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Gene: ENSG00000178821 |
Summary for TMEM52 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000178821 | Gene symbol | TMEM52 |
| Gene name | transmembrane protein 52 | |
| HGNC | 27916 | |
| Entrez ID | 339456 | |
| Gene type | protein_coding | |
| Synonyms | TMEM52| | |
| UniProtAcc | Q8NDY8 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TMEM52 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TMEM52 | 1.66e+02 | -1.68e+00 | 6.56e-01 | -2.55e+00 | 1.06e-02 | 2.62e-02 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TMEM52 | 2.96e+02 | 2.00e+00 | 4.36e-01 | 4.57e+00 | 4.78e-06 | 3.41e-05 | READ |
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Sex-biased somatic mutation for TMEM52 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TMEM52 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg05355142 | chr1:1919933 | CGI:chr1:1918659-1919952 | promoter | 3.93e-01 | 5.03e-01 | -2.11e+00 | 3.49e-02 | 4.36e-02 | -1.10e-01 |
| SARC | cg22718050 | chr1:1918836 | CGI:chr1:1918659-1919952 | promoter,exon,gene body | 4.76e-01 | 3.60e-01 | 2.96e+00 | 3.05e-03 | 8.06e-03 | 1.16e-01 |
| SARC | cg04758387 | chr1:1919945 | CGI:chr1:1918659-1919952 | promoter | 5.27e-01 | 4.25e-01 | 3.97e+00 | 7.17e-05 | 3.81e-04 | 1.02e-01 |
| ACC | cg04758387 | chr1:1919945 | CGI:chr1:1918659-1919952 | promoter | 6.07e-01 | 7.16e-01 | -3.11e+00 | 1.86e-03 | 8.62e-03 | -1.09e-01 |
| ACC | cg05355142 | chr1:1919933 | CGI:chr1:1918659-1919952 | promoter | 4.39e-01 | 5.82e-01 | -3.04e+00 | 2.35e-03 | 1.03e-02 | -1.43e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg10219957 | chr1:1919977 | CGI:chr1:1918659-1919952 | promoter | 5.34e-01 | 6.34e-01 | -4.54e+00 | 5.63e-06 | 2.37e-05 | -1.00e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BLCA | cg04758387 | chr1:1919945 | CGI:chr1:1918659-1919952 | promoter | 3.78e-01 | 4.78e-01 | -2.29e+00 | 2.21e-02 | 2.89e-02 | -1.00e-01 |
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Exon skipping events with PSI in TCGA for TMEM52 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TMEM52 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TMEM52 |
| TFs related to TMEM52. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TMEM52 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TMEM52 |
| RBPs related to ES in TMEM52. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TMEM52 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12729542 | chr1:3815395:C:T | - | 0.0960959622254757 | 0.0446814214930261 | LUSC | Female-baised eQTL |
| rs111353857 | chr1:6739298:G:C | - | 0.213457023230504 | 0.000441307463382053 | BLCA | Female-baised eQTL |
| rs113435004 | chr1:6741115:A:C | - | 0.213346728190792 | 0.000452558493977566 | BLCA | Female-baised eQTL |
| rs113112684 | chr1:6741289:G:T | - | 0.213346728190792 | 0.000452558493977566 | BLCA | Female-baised eQTL |
| rs77550681 | chr1:6741367:C:T | - | 0.213346728190792 | 0.000452558493977566 | BLCA | Female-baised eQTL |
| rs199701566 | chr1:6742122:A:T | - | 0.213346728190792 | 0.000452558493977566 | BLCA | Female-baised eQTL |
| rs111982758 | chr1:6743397:T:C | - | 0.213346728190792 | 0.000452558493977566 | BLCA | Female-baised eQTL |
| rs17029815 | chr1:6738919:G:A | - | 0.182581150454198 | 0.0027029636403907 | BLCA | Female-baised eQTL |
| rs666103 | chr1:10451532:T:C | - | -0.160179984962339 | 0.0158496192396887 | BLCA | Female-baised eQTL |
| rs1307497 | chr1:10451999:T:C | - | -0.160179984962339 | 0.0158496192396887 | BLCA | Female-baised eQTL |
| rs113538757 | chr1:6741222:G:A | - | 0.14161511539271 | 0.0207232585476234 | BLCA | Female-baised eQTL |
| rs35210752 | chr1:7643326:G:A | - | 0.131341224949491 | 0.0284839651425375 | BLCA | Female-baised eQTL |
| rs944973 | chr1:10456336:C:G | - | -0.148231844548034 | 0.0305685322581696 | BLCA | Female-baised eQTL |
| rs484416 | chr1:10431152:G:A | - | 0.146126788845512 | 0.0367608457346835 | BLCA | Female-baised eQTL |
| rs515423 | chr1:10425612:G:A | - | 0.146274398462495 | 0.0367639416499905 | BLCA | Female-baised eQTL |
| rs3753758 | chr1:3210974:G:A | - | 0.145096208301329 | 0.0396344590380487 | BLCA | Female-baised eQTL |
| rs2235690 | chr1:6358413:C:T | - | 0.0853293163495151 | 0.00156041217527631 | LUAD | Female-baised eQTL |
| rs61763927 | chr1:6362360:G:C | - | 0.0797874375044919 | 0.00627663755331795 | LUAD | Female-baised eQTL |
| rs2076477 | chr1:6358552:G:C | - | 0.079720457155097 | 0.00631707467529747 | LUAD | Female-baised eQTL |
| rs284268 | chr1:10596267:C:T | - | 0.0669610427913589 | 0.0110607255014019 | LUAD | Female-baised eQTL |
| rs12063432 | chr1:6403417:C:T | - | 0.0654329086314849 | 0.015453169367685 | LUAD | Female-baised eQTL |
| rs78228352 | chr1:6365626:G:A | - | 0.0692020694381231 | 0.0251370517416015 | LUAD | Female-baised eQTL |
| rs3827720 | chr1:6282166:A:G | - | 0.0429035259853135 | 0.0262931038068909 | LUAD | Female-baised eQTL |
| rs742504 | chr1:6348214:A:G | - | 0.0482273832056357 | 0.0426834173446513 | LUAD | Female-baised eQTL |
| rs2382831 | chr1:5557679:A:C | - | 0.0476171689909144 | 0.0483281130297404 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4282823 | chr1:11156608:C:T | - | 0.0962812828523232 | 0.0263833324949196 | LUAD | Male-baised eQTL |
| rs735000 | chr1:2581666:C:T | - | 0.0596361322806187 | 0.0311455154484132 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000178821 |
| CpG Site: cg22536775 | |
| Position to Gene: promoter | |
| Male Effect: -0.3268049589503 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg22536775 | chr1:1920000 | promoter | -0.3268049589503 | 2.10426386997273e-05 | -0.34594793827525977 | 1.1474044441178806e-07 | LUAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TMEM52 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
