468666012522018 | COAD | Male-baised eQTL |
| rs5019804 | chr17:54304925:G:T | - | 0.0424998143586526 | 0.0468666012522018 | COAD | Male-baised eQTL |
| rs1508005 | chr17:54281461:T:C | - | 0.0419740251443977 | 0.0491424107242919 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000180340 |
| CpG Site: cg09339219 | |
| Position to Gene: gene,exon,CDS,promoter | |
| Male Effect: -0.410370316142464 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg09339219 | chr17:44558421 | gene,exon,CDS,promoter | -0.410370316142464 | 4.09418828402412e-06 | -0.3732819428186185 | 9.51399284685619e-09 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of FZD2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000180340 | FZD2 | C0007102 | Malignant tumor of colon | 1 | CTD_human |
| ENSG00000180340 | FZD2 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
