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Gene: ENSG00000175356 |
Summary for SCUBE2 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000175356 | Gene symbol | SCUBE2 |
| Gene name | signal peptide, CUB domain and EGF like domain containing 2 | |
| HGNC | 30425 | |
| Entrez ID | 57758 | |
| Gene type | protein_coding | |
| Synonyms | SCUBE2|Cegf1|Cegb1|FLJ16792 | |
| UniProtAcc | Q9NQ36 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for SCUBE2 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| SCUBE2 | 2.11e+04 | 1.08e+00 | 2.05e-01 | 5.25e+00 | 1.56e-07 | 2.87e-07 | BRCA |
Top |
Sex-biased somatic mutation for SCUBE2 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for SCUBE2 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg19450302 | chr11:9139322 | CGI:chr11:9090914-9091815 | promoter | 5.04e-01 | 6.29e-01 | -2.44e+00 | 1.49e-02 | 1.89e-02 | -1.25e-01 |
| CHOL | cg12223997 | chr11:9138049 | CGI:chr11:9090914-9091815 | promoter,exon,gene body | 2.84e-01 | 6.04e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -3.20e-01 |
| CHOL | cg19450302 | chr11:9139322 | CGI:chr11:9090914-9091815 | promoter | 3.68e-01 | 8.06e-01 | -3.54e+00 | 4.02e-04 | 8.32e-03 | -4.38e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg19450302 | chr11:9139322 | CGI:chr11:9090914-9091815 | promoter | 4.98e-01 | 3.55e-01 | 2.30e+00 | 2.17e-02 | 2.89e-02 | 1.43e-01 |
Top |
Exon skipping events with PSI in TCGA for SCUBE2 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for SCUBE2 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for SCUBE2 |
| TFs related to SCUBE2. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| SCUBE2 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for SCUBE2 |
| RBPs related to ES in SCUBE2. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LGG | SRSF7 | exon_skip_68888 | 8.68e+00 | 9.86e-01 | 8.33e+00 | 8.85e-03 | Male-biased |
| PAAD | SRSF7 | exon_skip_68888 | 8.41e+00 | 4.43e-03 | 8.78e+00 | 9.90e-01 | Female-biased |
| SCUBE2 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7128160 | chr11:7139225:T:C | - | 0.283111270568045 | 0.000107151206821822 | GBM | Female-baised eQTL |
| rs7125371 | chr11:7139556:A:C | - | 0.283111270568045 | 0.000107151206821822 | GBM | Female-baised eQTL |
| rs1214812 | chr11:13747188:G:A | - | 0.276689715090899 | 0.000239674863236427 | GBM | Female-baised eQTL |
| rs11043018 | chr11:10916116:G:A | - | 0.47426324677245 | 0.0023106083080745 | GBM | Female-baised eQTL |
| rs74385338 | chr11:10918221:C:T | - | 0.47426324677245 | 0.0023106083080745 | GBM | Female-baised eQTL |
| rs11602344 | chr11:10918355:C:T | - | 0.47426324677245 | 0.0023106083080745 | GBM | Female-baised eQTL |
| rs79101573 | chr11:10922038:A:G | - | 0.47426324677245 | 0.0023106083080745 | GBM | Female-baised eQTL |
| rs12146617 | chr11:10925754:A:C | - | 0.47426324677245 | 0.0023106083080745 | GBM | Female-baised eQTL |
| rs476212 | chr11:10918258:G:A | - | 0.207264593999517 | 0.0143909914561465 | GBM | Female-baised eQTL |
| rs325673 | chr11:6144940:T:C | - | -0.197432012585091 | 0.0157872618440277 | GBM | Female-baised eQTL |
| rs2219723 | chr11:6107653:G:C | - | 0.183425406837731 | 0.0280361454944438 | GBM | Female-baised eQTL |
| rs7950024 | chr11:6118639:A:C | - | 0.171743251887692 | 0.0435361471593418 | GBM | Female-baised eQTL |
| rs7950500 | chr11:6119013:A:C | - | 0.171743251887692 | 0.0435361471593418 | GBM | Female-baised eQTL |
| rs4758387 | chr11:6107922:T:C | - | 0.170646796248569 | 0.0480756997653488 | GBM | Female-baised eQTL |
| rs16910305 | chr11:6219287:T:C | - | 0.14126355505071 | 3.22597715268354e-05 | LUSC | Female-baised eQTL |
| rs1115237 | chr11:11006812:G:A | - | 0.148783488057934 | 0.000253722855067546 | LUSC | Female-baised eQTL |
| rs451711 | chr11:5473193:A:G | - | -0.113150909241305 | 0.000885396448154285 | LUSC | Female-baised eQTL |
| rs10832853 | chr11:17721134:G:C | - | -0.159539113800839 | 0.00123468986756984 | LUSC | Female-baised eQTL |
| rs7105383 | chr11:10404106:A:T | - | -0.120558842050333 | 0.00136769372757321 | LUSC | Female-baised eQTL |
| rs10743140 | chr11:10403870:A:G | - | -0.117400070861969 | 0.0016683140460322 | LUSC | Female-baised eQTL |
| rs584428 | chr11:10955697:A:G | - | 0.130052670569077 | 0.00170172837412214 | LUSC | Female-baised eQTL |
| rs533972 | chr11:10956682:T:C | - | 0.130052670569077 | 0.00170172837412214 | LUSC | Female-baised eQTL |
| rs10770150 | chr11:10961040:G:C | - | -0.130052670569077 | 0.00170172837412214 | LUSC | Female-baised eQTL |
| rs118171251 | chr11:10965958:C:T | - | 0.130052670569077 | 0.00170172837412214 | LUSC | Female-baised eQTL |
| rs74584920 | chr11:10977458:C:A | - | 0.130052670569077 | 0.00170172837412214 | LUSC | Female-baised eQTL |
| rs11604384 | chr11:8249559:G:A | - | 0.154084305742587 | 0.00281504615077979 | LUSC | Female-baised eQTL |
| rs11041825 | chr11:8249630:A:G | - | 0.154084305742587 | 0.00281504615077979 | LUSC | Female-baised eQTL |
| rs6578947 | chr11:8251438:T:A | - | 0.154084305742587 | 0.00281504615077979 | LUSC | Female-baised eQTL |
| rs7119964 | chr11:10403963:C:T | - | -0.106861181595056 | 0.00335881417324634 | LUSC | Female-baised eQTL |
| rs11041908 | chr11:8404698:C:A | - | 0.146887218691165 | 0.00365854054015781 | LUSC | Female-baised eQTL |
| rs76359476 | chr11:8405024:G:A | - | 0.146887218691165 | 0.00365854054015781 | LUSC | Female-baised eQTL |
| rs4910021 | chr11:11579480:T:C | - | 0.152049611338185 | 0.00377812447808749 | LUSC | Female-baised eQTL |
| rs61870389 | chr11:11586064:T:C | - | 0.151972259189369 | 0.00379834035681496 | LUSC | Female-baised eQTL |
| rs10160505 | chr11:10404778:A:G | - | -0.112900790536035 | 0.00401252080979691 | LUSC | Female-baised eQTL |
| rs10160506 | chr11:10404779:A:G | - | -0.112900790536035 | 0.00401252080979691 | LUSC | Female-baised eQTL |
| rs12802274 | chr11:4838174:C:T | - | 0.103179822838915 | 0.00436838520555257 | LUSC | Female-baised eQTL |
| rs10840401 | chr11:10403089:G:A | - | -0.104831737737277 | 0.00500369437342202 | LUSC | Female-baised eQTL |
| rs4910203 | chr11:10943824:A:C | - | 0.120803407441827 | 0.00511167351865215 | LUSC | Female-baised eQTL |
| rs10840403 | chr11:10403392:T:C | - | -0.104473606812553 | 0.00540337206414753 | LUSC | Female-baised eQTL |
| rs2061038 | chr11:8245336:G:A | - | 0.142182890176214 | 0.0069993486108569 | LUSC | Female-baised eQTL |
| rs7104037 | chr11:10970750:A:G | - | -0.115694839924825 | 0.00790447424087966 | LUSC | Female-baised eQTL |
| rs78352842 | chr11:10987126:G:A | - | 0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs79879343 | chr11:10987611:C:T | - | 0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs79859479 | chr11:10989986:G:T | - | 0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs1872696 | chr11:10989157:A:C | - | -0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs2403379 | chr11:10992480:A:C | - | -0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs10770156 | chr11:10997883:C:T | - | -0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs11043046 | chr11:11001704:A:G | - | -0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs7109681 | chr11:11003886:G:T | - | -0.113618323141521 | 0.0106501267163627 | LUSC | Female-baised eQTL |
| rs12790312 | chr11:11630906:G:A | - | 0.115114825984491 | 0.0115628118709778 | LUSC | Female-baised eQTL |
| rs16931158 | chr11:5448263:T:C | - | 0.100475155271766 | 0.0119163037819898 | LUSC | Female-baised eQTL |
| rs10500642 | chr11:5448382:T:G | - | 0.100475155271766 | 0.0119163037819898 | LUSC | Female-baised eQTL |
| rs16931173 | chr11:5448729:A:C | - | 0.100475155271766 | 0.0119163037819898 | LUSC | Female-baised eQTL |
| rs7942830 | chr11:8399187:C:T | - | 0.133377648966109 | 0.0123936846240729 | LUSC | Female-baised eQTL |
| rs1482804 | chr11:7796924:C:T | - | 0.113916063712869 | 0.0139651199991909 | LUSC | Female-baised eQTL |
| rs7105696 | chr11:7803363:A:C | - | 0.113916063712869 | 0.0139651199991909 | LUSC | Female-baised eQTL |
| rs74806623 | chr11:11318035:A:T | - | 0.12462463556679 | 0.0147615307659705 | LUSC | Female-baised eQTL |
| rs1531753 | chr11:13238984:A:G | - | -0.124313808376404 | 0.0147660245697691 | LUSC | Female-baised eQTL |
| rs2445314 | chr11:5073873:A:G | - | 0.109001781336509 | 0.0155289680259912 | LUSC | Female-baised eQTL |
| rs12801368 | chr11:4837166:T:C | - | 0.0958890417224725 | 0.0158962672565949 | LUSC | Female-baised eQTL |
| rs452348 | chr11:8246798:C:G | - | -0.130730015340427 | 0.0171476971794556 | LUSC | Female-baised eQTL |
| rs404133 | chr11:8247504:A:G | - | -0.130718958517566 | 0.0171762810641788 | LUSC | Female-baised eQTL |
| rs455082 | chr11:8248831:C:G | - | -0.130718958517566 | 0.0171762810641788 | LUSC | Female-baised eQTL |
| rs76536821 | chr11:11015476:A:G | - | 0.108189613375999 | 0.0173078740244349 | LUSC | Female-baised eQTL |
| rs4910216 | chr11:11016087:C:A | - | 0.108189613375999 | 0.0173078740244349 | LUSC | Female-baised eQTL |
| rs74830646 | chr11:5447913:A:G | - | 0.0967290820741089 | 0.0174267389064162 | LUSC | Female-baised eQTL |
| rs76622742 | chr11:7793050:T:A | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs74539003 | chr11:7795801:T:C | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs77840152 | chr11:7795832:A:G | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs78371319 | chr11:7800100:G:A | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs11825769 | chr11:7803941:C:G | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs11828114 | chr11:7803961:A:C | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs78875419 | chr11:7804294:T:C | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs114807326 | chr11:7804546:C:G | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs77630321 | chr11:7807055:T:A | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs79119449 | chr11:7807058:A:C | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs77379199 | chr11:7807653:G:A | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs11827758 | chr11:7807892:T:A | - | 0.109899486054125 | 0.0179264906432111 | LUSC | Female-baised eQTL |
| rs113552009 | chr11:11013146:A:G | - | 0.10800471476842 | 0.0180075402795235 | LUSC | Female-baised eQTL |
| rs10840044 | chr11:8425393:G:C | - | 0.12287050814284 | 0.0180091780607648 | LUSC | Female-baised eQTL |
| rs58411917 | chr11:5448871:G:A | - | 0.102845255761443 | 0.0186987611438961 | LUSC | Female-baised eQTL |
| rs76315768 | chr11:11294703:G:C | - | 0.101850307654994 | 0.0194329784114659 | LUSC | Female-baised eQTL |
| rs901395 | chr11:10986497:T:C | - | -0.107278790949784 | 0.0196031314833785 | LUSC | Female-baised eQTL |
| rs627444 | chr11:10946476:C:G | - | 0.107357107445118 | 0.0196600533971361 | LUSC | Female-baised eQTL |
| rs72860896 | chr11:5006772:C:G | - | 0.10530732871211 | 0.0200715109369726 | LUSC | Female-baised eQTL |
| rs10743156 | chr11:10981679:G:C | - | -0.103820134785136 | 0.0201110177645794 | LUSC | Female-baised eQTL |
| rs76972556 | chr11:5448099:C:G | - | 0.0956192983292815 | 0.0210980787746497 | LUSC | Female-baised eQTL |
| rs10743139 | chr11:10403780:G:A | - | -0.0913463970945015 | 0.0212356873117665 | LUSC | Female-baised eQTL |
| rs55743755 | chr11:4583282:C:A | - | 0.100582746114649 | 0.0239365298643455 | LUSC | Female-baised eQTL |
| rs72860150 | chr11:5028796:C:T | - | 0.09596929089056 | 0.0245227733517013 | LUSC | Female-baised eQTL |
| rs72860169 | chr11:5039628:G:C | - | 0.09596929089056 | 0.0245227733517013 | LUSC | Female-baised eQTL |
| rs10743138 | chr11:10401382:C:A | - | -0.0870028419521228 | 0.025150001687859 | LUSC | Female-baised eQTL |
| rs10160667 | chr11:10405031:G:A | - | -0.0879802124889239 | 0.0253317504641581 | LUSC | Female-baised eQTL |
| rs6483573 | chr11:19037567:C:T | - | 0.115155981055728 | 0.0259125347270624 | LUSC | Female-baised eQTL |
| rs1433899 | chr11:4845260:G:A | - | 0.0840550965502788 | 0.026387820000778 | LUSC | Female-baised eQTL |
| rs35156506 | chr11:4846751:A:T | - | 0.0840550965502788 | 0.026387820000778 | LUSC | Female-baised eQTL |
| rs16909511 | chr11:5063576:G:A | - | 0.0996617380240545 | 0.0266558222711296 | LUSC | Female-baised eQTL |
| rs7942275 | chr11:1118819:G:A | - | -0.0907253470561035 | 0.0293438909351824 | LUSC | Female-baised eQTL |
| rs17352236 | chr11:5065318:C:T | - | 0.0988611046941782 | 0.0295031099515147 | LUSC | Female-baised eQTL |
| rs2268166 | chr11:4104779:T:G | - | 0.11640560785322 | 0.032026267450257 | LUSC | Female-baised eQTL |
| rs144629990 | chr11:8399846:T:C | - | 0.121432317002639 | 0.0325495687889489 | LUSC | Female-baised eQTL |
| rs7108764 | chr11:10979083:G:A | - | -0.0979350413035998 | 0.0348524592883397 | LUSC | Female-baised eQTL |
| rs12416774 | chr11:11253515:G:T | - | 0.109207813049817 | 0.0350723970099941 | LUSC | Female-baised eQTL |
| rs12419491 | chr11:11253517:A:G | - | 0.109207813049817 | 0.0350723970099941 | LUSC | Female-baised eQTL |
| rs10498198 | chr11:4103501:G:C | - | 0.118902481431904 | 0.0353774480073396 | LUSC | Female-baised eQTL |
| rs11021760 | chr11:11291410:G:C | - | 0.094334329521284 | 0.0360144987683772 | LUSC | Female-baised eQTL |
| rs11021761 | chr11:11292074:T:C | - | 0.094334329521284 | 0.0360144987683772 | LUSC | Female-baised eQTL |
| rs72873903 | chr11:5051778:G:A | - | 0.0905035077117424 | 0.0371756998480444 | LUSC | Female-baised eQTL |
| rs72873913 | chr11:5056581:C:A | - | 0.0905035077117424 | 0.0371756998480444 | LUSC | Female-baised eQTL |
| rs11021719 | chr11:11240434:C:G | - | 0.104341269052868 | 0.0391204142758391 | LUSC | Female-baised eQTL |
| rs11529533 | chr11:13088124:T:C | - | 0.119719660142657 | 0.0391623914463518 | LUSC | Female-baised eQTL |
| rs6597956 | chr11:1132567:G:T | - | -0.0888086566258829 | 0.039226299546968 | LUSC | Female-baised eQTL |
| rs6484611 | chr11:11013068:G:C | - | -0.0950072205176345 | 0.041357403140618 | LUSC | Female-baised eQTL |
| rs7115818 | chr11:1123911:T:G | - | -0.0871407090092453 | 0.0424669554394557 | LUSC | Female-baised eQTL |
| rs61867476 | chr11:1125619:A:G | - | -0.0871407090092453 | 0.0424669554394557 | LUSC | Female-baised eQTL |
| rs11021756 | chr11:11289981:T:G | - | 0.0960583302496016 | 0.0433274983181923 | LUSC | Female-baised eQTL |
| rs6484588 | chr11:10988674:A:G | - | -0.0973744504207661 | 0.0452865745203432 | LUSC | Female-baised eQTL |
| rs16908492 | chr11:5015615:G:C | - | 0.090479790486429 | 0.0456836883854175 | LUSC | Female-baised eQTL |
| rs72860900 | chr11:5017205:C:T | - | 0.090479790486429 | 0.0456836883854175 | LUSC | Female-baised eQTL |
| rs72860901 | chr11:5017285:C:T | - | 0.090479790486429 | 0.0456836883854175 | LUSC | Female-baised eQTL |
| rs72862707 | chr11:5021349:A:G | - | 0.090479790486429 | 0.0456836883854175 | LUSC | Female-baised eQTL |
| rs71480731 | chr11:4841761:C:T | - | 0.0822221342902379 | 0.0456959574119545 | LUSC | Female-baised eQTL |
| rs34460105 | chr11:4841911:C:A | - | 0.0822221342902379 | 0.0456959574119545 | LUSC | Female-baised eQTL |
| rs35692639 | chr11:4842004:C:G | - | 0.0822221342902379 | 0.0456959574119545 | LUSC | Female-baised eQTL |
| rs12418180 | chr11:10759608:G:A | - | 0.101640455055008 | 0.0477465801982874 | LUSC | Female-baised eQTL |
| rs11042954 | chr11:10759737:T:G | - | 0.101640455055008 | 0.0477465801982874 | LUSC | Female-baised eQTL |
| rs12417080 | chr11:11289941:G:A | - | 0.0937301344119199 | 0.0478966069342288 | LUSC | Female-baised eQTL |
| rs10734209 | chr11:13117692:C:T | - | -0.108835008769584 | 0.0481878588404377 | LUSC | Female-baised eQTL |
| rs7950540 | chr11:12173414:A:G | - | 0.0991948902386608 | 0.0484439717775733 | LUSC | Female-baised eQTL |
| rs118014327 | chr11:7801311:A:G | - | 0.0954460252444906 | 0.0488006600627621 | LUSC | Female-baised eQTL |
| rs4910212 | chr11:10981290:A:C | - | -0.0938409323170094 | 0.0498445989801066 | LUSC | Female-baised eQTL |
| rs7924611 | chr11:12643076:G:C | - | 0.387510565000512 | 9.16848833426291e-05 | BLCA | Female-baised eQTL |
| rs4310606 | chr11:11521608:C:T | - | -0.176191430997573 | 0.0098387658708801 | BLCA | Female-baised eQTL |
| rs6578942 | chr11:8221623:C:T | - | 0.143492048071967 | 0.0169104886036161 | BLCA | Female-baised eQTL |
| rs4264145 | chr11:11520886:A:G | - | -0.160727251172951 | 0.0217177537861316 | BLCA | Female-baised eQTL |
| rs10766369 | chr11:16997297:G:C | - | -0.178798730390276 | 0.0265955145459291 | BLCA | Female-baised eQTL |
| rs11036885 | chr11:5335818:T:G | - | 0.0798667079826123 | 0.0426555864000926 | LUAD | Female-baised eQTL |
| rs75108468 | chr11:5335909:G:C | - | 0.0768779438799798 | 0.0454139624408497 | LUAD | Female-baised eQTL |
| rs79685089 | chr11:5428443:C:T | - | 0.0905265725288324 | 0.0477917063471026 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs72914876 | chr11:6767976:G:C | - | 0.0739581294165945 | 4.67704164441159e-05 | LGG | Male-baised eQTL |
| rs10838356 | chr11:5572115:G:A | - | 0.037142526808092 | 0.0147638921492368 | LGG | Male-baised eQTL |
| rs60119353 | chr11:5573273:A:G | - | 0.037142526808092 | 0.0147638921492368 | LGG | Male-baised eQTL |
| rs10838367 | chr11:5577430:A:T | - | 0.0365691338573865 | 0.0148046243632509 | LGG | Male-baised eQTL |
| rs10838369 | chr11:5577806:G:A | - | 0.0365691338573865 | 0.0148046243632509 | LGG | Male-baised eQTL |
| rs10838370 | chr11:5577811:G:A | - | 0.0365691338573865 | 0.0148046243632509 | LGG | Male-baised eQTL |
| rs10838362 | chr11:5575900:C:T | - | 0.0364887785905356 | 0.0156845013014018 | LGG | Male-baised eQTL |
| rs2595453 | chr11:6877264:T:C | - | 0.0561664060147534 | 0.0199008987104678 | LGG | Male-baised eQTL |
| rs4608110 | chr11:5566142:A:T | - | 0.0354662172896027 | 0.0244184429798035 | LGG | Male-baised eQTL |
| rs10838355 | chr11:5571992:C:T | - | 0.0354343446237893 | 0.0258907522934532 | LGG | Male-baised eQTL |
| rs139154156 | chr11:13937447:G:A | - | 0.0628799076557566 | 0.0312239957323501 | LGG | Male-baised eQTL |
| rs189988901 | chr11:13937863:G:A | - | 0.0628799076557566 | 0.0312239957323501 | LGG | Male-baised eQTL |
| rs9704834 | chr11:13938221:G:A | - | 0.0628799076557566 | 0.0312239957323501 | LGG | Male-baised eQTL |
| rs12281949 | chr11:5579198:T:G | - | 0.0331167682058243 | 0.038712198762596 | LGG | Male-baised eQTL |
| rs10838341 | chr11:5564514:A:G | - | 0.0332928424441312 | 0.040917605265117 | LGG | Male-baised eQTL |
| rs11024318 | chr11:17521006:C:T | - | 0.0562889578330187 | 0.0457055363331322 | LGG | Male-baised eQTL |
| rs1384641 | chr11:18867319:G:C | - | -0.0723745775192601 | 0.00544666931511359 | BLCA | Male-baised eQTL |
| rs10833012 | chr11:18871163:G:T | - | -0.0692481716345366 | 0.0120827460475388 | BLCA | Male-baised eQTL |
| rs1384640 | chr11:18867171:T:C | - | -0.0651813259406927 | 0.0199390852623704 | BLCA | Male-baised eQTL |
| rs1384642 | chr11:18867894:A:G | - | -0.0634083427000261 | 0.0389451001420698 | BLCA | Male-baised eQTL |
| rs72860404 | chr11:15245276:C:T | - | 0.0645031570406966 | 0.0034651427027792 | LUAD | Male-baised eQTL |
| rs72857795 | chr11:15243344:C:A | - | 0.0555962161863617 | 0.016815102674268 | LUAD | Male-baised eQTL |
| rs58227988 | chr11:15240003:C:G | - | 0.0537983610280071 | 0.0228825896015127 | LUAD | Male-baised eQTL |
| rs72857779 | chr11:15237790:C:A | - | 0.0534589850490926 | 0.0281849750525002 | LUAD | Male-baised eQTL |
| rs72857781 | chr11:15238821:C:G | - | 0.0534589850490926 | 0.0281849750525002 | LUAD | Male-baised eQTL |
| rs72857783 | chr11:15239515:A:G | - | 0.0532674590095476 | 0.0293415938162502 | LUAD | Male-baised eQTL |
| rs72857790 | chr11:15243285:G:C | - | 0.0510699914737106 | 0.0316608357032548 | LUAD | Male-baised eQTL |
| rs72860413 | chr11:15247246:C:T | - | 0.0518605751324744 | 0.049869861643257 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000175356 |
| CpG Site: cg26723045 | |
| Position to Gene: gene,exon,UTR | |
| Male Effect: - | |
| Female Effect: -0.47604470132989 | |
 | Gene ID: ENSG00000175356 |
| CpG Site: cg01081263 | |
| Position to Gene: gene | |
| Male Effect: -0.134133119311124 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg01081263 | chr11:9090924 | gene | -0.134133119311124 | 1.81520364218696e-06 | -0.34102655488285527 | 6.457641008479028e-09 | LUSC |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg26723045 | chr11:9021034 | gene,exon,UTR | -0.47604470132989 | 1.32008911987375e-13 | -0.4817280938706787 | 3.20217869309032e-16 | LUAD |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_68905 | chr11:9033625:9033796 | In-frame | rs2742540 | chr11:8877981:A:G | Distant downstream | 0.0143140576559058 | 0.0255044250988983 | LGG | Male-baised sQTL |
| exon_skip_68905 | chr11:9033625:9033796 | In-frame | rs7944560 | chr11:8795729:A:T | Distant downstream | 0.0143193141257997 | 0.0465026631289728 | LGG | Male-baised sQTL |
| exon_skip_68905 | chr11:9033625:9033796 | In-frame | rs6484484 | chr11:8795659:A:G | Distant downstream | 0.0136832768346695 | 0.0467905554980809 | LGG | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of SCUBE2 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
