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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000178919

Summary for FOXE1

check button Gene summary

Gene informationEnsembl ID

ENSG00000178919

Gene symbol

FOXE1

Gene nameforkhead box E1
HGNC

3806

Entrez ID

2304

Gene typeprotein_coding
SynonymsFOXE1|TTF-2|HFKH4
UniProtAcc

O00358


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for FOXE1

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
FOXE11.16e+024.92e+006.19e-017.95e+001.89e-152.10e-14LUAD
FOXE15.07e+033.24e+001.10e+002.95e+003.16e-031.54e-02ESCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

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Sex-biased somatic mutation for FOXE1

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for FOXE1

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg13827859chr9:97852802CGI:chr9:97852952-97855228promoter2.25e-013.60e-01-1.99e+004.62e-024.85e-02-1.35e-01
BRCAcg15802898chr9:97852919CGI:chr9:97852952-97855228promoter2.27e-013.86e-01-2.01e+004.46e-024.79e-02-1.59e-01
BRCAcg19292008chr9:97853514CGI:chr9:97852952-97855228UTR,promoter,exon,gene body2.35e-013.84e-01-2.17e+002.99e-024.09e-02-1.49e-01
BRCAcg24393316chr9:97854187CGI:chr9:97852952-97855228promoter,exon,CDS,gene body3.94e-016.48e-01-2.02e+004.39e-024.76e-02-2.54e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
KIRCcg24393316chr9:97854187CGI:chr9:97852952-97855228promoter,exon,CDS,gene body1.91e-018.61e-022.57e+001.02e-021.22e-021.05e-01
LUADcg24393316chr9:97854187CGI:chr9:97852952-97855228promoter,exon,CDS,gene body2.38e-015.36e-023.32e+008.92e-041.76e-031.85e-01
BLCAcg13791254chr9:97854325CGI:chr9:97852952-97855228promoter,exon,CDS,gene body4.14e-011.31e-012.35e+001.88e-022.33e-022.83e-01
BLCAcg15802898chr9:97852919CGI:chr9:97852952-97855228promoter2.76e-018.21e-022.55e+001.07e-021.49e-021.94e-01
CHOLcg13564742chr9:97852597CGI:chr9:97851656-97852340promoter4.93e-012.31e-012.43e+001.50e-022.65e-022.62e-01
CHOLcg24393316chr9:97854187CGI:chr9:97852952-97855228promoter,exon,CDS,gene body8.24e-011.50e-013.10e+001.96e-031.07e-026.74e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg13791254chr9:97854325CGI:chr9:97852952-97855228promoter,exon,CDS,gene body5.95e-012.00e-011.20e+014.24e-339.31e-323.95e-01
BRCAcg13564742chr9:97852597CGI:chr9:97851656-97852340promoter5.20e-012.15e-011.28e+012.75e-371.21e-353.05e-01
BRCAcg13827859chr9:97852802CGI:chr9:97852952-97855228promoter2.25e-017.14e-021.04e+013.58e-253.09e-241.54e-01
BRCAcg15802898chr9:97852919CGI:chr9:97852952-97855228promoter2.27e-016.40e-021.00e+011.35e-231.01e-221.63e-01
BRCAcg02157015chr9:97852962CGI:chr9:97852952-97855228promoter2.12e-019.26e-028.28e+001.25e-165.15e-161.19e-01
BRCAcg19292008chr9:97853514CGI:chr9:97852952-97855228UTR,promoter,exon,gene body2.35e-017.35e-028.14e+004.03e-161.60e-151.61e-01
BRCAcg24393316chr9:97854187CGI:chr9:97852952-97855228promoter,exon,CDS,gene body3.94e-016.69e-024.78e+001.79e-063.24e-063.27e-01
LUADcg13827859chr9:97852802CGI:chr9:97852952-97855228promoter1.80e-017.62e-023.11e+001.87e-034.86e-031.03e-01
LUADcg15802898chr9:97852919CGI:chr9:97852952-97855228promoter1.66e-015.75e-023.02e+002.54e-036.00e-031.09e-01
LIHCcg13827859chr9:97852802CGI:chr9:97852952-97855228promoter2.35e-019.36e-022.17e+003.00e-023.33e-021.41e-01
LIHCcg15802898chr9:97852919CGI:chr9:97852952-97855228promoter2.13e-017.67e-022.61e+009.06e-031.29e-021.36e-01
LIHCcg02157015chr9:97852962CGI:chr9:97852952-97855228promoter1.98e-018.08e-024.01e+006.11e-052.65e-041.17e-01
KIRPcg13791254chr9:97854325CGI:chr9:97852952-97855228promoter,exon,CDS,gene body2.26e-017.48e-022.07e+003.81e-024.14e-021.51e-01

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Exon skipping events with PSI in TCGA for FOXE1

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for FOXE1

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for FOXE1

check buttonTFs related to FOXE1.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
GBMFERD3LFOXE14.47e+009.81e-013.44e+001.19e-02Male-biased
GBMNHLH2FOXE14.07e+009.81e-012.62e+003.17e-03Male-biased
GBMZNF141FOXE14.01e+009.82e-012.08e+006.12e-04Male-biased
GBMZNF2FOXE14.20e+009.85e-012.72e+002.89e-03Male-biased
GBMZNF311FOXE14.01e+009.81e-012.32e+001.40e-03Male-biased
GBMZNF335FOXE14.07e+009.82e-012.57e+002.65e-03Male-biased
GBMZNF460FOXE14.09e+009.81e-012.67e+003.46e-03Male-biased
GBMZNF543FOXE14.02e+009.81e-012.41e+001.89e-03Male-biased
GBMZNF566FOXE14.04e+009.81e-012.44e+001.97e-03Male-biased
GBMZNF674FOXE14.13e+009.82e-012.80e+004.58e-03Male-biased
PAADKLF11FOXE13.26e+006.43e-034.15e+009.83e-01Female-biased
PAADKLF5FOXE13.31e+008.29e-034.15e+009.81e-01Female-biased
PAADZFP64FOXE13.41e+007.29e-034.27e+009.84e-01Female-biased
PAADZNF180FOXE13.68e+001.02e-024.48e+009.84e-01Female-biased
PAADZNF304FOXE13.49e+004.90e-034.44e+009.88e-01Female-biased
PAADZNF311FOXE13.30e+003.77e-034.30e+009.88e-01Female-biased
PAADZNF383FOXE13.44e+001.05e-024.23e+009.80e-01Female-biased
PAADZNF44FOXE13.10e+003.56e-034.10e+009.85e-01Female-biased
PAADZNF460FOXE13.34e+008.15e-034.18e+009.82e-01Female-biased
PAADZNF543FOXE13.23e+002.37e-034.31e+009.90e-01Female-biased
PAADZNF566FOXE13.35e+005.50e-034.27e+009.86e-01Female-biased
PAADZNF611FOXE13.28e+004.25e-034.26e+009.87e-01Female-biased
PAADZNF792FOXE13.52e+004.37e-034.49e+009.90e-01Female-biased
THYMASCL1FOXE12.86e+001.16e-034.07e+009.84e-01Female-biased
THYMFERD3LFOXE13.98e+009.05e-034.69e+009.85e-01Female-biased
THYMNHLH1FOXE12.97e+007.10e-044.31e+009.89e-01Female-biased
THYMNHLH2FOXE13.35e+001.73e-034.48e+009.90e-01Female-biased
THYMNR1H4FOXE13.46e+002.06e-034.54e+009.90e-01Female-biased
THYMNR1I2FOXE14.14e+001.28e-024.77e+009.82e-01Female-biased
THYMPATZ1FOXE13.39e+001.50e-034.55e+009.91e-01Female-biased
THYMPRDM1FOXE14.73e+009.93e-013.65e+001.92e-03Male-biased
THYMSALL4FOXE13.11e+003.16e-034.07e+009.82e-01Female-biased
THYMSOX8FOXE15.18e+009.94e-014.23e+003.26e-03Male-biased
THYMTCF12FOXE12.93e+001.30e-034.12e+009.84e-01Female-biased
THYMTCF3FOXE12.95e+001.06e-034.19e+009.86e-01Female-biased
THYMZFP64FOXE13.82e+001.03e-024.50e+009.81e-01Female-biased
THYMZNF141FOXE13.49e+001.78e-034.61e+009.91e-01Female-biased
THYMZNF335FOXE13.44e+004.16e-034.34e+009.85e-01Female-biased
THYMZNF37AFOXE13.64e+009.18e-034.34e+009.80e-01Female-biased
THYMZNF394FOXE13.41e+005.23e-034.26e+009.83e-01Female-biased
THYMZNF460FOXE13.97e+001.03e-024.65e+009.83e-01Female-biased
THYMZNF479FOXE13.54e+003.45e-034.50e+009.88e-01Female-biased
THYMZNF674FOXE13.69e+003.66e-034.63e+009.90e-01Female-biased
THYMZNF823FOXE14.37e+009.82e-013.67e+008.82e-03Male-biased

check buttonFOXE1 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.
related_gene

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Sex-biased RBP-ES network for FOXE1

check buttonRBPs related to ES in FOXE1.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonFOXE1 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10120856chr9:92785243:A:G-0.112236507034580.0417473013512646HNSCFemale-baised eQTL
rs10120915chr9:92785443:A:C-0.112236507034580.0417473013512646HNSCFemale-baised eQTL
rs10121597chr9:92787928:G:A-0.112236507034580.0417473013512646HNSCFemale-baised eQTL
rs2181585chr9:92789548:G:A-0.112236507034580.0417473013512646HNSCFemale-baised eQTL
rs6479431chr9:92784607:G:A-0.114082785858180.0450197963587157HNSCFemale-baised eQTL
rs1022844chr9:92791182:A:T-0.1115151325285370.0474701092771427HNSCFemale-baised eQTL
rs4742989chr9:106342621:C:T--0.08345812914604140.00274346486779857LUADFemale-baised eQTL
rs7852451chr9:106346724:A:G--0.08345812914604140.00274346486779857LUADFemale-baised eQTL
rs9650727chr9:106339105:A:C--0.08334117675541680.00279400762794326LUADFemale-baised eQTL
rs2048100chr9:106335908:A:C--0.07978524950683820.00452699350620117LUADFemale-baised eQTL
rs7035003chr9:106336561:G:T--0.07978524950683820.00452699350620117LUADFemale-baised eQTL
rs9650726chr9:106338699:T:C--0.07978524950683820.00452699350620117LUADFemale-baised eQTL
rs10116613chr9:106327308:A:G--0.07881631800991780.00549172995876803LUADFemale-baised eQTL
rs10816381chr9:106330462:A:C--0.07881631800991780.00549172995876803LUADFemale-baised eQTL
rs620311chr9:90011623:A:C--0.06057058777294230.00681096672444661LUADFemale-baised eQTL
rs1484370chr9:106334474:C:T--0.07646470353484670.0070199316444314LUADFemale-baised eQTL
rs57060377chr9:90302560:A:G-0.06037932919998050.0211918987832173LUADFemale-baised eQTL
rs12344001chr9:90234328:G:A-0.05925402201693190.0252426810861001LUADFemale-baised eQTL
rs10820785chr9:105112203:A:C-0.04899417716219140.0252820374345209LUADFemale-baised eQTL
rs73512752chr9:102564524:A:G-0.0495511183757530.032806082657747LUADFemale-baised eQTL
rs10820862chr9:91510448:A:G-0.06124401601954760.0333965548370317LUADFemale-baised eQTL
rs10820864chr9:91511906:G:A-0.06124401601954760.0333965548370317LUADFemale-baised eQTL
rs17303618chr9:95841196:C:A-0.05885773022760870.0357088866898596LUADFemale-baised eQTL
rs79590813chr9:89992800:T:G-0.04853524245968180.0375427478418102LUADFemale-baised eQTL
rs117285410chr9:89993601:T:C-0.04853524245968180.0375427478418102LUADFemale-baised eQTL
rs75139152chr9:89993840:G:T-0.04844764970164280.0383704358155093LUADFemale-baised eQTL
rs10512262chr9:99042726:G:A-0.04239559963079660.0393706514908299LUADFemale-baised eQTL
rs10820863chr9:91511621:C:G-0.05892212401148530.0436994081504422LUADFemale-baised eQTL
rs74617655chr9:90005326:G:A-0.04739711291696220.0474764094312906LUADFemale-baised eQTL
rs78389330chr9:89953115:G:A-0.04367012177660270.0490733721977964LUADFemale-baised eQTL
rs59021050chr9:89942978:A:C-0.0435775468344340.0498767770168033LUADFemale-baised eQTL
rs77918388chr9:89944377:C:G-0.0435775468344340.0498767770168033LUADFemale-baised eQTL
rs78530397chr9:89944388:A:C-0.0435775468344340.0498767770168033LUADFemale-baised eQTL
rs75788647chr9:89946853:G:A-0.0435775468344340.0498767770168033LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs16925267chr9:106140405:T:C-0.06193690426792680.00106263262696451LUADMale-baised eQTL
rs62558503chr9:90666718:G:C-0.07656568763956830.00328971533667508LUADMale-baised eQTL
rs79139199chr9:90667561:T:C-0.07656568763956830.00328971533667508LUADMale-baised eQTL
rs7866564chr9:106397883:G:T--0.07609142656411120.00414862280138188LUADMale-baised eQTL
rs12683896chr9:94927408:A:G-0.07278788993950060.00432136356014292LUADMale-baised eQTL
rs1484371chr9:106393398:C:G--0.07336838838449320.00543104260493772LUADMale-baised eQTL
rs139495350chr9:102760580:A:C-0.06483735495753980.00615043740724657LUADMale-baised eQTL
rs12554043chr9:94931040:T:C-0.07035519100969940.00622904101111462LUADMale-baised eQTL
rs67490803chr9:94931275:A:G-0.07035519100969940.00622904101111462LUADMale-baised eQTL
rs12551506chr9:94940746:G:A-0.07035519100969940.00622904101111462LUADMale-baised eQTL
rs2095069chr9:94940218:T:C-0.07030162252078350.0063449361858646LUADMale-baised eQTL
rs56662263chr9:106153874:G:A-0.0471401361073260.0121808830939192LUADMale-baised eQTL
rs4742993chr9:106396651:C:T--0.06824316523871840.012609452620423LUADMale-baised eQTL
rs7038938chr9:106154614:A:G-0.04645521722952710.014278739539698LUADMale-baised eQTL
rs7867254chr9:96535584:C:G-0.06270824055683540.0162304714523735LUADMale-baised eQTL
rs6477511chr9:106393186:G:A--0.06216883304561630.0224522496780402LUADMale-baised eQTL
rs71494574chr9:105957251:G:A-0.05813877025283430.0301225563105179LUADMale-baised eQTL
rs7850106chr9:105969383:A:T-0.0580019472418940.0309196132146282LUADMale-baised eQTL
rs7858847chr9:106144159:T:A-0.04132888812487510.0343607659796946LUADMale-baised eQTL
rs7860539chr9:105327038:A:G-0.06163141336591690.0498951874586617LUADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription
eQTM boxplot analysisGene ID: ENSG00000178919
CpG Site: cg13696609
Position to Gene: gene,exon,enhancer,UTR
Male Effect: -
Female Effect: -0.150540545103232

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type
cg13696609chr9:97855428gene,exon,enhancer,UTR-0.1505405451032327.81414950798157e-06-0.34609447814590521.3795370661266369e-08LUAD

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of FOXE1

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000178919FOXE1C1855794Bamforth syndrome1CTD_human
ENSG00000178919FOXE1C1968699Hypothyroidism, Thyroidal, With Spiky Hair And Cleft Palate1CTD_human
ENSG00000178919FOXE1C4225293THYROID CANCER, NONMEDULLARY, 41CTD_human