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Gene: ENSG00000176371 |
Summary for ZSCAN2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000176371 | Gene symbol | ZSCAN2 |
| Gene name | zinc finger and SCAN domain containing 2 | |
| HGNC | 20994 | |
| Entrez ID | 54993 | |
| Gene type | protein_coding | |
| Synonyms | ZSCAN2|FLJ20595|ZNF854 | |
| UniProtAcc | Q7Z7L9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for ZSCAN2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ZSCAN2 | 3.60e+02 | 1.15e+00 | 1.27e-01 | 9.06e+00 | 1.36e-19 | 2.37e-18 | LUAD |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ZSCAN2 | 3.75e+02 | 1.10e+00 | 1.52e-01 | 7.23e+00 | 4.81e-13 | 8.42e-12 | LIHC |
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Sex-biased somatic mutation for ZSCAN2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for ZSCAN2 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg20353653 | chr15:84599988 | CGI:chr15:84600847-84601367 | promoter | 4.70e-01 | 6.39e-01 | -3.41e+00 | 6.38e-04 | 1.94e-03 | -1.69e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for ZSCAN2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for ZSCAN2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | ZSCAN2-008 | chr15_84623299_+ | 1.75e-01 | 1.32e-01 | 1.98e+00 | 4.83e-02 | 4.88e-02 | 4.34e-02 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
| chrX_54929134_+ | nonsynonymous SNV | ZSCAN2 | ENST00000541040.4 | c.A601G | p.S201G |
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Sex-biased TF-Gene network for ZSCAN2 |
| TFs related to ZSCAN2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | ZNF121 | ZSCAN2 | 4.13e+00 | 9.82e-01 | 3.39e+00 | 8.52e-03 | Male-biased |
| ESCA | ZNF235 | ZSCAN2 | 3.83e+00 | 9.81e-01 | 2.83e+00 | 1.97e-03 | Male-biased |
| ESCA | ZNF33A | ZSCAN2 | 4.17e+00 | 9.83e-01 | 3.41e+00 | 7.92e-03 | Male-biased |
| ESCA | ZNF443 | ZSCAN2 | 4.19e+00 | 9.83e-01 | 3.43e+00 | 7.77e-03 | Male-biased |
| LAML | ZNF418 | ZSCAN2 | 4.01e+00 | 9.81e-01 | 2.35e+00 | 5.01e-04 | Male-biased |
| PCPG | ZNF22 | ZSCAN2 | 2.84e+00 | 2.03e-03 | 3.99e+00 | 9.84e-01 | Female-biased |
| PCPG | ZNF235 | ZSCAN2 | 2.92e+00 | 1.46e-03 | 4.14e+00 | 9.88e-01 | Female-biased |
| PCPG | ZNF287 | ZSCAN2 | 2.92e+00 | 2.48e-03 | 4.03e+00 | 9.84e-01 | Female-biased |
| PCPG | ZNF487 | ZSCAN2 | 2.82e+00 | 2.24e-03 | 3.94e+00 | 9.83e-01 | Female-biased |
| READ | ZNF418 | ZSCAN2 | 4.89e+00 | 9.83e-01 | 4.13e+00 | 1.24e-02 | Male-biased |
| SARC | ZNF443 | ZSCAN2 | 4.50e+00 | 9.85e-01 | 3.89e+00 | 7.46e-03 | Male-biased |
| ZSCAN2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for ZSCAN2 |
| RBPs related to ES in ZSCAN2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ZSCAN2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17699249 | chr15:82117519:G:A | - | 0.292852266697275 | 0.0108518041817118 | GBM | Female-baised eQTL |
| rs71407346 | chr15:90911607:C:T | - | 0.235528416961221 | 0.0325146526054711 | LUSC | Female-baised eQTL |
| rs71407347 | chr15:90912730:G:T | - | 0.235034308477271 | 0.0332150464123071 | LUSC | Female-baised eQTL |
| rs76400732 | chr15:90964798:A:G | - | 0.246456016522 | 0.0407461420161891 | LUSC | Female-baised eQTL |
| rs62012291 | chr15:86385397:G:A | - | 0.103819107521524 | 0.0383357603606247 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11073977 | chr15:91071488:C:A | - | 0.111610714033258 | 0.0371848876492228 | SARC | Male-baised eQTL |
| rs73462609 | chr15:87663663:T:C | - | -0.117611499879105 | 0.0224228790559056 | LIHC | Male-baised eQTL |
| rs4777824 | chr15:92247375:T:G | - | -0.0827418858307968 | 0.0226256800225708 | LIHC | Male-baised eQTL |
| rs10520656 | chr15:87566028:T:C | - | -0.129511415132309 | 0.0337767053819605 | LIHC | Male-baised eQTL |
| rs7170624 | chr15:87657811:G:T | - | -0.114654526887448 | 0.0348538212385854 | LIHC | Male-baised eQTL |
| rs4254290 | chr15:87657595:T:A | - | -0.114344021940378 | 0.0355822571794023 | LIHC | Male-baised eQTL |
| rs4284602 | chr15:87658222:C:G | - | -0.114344021940378 | 0.0355822571794023 | LIHC | Male-baised eQTL |
| rs112537816 | chr15:87663180:G:A | - | -0.113791586899834 | 0.0356380610220699 | LIHC | Male-baised eQTL |
| rs16945239 | chr15:91121644:T:A | - | 0.0922591450330127 | 0.0124309361939084 | BLCA | Male-baised eQTL |
| rs746102 | chr15:88369258:G:A | - | 0.169031250870597 | 0.00798626612282298 | COAD | Male-baised eQTL |
| rs10163187 | chr15:85327287:C:T | - | 0.0756290985962989 | 0.0210388716028323 | COAD | Male-baised eQTL |
| rs7402111 | chr15:91664536:A:C | - | 0.0643388550903973 | 0.0255825229547639 | COAD | Male-baised eQTL |
| rs875641 | chr15:89354452:G:A | - | 0.081959880203887 | 0.0330663277108186 | COAD | Male-baised eQTL |
| rs7180128 | chr15:81105582:G:A | - | 0.0856053253161268 | 0.0389878664097037 | COAD | Male-baised eQTL |
| rs8027071 | chr15:93421823:C:T | - | 0.124197178675117 | 0.0398708244231478 | COAD | Male-baised eQTL |
| rs734447 | chr15:79035671:G:A | - | 0.0681810666340785 | 0.0485216532732098 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000176371 |
| CpG Site: cg20353653 | |
| Position to Gene: promoter | |
| Male Effect: - | |
| Female Effect: -0.132213815675731 | |
 | Gene ID: ENSG00000176371 |
| CpG Site: cg20353653 | |
| Position to Gene: promoter | |
| Male Effect: -0.213722906563317 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20353653 | chr15:84599988 | promoter | -0.213722906563317 | 7.759732854333e-05 | -0.32825023368063283 | 6.369284468465608e-07 | STAD |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg20353653 | chr15:84599988 | promoter | -0.132213815675731 | 1.81537672212419e-06 | -0.3618092658362526 | 2.6470500143739645e-09 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of ZSCAN2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
