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Gene: ENSG00000175820 |
Summary for CCDC168 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000175820 | Gene symbol | CCDC168 |
| Gene name | coiled-coil domain containing 168 | |
| HGNC | 26851 | |
| Entrez ID | 643677 | |
| Gene type | protein_coding | |
| Synonyms | CCDC168|FLJ40176 | |
| UniProtAcc | Q8NDH2 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for CCDC168 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for CCDC168 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CCDC168 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for CCDC168 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CCDC168 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CCDC168 |
| TFs related to CCDC168. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | BCL6B | CCDC168 | 7.57e+00 | 1.50e-02 | 8.31e+00 | 9.85e-01 | Female-biased |
| ACC | MEF2A | CCDC168 | 6.59e+00 | 4.97e-03 | 7.61e+00 | 9.95e-01 | Female-biased |
| ACC | NANOG | CCDC168 | 6.50e+00 | 2.42e-03 | 7.70e+00 | 9.97e-01 | Female-biased |
| ACC | ZNF418 | CCDC168 | 6.09e+00 | 6.05e-04 | 7.61e+00 | 9.99e-01 | Female-biased |
| ACC | ZNF519 | CCDC168 | 7.07e+00 | 9.99e-01 | 5.65e+00 | 7.88e-04 | Male-biased |
| ACC | ZNF662 | CCDC168 | 6.90e+00 | 9.85e-01 | 6.19e+00 | 1.46e-02 | Male-biased |
| CHOL | ZNF235 | CCDC168 | 6.49e+00 | 9.91e-01 | 5.47e+00 | 8.72e-03 | Male-biased |
| CHOL | ZNF287 | CCDC168 | 6.31e+00 | 9.83e-01 | 5.46e+00 | 1.64e-02 | Male-biased |
| CHOL | ZNF418 | CCDC168 | 7.66e+00 | 1.00e+00 | 5.69e+00 | 1.35e-04 | Male-biased |
| CHOL | ZNF662 | CCDC168 | 5.88e+00 | 7.47e-03 | 6.90e+00 | 9.92e-01 | Female-biased |
| LAML | ZNF235 | CCDC168 | 7.21e+00 | 1.68e-02 | 7.98e+00 | 9.83e-01 | Female-biased |
| MESO | ZNF418 | CCDC168 | 7.19e+00 | 9.97e-01 | 5.56e+00 | 2.56e-03 | Male-biased |
| PAAD | ZNF235 | CCDC168 | 7.25e+00 | 1.82e-02 | 7.94e+00 | 9.82e-01 | Female-biased |
| PAAD | ZNF418 | CCDC168 | 6.88e+00 | 2.76e-03 | 7.95e+00 | 9.97e-01 | Female-biased |
| PCPG | NANOG | CCDC168 | 7.52e+00 | 9.81e-01 | 6.85e+00 | 1.86e-02 | Male-biased |
| PCPG | ZNF418 | CCDC168 | 7.92e+00 | 9.90e-01 | 7.12e+00 | 1.03e-02 | Male-biased |
| READ | ZNF418 | CCDC168 | 9.16e+00 | 9.85e-01 | 8.44e+00 | 1.55e-02 | Male-biased |
| SARC | ZNF235 | CCDC168 | 8.08e+00 | 9.83e-01 | 7.60e+00 | 1.65e-02 | Male-biased |
| SARC | ZNF287 | CCDC168 | 7.79e+00 | 9.82e-01 | 7.31e+00 | 1.76e-02 | Male-biased |
| SARC | ZNF418 | CCDC168 | 8.03e+00 | 9.94e-01 | 7.38e+00 | 6.02e-03 | Male-biased |
| THYM | MEF2A | CCDC168 | 7.42e+00 | 1.71e-02 | 7.99e+00 | 9.83e-01 | Female-biased |
| THYM | NANOG | CCDC168 | 7.43e+00 | 1.92e-02 | 7.97e+00 | 9.81e-01 | Female-biased |
| THYM | ZNF418 | CCDC168 | 7.65e+00 | 4.34e-03 | 8.55e+00 | 9.96e-01 | Female-biased |
| CCDC168 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CCDC168 |
| RBPs related to ES in CCDC168. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CCDC168 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CCDC168 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
