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Gene: ENSG00000177169 |
Summary for ULK1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000177169 | Gene symbol | ULK1 |
| Gene name | unc-51 like autophagy activating kinase 1 | |
| HGNC | 12558 | |
| Entrez ID | 8408 | |
| Gene type | protein_coding | |
| Synonyms | ULK1|ATG1|ATG1A | |
| UniProtAcc | O75385 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000177169 | ULK1 | DB12010 | Fostamatinib | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ULK1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ULK1 | 4.58e+03 | 1.03e+00 | 1.84e-01 | 5.57e+00 | 2.59e-08 | 1.33e-07 | LUSC |
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Sex-biased somatic mutation for ULK1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ULK1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg02057134 | chr12:131893521 | CGI:chr12:131894397-131895507 | promoter | 8.44e-01 | 7.35e-01 | 4.99e+00 | 6.09e-07 | 2.36e-06 | 1.10e-01 |
| LUSC | cg02057134 | chr12:131893521 | CGI:chr12:131894397-131895507 | promoter | 6.08e-01 | 8.11e-01 | -3.65e+00 | 2.67e-04 | 1.14e-03 | -2.03e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for ULK1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for ULK1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for ULK1 |
| TFs related to ULK1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ULK1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ULK1 |
| RBPs related to ES in ULK1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | ZNF638 | exon_skip_88706 | 1.21e+01 | 9.92e-01 | 1.16e+01 | 7.78e-03 | Male-biased |
| UVM | ZNF638 | exon_skip_88706 | 1.19e+01 | 2.49e-03 | 1.23e+01 | 9.97e-01 | Female-biased |
| THYM | PPRC1 | exon_skip_88673 | 1.35e+01 | 4.53e-04 | 1.42e+01 | 9.99e-01 | Female-biased |
| THYM | ZNF638 | exon_skip_88706 | 1.20e+01 | 2.24e-03 | 1.25e+01 | 9.97e-01 | Female-biased |
| COAD | PPRC1 | exon_skip_88673 | 1.42e+01 | 5.15e-04 | 1.48e+01 | 9.99e-01 | Female-biased |
| COAD | ZNF638 | exon_skip_88706 | 1.20e+01 | 9.95e-01 | 1.16e+01 | 4.78e-03 | Male-biased |
| KIRP | PPRC1 | exon_skip_88673 | 1.43e+01 | 9.99e-01 | 1.37e+01 | 8.81e-04 | Male-biased |
| KIRP | SAMD4A | exon_skip_88678 | 8.47e+00 | 5.67e-03 | 8.85e+00 | 9.89e-01 | Female-biased |
| KIRP | ZNF638 | exon_skip_88706 | 1.18e+01 | 1.79e-03 | 1.22e+01 | 9.98e-01 | Female-biased |
| BRCA | ZNF638 | exon_skip_88706 | 1.20e+01 | 9.95e-01 | 1.13e+01 | 4.59e-03 | Male-biased |
| ESCA | PCBP2 | exon_skip_88686 | 8.44e+00 | 9.83e-01 | 8.00e+00 | 1.06e-02 | Male-biased |
| ESCA | ZNF638 | exon_skip_88706 | 1.12e+01 | 4.58e-03 | 1.17e+01 | 9.95e-01 | Female-biased |
| READ | PPRC1 | exon_skip_88673 | 1.49e+01 | 1.00e+00 | 1.42e+01 | 4.29e-04 | Male-biased |
| READ | ZNF638 | exon_skip_88706 | 1.20e+01 | 9.92e-01 | 1.17e+01 | 7.74e-03 | Male-biased |
| THCA | SAMD4A | exon_skip_88678 | 8.30e+00 | 3.51e-03 | 8.68e+00 | 9.91e-01 | Female-biased |
| THCA | ZC3H10 | exon_skip_88706 | 6.85e+00 | 9.83e-01 | 6.45e+00 | 2.32e-03 | Male-biased |
| PCPG | PCBP2 | exon_skip_88686 | 7.98e+00 | 4.84e-03 | 8.36e+00 | 9.88e-01 | Female-biased |
| PCPG | ZNF638 | exon_skip_88706 | 1.14e+01 | 3.99e-04 | 1.20e+01 | 9.99e-01 | Female-biased |
| LGG | PPRC1 | exon_skip_88673 | 1.41e+01 | 5.45e-04 | 1.47e+01 | 9.99e-01 | Female-biased |
| LGG | SAMD4A | exon_skip_88678 | 8.72e+00 | 9.92e-01 | 8.28e+00 | 3.03e-03 | Male-biased |
| PAAD | ENOX1 | exon_skip_88679 | 7.40e+00 | 9.81e-01 | 7.08e+00 | 7.66e-03 | Male-biased |
| PAAD | ZNF638 | exon_skip_88706 | 1.14e+01 | 8.63e-04 | 1.19e+01 | 9.99e-01 | Female-biased |
| KIRC | SAMD4A | exon_skip_88678 | 8.55e+00 | 9.91e-01 | 8.12e+00 | 2.45e-03 | Male-biased |
| KIRC | ZC3H10 | exon_skip_88706 | 6.37e+00 | 3.52e-03 | 6.78e+00 | 9.81e-01 | Female-biased |
| KICH | ESRP2 | exon_skip_88682 | 8.69e+00 | 9.86e-01 | 8.35e+00 | 8.59e-03 | Male-biased |
| KICH | ZNF638 | exon_skip_88706 | 1.13e+01 | 1.19e-03 | 1.19e+01 | 9.98e-01 | Female-biased |
| HNSC | PCBP2 | exon_skip_88686 | 8.48e+00 | 9.83e-01 | 8.15e+00 | 1.08e-02 | Male-biased |
| SARC | PCBP2 | exon_skip_88686 | 8.25e+00 | 1.33e-02 | 8.58e+00 | 9.80e-01 | Female-biased |
| SARC | PPRC1 | exon_skip_88673 | 1.44e+01 | 9.94e-01 | 1.40e+01 | 5.47e-03 | Male-biased |
| SARC | SAMD4A | exon_skip_88678 | 8.45e+00 | 1.14e-02 | 8.80e+00 | 9.83e-01 | Female-biased |
| ULK1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7306643 | chr12:124127614:C:T | - | 0.169494063897736 | 0.0316935548345987 | KIRP | Female-baised eQTL |
| rs7961797 | chr12:128791348:G:A | - | 0.118851024043349 | 0.0352963895857531 | STAD | Female-baised eQTL |
| rs61940606 | chr12:127825796:A:G | - | 0.0973215748456907 | 0.0141582288496131 | LGG | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7965322 | chr12:130708295:T:C | - | 0.0563101226795754 | 0.00214147772582263 | KIRC | Male-baised eQTL |
| rs11147024 | chr12:132728018:C:T | - | 0.0653530332198944 | 0.0232738289793965 | KIRC | Male-baised eQTL |
| rs7973007 | chr12:132622323:T:C | - | 0.0432802583451958 | 0.0325855549612992 | KIRC | Male-baised eQTL |
| rs4883626 | chr12:132631381:G:C | - | 0.0411373592040173 | 0.0363528099323878 | KIRC | Male-baised eQTL |
| rs6560891 | chr12:132620432:G:A | - | 0.0437355314624781 | 0.0374124625193622 | KIRC | Male-baised eQTL |
| rs7964872 | chr12:132620187:T:G | - | 0.043562768671144 | 0.0391257629950956 | KIRC | Male-baised eQTL |
| rs2695884 | chr12:130702376:T:C | - | 0.0456754088440356 | 0.046624187646026 | KIRC | Male-baised eQTL |
| rs4883611 | chr12:132653619:C:T | - | 0.0404343910595216 | 0.0492811221956942 | KIRC | Male-baised eQTL |
| rs5744873 | chr12:132658746:T:G | - | 0.0404146789588268 | 0.0494461465812568 | KIRC | Male-baised eQTL |
| rs5744839 | chr12:132663258:G:A | - | 0.0404080686961177 | 0.0494481316181889 | KIRC | Male-baised eQTL |
| rs4883576 | chr12:132667231:C:T | - | 0.0404080686961177 | 0.0494481316181889 | KIRC | Male-baised eQTL |
| rs12372807 | chr12:129076787:G:A | - | 0.0677217617961464 | 0.0325764117720022 | BLCA | Male-baised eQTL |
| rs1403399 | chr12:125893892:C:G | - | 0.0529581497249181 | 0.0283249066777229 | COAD | Male-baised eQTL |
| rs12304083 | chr12:127701109:C:T | - | -0.0635388918409305 | 0.0320443475540855 | COAD | Male-baised eQTL |
| rs4540877 | chr12:125760247:C:G | - | 0.0478128641363161 | 0.0447171240587685 | COAD | Male-baised eQTL |
| rs7952970 | chr12:124640717:A:G | - | -0.0535518592895878 | 0.0447674053721974 | COAD | Male-baised eQTL |
| rs7966665 | chr12:124640718:C:T | - | -0.0535518592895878 | 0.0447674053721974 | COAD | Male-baised eQTL |
| rs11057975 | chr12:125002557:C:T | - | 0.102334564948066 | 0.0462531883236691 | COAD | Male-baised eQTL |
| rs11057977 | chr12:125003271:G:A | - | 0.102334564948066 | 0.0462531883236691 | COAD | Male-baised eQTL |
| rs11057969 | chr12:125002110:C:T | - | 0.101982979261308 | 0.0477135730107681 | COAD | Male-baised eQTL |
| rs12314947 | chr12:125000353:A:G | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs11057963 | chr12:125000399:T:C | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs71458884 | chr12:125000555:G:A | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs11057965 | chr12:125000600:C:A | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs11057966 | chr12:125000601:C:T | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs11057967 | chr12:125000982:A:G | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs11057968 | chr12:125001077:C:T | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12425990 | chr12:125001272:A:G | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12426263 | chr12:125001298:T:C | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12422229 | chr12:125001352:G:A | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12422239 | chr12:125001434:G:A | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12424916 | chr12:125001496:C:A | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12426559 | chr12:125001666:T:G | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12426570 | chr12:125001713:T:G | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs12424949 | chr12:125001714:C:T | - | 0.10195280553271 | 0.0477182512877614 | COAD | Male-baised eQTL |
| rs370828678 | chr12:125002330:T:A | - | 0.10184526047007 | 0.04801889191872 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000177169 |
| CpG Site: cg08013109 | |
| Position to Gene: gene | |
| Male Effect: -0.381861829841451 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg08013109 | chr12:131902800 | gene | -0.381861829841451 | 8.2424460093075e-06 | -0.36996000089621234 | 6.466572311327142e-08 | KIRP |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ULK1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
